{"id":"https://openalex.org/W2922136149","doi":"https://doi.org/10.2337/dc18-2173","title":"Uric Acid Is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Events, and Mortality in Patients With Type 1 Diabetes","display_name":"Uric Acid Is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Events, and Mortality in Patients With Type 1 Diabetes","publication_year":2019,"publication_date":"2019-03-18","ids":{"openalex":"https://openalex.org/W2922136149","doi":"https://doi.org/10.2337/dc18-2173","mag":"2922136149","pmid":"https://pubmed.ncbi.nlm.nih.gov/30885950"},"language":"en","primary_location":{"id":"doi:10.2337/dc18-2173","doi":"https://doi.org/10.2337/dc18-2173","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc18-2173","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007062347","display_name":"Sascha Pilemann-Lyberg","orcid":"https://orcid.org/0000-0001-6546-9502","observed_orcids":["https://orcid.org/0000-0001-6546-9502"]},"institutions":[{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Sascha Pilemann-Lyberg","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6546-9502","affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016588114","display_name":"Tine W. Hansen","orcid":"https://orcid.org/0000-0003-2274-0352","observed_orcids":["https://orcid.org/0000-0003-2274-0352","https://orcid.org/0000-0003-3241-047X"]},"institutions":[{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tine Willum Hansen","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074649341","display_name":"Nete Tofte","orcid":"https://orcid.org/0000-0002-5331-9168","observed_orcids":["https://orcid.org/0000-0002-5331-9168"]},"institutions":[{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nete Tofte","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5331-9168","affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072393536","display_name":"Signe Abitz Winther","orcid":"https://orcid.org/0000-0001-7949-0193","observed_orcids":["https://orcid.org/0000-0001-7949-0193"]},"institutions":[{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Signe Abitz Winther","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064636487","display_name":"Simone Theilade","orcid":"https://orcid.org/0000-0002-1151-8951","observed_orcids":["https://orcid.org/0000-0002-1151-8951"]},"institutions":[{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Simone Theilade","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022907613","display_name":"Tarunveer S. Ahluwalia","orcid":"https://orcid.org/0000-0002-7464-3354","observed_orcids":["https://orcid.org/0000-0002-7464-3354"]},"institutions":[{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tarunveer Singh Ahluwalia","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085592050","display_name":"Peter R Rossing","orcid":"https://orcid.org/0000-0002-1531-4294","observed_orcids":["https://orcid.org/0000-0002-1531-4294","https://orcid.org/0009-0004-5073-0009"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Rossing","raw_affiliation_strings":["Steno Diabetes Center Copenhagen, Gentofte, Denmark","University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]},{"raw_affiliation_string":"University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007062347"],"corresponding_institution_ids":["https://openalex.org/I4405255865"],"apc_list":null,"apc_paid":null,"fwci":9.4382,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.98703428,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"42","issue":"6","first_page":"1088","last_page":"1094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.8709999918937683},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9120000004768372},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.906000018119812},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9760000109672546},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cardiovascular-risk-stratification","display_name":"cardiovascular risk stratification","score":0.5879999995231628},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.5479999780654907},{"id":"https://openalex.org/keywords/mortality-risk-stratification","display_name":"mortality risk stratification","score":0.4690000116825104},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.948593258857727},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.7161918878555298},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7066852450370789},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7000159621238708},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.6890567541122437},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6406676769256592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6235763430595398},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.423959881067276},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4184833765029907}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/dc18-2173","doi":"https://doi.org/10.2337/dc18-2173","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc18-2173","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:30885950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30885950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/fb1b95ca-59e6-462f-9730-fb78b45ee81a","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/fb1b95ca-59e6-462f-9730-fb78b45ee81a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pilemann-Lyberg, S, Hansen, T W, Tofte, N, Winther, S A, Theilade, S, Ahluwalia, T S & Rossing, P 2019, 'Uric acid is an independent risk factor for decline in kidney function, cardiovascular events, and mortality in patients with