{"id":"https://openalex.org/W2921669593","doi":"https://doi.org/10.1161/circ.139.suppl_1.p106","title":"Abstract P106: Genetically Determined Fibrinogen, Gamma Prime Fibrinogen and Risk of Venous Thromboembolism and Ischemic Stroke: Evidence From Mendelian Randomization","display_name":"Abstract P106: Genetically Determined Fibrinogen, Gamma Prime Fibrinogen and Risk of Venous Thromboembolism and Ischemic Stroke: Evidence From Mendelian Randomization","publication_year":2019,"publication_date":"2019-03-05","ids":{"openalex":"https://openalex.org/W2921669593","doi":"https://doi.org/10.1161/circ.139.suppl_1.p106","mag":"2921669593"},"language":"en","primary_location":{"id":"doi:10.1161/circ.139.suppl_1.p106","doi":"https://doi.org/10.1161/circ.139.suppl_1.p106","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.139.suppl_1.p106","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030647439","display_name":"Jillian Maners","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian Maners","raw_affiliation_strings":["Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","Jillian Maners"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Jillian Maners","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054061856","display_name":"Dipender Gill","orcid":"https://orcid.org/0000-0001-7312-7078","observed_orcids":["https://orcid.org/0000-0001-7312-7078"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dipender Gill","raw_affiliation_strings":["Imperial College London, London, United Kingdom","Dipender Gill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Dipender Gill","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030905089","display_name":"Nathan Pankratz","orcid":"https://orcid.org/0000-0001-5958-693X","observed_orcids":["https://orcid.org/0000-0001-5958-693X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Pankratz","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","Nathan Pankratz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Nathan Pankratz","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063972278","display_name":"Weihong Tang","orcid":"https://orcid.org/0000-0003-1200-0270","observed_orcids":["https://orcid.org/0000-0003-1200-0270"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihong Tang","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","Weihong Tang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Weihong Tang","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cohorts for Heart and Aging Rsch in Genomic Epidemiology (CHARGE) Hemostasis Working Group","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cohorts for Heart and Aging Rsch in Genomic Epidemiology (CHARGE) Hemostasis Working Group","raw_affiliation_strings":["","Nicholas L Smith","Univ of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Nicholas L Smith","institution_ids":[]},{"raw_affiliation_string":"Univ of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101789217","display_name":"Nicholas L. Smith","orcid":"https://orcid.org/0000-0003-3483-353X","observed_orcids":["https://orcid.org/0000-0003-3483-353X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas L Smith","raw_affiliation_strings":["Univ of Washington, Seattle, WA","Alanna C Morrison","Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Alanna C Morrison","institution_ids":[]},{"raw_affiliation_string":"Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080311961","display_name":"Alanna C. Morrison","orcid":"https://orcid.org/0000-0001-6381-4296","observed_orcids":["https://orcid.org/0000-0001-6381-4296"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Alanna C Morrison","raw_affiliation_strings":["Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","Abbas Dehghan","Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Abbas Dehghan","institution_ids":[]},{"raw_affiliation_string":"Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081896930","display_name":"Abbas Dehghan","orcid":"https://orcid.org/0000-0001-6403-016X","observed_orcids":["https://orcid.org/0000-0001-6403-016X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Abbas Dehghan","raw_affiliation_strings":["Imperial College London, London, United Kingdom","Paul S de Vries","Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Paul S de Vries","institution_ids":[]},{"raw_affiliation_string":"Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054782619","display_name":"Paul S. de Vries","orcid":"https://orcid.org/0000-0003-0964-0111","observed_orcids":["https://orcid.org/0000-0003-0964-0111"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S de Vries","raw_affiliation_strings":["Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sch of Public Health, Univ of Texas Health Science Cntr at Houston, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"139","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.15279999375343323,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.09560000151395798,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":1.0},{"id":"https://openalex.org/keywords/cardioembolic-stroke","display_name":"cardioembolic