{"id":"https://openalex.org/W2922556255","doi":"https://doi.org/10.1097/cji.0000000000000258","title":"Clinical Correlates of Response to Anti-PD-1\u2013based Therapy in Patients With Metastatic Melanoma","display_name":"Clinical Correlates of Response to Anti-PD-1\u2013based Therapy in Patients With Metastatic Melanoma","publication_year":2019,"publication_date":"2019-03-26","ids":{"openalex":"https://openalex.org/W2922556255","doi":"https://doi.org/10.1097/cji.0000000000000258","mag":"2922556255","pmid":"https://pubmed.ncbi.nlm.nih.gov/30882548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6561788"},"language":"en","primary_location":{"id":"doi:10.1097/cji.0000000000000258","doi":"https://doi.org/10.1097/cji.0000000000000258","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cji.0000000000000258","pdf_url":null,"source":{"id":"https://openalex.org/S177451610","display_name":"Journal of Immunotherapy","issn_l":"1524-9557","issn":["1524-9557","1537-4513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6561788","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068498659","display_name":"Elizabeth J. Davis","orcid":"https://orcid.org/0000-0001-7626-2435","observed_orcids":["https://orcid.org/0000-0001-7626-2435"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elizabeth J. Davis","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037409489","display_name":"Matthew C Perez","orcid":"https://orcid.org/0009-0005-5348-3020","observed_orcids":["https://orcid.org/0009-0005-5348-3020"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew C. Perez","raw_affiliation_strings":["Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063249211","display_name":"Noura Ayoubi","orcid":"https://orcid.org/0000-0001-6462-8620","observed_orcids":["https://orcid.org/0000-0001-6462-8620"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noura Ayoubi","raw_affiliation_strings":["Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084130453","display_name":"Shilin Zhao","orcid":"https://orcid.org/0000-0002-3921-3965","observed_orcids":["https://orcid.org/0000-0002-3921-3965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shilin Zhao","raw_affiliation_strings":["Biostatistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357202","display_name":"Fei Ye","orcid":"https://orcid.org/0000-0001-6472-5076","observed_orcids":["https://orcid.org/0000-0001-6472-5076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Ye","raw_affiliation_strings":["Biostatistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089223773","display_name":"Daniel Y. Wang","orcid":"https://orcid.org/0000-0002-3341-8652","observed_orcids":["https://orcid.org/0000-0002-3341-8652"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Y. Wang","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075566772","display_name":"Jeffrey Alan Sosman","orcid":"https://orcid.org/0000-0002-0650-9698","observed_orcids":["https://orcid.org/0000-0002-0650-9698"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Sosman","raw_affiliation_strings":["Department of Medicine, Northwestern University Medical Center and Robert H. Lurie Cancer Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Northwestern University Medical Center and Robert H. Lurie Cancer Center, Chicago, IL","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055625321","display_name":"Rami Nayef Al-Rohil","orcid":"https://orcid.org/0000-0002-9431-0530","observed_orcids":["https://orcid.org/0000-0002-9431-0530"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rami N. Al-Rohil","raw_affiliation_strings":["Pathology, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025872938","display_name":"Zeynep Eroglu","orcid":"https://orcid.org/0000-0002-2307-7030","observed_orcids":["https://orcid.org/0000-0002-2307-7030"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeynep Eroglu","raw_affiliation_strings":["Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025067315","display_name":"Douglas Buckner Johnson","orcid":"https://orcid.org/0000-0002-6390-773X","observed_orcids":["https://orcid.org/0000-0002-6390-773X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Douglas B. Johnson","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025067315","https://openalex.org/A5068498659","https://openalex.org/A5089223773"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9803,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8789138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"6","first_page":"221","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9520000219345093},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tumor-bulk","display_name":"tumor bulk","score":0.7360000014305115},{"id":"https://openalex.org/keywords/number-of-metastases","display_name":"number of metastases","score":0.7229999899864197},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6819999814033508},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.873578667640686},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.8699546456336975},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.758455753326416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6471316814422607},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5591663718223572},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.5207238793373108},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4008338749408722},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35386353731155396},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3480478823184967},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16457483172416687}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/cji.0000000000000258","doi":"https://doi.org/10.1097/cji.0000000000000258","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cji.0000000000000258","pdf_url":null,"source":{"id":"https://openalex.org/S177451610","display_name":"Journal