{"id":"https://openalex.org/W2922155282","doi":"https://doi.org/10.1182/blood-2018-99-116858","title":"Hotspot Mutations in SF3B1 Result in Increased Alternative Splicing in Multiple Myeloma and Activation of Key Cellular Pathways","display_name":"Hotspot Mutations in SF3B1 Result in Increased Alternative Splicing in Multiple Myeloma and Activation of Key Cellular Pathways","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2922155282","doi":"https://doi.org/10.1182/blood-2018-99-116858","mag":"2922155282"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-116858","doi":"https://doi.org/10.1182/blood-2018-99-116858","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-116858","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007618693","display_name":"Michael Bauer","orcid":"https://orcid.org/0000-0003-2498-7295","observed_orcids":["https://orcid.org/0000-0003-2498-7295"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Bauer","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090728387","display_name":"Cody Ashby","orcid":"https://orcid.org/0000-0002-9361-0283","observed_orcids":["https://orcid.org/0000-0002-9361-0283"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cody Ashby","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133067","display_name":"Christopher P. Wardell","orcid":"https://orcid.org/0000-0002-9416-7818","observed_orcids":["https://orcid.org/0000-0002-9416-7818"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Wardell","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103016880","display_name":"Mar\u00eda Ortiz","orcid":"https://orcid.org/0000-0002-8973-0493","observed_orcids":["https://orcid.org/0000-0002-8973-0493"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Ortiz","raw_affiliation_strings":["CITRE, Celgene Corporation, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CITRE, Celgene Corporation, Sevilla, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000244748","display_name":"Erin Flynt","orcid":"https://orcid.org/0000-0002-1524-6156","observed_orcids":["https://orcid.org/0000-0002-1524-6156"]},"institutions":[{"id":"https://openalex.org/I4387155837","display_name":"Celgene (United States)","ror":"https://ror.org/0527yg379","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387155837"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erin Flynt","raw_affiliation_strings":["Translational Development and Diagnostics, Celgene Corporation, Summit, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Development and Diagnostics, Celgene Corporation, Summit, NJ","institution_ids":["https://openalex.org/I4387155837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028526208","display_name":"Anjan Thakurta","orcid":"https://orcid.org/0000-0003-0415-1706","observed_orcids":["https://orcid.org/0000-0003-0415-1706"]},"institutions":[{"id":"https://openalex.org/I4387155837","display_name":"Celgene (United States)","ror":"https://ror.org/0527yg379","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387155837"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anjan Thakurta","raw_affiliation_strings":["Celgene Corporation, Summit, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Summit, NJ","institution_ids":["https://openalex.org/I4387155837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth Morgan","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A Walker","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000244748","https://openalex.org/A5028526208","https://openalex.org/A5084133067","https://openalex.org/A5090728387","https://openalex.org/A5103016880"],"corresponding_institution_ids":["https://openalex.org/I4387155837","https://openalex.org/I79620101"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"4454","last_page":"4454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.16850000619888306,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sf3b1","display_name":"SF3B1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.8809999823570251},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9879999756813049},{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.8330000042915344},{"id":"https://openalex.org/keywords/isoform-switching","display_name":"isoform