{"id":"https://openalex.org/W2921594435","doi":null,"title":"Discovery and Characterization of Novel Tetrodecamycins","display_name":"Discovery and Characterization of Novel Tetrodecamycins","publication_year":2017,"publication_date":"2017-06-01","ids":{"openalex":"https://openalex.org/W2921594435","mag":"2921594435"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/78988","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/78988","pdf_url":"https://utoronto.scholaris.ca/bitstreams/04945c66-bae6-4159-ab24-cf12202a23c5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/04945c66-bae6-4159-ab24-cf12202a23c5/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044914518","display_name":"Tomas Gverzdys","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tomas Gverzdys","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044914518"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antibiotic-biosynthesis","display_name":"antibiotic biosynthesis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.9810000061988831},{"id":"https://openalex.org/keywords/streptomyces-atroolivaceus","display_name":"Streptomyces atroolivaceus","score":0.9319999814033508},{"id":"https://openalex.org/keywords/streptomyces-globisporus","display_name":"Streptomyces globisporus","score":1.0},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8370000123977661},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9100000262260437},{"id":"https://openalex.org/keywords/novel-antibiotic-discovery","display_name":"new antibiotic development","score":0.5889999866485596},{"id":"https://openalex.org/keywords/deletion-mutants","display_name":"deletion mutants","score":0.41499999165534973},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.4780222177505493},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3676746189594269},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2685721814632416},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1908785104751587},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15423798561096191}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/78988","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/78988","pdf_url":"https://utoronto.scholaris.ca/bitstreams/04945c66-bae6-4159-ab24-cf12202a23c5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2921594435","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/78988/3/Gverzdys_Tomas_A_201706_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/78988","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/78988","pdf_url":"https://utoronto.scholaris.ca/bitstreams/04945c66-bae6-4159-ab24-cf12202a23c5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921594435.pdf","grobid_xml":"https://content.openalex.org/works/W2921594435.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W180083522","https://openalex.org/W1023183953","https://openalex.org/W1494581922","https://openalex.org/W1505877917","https://openalex.org/W1524732248","https://openalex.org/W1563870371","https://openalex.org/W1859880692","https://openalex.org/W1915856409","https://openalex.org/W1927652072","https://openalex.org/W1933115513","https://openalex.org/W1959927121","https://openalex.org/W1967164846","https://openalex.org/W1967537422","https://openalex.org/W1968962968","https://openalex.org/W1970274030","https://openalex.org/W1970798262","https://openalex.org/W1971860380","https://openalex.org/W1977264319","https://openalex.org/W1980747143","https://openalex.org/W1980798823","https://openalex.org/W1982793579","https://openalex.org/W1983403167","https://openalex.org/W1983917432","https://openalex.org/W1984754431","https://openalex.org/W1985318956","https://openalex.org/W1988298386","https://openalex.org/W1988454721","https://openalex.org/W1988543041","https://openalex.org/W1988918690","https://openalex.org/W1989259240","https://openalex.org/W1992575467","https://openalex.org/W1994767237","https://openalex.org/W1995313179","https://openalex.org/W1995995599","https://openalex.org/W1998748411","https://openalex.org/W2001396254","https://openalex.org/W2001670575","https://openalex.org/W2006596001","https://openalex.org/W2007066364","https://openalex.org/W2008541744","https://openalex.org/W2012025811","https://openalex.org/W2012251902","https://openalex.org/W2012960603","https://openalex.org/W2013003830","https://openalex.org/W2014013498","https://openalex.org/W2019477751","https://openalex.org/W2022764628","https://openalex.org/W2022800284","https://openalex.org/W2025278228","https://openalex.org/W2033704299","https://openalex.org/W2034011943","https://openalex.org/W2039947832","https://openalex.org/W2041537722","https://openalex.org/W2042336337","https://openalex.org/W2044889385","https://openalex.org/W2050806870","https://openalex.org/W2051033712","https://openalex.org/W2053918931","https://openalex.org/W2059397761","https://openalex.org/W2062516940","https://openalex.org/W2063195137","https://openalex.org/W2064157736","https://openalex.org/W2065018402","https://openalex.org/W2065704659","https://openalex.org/W2066068993","https://openalex.org/W2068641798","https://openalex.org/W2069451484","https://openalex.org/W2072094617","https://openalex.org/W2073846569","https://openalex.org/W2079228339","https://openalex.org/W2081633878","https://openalex.org/W2084250420","https://openalex.org/W2086242455","https://openalex.org/W2086416477","https://openalex.org/W2087901245","https://openalex.org/W2089778735","https://openalex.org/W2091874125","https