{"id":"https://openalex.org/W2921595271","doi":"https://doi.org/10.7554/elife.43808","title":"Dual control of NAD+ synthesis by purine metabolites in yeast","display_name":"Dual control of NAD+ synthesis by purine metabolites in yeast","publication_year":2019,"publication_date":"2019-03-12","ids":{"openalex":"https://openalex.org/W2921595271","doi":"https://doi.org/10.7554/elife.43808","mag":"2921595271","pmid":"https://pubmed.ncbi.nlm.nih.gov/30860478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6430606"},"language":"en","primary_location":{"id":"doi:10.7554/elife.43808","doi":"https://doi.org/10.7554/elife.43808","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.43808","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.43808","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083989677","display_name":"Beno\u0131\u0302t Pinson","orcid":"https://orcid.org/0000-0003-2936-9058","observed_orcids":["https://orcid.org/0000-0003-2936-9058"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Pinson","raw_affiliation_strings":["Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","IBGC, Universit\u00e9 de Bordeaux UMR 5095, Bordeaux, France"],"raw_orcid":"https://orcid.org/0000-0003-2936-9058","affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210140961"]},{"raw_affiliation_string":"IBGC, Universit\u00e9 de Bordeaux UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053604722","display_name":"Johanna Ceschin","orcid":"https://orcid.org/0000-0001-7771-531X","observed_orcids":["https://orcid.org/0000-0001-7771-531X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Johanna Ceschin","raw_affiliation_strings":["Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","IBGC, Universit\u00e9 de Bordeaux UMR 5095, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210140961"]},{"raw_affiliation_string":"IBGC, Universit\u00e9 de Bordeaux UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008557150","display_name":"Christelle Saint\u2010Marc","orcid":"https://orcid.org/0000-0001-9537-1848","observed_orcids":["https://orcid.org/0000-0001-9537-1848"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christelle Saint-Marc","raw_affiliation_strings":["Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","IBGC, Universit\u00e9 de Bordeaux UMR 5095, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210140961"]},{"raw_affiliation_string":"IBGC, Universit\u00e9 de Bordeaux UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088388229","display_name":"Bertrand Daignan\u2010Fornier","orcid":"https://orcid.org/0000-0003-2352-9700","observed_orcids":["https://orcid.org/0000-0003-2352-9700"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bertrand Daignan-Fornier","raw_affiliation_strings":["Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France"],"raw_orcid":"https://orcid.org/0000-0003-2352-9700","affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique IBGC UMR 5095, Bordeaux, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210140961"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088388229"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210140961"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":1.6115,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.83213388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nad-biosynthesis","display_name":"NAD biosynthesis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9589999914169312},{"id":"https://openalex.org/keywords/adenine","display_name":"adenine","score":0.4729999899864197},{"id":"https://openalex.org/keywords/zero-moment-point","display_name":"zero moment point","score":0.6539999842643738},{"id":"https://openalex.org/keywords/bas1","display_name":"BAS1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pho2","display_name":"PHO2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/metabolic-crosstalk","display_name":"metabolic crosstalk","score":0.828000009059906},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.8415737748146057},{"id":"https://openalex.org/C2777088662","wikidata":"https://www.wikidata.org/wiki/Q21547155","display_name":"Nicotinamide mononucleotide","level":5,"score":0.7056224346160889},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6407616138458252},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.611214280128479},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.5801378488540649},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.5351795554161072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47014525532722473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46227508783340454},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.42238831520080566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3878766894340515},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37651610374450684}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009612","descriptor_name":"Nicotinamide-Nucleotide Adenylyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009612","descriptor_name":"Nicotinamide-Nucleotide Adenylyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.7554/elife.43808","doi":"https://doi.org/10.7554/elife.43808","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.43808","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5413945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6430606","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6430606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6430606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:30860478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30860478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02346546v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02346546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 2019, 8, &#x27E8;10.7554/eLife.43808&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e5cdb278106e458e886146dad1811a14","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5cdb278106e458e886146dad1811a14","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 8 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.43808","doi":"https://doi.org/10.7554/elife.43808","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.43808","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1553096032","https://openalex.org/W1569006646","https://openalex.org/W1587804137","https://openalex.org/W1830973753","https://openalex.org/W1951330234","https://openalex.org/W1968516203","https://openalex.org/W1974785470","https://openalex.org/W1984354326","https://openalex.org/W1989674299","https://openalex.org/W1995995646","https://openalex.org/W1996783999","https://openalex.org/W2004401468","https://openalex.org/W2017525855","https://openalex.org/W2018290536","https://openalex.org/W2028062494","https://openalex.org/W2030630765","https://openalex.org/W2030712030","https://openalex.org/W2032675883","https://openalex.org/W2040047628","https://openalex.org/W2041243532","https://openalex.org/W2055192452","https://openalex.org/W2070955414","https://openalex.org/W2072307255","https://openalex.org/W2079911379","https://openalex.org/W2081588531","https://openalex.org/W2082594072","https://openalex.org/W2082750628","https://openalex.org/W2087576311","https://openalex.org/W2088127501","https://openalex.org/W2089488917","https://openalex.org/W2114512247","https://openalex.org/W2117698167","https://openalex.org/W2118084468","https://openalex.org/W2118515401","https://openalex.org/W2128129151","https://openalex.org/W2132412147","https://openalex.org/W2136949260","https://openalex.org/W2140380026","https://openalex.org/W2143328924","https://openalex.org/W2149516140","https://openalex.org/W2164230996","https://openalex.org/W2168974900","https://openalex.org/W2284984697","https://openalex.org/W2560255046","https://openalex.org/W2615545356","https://openalex.org/W2775008495","https://openalex.org/W2775486301","https://openalex.org/W2784183910","https://openalex.org/W2789621916","https://openalex.org/W2791070352","https://openalex.org/W2791758888","https://openalex.org/W2895826492"],"related_works":["https://openalex.org/W1632858117","https://openalex.org/W1996624838","https://openalex.org/W4367311433","https://openalex.org/W2040047628","https://openalex.org/W7221485956","https://openalex.org/W2939791112","https://openalex.org/W195705601","https://openalex.org/W2070955414","https://openalex.org/W2136949260","https://openalex.org/W258524700"],"abstract_inverted_index":{"Metabolism":[0],"is":[1,121],"a":[2,37,67,131],"highly":[3],"integrated":[4,142],"process":[5],"resulting":[6,87],"in":[7,44,88,117,140],"energy":[8],"and":[9,41,74,108,128],"biomass":[10],"production.":[11],"While":[12],"individual":[13],"metabolic":[14],"routes":[15],"are":[16,25,30],"well":[17],"characterized,":[18],"the":[19,60,70,75,83,99,102,123],"mechanisms":[20],"ensuring":[21],"crosstalk":[22],"between":[23],"pathways":[24],"poorly":[26],"described,":[27],"although":[28],"they":[29],"crucial":[31],"for":[32,136],"homeostasis.":[33],"Here,":[34],"we":[35],"establish":[36],"co-regulation":[38],"of":[39,59,92,101,126],"purine":[40],"pyridine":[42,84,119],"metabolism":[43,120],"response":[45],"to":[46],"external":[47],"adenine":[48,54,80],"through":[49],"two":[50],"separable":[51],"mechanisms.":[52],"First,":[53],"depletion":[55],"promotes":[56],"transcriptional":[57],"upregulation":[58],"de":[61],"novo":[62],"NAD+":[63],"biosynthesis":[64,143],"genes":[65],"by":[66,112],"mechanism":[68],"requiring":[69],"key-purine":[71],"intermediates":[72],"ZMP/SZMP":[73,127],"Bas1/Pho2":[76],"transcription":[77],"factors.":[78],"Second,":[79],"supplementation":[81],"favors":[82],"salvage":[85],"route":[86],"an":[89,141],"ATP-dependent":[90],"increase":[91],"intracellular":[93],"NAD+.":[94],"This":[95],"control":[96,125],"operates":[97],"at":[98],"level":[100],"nicotinic":[103],"acid":[104],"mononucleotide":[105],"adenylyl-transferase":[106],"Nma1":[107],"can":[109],"be":[110],"bypassed":[111],"overexpressing":[113],"this":[114],"enzyme.":[115],"Therefore,":[116],"yeast,":[118],"under":[122],"dual":[124],"ATP,":[129],"revealing":[130],"much":[132],"wider":[133],"regulatory":[134],"role":[135],"these":[137],"intermediate":[138],"metabolites":[139],"network.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-22T00:00:00"}
