{"id":"https://openalex.org/W2922074784","doi":"https://doi.org/10.14309/00000434-201810001-00298","title":"Assessment of Risk Stratification and Genetic Testing of Patients Referred for Polyposis to a High-Risk Colorectal Cancer Prevention Program","display_name":"Assessment of Risk Stratification and Genetic Testing of Patients Referred for Polyposis to a High-Risk Colorectal Cancer Prevention Program","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2922074784","doi":"https://doi.org/10.14309/00000434-201810001-00298","mag":"2922074784"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201810001-00298","doi":"https://doi.org/10.14309/00000434-201810001-00298","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201810001-00298","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036833313","display_name":"Kiranmayi Bulusu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiranmayi Bulusu","raw_affiliation_strings":["Seattle Cancer Care Alliance, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA","institution_ids":["https://openalex.org/I1332479046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007907319","display_name":"Mercy Laurino","orcid":"https://orcid.org/0000-0001-7152-5048","observed_orcids":["https://orcid.org/0000-0001-7152-5048","https://orcid.org/0009-0000-2513-2884"]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mercy Laurino","raw_affiliation_strings":["Seattle Cancer Care Alliance, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA","institution_ids":["https://openalex.org/I1332479046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026291650","display_name":"Teri Brentnall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teri Brentnall","raw_affiliation_strings":["Seattle Cancer Care Alliance, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA","institution_ids":["https://openalex.org/I1332479046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021652174","display_name":"Robin L. Bennett","orcid":"https://orcid.org/0000-0001-6748-9582","observed_orcids":["https://orcid.org/0000-0001-6748-9582","https://orcid.org/0000-0002-4644-9933"]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Bennett","raw_affiliation_strings":["Seattle Cancer Care Alliance, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA","institution_ids":["https://openalex.org/I1332479046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030095493","display_name":"Neelendu Dey","orcid":"https://orcid.org/0000-0001-8825-5689","observed_orcids":["https://orcid.org/0000-0001-8825-5689"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelendu Dey","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068477057","display_name":"William M. Grady","orcid":"https://orcid.org/0000-0002-0129-7809","observed_orcids":["https://orcid.org/0000-0002-0129-7809"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Grady","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062531028","display_name":"Stacey A. Cohen","orcid":"https://orcid.org/0000-0002-6207-9856","observed_orcids":["https://orcid.org/0000-0002-6207-9856"]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Cohen","raw_affiliation_strings":["Seattle Cancer Care Alliance, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA","institution_ids":["https://openalex.org/I1332479046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"113","issue":"Supplement","first_page":"S165","last_page":"S165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-polyposis","display_name":"colorectal polyposis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/colorectal-cancer-risk-stratification","display_name":"colorectal cancer risk stratification","score":0.7820000052452087},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.824999988079071},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.6430000066757202},{"id":"https://openalex.org/keywords/colorectal-cancer-prevention","display_name":"colorectal cancer prevention","score":0.6449999809265137},{"id":"https://openalex.org/keywords/germline-pathogenic-variants","display_name":"germline pathogenic variants","score":0.7850000262260437},{"id":"https://openalex.org/keywords/familial-pancreatic-cancer","display_name":"familial pancreatic cancer","score":0.753000020980835},{"id":"https://openalex.org/keywords/polyp-recurrence","display_name":"polyp recurrence","score":0.5080000162124634},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9047446250915527},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.802221953868866},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.715277373790741},{"id":"https://openalex.org/C2776559941","wikidata":"https://www.wikidata.org/wiki/Q783644","display_name":"Lynch