://openalex.org/W2092238543","https://openalex.org/W2092643722","https://openalex.org/W2095063801","https://openalex.org/W2099695755","https://openalex.org/W2102964870","https://openalex.org/W2105364540","https://openalex.org/W2105754139","https://openalex.org/W2107019090","https://openalex.org/W2111967267","https://openalex.org/W2112606051","https://openalex.org/W2117753850","https://openalex.org/W2118812289","https://openalex.org/W2120457919","https://openalex.org/W2121131775","https://openalex.org/W2124753857","https://openalex.org/W2132526039","https://openalex.org/W2132926880","https://openalex.org/W2136216414","https://openalex.org/W2136520405","https://openalex.org/W2142500173","https://openalex.org/W2142517920","https://openalex.org/W2142678478","https://openalex.org/W2142844050","https://openalex.org/W2143485490","https://openalex.org/W2143999758","https://openalex.org/W2145974700","https://openalex.org/W2146172880","https://openalex.org/W2148094012","https://openalex.org/W2149068296","https://openalex.org/W2152207030","https://openalex.org/W2153584471","https://openalex.org/W2155028614","https://openalex.org/W2158658436","https://openalex.org/W2163243128","https://openalex.org/W2166801599","https://openalex.org/W2169942471","https://openalex.org/W2177846120","https://openalex.org/W2224175912","https://openalex.org/W2293302521","https://openalex.org/W2304674135","https://openalex.org/W2317537758","https://openalex.org/W2321887950","https://openalex.org/W2325419907","https://openalex.org/W2330792613","https://openalex.org/W2332821092","https://openalex.org/W2333313282","https://openalex.org/W2338991222","https://openalex.org/W2345729103","https://openalex.org/W2398193949","https://openalex.org/W2407924847","https://openalex.org/W2417086693","https://openalex.org/W2424696256","https://openalex.org/W2951328015","https://openalex.org/W2952009795","https://openalex.org/W2953351676"],"related_works":["https://openalex.org/W2345729103","https://openalex.org/W2272923834","https://openalex.org/W2407924847","https://openalex.org/W1974139453","https://openalex.org/W2012025811","https://openalex.org/W2396290830","https://openalex.org/W1987557233","https://openalex.org/W2028686308","https://openalex.org/W2952600328","https://openalex.org/W2044318039"],"abstract_inverted_index":{"Antibiotics":[0],"are":[1],"one":[2],"of":[3,8,30,42,47,90,96,103,141,156,165,172,199,246,268,291,299],"the":[4,27,38,75,88,94,101,110,118,136,139,154,163,182,187,205,226,259,266,274,288,292],"most":[5],"important":[6],"groups":[7],"drugs":[9],"ever":[10],"discovered.":[11],"In":[12,150,257],"addition":[13,151],"to":[14,50,87,152,238],"their":[15,176,297],"clinical":[16],"use,":[17],"these":[18,124,158,173,241],"small":[19,44],"molecules":[20,45,294],"have":[21],"also":[22,209,244],"been":[23],"essential":[24],"for":[25,128,279],"understanding":[26],"molecular":[28],"details":[29],"numerous":[31],"fundamental":[32],"biological":[33],"processes.":[34],"As":[35],"a":[36,60,83,147,190,269],"result,":[37],"discovery":[39,267],"and":[40,53,78,146,174,219,232,255,295],"characterization":[41],"novel":[43,191,270],"is":[46,59],"extraordinary":[48],"value":[49],"both":[51],"society":[52],"science.":[54],"Streptomyces":[55,215,217,220],"sp.":[56,221],"strain":[57,145],"WAC04657":[58,104],"wild-isolate":[61],"bacterium":[62],"that":[63,123,193,204,240],"produces":[64],"an":[65,143],"antibiotic":[66,85,271],"activity":[67],"against":[68],"multi-drug":[69],"resistant":[70],"Staphylococcus":[71],"aureus.":[72],"I":[73,99,114,131,169,179,194,235],"purified":[74,170],"responsible":[76,127,278],"molecule":[77,184,192],"characterized":[79],"it":[80],"as":[81,181,272],"13-deoxytetrodecamycin,":[82,130,157],"new":[84],"belonging":[86],"tetrodecamycin-group":[89,293],"molecules.":[91,168,250],"To":[92,121],"study":[93],"biosynthesis":[95],"this":[97,116,263],"molecule,":[98],"sequenced":[100],"genome":[102,201],"and,":[105],"using":[106],"bioinformatic":[107],"methods,":[108],"identified":[109,180],"biosynthetic":[111,275],"gene":[112,276],"cluster.":[113,120],"named":[115,195],"cluster":[117,137,207,228,277],"ted":[119,206,227],"confirm":[122,239],"genes":[125,134],"were":[126,243],"producing":[129,280],"genetically":[132,224],"manipulated":[133],"within":[135],"with":[138],"goal":[140],"making":[142],"overproducer":[144],"non-producer":[148],"strain.":[149],"affecting":[153],"expression":[155,164],"mutants":[159],"show":[160],"alterations":[161],"in":[162,211,229,262],"four":[166],"other":[167,213],"two":[171],"solved":[175],"structures.":[177],"One":[178],"known":[183],"tetrodecamycin,":[185],"while":[186],"second":[188],"was":[189,208,236],"W5.9.":[196],"A":[197],"search":[198],"public":[200],"sequences":[202],"revealed":[203],"found":[210],"three":[212],"bacteria:":[214],"atroolivaceus,":[216],"globisporus,":[218,234],"LaPpAH-202.":[222],"By":[223],"manipulating":[225],"S.":[230,233],"atroolivaceus":[231],"able":[237],"bacteria":[242],"producers":[245],"tetrodecamycin":[247,254],"\u00e2":[248],"group":[249],"Specifically,":[251],"they":[252],"produced":[253],"dihydrotetrodecamycin.":[256],"summary,":[258],"work":[260,283],"reported":[261],"thesis":[264],"describes":[265],"well":[273],"it.":[281],"Future":[282],"will":[284],"focus":[285],"on":[286],"assessing":[287],"therapeutic":[289],"potential":[290],"identifying":[296],"mechanism":[298],"action.":[300]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-22T00:00:00"}