switching","score":0.7149999737739563},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6349999904632568},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.753000020980835},{"id":"https://openalex.org/keywords/ackr3","display_name":"CXCR7","score":0.9480000138282776},{"id":"https://openalex.org/keywords/crlf2","display_name":"CRLF2","score":0.996999979019165},{"id":"https://openalex.org/keywords/cellular-pathways","display_name":"cellular pathways","score":0.3160000145435333},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5080000162124634},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6848387718200684},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6050189733505249},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6019544005393982},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5807289481163025},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5759909749031067},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.54128497838974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5108970999717712},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.4814407229423523},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4749082326889038},{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.4746706485748291},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.422852098941803},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38929688930511475},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.38601934909820557},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38112396001815796},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.33127692341804504},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3087460398674011}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-116858","doi":"https://doi.org/10.1182/blood-2018-99-116858","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-116858","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1550983741","https://openalex.org/W2409349325","https://openalex.org/W2907120738","https://openalex.org/W2979999409","https://openalex.org/W4402549085","https://openalex.org/W4417009181","https://openalex.org/W3008919229","https://openalex.org/W2979716842","https://openalex.org/W3011151725","https://openalex.org/W2549135197"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Mutations":[2],"in":[3,18,33,44,48,54,63,69,221,228,336,393,410,510,519,522,542,574,600],"the":[4,7,65,75,79,117,120,124,139,204,212,229,240,256,261,296,299,314,329,411,440,530,550,553,580],"components":[5],"of":[6,67,84,111,119,143,217,223,232,239,324,398,429,478,487,505,525,532,552,566,591,597],"spliceosome":[8],"have":[9],"been":[10,60],"shown":[11],"to":[12,115,127,173,246,260,423,435,452,576],"occur":[13],"at":[14,278,304,439],"relatively":[15],"high":[16],"frequency":[17],"many":[19,284],"cancers":[20,512],"such":[21],"as":[22,448,462,464,527,529,547,549],"chronic":[23],"lymphocytic":[24],"leukemia,":[25],"myelodysplastic":[26],"syndromes":[27],"and":[28,62,71,101,103,126,170,179,186,195,197,234,298,321,331,338,352,428,469,490,502,582],"breast":[29],"cancer.":[30],"One":[31],"component":[32],"particular,":[34],"encoded":[35],"by":[36,492],"SF3B1,":[37],"has":[38,58],"hotspot":[39,265,301,540],"missense":[40],"mutations":[41,68,98,107,122,220,227,266,518,541],"that":[42,167,273,286,402,444,538,589],"result":[43,521],"a":[45,165,476],"significant":[46,339,472,485],"increase":[47],"alternatively":[49],"spliced":[50,427],"transcripts.":[51,253],"RNA":[52],"splicing":[53,189,399,418,446,489,524,546,557],"Multiple":[55],"Myeloma":[56],"(MM)":[57],"not":[59,250,288,433],"investigated":[61],"particular":[64],"extent":[66],"SF3B1":[70,106,121,144,222,242,300,332,394,412,520,539,603],"its":[72],"effects":[73],"on":[74,123],"transcriptome.":[76],"Methods:":[77],"Using":[78,132],"MMRF":[80],"CoMMpass":[81],"dataset":[82],"(N=1273)":[83],"newly":[85],"diagnosed":[86],"MM":[87,156,543],"patients,":[88],"samples":[89,104,137,150,218,244,248,263,568],"with":[90,105,134,264,475,483,513,602],"whole":[91],"exome":[92],"sequencing":[93],"(WES)":[94],"were":[95,113,152,274,334,406,432,460,497],"analyzed":[96,163],"for":[97,154,198],"using":[99,164],"Strelka":[100],"Mutect,":[102],"identified.":[108],"A":[109],"range":[110],"approaches":[112],"used":[114,335],"explore":[116],"effect":[118],"transcriptome":[125],"determine":[128],"possible":[129],"downstream":[130],"effects.":[131],"RNA-seq":[133,160],"matched":[135,153],"WES":[136,213],"(n=615),":[138],"splice":[140,404,458,467,534],"junction":[141],"usage":[142,191,474],"mutants":[145,302,333,413],"was":[146,162,208,258],"compared":[147,245],"against":[148],"non-mutated":[149,247],"which":[151,224,312,506],"key":[155,570],"molecular":[157],"sub-types.":[158],"The":[159,481,536],"data":[161,214],"pipeline":[166],"included":[168,313],"STAR":[169],"Salmon,":[171],"aligning":[172],"human":[174],"reference":[175],"genome":[176],"hg38,":[177],"gene":[178,268,292,326,441,453],"transcript":[180],"differential":[181,188,267,325,473],"expression":[182,269,293,454,564],"analysis":[183,238,257,327,419,565],"tools":[184,192],"DESeq2":[185],"StringTie/Ballgown,":[187],"exon":[190,471],"JunctionSeq/QoRTs,":[193],"DEXSeq,":[194],"SUPPA":[196],"Gene":[199,563],"Set":[200],"Enrichment":[201],"Analysis":[202],"(GSEA)":[203],"R":[205],"package":[206],"FGSEA":[207],"used.":[209],"Results:":[210],"From":[211],"1.7%":[215],"(22/1273)":[216],"had":[219,226],"5":[225,262],"hotpot":[230],"codons":[231],"K666":[233],"K700.":[235],"Differential":[236,417],"isoform":[237,310],"22":[241],"mutant":[243,395],"did":[249,287,303],"identify":[251],"any":[252],"However,":[254],"when":[255],"restricted":[259],"identified":[270,366],"146":[271],"genes":[272,285,317,422,482,526,554],"significantly":[275,407,425],"differentially":[276,426,437],"expressed":[277,438],"an":[279,290],"adjusted":[280],"p-value":[281,477],"<0.05.":[282],"Additionally,":[283],"show":[289],"overall":[291],"change":[294],"between":[295,328],"control":[297,330,415],"transcriptional":[305],"level":[306],"where":[307],"we":[308],"observed":[309],"switching":[311],"protein":[315,346,354,583],"coding":[316],"BCL2L1,":[318,503],"SNUR,":[319],"ACKR3":[320],"CRLF2.":[322],"Results":[323],"GSEA":[337,365],"normalized":[340],"enrichment":[341],"scores":[342],"(NES)":[343],"identifying":[344],"increased":[345],"secretion":[347,584],"(p-value":[348,357,369,377,387],"=0.009,":[349],"NES=":[350,390],"1.9)":[351],"unfolded":[353],"response":[355,575],"(UPR)":[356],"=":[358,361,370,373,378,381,388],"0.02,":[359],"NES":[360,372,380],"1.52)":[362],"pathways.":[363,585],"Conversely":[364],"decreased":[367],"apoptosis":[368],"0.008,":[371,379,389],"-1.76),":[374],"KRAS":[375],"signaling":[376,384],"-1.92),":[382],"TNFA":[383],"via":[385],"NF-\u03baB":[386],"2.12)":[391],"pathways":[392,593],"samples.":[396,416],"Investigation":[397],"loci":[400,405],"revealed":[401],"novel":[403,457,533,560],"more":[408,493],"abundant":[409],"versus":[414],"detected":[420],"474":[421],"be":[424,436],"those":[430],"311":[431],"found":[434,491],"level,":[442],"indicating":[443],"alternative":[445,450,488,523,545,556,577],"is":[447],"important":[449],"mechanism":[451],"differences.":[455],"59":[456],"sites":[459,468],"identified,":[461],"well":[463,528,548],"152":[465],"known":[466],"218":[470],"<":[479],"0.05.":[480],"most":[484],"levels":[486],"than":[494],"one":[495],"approach":[496],"DYNLL1,":[498],"TMEM14C,":[499],"CRNDE,":[500],"BRD4":[501],"several":[504],"are":[507,594],"also":[508],"seen":[509],"other":[511],"mutated":[514],"SF3B1.":[515],"Conclusions:":[516],"Hotspot":[517],"introduction":[531],"sites.":[535],"confirmation":[537],"increases":[544],"identification":[551],"undergoing":[555],"may":[558],"present":[559],"therapeutic":[561,598],"targets.":[562],"these":[567,592],"identifies":[569],"deregulated":[571],"pathways,":[572],"perhaps":[573],"splicing,":[578],"including":[579],"UPR":[581],"These":[586],"analyses":[587],"indicate":[588],"disruption":[590],"potential":[595],"avenues":[596],"intervention":[599],"patients":[601],"mutations.":[604],"Disclosures":[605],"Ortiz:":[606],"Celgene":[607],"Corporation:":[608,613,618],"Employment,":[609,614,619],"Equity":[610,615,620],"Ownership.":[611,616,621],"Flynt:Celgene":[612],"Thakurta:Celgene":[617],"Morgan:Celgene:":[622],"Consultancy,":[623,628,635],"Honoraria,":[624],"Research":[625,631],"Funding;":[626,632],"Takeda:":[627],"Honoraria;":[629],"Janssen:":[630],"Bristol-Myers":[633],"Squibb:":[634],"Honoraria.":[636]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-03-22T00:00:00"}