{"id":"https://openalex.org/W2921387265","doi":null,"title":"Mechanisms of Osmotically-Induced T-tubule Remodeling in Mouse Cardiomyocytes","display_name":"Mechanisms of Osmotically-Induced T-tubule Remodeling in Mouse Cardiomyocytes","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2921387265","mag":"2921387265"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/145848","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/145848","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/663bfa7c-6d51-43e2-9887-02f504771b89/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://deepblue.lib.umich.edu/bitstreams/663bfa7c-6d51-43e2-9887-02f504771b89/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088251959","display_name":"Keita Uchida","orcid":"https://orcid.org/0000-0001-8458-9796","observed_orcids":["https://orcid.org/0000-0001-8458-9796"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Keita Uchida","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8458-9796","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088251959"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.9589999914169312},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dextran-diffusion","display_name":"dextran diffusion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.8939999938011169},{"id":"https://openalex.org/keywords/detubulation","display_name":"detubulation","score":0.671999990940094},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.6919999718666077},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dyadic-relationships","display_name":"dyads","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.5445587038993835},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5192599296569824},{"id":"https://openalex.org/C2780498532","wikidata":"https://www.wikidata.org/wiki/Q7850941","display_name":"Tubule","level":3,"score":0.48600754141807556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41317328810691833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29592567682266235},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23760256171226501},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.1432490348815918}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/145848","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/145848","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/663bfa7c-6d51-43e2-9887-02f504771b89/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2921387265","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/145848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/145848","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/145848","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/663bfa7c-6d51-43e2-9887-02f504771b89/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921387265.pdf","grobid_xml":"https://content.openalex.org/works/W2921387265.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W136225400","https://openalex.org/W185505243","https://openalex.org/W203775048","https://openalex.org/W1480308981","https://openalex.org/W1481378243","https://openalex.org/W1485384468","https://openalex.org/W1513594647","https://openalex.org/W1520017461","https://openalex.org/W1578573729","https://openalex.org/W1963623014","https://openalex.org/W1964282514","https://openalex.org/W1965976825","https://openalex.org/W1966528469","https://openalex.org/W1978660000","https://openalex.org/W1979443037","https://openalex.org/W1981616271","https://openalex.org/W1982260907","https://openalex.org/W1982913412","https://openalex.org/W1985578759","https://openalex.org/W1986889002","https://openalex.org/W1990337343","https://openalex.org/W1991872205","https://openalex.org/W1992508893","https://openalex.org/W1993032936","https://openalex.org/W1996344039","https://openalex.org/W1996841780","https://openalex.org/W1998399969","https://openalex.org/W2001160771","https://openalex.org/W2002287850","https://openalex.org/W2003046582","https://openalex.org/W2006512709","https://openalex.org/W2008297317","https://openalex.org/W2009500267","https://openalex.org/W2012418743","https://openalex.org/W2012739206","https://openalex.org/W2013548576","https://openalex.org/W2015154923","https://openalex.org/W2017596484","https://openalex.org/W2019318168","https://openalex.org/W2