{"id":"https://openalex.org/W2922229986","doi":"https://doi.org/10.3892/ol.2019.10148","title":"TP53BP2 decreases cell proliferation and induces autophagy in neuroblastoma cell lines","display_name":"TP53BP2 decreases cell proliferation and induces autophagy in neuroblastoma cell lines","publication_year":2019,"publication_date":"2019-03-15","ids":{"openalex":"https://openalex.org/W2922229986","doi":"https://doi.org/10.3892/ol.2019.10148","mag":"2922229986","pmid":"https://pubmed.ncbi.nlm.nih.gov/31186708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6507348"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2019.10148","doi":"https://doi.org/10.3892/ol.2019.10148","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2019.10148","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2019.10148/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/ol.2019.10148/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yi Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280019","display_name":"Chongqing Three Gorges Medical College","ror":"https://ror.org/02ahdxf84","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280019"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Pang","raw_affiliation_strings":["Chongqing Engineering Research Center of Antitumor Natural Drugs, Chongqing Three Gorges Medical College, Chongqing 404110, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Engineering Research Center of Antitumor Natural Drugs, Chongqing Three Gorges Medical College, Chongqing 404110, P.R. China","institution_ids":["https://openalex.org/I4405280019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013095807","display_name":"Lianhong Pan","orcid":"https://orcid.org/0000-0002-2788-8455","observed_orcids":["https://orcid.org/0000-0002-2788-8455","https://orcid.org/0000-0002-5108-0763"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianhong Pan","raw_affiliation_strings":["National Innovation and Attracting Talents \u2018111\u2019 Base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering Chongqing University, Chongqing 400030, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Innovation and Attracting Talents \u2018111\u2019 Base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering Chongqing University, Chongqing 400030, P.R. China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340700","display_name":"Yonghui Zhang","orcid":"https://orcid.org/0000-0001-9559-4793","observed_orcids":["https://orcid.org/0000-0001-9559-4793"]},"institutions":[{"id":"https://openalex.org/I4405280019","display_name":"Chongqing Three Gorges Medical College","ror":"https://ror.org/02ahdxf84","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280019"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghui Zhang","raw_affiliation_strings":["Chongqing Engineering Research Center of Antitumor Natural Drugs, Chongqing Three Gorges Medical College, Chongqing 404110, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Engineering Research Center of Antitumor Natural Drugs, Chongqing Three Gorges Medical College, Chongqing 404110, P.R. China","institution_ids":["https://openalex.org/I4405280019"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013264160","display_name":"Guiyuan Liu","orcid":"https://orcid.org/0009-0001-0192-8455","observed_orcids":["https://orcid.org/0009-0001-0192-8455"]},"institutions":[{"id":"https://openalex.org/I4405280019","display_name":"Chongqing Three Gorges Medical College","ror":"https://ror.org/02ahdxf84","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280019"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guiyuan Liu","raw_affiliation_strings":["General Surgery Department, The Affiliated Hospital of Chongqing Three Gorges Medical College, Chongqing 404110, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery Department, The Affiliated Hospital of Chongqing Three Gorges Medical College, Chongqing 404110, P.R. China","institution_ids":["https://openalex.org/I4405280019"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013264160"],"corresponding_institution_ids":["https://openalex.org/I4405280019"],"apc_list":null,"apc_paid":null,"fwci":0.1119,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.45247216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"17","issue":"6","first_page":"4976","last_page":"4984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53bp2","display_name":"TP53BP2","score":1.0},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.921999990940094},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.996999979019165},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.7590000033378601},{"id":"https://openalex.org/keywords/atg3","display_name":"ATG3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":1.0},{"id":"https://openalex.org/keywords/atg7","display_name":"ATG7","score":1.0},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6790000200271606},{"id":"https://openalex.org/keywords/be-2-c-cells","display_name":"BE(2)-C cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8437774181365967},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.7784421443939209},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7399815917015076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6658363342285156},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6416671276092529},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5733109712600708},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5716827511787415},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5029520392417908},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5026862621307373},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.500380277633667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45946526527404785},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.43529263138771057},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42781126499176025},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