{"id":"https://openalex.org/W2921998320","doi":"https://doi.org/10.1210/er.2018-00146","title":"Nonclassical GH Insensitivity: Characterization of Mild Abnormalities of GH Action","display_name":"Nonclassical GH Insensitivity: Characterization of Mild Abnormalities of GH Action","publication_year":2018,"publication_date":"2018-09-27","ids":{"openalex":"https://openalex.org/W2921998320","doi":"https://doi.org/10.1210/er.2018-00146","mag":"2921998320","pmid":"https://pubmed.ncbi.nlm.nih.gov/30265312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6607971"},"language":"en","primary_location":{"id":"doi:10.1210/er.2018-00146","doi":"https://doi.org/10.1210/er.2018-00146","is_oa":true,"landing_page_url":"https://doi.org/10.1210/er.2018-00146","pdf_url":"https://academic.oup.com/edrv/article-pdf/40/2/476/28900563/er.2018-00146.pdf","source":{"id":"https://openalex.org/S13493133","display_name":"Endocrine Reviews","issn_l":"0163-769X","issn":["0163-769X","1945-7189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/edrv/article-pdf/40/2/476/28900563/er.2018-00146.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053984852","display_name":"Helen Louise Storr","orcid":"https://orcid.org/0000-0002-9963-1931","observed_orcids":["https://orcid.org/0000-0002-9963-1931"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Helen L Storr","raw_affiliation_strings":["Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9963-1931","affiliations":[{"raw_affiliation_string":"Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101975380","display_name":"Sumana Chatterjee","orcid":"https://orcid.org/0000-0001-5273-0046","observed_orcids":["https://orcid.org/0000-0001-5273-0046"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sumana Chatterjee","raw_affiliation_strings":["Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026610897","display_name":"Louise Metherell","orcid":"https://orcid.org/0000-0002-0530-3524","observed_orcids":["https://orcid.org/0000-0002-0530-3524"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise A Metherell","raw_affiliation_strings":["Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069365376","display_name":"Corinne L. Foley","orcid":"https://orcid.org/0000-0001-7881-8169","observed_orcids":["https://orcid.org/0000-0001-7881-8169"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinne Foley","raw_affiliation_strings":["Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001402556","display_name":"Ron G. Rosenfeld","orcid":"https://orcid.org/0000-0002-4030-5998","observed_orcids":["https://orcid.org/0000-0002-4030-5998"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron G Rosenfeld","raw_affiliation_strings":["Department of Pediatrics, Oregon Health and Science University, Portland, Oregon"],"raw_orcid":"https://orcid.org/0000-0002-4030-5998","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Oregon Health and Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091887291","display_name":"Philippe Ferdinand Backeljauw","orcid":"https://orcid.org/0000-0003-2398-9520","observed_orcids":["https://orcid.org/0000-0003-2398-9520"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippe F Backeljauw","raw_affiliation_strings":["Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-2398-9520","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039731517","display_name":"Andrew Nahum Dauber","orcid":"https://orcid.org/0000-0003-4890-0262","observed_orcids":["https://orcid.org/0000-0003-4890-0262"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Dauber","raw_affiliation_strings":["Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-4890-0262","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045829884","display_name":"Martin Oswald Savage","orcid":"https://orcid.org/0000-0001-7902-3376","observed_orcids":["https://orcid.org/0000-0001-7902-3376"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin O Savage","raw_affiliation_strings":["Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7902-3376","affiliations":[{"raw_affiliation_string":"Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024238698","display_name":"Vivian Hwa","orcid":"https://orcid.org/0000-0003-0517-9049","observed_orcids":["https://orcid.org/0000-0003-0517-9049"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivian Hwa","raw_affiliation_strings":["Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-0517-9049","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024238698","https://openalex.org/A5053984852"],"corresponding_institution_ids":["https://openalex.org/I124357947","https://openalex.org/I1285204247","https://openalex.org/I166337079","https://openalex.org/I4210149920","https://openalex.org/I63135867"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.0392,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.73764988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"40","issue":"2","first_page":"476","last_page":"505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-insensitivity","display_name":"growth hormone insensitivity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/short-stature-syndromes","display_name":"short stature