021693681","https://openalex.org/W2021735829","https://openalex.org/W2021881382","https://openalex.org/W2022142440","https://openalex.org/W2022607662","https://openalex.org/W2023033209","https://openalex.org/W2023758830","https://openalex.org/W2023922465","https://openalex.org/W2030267203","https://openalex.org/W2031159210","https://openalex.org/W2035779164","https://openalex.org/W2036424054","https://openalex.org/W2036667288","https://openalex.org/W2036844107","https://openalex.org/W2038501159","https://openalex.org/W2039790097","https://openalex.org/W2040317494","https://openalex.org/W2050824263","https://openalex.org/W2052873131","https://openalex.org/W2053275151","https://openalex.org/W2058607911","https://openalex.org/W2059835601","https://openalex.org/W2062331117","https://openalex.org/W2063742728","https://openalex.org/W2065173077","https://openalex.org/W2065462886","https://openalex.org/W2066020583","https://openalex.org/W2067991877","https://openalex.org/W2068310937","https://openalex.org/W2070500034","https://openalex.org/W2070951720","https://openalex.org/W2072670197","https://openalex.org/W2074377740","https://openalex.org/W2076700296","https://openalex.org/W2078701563","https://openalex.org/W2079725368","https://openalex.org/W2079935372","https://openalex.org/W2080484884","https://openalex.org/W2083392577","https://openalex.org/W2083465797","https://openalex.org/W2084011431","https://openalex.org/W2085923980","https://openalex.org/W2086041680","https://openalex.org/W2090630705","https://openalex.org/W2096667649","https://openalex.org/W2099487878","https://openalex.org/W2100687920","https://openalex.org/W2102109717","https://openalex.org/W2102311103","https://openalex.org/W2106972592","https://openalex.org/W2107417311","https://openalex.org/W2109665703","https://openalex.org/W2112758886","https://openalex.org/W2113579017","https://openalex.org/W2113819079","https://openalex.org/W2116187776","https://openalex.org/W2119028999","https://openalex.org/W2120076709","https://openalex.org/W2121900309","https://openalex.org/W2122509573","https://openalex.org/W2124579523","https://openalex.org/W2124977931","https://openalex.org/W2131236986","https://openalex.org/W2135515146","https://openalex.org/W2136260730","https://openalex.org/W2142393775","https://openalex.org/W2150395026","https://openalex.org/W2151155243","https://openalex.org/W2154988431","https://openalex.org/W2155195157","https://openalex.org/W2155348905","https://openalex.org/W2155698285","https://openalex.org/W2160546031","https://openalex.org/W2161639212","https://openalex.org/W2166003879","https://openalex.org/W2169296313","https://openalex.org/W2170056053","https://openalex.org/W2171131379","https://openalex.org/W2216866477","https://openalex.org/W2229276467","https://openalex.org/W2240607464","https://openalex.org/W2255395598","https://openalex.org/W2267030154","https://openalex.org/W2267952155","https://openalex.org/W2281355947","https://openalex.org/W2300491928","https://openalex.org/W2318369880","https://openalex.org/W2398206791","https://openalex.org/W2404165395","https://openalex.org/W2464729566","https://openalex.org/W2569513212","https://openalex.org/W2602896452","https://openalex.org/W2615372385","https://openalex.org/W2731942167","https://openalex.org/W2769969480","https://openalex.org/W2784207539","https://openalex.org/W2785202926","https://openalex.org/W2977097895"],"related_works":["https://openalex.org/W2791190180","https://openalex.org/W2785202926","https://openalex.org/W2066413994","https://openalex.org/W2464729566","https://openalex.org/W1480308981","https://openalex.org/W2790550358","https://openalex.org/W2795694751","https://openalex.org/W1966568818","https://openalex.org/W4385519266","https://openalex.org/W2109660169"],"abstract_inverted_index":{"T-tubules":[0,21],"are":[1,14,22],"invaginations":[2],"of":[3,17,43,85,93,122,150,173,185,208,219,238,242,278,283,300,309,323,337,354,365,386,397,413,420,433],"the":[4,26,44,76,91,96,106,117,148,170,179,204,211,216,236,259,275,281,298,306,316,321,330,335,346,351,359,362,395,408,418],"surface":[5],"sarcolemma":[6],"that":[7,98,109,195,224,261,292,305,329,361,389],"form":[8,31],"a":[9,228,368,384],"complex,":[10],"interconnected":[11],"network":[12],"and":[13,53,95,114,120