.41709062457084656},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4141272008419037},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4131263494491577},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.34812015295028687},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.23160690069198608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18415260314941406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06512528657913208}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/ol.2019.10148","doi":"https://doi.org/10.3892/ol.2019.10148","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2019.10148","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2019.10148/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmid:31186708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31186708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6507348","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6507348/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ol.2019.10148","doi":"https://doi.org/10.3892/ol.2019.10148","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2019.10148","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2019.10148/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2922229986.pdf","grobid_xml":"https://content.openalex.org/works/W2922229986.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1778801908","https://openalex.org/W1964587150","https://openalex.org/W1974233363","https://openalex.org/W1979562942","https://openalex.org/W1985124617","https://openalex.org/W1985547691","https://openalex.org/W1991692801","https://openalex.org/W1993679773","https://openalex.org/W2001087201","https://openalex.org/W2011716233","https://openalex.org/W2012687605","https://openalex.org/W2017268708","https://openalex.org/W2025364264","https://openalex.org/W2025684895","https://openalex.org/W2028536701","https://openalex.org/W2047721594","https://openalex.org/W2047937356","https://openalex.org/W2051678636","https://openalex.org/W2068374753","https://openalex.org/W2068451609","https://openalex.org/W2069552272","https://openalex.org/W2079547337","https://openalex.org/W2085545862","https://openalex.org/W2094302288","https://openalex.org/W2095296988","https://openalex.org/W2100434800","https://openalex.org/W2107277218","https://openalex.org/W2114201316","https://openalex.org/W2114360920","https://openalex.org/W2118071133","https://openalex.org/W2123275987","https://openalex.org/W2124050431","https://openalex.org/W2146987863","https://openalex.org/W2170979457","https://openalex.org/W2192385891","https://openalex.org/W2345989225","https://openalex.org/W2407254046","https://openalex.org/W2534820515","https://openalex.org/W2606075134","https://openalex.org/W2754676266","https://openalex.org/W4240244794"],"related_works":["https://openalex.org/W2782235483","https://openalex.org/W4295854121","https://openalex.org/W2914826282","https://openalex.org/W4408678709","https://openalex.org/W4416398297","https://openalex.org/W2996764335","https://openalex.org/W7119388274","https://openalex.org/W4410152536","https://openalex.org/W2912713821","https://openalex.org/W1985410389"],"abstract_inverted_index":{"Tumor":[0],"protein":[1,3,11,82],"p53-binding":[2],"2":[4],"(TP53BP2),":[5],"a":[6,89],"member":[7],"of":[8,12,30,35,45,54,61,159,180,188,197,219,238,265,269],"the":[9,28,33,46,52,57,76,121,140,157,177,181,189,194,211,235,249],"apoptosis-stimulating":[10],"p53":[13],"(ASPP)":[14],"family,":[15],"has":[16,39],"previously":[17],"been":[18,41],"reported":[19],"to":[20,27,50],"be":[21,172,226],"associated":[22,155,199,227,261],"with":[23,156,161,186,200,223,228,262],"tumor":[24],"development.":[25],"However,":[26],"best":[29],"our":[31],"knowledge,":[32],"role":[34],"TP53BP2":[36,55,152,170,220],"in":[37,56,174,210,221],"neuroblastoma":[38,224,239],"not":[40],"elucidated.":[42],"The":[43],"aim":[44],"present":[47],"study":[48],"was":[49,73,86,93,99,112,154],"investigate":[51],"function":[53],"proliferation":[58,92],"and":[59,79,117,120,130,165,193,207,231,243,254,259],"autophagy":[60,266],"neuroblastoma.":[62,162],"An":[63],"expression":[64,110,135,153,195,218,256],"vector":[65],"that":[66,151,169,187],"expresses":[67],"TP53BP2-specific":[68],"short":[69,83],"hairpin":[70,84],"RNA":[71,85],"(shTP53BP2)":[72],"used":[74,87],"for":[75],"experimental":[77,182,212],"group":[78,183,191],"green":[80],"fluorescent":[81],"as":[88,176],"control.":[90],"Cell":[91],"measured":[94],"using":[95,101,139],"MTT":[96],"assays,":[97,104],"self-renewal":[98],"evaluated":[100],"soft":[102],"agar":[103],"light":[105],"chain":[106,144],"3":[107,123],"(LC3)":[108],"II":[109],"level":[111],"examined":[113,138],"by":[114],"western":[115],"blot":[116,164],"immunofluorescence":[118],"analysis,":[119],"autophagy-related":[122,126,131],"homolog":[124,128,133],"(ATG3),":[125],"5":[127],"(ATG5)":[129],"9":[132],"(ATG7)":[134],"levels":[136,196,257],"were":[137,260],"reverse":[141],"transcription-quantitative":[142],"polymerase":[143],"reaction":[145],"(RT-qPCR).":[146],"A":[147],"genomics":[148],"analysis":[149],"revealed":[150],"survival":[158,230],"patients":[160,222],"Western":[163],"RT-qPCR":[166],"assays":[167],"indicated":[168],"could":[171],"implicated":[173],"neuroblastoma,":[175],"proliferative":[178,236],"ability":[179],"decreased":[184],"compared":[185],"control":[190],"(P<0.001)":[192],"genes":[198],"autophagy,":[201],"including":[202,241],"LC3":[203,250],"II.":[204],"ATG3,":[205,252],"ATG5":[206,253],"ATG7,":[208],"increased":[209,217,258,263],"group.":[213],"In":[214,247],"conclusion,":[215],"an":[216],"may":[225,233],"poor":[229],"shTP53BP2":[232],"decrease":[234],"abilities":[237],"cells,":[240],"BE(2)C":[242],"SK-N-DZ":[244],"cell":[245],"lines.":[246],"addition,":[248],"II,":[251],"ATG7":[255],"rates":[264],"following":[267],"upregulation":[268],"TP53BP2.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-03-22T00:00:00"}