syndrome","level":5,"score":0.6330636143684387},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5988268852233887},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.5981168746948242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5964792966842651},{"id":"https://openalex.org/C206179267","wikidata":"https://www.wikidata.org/wiki/Q188952","display_name":"Medical history","level":2,"score":0.49587902426719666},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48988860845565796},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44136354327201843},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201810001-00298","doi":"https://doi.org/10.14309/00000434-201810001-00298","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201810001-00298","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2977571847","https://openalex.org/W3121640127","https://openalex.org/W2067976530","https://openalex.org/W125344700","https://openalex.org/W2567564184","https://openalex.org/W2026392412","https://openalex.org/W2969912460","https://openalex.org/W2410146843","https://openalex.org/W2979250948","https://openalex.org/W2989819958"],"abstract_inverted_index":{"Introduction:":[0],"Established":[1],"in":[2,78,93,140,147,173,330],"2004,":[3],"the":[4,55,68,79,84,218,268,275,288,303,324],"Seattle":[5],"Cancer":[6,10],"Care":[7],"Alliance":[8],"Gastrointestinal":[9],"Prevention":[11],"Program\u2019s":[12],"(GICPP)":[13],"goal":[14],"is":[15,52],"to":[16,53,67,187,322],"provide":[17],"personalized":[18],"cancer":[19,96,111],"risk":[20,31,57],"assessment,":[21],"screening,":[22],"and":[23,60,118,208,212,241,255],"prevention":[24],"recommendations":[25],"for":[26,32,42,89,222,285,306],"individuals":[27],"considered":[28],"at":[29,165],"higher-than-average":[30],"gastrointestinal":[33],"cancers.":[34],"To":[35],"date,":[36],"1358":[37],"patients":[38,65,148,174,183,220,276,289,304],"have":[39],"been":[40],"seen":[41,77,184],"a":[43,71,90,94,104,134,141,226],"variety":[44],"of":[45,49,64,73,103,115,122,143,198,205,210,229,235,246,253,262,267,287,302,315,348],"indications.":[46],"The":[47],"aim":[48],"this":[50],"study":[51],"characterize":[54],"post-clinic":[56],"stratification":[58],"assessment":[59],"genetic":[61,213,272,280,296],"testing":[62,214,282,297,352],"results":[63],"referred":[66,221,305],"GICP":[69],"with":[70,149,175,277,309],"diagnosis":[72,102],"polyposis.":[74,124],"Methods:":[75],"Patients":[76,339],"GICPP":[80],"were":[81,249],"classified":[82],"by":[83],"following:":[85],"1)":[86,129],"known":[87,150,155,176],"carrier":[88],"pathogenic":[91,158],"variant":[92,159],"colorectal":[95,123],"(CRC)":[97],"associated":[98],"gene":[99],"2)":[100,136],"clinical":[101],"familial":[105,109,151,156],"CRC":[106,152,316],"syndrome":[107],"3)":[108,145],"pancreatic":[110],"4)":[112,160],"family":[113,233,244,313],"history":[114,121,153,209,228,234,245,314],"multiple":[116],"cancers,":[117],"5)":[119,170],"personal":[120,207,227,311],"Polyposis":[125],"was":[126,189,193,283],"defined":[127],"by:":[128],"\u2265100":[130],"polyps":[131,139,146,164,254],"identified":[132],"during":[133],"colonoscopy":[135,144],">":[137],"10":[138],"series":[142],"or":[154,162,169,203,317],"germline":[157,350],"large":[161],"precancerous":[163],"an":[166,331],"early":[167],"age":[168],"recurrent":[171],"polyposis":[172,307],"CRC.":[177,247],"Retrospective":[178],"medical":[179],"review":[180,301],"analysis":[181],"on":[182,264],"from":[185,326],"2004":[186],"5/2018":[188],"conducted.":[190],"Clinical":[191],"information":[192],"descriptively":[194],"evaluated,":[195],"including":[196],"number":[197],"polyps,":[199],"pathological":[200],"diagnosis,":[201],"recurrence":[202],"development":[204],"CRC,":[206,230],"cancer,":[211],"outcomes.":[215],"Results:":[216],"Of":[217,274,291],"161":[219],"polyposis,":[223],"3.7%":[224],"had":[225,232,243,257,270,295],"24%":[231],"high-risk":[236,319],"cancers":[237,320],"and/or":[238],"Lynch":[239],"Syndrome":[240],"13.6%":[242],"8.1%":[248],"described":[250],"as":[251],"100\u2019s":[252],"28%":[256],"more":[258],"than":[259],"1":[260],"kind":[261],"polyp":[263],"pathology.":[265],"20%":[266],"referrals":[269],"prior":[271,279],"testing.":[273],"no":[278],"testing,":[281],"recommended":[284],"30%":[286],"(N=47).":[290],"these":[292],"patients,":[293],"89%":[294],"done.":[298],"Conclusion:":[299],"Upon":[300],"those":[308],"positive":[310,349],"+/-":[312],"other":[318],"appear":[321],"benefit":[323],"most":[325],"focused":[327],"multispecialty":[328],"consultation":[329],"academic":[332],"tertiary":[333],"care":[334],"referral":[335],"clinic.298_A":[336],"Figure":[337,345],"1.":[338],"Who":[340],"Were":[341],"Recommended":[342],"Genetic":[343],"Testing.298_B":[344],"2.":[346],"Distribution":[347],"mutation":[351],"results.":[353]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-22T00:00:00"}