,137,140,198,214,231,253,280,294,393,410],"distinctive":[15],"structures":[16,32,112,153,423],"adult":[18],"ventricular":[19],"cardiomyocytes.":[20],"intimately":[23],"linked":[24],"to":[25,30,89,100,126,154,168,203,215,246,266,325,341,377,399],"intracellular":[27],"sarcoplasmic":[28],"reticulum":[29],"called":[33],"dyads,":[34],"which":[35,176,333],"house":[36],"proteins":[37],"critical":[38,387],"for":[39],"excitation-contraction":[40],"coupling.":[41],"Disruption":[42],"t-tubule":[45,48,73,262,284],"network,":[46],"particularly":[47],"loss,":[49],"causes":[50],"contractile":[51],"dysfunction":[52],"has":[54,157],"been":[55,132,145,158],"extensively":[56],"characterized":[57],"in":[58,124,188,371,375,404],"various":[59],"cardiovascular":[60,70],"diseases.":[61],"Multiple":[62],"studies":[63],"have":[64,131,144,382],"correlated":[65],"mechanical":[66],"stress":[67,252,288],"associated":[68],"with":[69,72,191],"diseases":[71],"remodeling":[74],"but":[75],"underlying":[77],"causal":[78],"mechanism":[79,237],"remains":[80],"unknown.":[81],"The":[82,401],"overall":[83],"goal":[84],"this":[86,405],"thesis":[87,104],"is":[88,227],"study":[90],"function":[92],"t-tubules":[94,123,130,143,189,265,279,324,366,398],"factors":[97,388],"contribute":[99],"their":[101,373],"remodeling.":[102,435],"This":[103],"tests":[105],"central":[107],"hypothesis":[108,260],"sub-microscopic":[110,152,363,414,421],"t-tubular":[111,181,196,212,248,391,415,422,434],"(constrictions":[113],"dilations)":[115],"regulate":[116,390],"diffusional":[118,171,276],"properties":[119,172,218],"stability":[121,299,374,392],"response":[125,376,396],"osmotic":[127,225,251,269,287,378],"stress.":[128,270,400],"Generally,":[129],"modeled":[133],"as":[134],"cylindrical":[135],"tubes":[136],"although":[138],"constrictions":[139,197,249,263,293],"dilations":[141,199,295],"within":[142,210],"well":[146],"documented,":[147],"contributions":[149,202],"these":[151],"cardiac":[155,174],"physiology":[156],"largely":[159],"unrecognized.":[160],"A":[161,240,271],"novel":[162],"fluorescence":[163],"based":[164],"assay":[165],"was":[166,289],"developed":[167,245],"characterize":[169],"t-tubules,":[175],"depend":[177],"on":[178],"fine":[180],"structure.":[182],"Quantitative":[183],"measurements":[184],"dextran":[186],"diffusion":[187,206],"combined":[190],"computational":[192],"modeling":[193],"revealed":[194],"make":[200],"significant":[201],"apparent":[205],"coefficient":[207],"molecules":[209,313],"lumen":[213],"electrical":[217],"t-tubules.":[220,301],"Subsequent":[221],"experiments":[222],"demonstrated":[223],"detubulation":[226],"threshold":[229],"phenomenon":[230],"provided":[232],"quantitative":[233],"insights":[234],"into":[235,427],"detubulation.":[239,326],"series":[241],"conditions":[243],"were":[244],"induce":[247],"through":[250],"chemical":[254],"modifications.":[255],"Next,":[256],"I":[257],"tested":[258],"predispose":[264],"seal":[267],"following":[268,286],"strong":[272],"correlation":[273],"between":[274],"accessibility":[277],"magnitude":[282],"sealing":[285],"established,":[290],"suggesting":[291],"strongly":[296,319],"modulate":[297],"Finally,":[302],"we":[303,381],"found":[304],"concentration":[307],"gradient":[308],"small":[310],"membrane":[311,317,338,342],"permeable":[312],"(SMPMs)":[314],"across":[315,345],"could":[318],"affect":[320],"susceptibility":[322],"We":[327],"proposed":[328],"\u201cbilayer-couple":[331],"hypothesis\u201d,":[332],"describes":[334],"formation":[336],"curvature":[339],"due":[340],"area":[343],"asymmetry":[344],"membrane,":[347],"can":[348],"effectively":[349],"explain":[350],"modulatory":[352],"roles":[353],"SMPMs.":[355],"These":[356],"results":[357,402],"support":[358],"notion":[360],"structure":[364],"play":[367],"key":[369],"role":[370],"determining":[372],"stresses.":[379],"Overall,":[380],"identified":[383],"number":[385],"determine":[394],"presented":[403],"dissertation":[406],"demonstrate":[407],"functional":[409],"structural":[411],"significance":[412],"structures.":[416],"Furthermore,":[417],"contribution":[419],"must":[424],"be":[425],"taken":[426],"account":[428],"when":[429],"developing":[430],"future":[431],"models":[432]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-03-22T00:00:00"}