syndromes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/growth-failure","display_name":"growth failure","score":0.746999979019165},{"id":"https://openalex.org/keywords/genetic-characterization","display_name":"genetic characterization","score":0.46700000762939453},{"id":"https://openalex.org/keywords/biochemical-properties","display_name":"biochemical properties","score":0.5360000133514404},{"id":"https://openalex.org/keywords/treatment-challenges","display_name":"treatment challenges","score":0.45500001311302185},{"id":"https://openalex.org/keywords/pediatric-growth-disorders","display_name":"pediatric growth disorders","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2777871287","wikidata":"https://www.wikidata.org/wiki/Q7502090","display_name":"Short stature","level":2,"score":0.6925150752067566},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.49396711587905884},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4772112965583801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.450933575630188},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3643781542778015},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33946144580841064},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3051415681838989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30424976348876953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28356224298477173},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14166969060897827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12371063232421875}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1210/er.2018-00146","doi":"https://doi.org/10.1210/er.2018-00146","is_oa":true,"landing_page_url":"https://doi.org/10.1210/er.2018-00146","pdf_url":"https://academic.oup.com/edrv/article-pdf/40/2/476/28900563/er.2018-00146.pdf","source":{"id":"https://openalex.org/S13493133","display_name":"Endocrine Reviews","issn_l":"0163-769X","issn":["0163-769X","1945-7189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6607971","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6607971","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocr Rev","raw_type":"Text"},{"id":"pmid:30265312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30265312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine reviews","raw_type":"Journal Article"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/45844","doi":null,"is_oa":false,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/45844","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1210/er.2018-00146","doi":"https://doi.org/10.1210/er.2018-00146","is_oa":true,"landing_page_url":"https://doi.org/10.1210/er.2018-00146","pdf_url":"https://academic.oup.com/edrv/article-pdf/40/2/476/28900563/er.2018-00146.pdf","source":{"id":"https://openalex.org/S13493133","display_name":"Endocrine Reviews","issn_l":"0163-769X","issn":["0163-769X","1945-7189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2200626524","display_name":null,"funder_award_id":"MGU0438","funder_id":"https://openalex.org/F4320315977","funder_display_name":"Barts Charity"},{"id":"https://openalex.org/G4564920735","display_name":null,"funder_award_id":"MGU0361","funder_id":"https://openalex.org/F4320315977","funder_display_name":"Barts Charity"},{"id":"https://openalex.org/G5357093178","display_name":"Roles of STAT5b in IGF-I Production and Human Growth","funder_award_id":"R01HD078592","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5419362115","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM063483","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8967341117","display_name":null,"funder_award_id":"MRC0161","funder_id":"https://openalex.org/F4320315977","funder_display_name":"Barts Charity"}],"funders":[{"id":"https://openalex.org/F4320315977","display_name":"Barts Charity","ror":"https://ror.org/0513pp416"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921998320.pdf","grobid_xml":"https://content.openalex.org/works/W2921998320.grobid-xml"},"referenced_works_count":281,"referenced_works":["https://openalex.org/W733633","https://openalex.org/W3765645","https://openalex.org/W43675721","https://openalex.org/W102166461","https://openalex.org/W576111033","https://openalex.org/W977201031","https://openalex.org/W1481442945","https://openalex.org/W1488903292","https://openalex.org/W1526933908","https://openalex.org/W1543222911","https://openalex.org/W1556332247","https://openalex.org/W1580425155","https://openalex.org/W1629149231","https://openalex.org/W1722468035","https://openalex.org/W1821858011","https://openalex.org/W1964595880","https://openalex.org/W1964916243","https://openalex.org/W1965176171","https://openalex.org/W1965534968","https://openalex.org/W1967493115","https://openalex.org/W1967931968","https://openalex.org/W1968124424","https://openalex.org/W1971712138","https://openalex.org/W1972213198","https://openalex.org/W1975792563","https://openalex.org/W1975892163","https://openalex.org/W1976184389","https://openalex.org/W1976845089","https://openalex.org/W1977198374","https://openalex.org/W1978481014","https://openalex.org/W1981053516","https://openalex.org/W1981177140","https://openalex.org/W1982448036","https://openalex.org/W1983323920","https://openalex.org/W1984828633","https://openalex.org/W1985594739","https://openalex.org/W1986161955","https://openalex.org/W1987587625","https://openalex.org/W1990043027","https://openalex.org/W1990413556","https://openalex.org/W1990519487","https://openalex.org/W1993672117","https://openalex.org/W1994994219","https://openalex.org/W1995645285","https://openalex.org/W1996757852","https://openalex.org/W1997437691","https://openalex.org/W1997637607","https://openalex.org/W1999234197","https://openalex.org/W1999401729","https://openalex.org/W2000921015","https://openalex.org/W2002269529","https://openalex.org/W2002323883","https://openalex.org/W2007573212","https://openalex.org/W2008257976","https://openalex.org/W2009928628","https://openalex.org/W2015180872","https://openalex.org/W2016596969","https://openalex.org/W2016918233","https://openalex.org/W2018141684","https://openalex.org/W2018200926","https://openalex.org/W2018750576","https://openalex.org/W2019548209","https://openalex.org/W2021292007","https://openalex.org/W2021365471","https://openalex.org/W2022200688","https://openalex.org/W2023842319","https://openalex.org/W2024394264","https://openalex.org/W2024662626","https://openalex.org/W2024895769","https://openalex.org/W2026436880","https://openalex.org/W2026753894","https://openalex.org/W2027062663","https://openalex.org/W2027567560","https://openalex.org/W2027937382","https://openalex.org/W2028578415","https://openalex.org/W2032472474","https://openalex.org/W2034779436","https://openalex.org/W2035533786","https://openalex.org/W2036443865","https://openalex.org/W2036799056","https://openalex.org/W2038619963","https://openalex.org/W2038813685","https://openalex.org/W2038987750","https://openalex.org/W2039097372","https://openalex.org/W2039494120","https://openalex.org/W2039825798","https://openalex.org/W2040002852","https://openalex.org/W2040178108","https://openalex.org/W2041467264","https://openalex.org/W2042389086","https://openalex.org/W2042802855","https://openalex.org/W2046251114","https://openalex.org/W2046329980","https://openalex.org/W2048237877","https://openalex.org/W2050178721","https://openalex.org/W2050853712","https://openalex.org/W2051018333","https://openalex.org/W2051917084","https://openalex.org/W2051978340","https://openalex.org/W2052113944","https://openalex.org/W2052236590","https://openalex.org/W2052764940","https://openalex.org/W2053401301","https://openalex.org/W2054121324","https://openalex.org/W2055647624","https://openalex.org/W2055764572","https://openalex.org/W2058994091","https://openalex.org/W2059274903","https://openalex.org/W2061573600","https://openalex.org/W2063091345","https://openalex.org/W2064369191","https://openalex.org/W2067667710","https://openalex.org/W2068672095","https://openalex.org/W2069659984","https://openalex.org/W2069924892","https://openalex.org/W2070866947","https://openalex.org/W2071645006","https://openalex.org/W2072514327","https://openalex.org/W2074611556","https://openalex.org/W2074757878","https://openalex.org/W2075003126","https://openalex.org/W2076728417","https://openalex.org/W2076848886","https://openalex.org/W2077551460","https://openalex.org/W2077704944","https://openalex.org/W2079137397","https://openalex.org/W2079178172","https://openalex.org/W2079774691","https://openalex.org/W2079886125","https://openalex.org/W2081635903","https://openalex.org/W2082813362","https://openalex.org/W2082861965","https://openalex.org/W2083066292","https://openalex.org/W2083137480","https://openalex.org/W2084409051","https://openalex.org/W2084859145","https://openalex.org/W2087867044","https://openalex.org/W2088659156","https://openalex.org/W2088879509","https://openalex.org/W2090170748","https://openalex.org/W2090663991","https://openalex.org/W2091981096","https://openalex.org/W2095043349","https://openalex.org/W2095462885","https://openalex.org/W2098065500","https://openalex.org/W2099211382","https://openalex.org/W2100029108","https://openalex.org/W2102303758","https://openalex.org/W2104243709","https://openalex.org/W2104497596","https://openalex.org/W2104794017","https://openalex.org/W2105026438","https://openalex.org/W2107374737","https://openalex.org/W2109066322","https://openalex.org/W2109793907","https://openalex.org/W2109799774","https://openalex.org/W2109997752","https://openalex.org/W2112771237","https://openalex.org/W2115085476","https://openalex.org/W2118198468","https://openalex.org/W2120166425","https://openalex.org/W2121195198","https://openalex.org/W2121394848","https://openalex.org/W2127366415","https://openalex.org/W2128962458","https://openalex.org/W2129137447","https://openalex.org/W2131786464","https://openalex.org/W2132473139","https://openalex.org/W2132555220","https://openalex.org/W2133584619","https://openalex.org/W2133860650","https://openalex.org/W2134378595","https://openalex.org/W2135762116","https://openalex.org/W2136396947","https://openalex.org/W2137828588","https://openalex.org/W2139198972","https://openalex.org/W2140073088","https://openalex.org/W2140185460","https://openalex.org/W2140790846","https://openalex.org/W2140868727","https://openalex.org/W2142105809","https://openalex.org/W2144678487","https://openalex.org/W2146179163","https://openalex.org/W2147016415","https://openalex.org/W2147185790","https://openalex.org/W2147888714","https://openalex.org/W2148042413","https://openalex.org/W2148301755","https://openalex.org/W2151513117","https://openalex.org/W2152311240","https://openalex.org/W2152314371","https://openalex.org/W2155034495","https://openalex.org/W2156574185","https://openalex.org/W2157247721","https://openalex.org/W2157639904","https://openalex.org/W2157945438","https://openalex.org/W2158033922","https://openalex.org/W2158937510","https://openalex.org/W2161998322","https://openalex.org/W2162721157","https://openalex.org/W2163035954","https://openalex.org/W2163914247","https://openalex.org/W2164301822","https://openalex.org/W2164826326","https://openalex.org/W2167898988","https://openalex.org/W2169129533","https://openalex.org/W2169248706","https://openalex.org/W2170197481","https://openalex.org/W2183412811","https://openalex.org/W2199311095","https://openalex.org/W2225030623","https://openalex.org/W2271138696","https://openalex.org/W2275811379","https://openalex.org/W2280446205","https://openalex.org/W2288785100","https://openalex.org/W2312763514","https://openalex.org/W2314174921","https://openalex.org/W2320296534","https://openalex.org/W2324179034","https://openalex.org/W2325926763","https://openalex.org/W2333450132","https://openalex.org/W2337250833","https://openalex.org/W2340201678","https://openalex.org/W2342109369","https://openalex.org/W2406200167","https://openalex.org/W2409042717","https://openalex.org/W2411152373","https://openalex.org/W2412459279","https://openalex.org/W2414424074","https://openalex.org/W2414821081","https://openalex.org/W2418874349","https://openalex.org/W2472913205","https://openalex.org/W2507689999","https://openalex.org/W2523511963","https://openalex.org/W2540778523","https://openalex.org/W2552003712","https://openalex.org/W2555766993","https://openalex.org/W2592087460","https://openalex.org/W2593285211","https://openalex.org/W2593491675","https://openalex.org/W2604330383","https://openalex.org/W2613662456","https://openalex.org/W2615615537","https://openalex.org/W2618338771","https://openalex.org/W2733646126","https://openalex.org/W2740436130","https://openalex.org/W2742474598","https://openalex.org/W2743565800","https://openalex.org/W2751511914","https://openalex.org/W2760046641","https://openalex.org/W2766203164","https://openalex.org/W2768988635","https://openalex.org/W2769275389","https://openalex.org/W2769631051","https://openalex.org/W2774408568","https://openalex.org/W2786847183","https://openalex.org/W2788558056","https://openalex.org/W2789677699","https://openalex.org/W2790823619","https://openalex.org/W2800554073","https://openalex.org/W2806826340","https://openalex.org/W2888639031","https://openalex.org/W2899549805","https://openalex.org/W4210729786","https://openalex.org/W4236757670","https://openalex.org/W4238777291","https://openalex.org/W4243387549","https://openalex.org/W4247296375","https://openalex.org/W4247367182","https://openalex.org/W4254451072","https://openalex.org/W4255416360","https://openalex.org/W6644756826","https://openalex.org/W6648938552","https://openalex.org/W6665258748","https://openalex.org/W6668058103","https://openalex.org/W6680376689","https://openalex.org/W6684884987","https://openalex.org/W6702684671","https://openalex.org/W6703104256","https://openalex.org/W6825096044","https://openalex.org/W6828547255"],"related_works":["https://openalex.org/W3212943950","https://openalex.org/W3172415901","https://openalex.org/W3092033445","https://openalex.org/W2556157418","https://openalex.org/W2076782099","https://openalex.org/W2051025870","https://openalex.org/W2032472474","https://openalex.org/W4324378188","https://openalex.org/W1975792563","https://openalex.org/W2018200926"],"abstract_inverted_index":{"GH":[0],"insensitivity":[1],"(GHI)":[2],"presents":[3],"in":[4,10],"childhood":[5],"with":[6,16,71],"growth":[7,108],"failure":[8],"and":[9,20,22,31,36,53,86,100],"its":[11],"severe":[12],"form":[13],"is":[14,94],"associated":[15],"extreme":[17],"short":[18,39],"stature":[19,40],"dysmorphic":[21],"metabolic":[23],"abnormalities.":[24],"In":[25],"recent":[26],"years,":[27],"the":[28,74,78,97,113],"clinical,":[29,84],"biochemical,":[30,85],"genetic":[32,51,87],"characteristics":[33],"of":[34,57,60,67,77,91,102,107,116],"GHI":[35,79],"other":[37],"overlapping":[38],"syndromes":[41],"have":[42],"rapidly":[43],"expanded.":[44],"This":[45],"can":[46],"be":[47],"attributed":[48],"to":[49,95],"advancing":[50],"techniques":[52],"a":[54],"greater":[55],"awareness":[56],"this":[58,64,92,103],"group":[59,106],"disorders.":[61],"We":[62,81,110],"review":[63,93,112],"important":[65],"spectrum":[66],"defects,":[68],"which":[69],"present":[70],"phenotypes":[72],"at":[73],"milder":[75],"end":[76],"continuum.":[80],"discuss":[82],"their":[83],"characteristics.":[88],"The":[89],"objective":[90],"clarify":[96],"definition,":[98],"identification,":[99],"investigation":[101],"clinically":[104],"relevant":[105],"defects.":[109],"also":[111],"therapeutic":[114],"challenges":[115],"mild":[117],"GHI.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-03-22T00:00:00"}