{"id":"https://openalex.org/W2921499306","doi":null,"title":"DNA-based ligands for Human Cathepsin and medicaments thereof","display_name":"DNA-based ligands for Human Cathepsin and medicaments thereof","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2921499306","mag":"2921499306"},"language":"en","primary_location":{"id":"pmh:oai:www.research.unipd.it:11577/184537","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/184537","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/patent"},"volume":null,"type":"other","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001638640","display_name":"Manlio Palumbo","orcid":"https://orcid.org/0000-0002-3163-1564","observed_orcids":["https://orcid.org/0000-0002-3163-1564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manlio Palumbo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3163-1564","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088792877","display_name":"Barbara Gatto","orcid":"https://orcid.org/0000-0001-9465-6913","observed_orcids":["https://orcid.org/0000-0001-9465-6913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Gatto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9465-6913","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003496351","display_name":"Rodolfo Pescador","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Pescador","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023178240","display_name":"Raffaele La Porta","orcid":"https://orcid.org/0000-0002-0569-369X","observed_orcids":["https://orcid.org/0000-0002-0569-369X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaele La Porta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Luke S. Ferro","orcid":"https://orcid.org/0000-0001-5037-8464","observed_orcids":["https://orcid.org/0000-0001-5037-8464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke S. Ferro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5037-8464","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-g","display_name":"cathepsin G","score":0.9629999995231628},{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.7580000162124634},{"id":"https://openalex.org/keywords/non-peptidic-inhibitors","display_name":"non-peptidic inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5370000004768372},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.7850000262260437},{"id":"https://openalex.org/keywords/base-pairing","display_name":"base pairing","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5229142904281616},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49718335270881653},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3773432672023773},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3762674331665039},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31878018379211426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.266696572303772}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.research.unipd.it:11577/184537","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/184537","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/patent"},{"id":"mag:2921499306","doi":null,"is_oa":false,"landing_page_url":"https://dissem.in/p/81957538/dna-based-ligands-for-human-cathepsin-and-medicaments-thereof","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6999958093","https://openalex.org/W2100012130","https://openalex.org/W7027999571","https://openalex.org/W7100268113","https://openalex.org/W7096104316","https://openalex.org/W2022603931","https://openalex.org/W2130900149","https://openalex.org/W1964123656","https://openalex.org/W2014668440","https://openalex.org/W804220713"],"abstract_inverted_index":{"The":[0,37],"present":[1],"research":[2],"is":[3],"directed":[4],"to":[5,42,66],"the":[6,27,43],"identification":[7],"of":[8,11,18,31,46,56],"non-peptidic":[9],"inhibitors":[10],"cathepsin":[12,38],"G":[13],"characterised":[14],"by":[15],"high":[16],"levels":[17],"selectivity":[19],"and":[20,29,34,61],"which":[21],"can":[22],"be":[23],"efficaciously":[24],"used":[25],"in":[26],"treatment":[28],"prophylaxis":[30],"inflammatory":[32],"occurrences":[33],"procoagulant":[35],"conditions.":[36],"G-inhibiting":[39],"aptamers":[40],"according":[41],"invention":[44],"consist":[45],"linear":[47],"DNA":[48],"or":[49],"polynucleotide":[50],"sequences":[51],"having":[52],"a":[53],"chaing":[54],"length":[55],"at":[57],"least":[58],"60":[59],"nucleotides":[60],"being":[62],"substantially":[63],"not":[64],"subjected":[65],"undergo":[67],"efficient":[68],"base":[69],"pairing.":[70]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-03-22T00:00:00"}