stroke","score":0.9779999852180481},{"id":"https://openalex.org/keywords/large-artery-atherosclerotic-stroke","display_name":"large artery atherosclerotic stroke","score":0.8840000033378601},{"id":"https://openalex.org/keywords/small-vessel-stroke","display_name":"small vessel stroke","score":0.9879999756813049},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/causal-effects","display_name":"causal effects","score":0.44600000977516174},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.49399998784065247},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.8699095249176025},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8580114245414734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.827923059463501},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6200666427612305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5126356482505798},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5096874237060547},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.42040228843688965},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.1984332799911499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16039374470710754},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.11359700560569763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08792325854301453},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08414223790168762},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.139.suppl_1.p106","doi":"https://doi.org/10.1161/circ.139.suppl_1.p106","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.139.suppl_1.p106","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045981737","https://openalex.org/W2955606794","https://openalex.org/W4405395264","https://openalex.org/W4403777661","https://openalex.org/W2944244670","https://openalex.org/W4409198637","https://openalex.org/W3142106486","https://openalex.org/W4394819879","https://openalex.org/W4308545225","https://openalex.org/W2064898260"],"abstract_inverted_index":{"Introduction:":[0],"Fibrinogen":[1],"is":[2],"a":[3,170],"key":[4],"component":[5],"of":[6,41,52,66,76,127,173,190,197,212,241,251,273,279],"the":[7,38,114,125,188,195,210,231,239,270,274,277],"coagulation":[8],"cascade,":[9],"and":[10,26,44,54,69,72,84,139,161,176,200,218,255,261],"variation":[11],"in":[12,113,131,282],"its":[13,45],"circulating":[14,42],"levels":[15,180,186,208],"may":[16,268],"contribute":[17],"to":[18,36,95,110,124,235,238],"thrombotic":[19,283],"diseases,":[20],"such":[21],"as":[22],"venous":[23],"thromboembolism":[24],"(VTE)":[25],"ischemic":[27,55,70,214,262],"stroke.":[28,203,221,263],"Methods:":[29],"Two-sample":[30],"Mendelian":[31],"randomization":[32],"(MR)":[33],"was":[34,108],"applied":[35,130],"estimate":[37,111],"causal":[39],"effect":[40,172],"fibrinogen":[43,83,87,160,168,175,179,185,207,254,258],"isoform,":[46],"gamma":[47,77,85,166,177,205,256],"prime":[48,78,86,167,178,206,257],"fibrinogen,":[49,67,275],"on":[50,155,181,259],"risk":[51,189,196,211],"VTE":[53,182,260],"stroke":[56,192],"subtypes":[57],"using":[58],"summary":[59],"statistics":[60],"from":[61],"published":[62],"genome-wide":[63,92],"association":[64],"studies":[65],"VTE,":[68],"stroke,":[71,215,217],"an":[73],"unpublished":[74],"study":[75],"fibrinogen.":[79],"Genetic":[80],"instruments":[81,158,164],"for":[82,159,165],"were":[88,224],"selected":[89],"by":[90],"pruning":[91],"significant":[93],"variants":[94,129],"linkage":[96],"disequilibrium":[97],"r":[98],"2":[99],"<":[100],"0.1.":[101],"The":[102,144,264],"inverse":[103,146],"variance":[104,147],"weighted":[105,136,140,148],"MR":[106,149],"approach":[107],"used":[109],"effects":[112,250,267],"main":[115,145],"analysis,":[116],"with":[117,249,285],"additional":[118],"approaches":[119],"that":[120,230],"are":[121,233,247],"more":[122],"robust":[123],"inclusion":[126,240],"pleiotropic":[128,242],"sensitivity":[132,227],"analyses,":[133,228],"including":[134],"MR-Egger,":[135],"median":[137],"MR,":[138],"mode":[141],"MR.":[142],"Results:":[143],"estimates":[150,223],"(":[151],"Table":[152],")":[153],"based":[154],"85":[156],"genetic":[157,163],"27":[162],"indicated":[169],"protective":[171,266],"both":[174],"risk.":[183],"Higher":[184,204],"decreased":[187,209],"cardioembolic":[191,216],"but":[193],"increased":[194],"large":[198,219],"artery":[199,220],"small":[201],"vessel":[202],"all":[213],"Effect":[222],"consistent":[225,248],"across":[226],"indicating":[229],"results":[232,246],"unlikely":[234],"be":[236],"attributable":[237],"variants.":[243],"Conclusion:":[244],"Our":[245],"genetically":[252],"determined":[253],"identified":[265],"reflect":[269],"diverse":[271],"roles":[272],"beyond":[276],"formation":[278],"fibrin":[280],"clots,":[281],"diseases":[284],"different":[286],"etiologies.":[287]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2019-03-22T00:00:00"}