type 1 diabetes', Diabetes Care, vol. 42, no. 6, pp. 1088-1094. https://doi.org/10.2337/dc18-2173","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2131293949","display_name":null,"funder_award_id":"NNF18OC0052457","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G6433152044","display_name":null,"funder_award_id":"SDCC 3.A Complications","funder_id":"https://openalex.org/F4320318293","funder_display_name":"Steno Diabetes Center Copenhagen"}],"funders":[{"id":"https://openalex.org/F4320318293","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1981055539","https://openalex.org/W1983296586","https://openalex.org/W1990962727","https://openalex.org/W2012967253","https://openalex.org/W2019158416","https://openalex.org/W2025768469","https://openalex.org/W2064102791","https://openalex.org/W2077303357","https://openalex.org/W2078718265","https://openalex.org/W2079911401","https://openalex.org/W2101634568","https://openalex.org/W2102924526","https://openalex.org/W2106403351","https://openalex.org/W2108093474","https://openalex.org/W2113961225","https://openalex.org/W2115016000","https://openalex.org/W2119433336","https://openalex.org/W2122730408","https://openalex.org/W2122983268","https://openalex.org/W2123162884","https://openalex.org/W2130062878","https://openalex.org/W2132895884","https://openalex.org/W2147108549","https://openalex.org/W2150619497","https://openalex.org/W2155965977","https://openalex.org/W2164240578","https://openalex.org/W2168192831","https://openalex.org/W2169195258","https://openalex.org/W2170667494","https://openalex.org/W2462733001","https://openalex.org/W2782606497","https://openalex.org/W2788881346","https://openalex.org/W2797693754","https://openalex.org/W2971885093","https://openalex.org/W2977728615","https://openalex.org/W2981496710","https://openalex.org/W3016145915","https://openalex.org/W3020049097"],"related_works":["https://openalex.org/W2989783128","https://openalex.org/W2990963021","https://openalex.org/W2168192831","https://openalex.org/W2788881346","https://openalex.org/W2797693754","https://openalex.org/W1996856882","https://openalex.org/W3202024584","https://openalex.org/W2922375772","https://openalex.org/W2808996430","https://openalex.org/W3035162481"],"abstract_inverted_index":{"OBJECTIVE":[0],"Previous":[1],"studies":[2],"have":[3],"provided":[4],"inconclusive":[5],"results":[6,314],"on":[7],"the":[8,22,27,33,156,216,224],"role":[9,321],"of":[10,26,30,35,68,76,86,110,139,155,171,175,236,300,309],"uric":[11],"acid":[12],"(UA)":[13],"in":[14,37,45,60,108,118,162,173,210,234,256,266,275,282,302,322],"risk":[15,34,170,221,299,311,323],"prediction.":[16],"Here":[17],"we":[18],"aimed":[19],"to":[20,73,215],"improve":[21],"power":[23],"and":[24,43,65,89,127,136,144,198,247,271,306],"precision":[25],"predictive":[28],"value":[29],"UA":[31,57,77,140,157,163,214,257,292,317],"for":[32,105,116,125,132,231,242,252],"decline":[36,85,107,172,233,265,301],"kidney":[38,303],"function,":[39,304],"cardiovascular":[40],"events":[41],"(CVEs),":[42],"mortality":[44,90,199],"patients":[46,62],"with":[47,63,78,141,167,262,288,296,327],"type":[48],"1":[49],"diabetes":[50],"(T1D).":[51],"RESEARCH":[52],"DESIGN":[53],"AND":[54],"METHODS":[55],"Plasma":[56],"was":[58,97,165,259],"measured":[59],"670":[61],"T1D":[64],"various":[66],"degrees":[67],"albuminuria,":[69],"ranging":[70],"from":[71],"normoalbuminuria":[72],"macroalbuminuria.":[74],"Associations":[75],"an":[79],"estimated":[80],"glomerular":[81],"filtration":[82],"rate":[83],"(eGFR)":[84],"\u226530%,":[87,111],"CVEs,":[88],"were":[91,146,151],"analyzed.":[92],"The":[93],"median":[94],"follow-up":[95],"time":[96],"5.3":[98],"years":[99,113,122,129],"[interquartile":[100],"range":[101],"(IQR)":[102],"2.7\u20136.2":[103],"years]":[104],"a":[106,168,232,263,272,290,297,319],"eGFR":[109,174,235,267],"5.8":[112],"(2.5\u20136.4":[114],"years)":[115,124,131],"progression":[117],"albuminuria":[119],"status,":[120],"5.1":[121],"(4.7\u20135.6":[123],"CVE,":[126,305],"6.2":[128],"(5.8\u20136.7":[130],"mortality.":[133,253],"Both":[134],"univariable":[135],"multivariable":[137],"associations":[138],"relevant":[142],"outcomes":[143],"variables":[145],"reported.":[147],"Hazard":[148],"ratios":[149],"(HRs)":[150],"calculated":[152],"per":[153],"doubling":[154,161,255],"level.":[158],"RESULTS":[159],"A":[160,254],"level":[164,258,293],"associated":[166,261,295],"higher":[169,291,298],"\u226530%":[176,237],"(n":[177,188,200],"=":[178,189,196,201,208,245,250],"89)":[179],"(HR":[180,191,203],"3.18":[181],"[IQR":[182,193,205],"1.71\u20135.93];":[183],"P":[184,195,207],"<":[185,239,269,280],"0.001),":[186,240],"CVE":[187,243],"94)":[190],"2.25":[192],"1.20\u20134.21];":[194],"0.011),":[197],"58)":[202],"2.58":[204],"1.12\u20135.90];":[206],"0.025)":[209],"adjusted":[211,217,283],"analyses.":[212],"Adding":[213],"model":[218],"including":[219],"conventional":[220],"factors":[222],"improved":[223],"relative":[225],"integrated":[226],"discrimination":[227],"index":[228],"by":[229],"12.6%":[230],"(P":[238,244,249,268,279],"6.5%":[241],"0.010),":[246],"11.8%":[248],"0.003)":[251],"also":[260],"steeper":[264,273],"0.0026)":[270],"increase":[274],"urine":[276],"albumin-to-creatinine":[277],"ratio":[278],"0.0027)":[281],"analysis.":[284],"CONCLUSIONS":[285],"In":[286],"individuals":[287,326],"T1D,":[289],"is":[294],"mortality,":[307],"independently":[308],"other":[310],"factors.":[312],"Our":[313],"suggest":[315],"that":[316],"has":[318],"promising":[320],"stratification":[324],"among":[325],"T1D.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-03-22T00:00:00"}