of Immunotherapy","issn_l":"1524-9557","issn":["1524-9557","1537-4513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy","raw_type":"journal-article"},{"id":"pmid:30882548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30882548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunotherapy (Hagerstown, Md. : 1997)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6561788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6561788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6561788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6561788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunother","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G26160426","display_name":"Predicting and profiling long-term survival after immune checkpoint inhibition","funder_award_id":"K23CA204726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6907566170","display_name":"Novel mechanisms and predictors of VEGF receptor inhibitor-associated hypertension","funder_award_id":"R01HL141466","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000083166","display_name":"Vanderbilt Clinical Oncology Research Career Development Award","funder_award_id":"K12CA090625","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000919000","display_name":"Long-Term Cardiovascular Sequelae of Cancer Immunotherapies","funder_award_id":"R01HL155990","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W2097995306","https://openalex.org/W2152897456","https://openalex.org/W2160834915","https://openalex.org/W2166662937","https://openalex.org/W2299181842","https://openalex.org/W2301707196","https://openalex.org/W2338494814","https://openalex.org/W2344221521","https://openalex.org/W2515516401","https://openalex.org/W2519107733","https://openalex.org/W2519469881","https://openalex.org/W2526607882","https://openalex.org/W2529040040","https://openalex.org/W2560367415","https://openalex.org/W2572174216","https://openalex.org/W2581283430","https://openalex.org/W2605630275","https://openalex.org/W2607272476","https://openalex.org/W2655262992","https://openalex.org/W2753432434","https://openalex.org/W2768434636","https://openalex.org/W2784063247","https://openalex.org/W2801510798"],"related_works":["https://openalex.org/W2890914137","https://openalex.org/W2675844807","https://openalex.org/W4211025067","https://openalex.org/W2725149089","https://openalex.org/W2607272476","https://openalex.org/W2600280744","https://openalex.org/W2214678638","https://openalex.org/W3081802418","https://openalex.org/W3171392184","https://openalex.org/W4387811017"],"abstract_inverted_index":{"Anti-PD-1":[0],"agents,":[1],"alone":[2],"or":[3,41],"in":[4,11,109,194,197,218,222],"combination":[5],"with":[6,19,58,70,83,94,111,115,117,134,163,171,179,215,226],"ipilimumab,":[7],"produce":[8],"durable":[9],"responses":[10],"some":[12],"melanoma":[13,31],"patients.":[14],"Tumor":[15,202],"features":[16],"that":[17],"correlate":[18],"response":[20,59],"are":[21],"not":[22,169,186,191,221],"well":[23],"defined.":[24],"We":[25,44],"collected":[26],"clinical":[27,216,229],"data":[28],"from":[29],"metastatic":[30],"patients":[32,110,161],"treated":[33,162],"at":[34],"2":[35],"centers":[36],"who":[37],"received":[38],"anti-PD-1":[39,106,219],"(n=303)":[40],"anti-PD-1+ipilimumab":[42],"(n=57).":[43],"correlated":[45],"number":[46,152,174],"of":[47,50,72,127,153,175,207,235],"metastases,":[48,148,154],"diameter":[49,71,206],"largest":[51,73,84,129,208],"tumor":[52,74,85,130,166],"(tumor":[53],"bulk),":[54],"and":[55,65,139,155,182,212],"organ":[56],"involvement":[57],"rate":[60],"(RR),":[61],"progression-free":[62],"survival":[63,67],"(PFS),":[64],"overall":[66],"(OS).":[68],"Patients":[69],"\u22642":[75],"cm":[76,87],"had":[77,88,97],"a":[78,89],"53%":[79],"RR,":[80],"whereas":[81,142],"those":[82,116],">2":[86],"38%":[90],"RR":[91,99,104,140,183],"(P=0.009).":[92],"Those":[93],"liver":[95,147],"metastases":[96,113,176],"lower":[98],"(25%":[100],"vs.":[101,120],"43%;":[102],"P=0.002).":[103],"to":[105],"was":[107,131,168,177,210],"greater":[108],"\u226410":[112],"compared":[114],">10":[118],"(39%":[119],"27%;":[121],"P=0.027).":[122],"In":[123,160,224],"multivariable":[124],"analyses,":[125],"size":[126],"the":[128],"independently":[132,213],"associated":[133,170,178,214],"PFS":[135,180],"(P=0.0005),":[136],"OS":[137],"(P<0.0001),":[138],"(P=0.02),":[141],"AJCC":[143],"stage,":[144],"lactate":[145],"dehydrogenase,":[146],"ECOG":[149],"performance":[150],"status,":[151],"prior":[156],"therapies":[157],"were":[158],"not.":[159],"anti-PD-1+ipilimumab,":[164],"however,":[165],"bulk":[167],"outcomes,":[172],"although":[173],"(P=0.035)":[181],"(P=0.009)":[184],"but":[185,220],"OS.":[187],"Pathologic":[188],"analysis":[189],"did":[190],"reveal":[192],"differences":[193],"T-cell":[195],"infiltration":[196],"bulky":[198],"versus":[199],"small":[200],"tumors.":[201],"bulk,":[203],"defined":[204],"by":[205],"tumor,":[209],"strongly":[211],"outcomes":[217],"anti-PD-1+ipilimumab.":[223],"conjunction":[225],"molecular":[227],"biomarkers,":[228],"predictors":[230],"may":[231],"help":[232],"guide":[233],"selection":[234],"immunotherapy":[236],"agents.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-01T00:00:00"}
