{"id":"https://openalex.org/W2922052838","doi":"https://doi.org/10.1200/jco.2019.37.7_suppl.520","title":"Risk factors for venous thromboembolism (VTE) during chemotherapy in patients with germ cell tumors (GCT).","display_name":"Risk factors for venous thromboembolism (VTE) during chemotherapy in patients with germ cell tumors (GCT).","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2922052838","doi":"https://doi.org/10.1200/jco.2019.37.7_suppl.520","mag":"2922052838"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.7_suppl.520","doi":"https://doi.org/10.1200/jco.2019.37.7_suppl.520","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.7_suppl.520","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055275746","display_name":"Cassia R. Griswold","orcid":"https://orcid.org/0009-0004-5143-9221","observed_orcids":["https://orcid.org/0009-0004-5143-9221"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassia R Griswold","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061173051","display_name":"Erin B. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin B. Bailey","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081251939","display_name":"Jessica Campaign Mauser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Campaign Mauser","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082070319","display_name":"Kenneth M. Boucher","orcid":"https://orcid.org/0000-0003-2833-0127","observed_orcids":["https://orcid.org/0000-0003-2833-0127"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. Boucher","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763587","display_name":"Neeraj Agarwal","orcid":"https://orcid.org/0000-0003-1076-0428","observed_orcids":["https://orcid.org/0000-0003-1076-0428","https://orcid.org/0000-0001-6574-8499"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neeraj Agarwal","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013942253","display_name":"Sumati V. Gupta","orcid":"https://orcid.org/0000-0001-6271-0831","observed_orcids":["https://orcid.org/0000-0001-6271-0831"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumati Gupta","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022744341","display_name":"Benjamin Louis Maughan","orcid":"https://orcid.org/0000-0002-0010-8551","observed_orcids":["https://orcid.org/0000-0002-0010-8551"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Louis Maughan","raw_affiliation_strings":["Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"7_suppl","first_page":"520","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":1.0},{"id":"https://openalex.org/keywords/germ-cell-tumors","display_name":"germ cell tumors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/khorana-score","display_name":"Khorana score","score":0.8130000233650208},{"id":"https://openalex.org/keywords/central-venous-access","display_name":"central venous access","score":0.703000009059906},{"id":"https://openalex.org/keywords/peripheral-venous-access","display_name":"peripheral venous access","score":0.8169999718666077},{"id":"https://openalex.org/keywords/superficial-venous-thrombosis","display_name":"superficial thrombophlebitis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9218551516532898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.636078953742981},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5631895661354065},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5384803414344788},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5119884610176086},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.49774792790412903},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45379364490509033},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.44843876361846924},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4354351758956909},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4266106188297272},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4180889129638672},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40261366963386536},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.32493874430656433},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.7_suppl.520","doi":"https://doi.org/10.1200/jco.2019.37.7_suppl.520","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.7_suppl.520","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2597463500","https://openalex.org/W2589977168","https://openalex.org/W2987211303","https://openalex.org/W4385851478","https://openalex.org/W1985832824","https://openalex.org/W2329740067","https://openalex.org/W3005543968","https://openalex.org/W4403300100","https://openalex.org/W4379282235","https://openalex.org/W2050555037"],"abstract_inverted_index":{"520":[0],"Background:":[1],"The":[2],"Khorana":[3,46,105],"score":[4,19],"is":[5,237,257],"the":[6,45,148,216],"primary":[7,21,217],"tool":[8],"utilized":[9],"to":[10,72,202,247,252,261,278],"predict":[11],"VTE":[12,41,75,79,111,171,221,249],"risk":[13,38,63,76,106,222,268],"in":[14,44,81,177,195,223,266],"patients":[15,83,165,178,197,277],"with":[16,78,84,166,179,186,198,205,220,281],"cancer.":[17],"This":[18],"incorporates":[20],"cancer":[22,101],"site,":[23],"pretreatment":[24],"hematologic":[25],"parameters,":[26],"and":[27,61,103,108,112,141,152,184,226,230],"body":[28],"mass":[29],"index.":[30],"GCT":[31,52,85,167],"are":[32,155],"considered":[33],"high-risk":[34],"for":[35,40,51,138,144],"VTE.":[36],"However,":[37],"factors":[39,77],"not":[42],"included":[43,90],"Score":[47],"have":[48],"been":[49],"reported":[50],"including":[53],"retroperitoneal":[54],"lymph":[55],"node":[56],"(RPLN)":[57],"size,":[58,95],"elevated":[59],"LDH,":[60,96],"poor":[62],"disease.":[64],"Methods:":[65],"A":[66],"retrospective":[67],"chart":[68],"review":[69],"was":[70,136,215],"conducted":[71],"correlate":[73],"known":[74,267],"incidence":[80,174],"male":[82],"undergoing":[86],"first-line":[87],"chemotherapy.":[88],"Variables":[89],"venous":[91],"access":[92,214,235],"type,":[93],"RPLN":[94],"chemotherapy":[97,130],"regimen,":[98],"procedure":[99],"history,":[100],"stage":[102],"histology,":[104],"factors,":[107],"pertinent":[109],"demographics.":[110],"superficial":[113],"vein":[114],"thrombosis":[115],"(SVT)":[116],"events":[117],"that":[118,243],"occurred":[119,172],"within":[120],"1":[121,185,203],"month":[122],"prior":[123],"through":[124],"6":[125],"months":[126],"after":[127],"start":[128],"of":[129,147,161],"were":[131,168,193],"recorded.":[132],"Fisher\u2019s":[133],"Exact":[134],"test":[135],"used":[137],"univariate":[139,225],"analysis":[140,146,228],"logistic":[142],"regression":[143],"multivariate":[145,227],"relationship":[149],"between":[150],"predictors":[151],"thrombosis.":[153],"P-values":[154],"two-sided":[156],"at":[157],"an":[158],"alpha":[159],"level":[160],"0.05.":[162],"Results:":[163],"47":[164],"identified.":[169],"12":[170],"(overall":[173],"25.5%),":[175],"11":[176],"central":[180,207],"lines":[181,200],"(39.3%":[182],"incidence)":[183],"a":[187,206,238],"peripheral":[188,199],"line":[189,208,213],"(5.3%":[190],"incidence).":[191],"SVT":[192],"observed":[194],"5":[196],"compared":[201],"patient":[204],"(26.3%":[209],"vs.":[210],"3.6%).":[211],"Central":[212],"variable":[218],"associated":[219],"both":[224],"(p=0.01":[229],"p=0.03,":[231],"respectively).":[232],"Conclusions:":[233],"Venous":[234],"type":[236],"significant":[239],"but":[240],"modifiable":[241],"factor":[242],"can":[244],"be":[245,279],"targeted":[246],"reduce":[248],"risk.":[250],"Due":[251],"small":[253],"sample":[254],"size":[255],"there":[256],"limited":[258],"statistical":[259],"power":[260],"detect":[262],"potentially":[263],"meaningful":[264],"differences":[265],"factors.":[269],"If":[270],"validated,":[271],"these":[272],"results":[273],"may":[274],"identify":[275],"specific":[276],"treated":[280],"prophylactic":[282],"anticoagulation.":[283],"[Table:":[284],"see":[285],"text]":[286]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2019-03-22T00:00:00"}