{"id":"https://openalex.org/W2921858013","doi":"https://doi.org/10.1080/15592294.2019.1588684","title":"Integrative analysis identifies DNMTs against immune-infiltrating neutrophils and dendritic cells in colorectal cancer","display_name":"Integrative analysis identifies DNMTs against immune-infiltrating neutrophils and dendritic cells in colorectal cancer","publication_year":2019,"publication_date":"2019-03-16","ids":{"openalex":"https://openalex.org/W2921858013","doi":"https://doi.org/10.1080/15592294.2019.1588684","mag":"2921858013","pmid":"https://pubmed.ncbi.nlm.nih.gov/30880552","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6557545"},"language":"en","primary_location":{"id":"doi:10.1080/15592294.2019.1588684","doi":"https://doi.org/10.1080/15592294.2019.1588684","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15592294.2019.1588684","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15592294.2019.1588684?needAccess=true&role=button","source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15592294.2019.1588684?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037090736","display_name":"Qili Shi","orcid":"https://orcid.org/0009-0002-4021-2414","observed_orcids":["https://orcid.org/0009-0002-4021-2414"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qili Shi","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017936091","display_name":"Libing Shen","orcid":"https://orcid.org/0000-0002-3745-0473","observed_orcids":["https://orcid.org/0000-0002-3745-0473"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Libing Shen","raw_affiliation_strings":["Institute of Neuroscience, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102643276","display_name":"Jun Gan","orcid":"https://orcid.org/0009-0000-5349-7303","observed_orcids":["https://orcid.org/0009-0000-5349-7303"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Gan","raw_affiliation_strings":["School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074083726","display_name":"Lirong He","orcid":"https://orcid.org/0000-0001-5146-8074","observed_orcids":["https://orcid.org/0000-0001-5146-8074","https://orcid.org/0000-0002-7244-9064"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lirong He","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101666779","display_name":"Jing Lin","orcid":"https://orcid.org/0000-0002-0700-4448","observed_orcids":["https://orcid.org/0000-0002-0700-4448"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Lin","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0700-4448","affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107247935","display_name":"Shiyu Guo","orcid":"https://orcid.org/0009-0008-0879-0517","observed_orcids":["https://orcid.org/0009-0008-0879-0517"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Guo","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089968617","display_name":"Zi Xiong","orcid":"https://orcid.org/0000-0002-8528-9207","observed_orcids":["https://orcid.org/0000-0002-8528-9207"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zi Xiong","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080712506","display_name":"Jie Lin","orcid":"https://orcid.org/0000-0003-2364-7993","observed_orcids":["https://orcid.org/0000-0003-2364-7993"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Lin","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":"https://orcid.org/0000-0003-2364-7993","affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100415435","display_name":"Shun Zhang","orcid":"https://orcid.org/0000-0002-3804-7475","observed_orcids":["https://orcid.org/0000-0002-3804-7475"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shun Zhang","raw_affiliation_strings":["Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, P.R. China","institution_ids":["https://openalex.org/I4210101660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080712506","https://openalex.org/A5100415435"],"corresponding_institution_ids":["https://openalex.org/I4210101660"],"apc_list":null,"apc_paid":null,"fwci":0.7325,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.6467941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"4","first_page":"392","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.9179999828338623},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gene-co-expression-modules","display_name":"gene co-expression modules","score":0.5350000262260437},{"id":"https://openalex.org/keywords/prognostic-genes","display_name":"prognostic genes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cimp","display_name":"CpG island methylator phenotype","score":0.9490000009536743},{"id":"https://openalex.org/keywords/alox5ap","display_name":"ALOX5AP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/csf3r","display_name":"CSF3R","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9068263173103333},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7581923604011536},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.7572106719017029},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7186117172241211},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.7134699821472168},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5841342210769653},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5241672992706299},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.503135621547699},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49549949169158936},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.4597916603088379},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42771977186203003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41284847259521484},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35169997811317444},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3327784240245819},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.22237643599510193},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2064341902732849},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016184","descriptor_name":"Receptors, Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058927","descriptor_name":"5-Lipoxygenase-Activating Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/15592294.2019.1588684","doi":"https://doi.org/10.1080/15592294.2019.1588684","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15592294.2019.1588684","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15592294.2019.1588684?needAccess=true&role=button","source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6006576","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6557545","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30880552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30880552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6557545","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6557545/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fbebd30e433e41899b6273b652738381","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fbebd30e433e41899b6273b652738381","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Epigenetics, Vol 14, Iss 4, Pp 392-404 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/15592294.2019.1588684","doi":"https://doi.org/10.1080/15592294.2019.1588684","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15592294.2019.1588684","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15592294.2019.1588684?needAccess=true&role=button","source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8924467103","display_name":null,"funder_award_id":"LY15H160046","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320336609","display_name":"Ningbo Municipal Science and Technology Innovative Research Team","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921858013.pdf","grobid_xml":"https://content.openalex.org/works/W2921858013.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W3724994","https://openalex.org/W1966327575","https://openalex.org/W1973012451","https://openalex.org/W1974033269","https://openalex.org/W1989949054","https://openalex.org/W2015981241","https://openalex.org/W2018871664","https://openalex.org/W2031698214","https://openalex.org/W2035618305","https://openalex.org/W2037900813","https://openalex.org/W2054047930","https://openalex.org/W2057133574","https://openalex.org/W2067299927","https://openalex.org/W2067520769","https://openalex.org/W2076124116","https://openalex.org/W2083457841","https://openalex.org/W2088621765","https://openalex.org/W2096139566","https://openalex.org/W2100545040","https://openalex.org/W2111104903","https://openalex.org/W2116407404","https://openalex.org/W2128146359","https://openalex.org/W2131214382","https://openalex.org/W2132399107","https://openalex.org/W2139108492","https://openalex.org/W2142249788","https://openalex.org/W2150633526","https://openalex.org/W2167898988","https://openalex.org/W2171115585","https://openalex.org/W2258320918","https://openalex.org/W2262414037","https://openalex.org/W2267145743","https://openalex.org/W2292022254","https://openalex.org/W2339723519","https://openalex.org/W2421455087","https://openalex.org/W2507880739","https://openalex.org/W2538288310","https://openalex.org/W2741304577","https://openalex.org/W2748101858","https://openalex.org/W2765224588","https://openalex.org/W2767507186","https://openalex.org/W2783494975"],"related_works":["https://openalex.org/W2945851632","https://openalex.org/W1836451835","https://openalex.org/W4405098697","https://openalex.org/W4214746501","https://openalex.org/W6977159906","https://openalex.org/W4414444244","https://openalex.org/W2082413644","https://openalex.org/W3204920848","https://openalex.org/W7164518474","https://openalex.org/W4297150632"],"abstract_inverted_index":{"Molecular":[0],"characterizations,":[1],"including":[2,140],"microsatellite":[3],"instability":[4],"(MSI)":[5],"and":[6,20,37,69,82,89,123,142],"the":[7,26,31,49,64,135,175],"CpG":[8],"island":[9],"methylator":[10],"phenotype":[11],"(CIMP)":[12],"showed":[13],"strong":[14,84],"associations":[15,85],"in":[16,39,42,92,99,149,163,181],"colorectal":[17],"carcinoma":[18],"(CRC)":[19],"provided":[21,130,168],"a":[22,58,169],"deeper":[23],"understanding":[24],"of":[25,28,51,138],"etiology":[27],"disease.":[29],"However,":[30],"global":[32,65,136],"relationship":[33],"between":[34,67,120],"epigenetic":[35],"alternations":[36],"changes":[38],"mRNA":[40,124],"expression":[41,125],"CRC":[43],"remains":[44],"largely":[45],"undefined,":[46],"especially":[47],"regarding":[48],"roles":[50],"DNA":[52,121],"methyltransferases":[53],"(DNMTs).":[54],"Here,":[55],"we":[56,95,129],"conducted":[57],"systematic":[59],"network":[60],"comparison":[61],"to":[62,158,173],"explore":[63],"conservation":[66],"co-expressed":[68],"co-methylated":[70],"modules.":[71],"We":[72],"successfully":[73],"identified":[74],"immune-related":[75],"modules":[76,101],"that":[77,97,132,144],"were":[78,102,154],"regulated":[79],"by":[80,112],"DNMTs":[81,133],"had":[83],"with":[86,106],"immune-infiltrating":[87],"neutrophils":[88],"dendritic":[90],"cells":[91],"CRC.":[93,164],"Moreover,":[94],"found":[96],"genes":[98,153],"those":[100],"prognostic":[103],"for":[104],"CRC,":[105],"97.1%":[107],"(168/173)":[108],"being":[109],"significantly":[110],"influenced":[111],"DNMTs.":[113,127],"Thus,":[114],"this":[115],"study":[116],"resolved":[117],"an":[118],"interaction":[119],"methylation":[122,148],"through":[126],"Additionally,":[128],"evidence":[131],"control":[134],"hypomethylation":[137],"oncogenes,":[139],"ALOX5AP":[141],"CSF3R":[143],"otherwise":[145],"have":[146],"high":[147],"normal":[150],"colons.":[151],"Such":[152],"also":[155],"more":[156],"sensitive":[157],"DNMT":[159],"changes,":[160],"such":[161],"as":[162],"Collectively,":[165],"our":[166],"analyzes":[167],"systems":[170],"biology":[171],"approach":[172],"investigate":[174],"association":[176],"among":[177],"different":[178],"molecular":[179],"phenotypes":[180],"diseases.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-03-22T00:00:00"}