{"id":"https://openalex.org/W2921344997","doi":"https://doi.org/10.18632/genesandcancer.177","title":"MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer","display_name":"MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer","publication_year":2018,"publication_date":"2018-09-07","ids":{"openalex":"https://openalex.org/W2921344997","doi":"https://doi.org/10.18632/genesandcancer.177","mag":"2921344997","pmid":"https://pubmed.ncbi.nlm.nih.gov/30603058","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6305104"},"language":"en","primary_location":{"id":"doi:10.18632/genesandcancer.177","doi":"https://doi.org/10.18632/genesandcancer.177","is_oa":true,"landing_page_url":"https://doi.org/10.18632/genesandcancer.177","pdf_url":"https://www.genesandcancer.com/article/177/pdf/","source":{"id":"https://openalex.org/S47803330","display_name":"Genes & Cancer","issn_l":"1947-6019","issn":["1947-6019","1947-6027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.genesandcancer.com/article/177/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041726238","display_name":"Lila E. Mullany","orcid":"https://orcid.org/0000-0003-0936-5957","observed_orcids":["https://orcid.org/0000-0003-0936-5957"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lila E. Mullany","raw_affiliation_strings":["Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059108165","display_name":"Jennifer S. Herrick","orcid":"https://orcid.org/0000-0001-9257-8843","observed_orcids":["https://orcid.org/0000-0001-9257-8843"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Herrick","raw_affiliation_strings":["Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044332098","display_name":"Lori C. Sakoda","orcid":"https://orcid.org/0000-0002-0900-5735","observed_orcids":["https://orcid.org/0000-0002-0900-5735"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori C. Sakoda","raw_affiliation_strings":["Division of Research, Kaiser Permanente Northern California, Oakland, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research, Kaiser Permanente Northern California, Oakland, California","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018021008","display_name":"Wade S. Samowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wade Samowitz","raw_affiliation_strings":["Department of Pathology, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058847502","display_name":"John R. Stevens","orcid":"https://orcid.org/0000-0002-2908-7918","observed_orcids":["https://orcid.org/0000-0002-2908-7918"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Stevens","raw_affiliation_strings":["Department of Mathematics and Statistics, Utah State University, Logan, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Utah State University, Logan, Utah","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060833617","display_name":"Roger K. Wolff","orcid":"https://orcid.org/0000-0003-3218-1953","observed_orcids":["https://orcid.org/0000-0003-3218-1953"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger K. Wolff","raw_affiliation_strings":["Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073774490","display_name":"Martha L. Slattery","orcid":"https://orcid.org/0000-0002-1655-6543","observed_orcids":["https://orcid.org/0000-0002-1655-6543"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha L. Slattery","raw_affiliation_strings":["Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041726238"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":0.3049,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.48114624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"5-6","first_page":"232","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mrna","display_name":"mRNA","score":0.39100000262260437},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.984000027179718},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/mirna-mrna-interactions","display_name":"miRNA-mRNA interactions","score":0.8130000233650208},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.7940000295639038},{"id":"https://openalex.org/keywords/microsatellite-stable-tumors","display_name":"microsatellite stable tumors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mirna-seed-sequence","display_name":"miRNA seed sequence","score":0.671999990940094},{"id":"https://openalex.org/keywords/receptor-degradation","display_name":"receptor degradation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.770788311958313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5905550718307495},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5134249925613403},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4877634644508362},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45938020944595337},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.44304946064949036},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43972715735435486},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.43839117884635925},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.438239723443985},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.43443506956100464},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.41022342443466187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4085993766784668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27388209104537964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27212977409362793},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.11191511154174805}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18632/genesandcancer.177","doi":"https://doi.org/10.18632/genesandcancer.177","is_oa":true,"landing_page_url":"https://doi.org/10.18632/genesandcancer.177","pdf_url":"https://www.genesandcancer.com/article/177/pdf/","source":{"id":"https://openalex.org/S47803330","display_name":"Genes & Cancer","issn_l":"1947-6019","issn":["1947-6019","1947-6027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5288814","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6305104","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6305104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6305104","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Cancer","raw_type":"Text"},{"id":"pmid:30603058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30603058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/genesandcancer.177","doi":"https://doi.org/10.18632/genesandcancer.177","is_oa":true,"landing_page_url":"https://doi.org/10.18632/genesandcancer.177","pdf_url":"https://www.genesandcancer.com/article/177/pdf/","source":{"id":"https://openalex.org/S47803330","display_name":"Genes & Cancer","issn_l":"1947-6019","issn":["1947-6019","1947-6027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1701807096","display_name":"miRNA and colorectal cancer: associations with tumor phenotype and survival","funder_award_id":"R01CA163683","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308849","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921344997.pdf","grobid_xml":"https://content.openalex.org/works/W2921344997.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1483308173","https://openalex.org/W1517245545","https://openalex.org/W1756055907","https://openalex.org/W1821858011","https://openalex.org/W1966832659","https://openalex.org/W1982677132","https://openalex.org/W1997785224","https://openalex.org/W2010009559","https://openalex.org/W2013462103","https://openalex.org/W2017270642","https://openalex.org/W2045979867","https://openalex.org/W2064520719","https://openalex.org/W2067742553","https://openalex.org/W2069009920","https://openalex.org/W2082552489","https://openalex.org/W2086221920","https://openalex.org/W2089001345","https://openalex.org/W2089114442","https://openalex.org/W2093716255","https://openalex.org/W2098637032","https://openalex.org/W2103796092","https://openalex.org/W2106171508","https://openalex.org/W2108871359","https://openalex.org/W2110065044","https://openalex.org/W2113764711","https://openalex.org/W2123847993","https://openalex.org/W2159659449","https://openalex.org/W2159675211","https://openalex.org/W2174734928","https://openalex.org/W2283914130","https://openalex.org/W2293040856","https://openalex.org/W2342525843","https://openalex.org/W2482634524"],"related_works":["https://openalex.org/W2790513846","https://openalex.org/W4390650761","https://openalex.org/W1983759912","https://openalex.org/W7095492206","https://openalex.org/W2886838525","https://openalex.org/W3186157827","https://openalex.org/W2793403158","https://openalex.org/W2945974221","https://openalex.org/W2805961026","https://openalex.org/W1866659834"],"abstract_inverted_index":{"JAK-STAT":[0,26,171],"signaling":[1,172],"influences":[2],"many":[3],"downstream":[4,190],"processes":[5],"that,":[6],"unchecked,":[7],"contribute":[8],"to":[9,20,62],"carcinogenesis":[10],"and":[11,35,43,47,196],"metastasis.":[12],"MicroRNAs":[13],"(miRNAs)":[14],"are":[15],"hypothesized":[16],"as":[17],"a":[18,56,80,90],"mechanism":[19],"prevent":[21],"uncontrolled":[22],"growth":[23],"from":[24],"continuous":[25],"activation.":[27],"We":[28],"investigated":[29],"differential":[30,120],"expression":[31,121],"between":[32],"paired":[33],"carcinoma":[34],"normal":[36],"colorectal":[37,69],"mucosa":[38],"of":[39,83,94,122,138,158,192],"messenger":[40],"RNAs":[41],"(mRNAs)":[42],"miRNAs":[44,179],"using":[45,55],"RNA-Seq":[46],"Agilent":[48],"Human":[49],"miRNA":[50,147,198],"Microarray":[51],"V19.0":[52],"data,":[53],"respectively,":[54],"negative":[57,143],"binomial":[58],"mixed":[59],"effects":[60,191],"model":[61],"test":[63],"122":[64],"JAK-STAT-signaling":[65],"genes":[66],"in":[67,100],"217":[68],"cancer":[70],"(CRC)":[71],"cases.":[72],"Overall,":[73],"42":[74],"mRNAs":[75,160],"were":[76,98,106,117,129],"differentially":[77],"expressed":[78],"with":[79,89,119,142,151],"fold":[81],"change":[82],">1.50":[84],"or":[85],"<0.67,":[86],"remaining":[87],"significant":[88,130],"false":[91],"discovery":[92],"rate":[93],"<":[95],"0.05;":[96],"four":[97],"dysregulated":[99],"microsatellite":[101,108],"stable":[102],"(MSS)":[103],"tumors,":[104],"eight":[105],"for":[107,133,162],"unstable":[109],"(MSI)-specific":[110],"tumors.":[111],"Of":[112],"these":[113,159],"54":[114],"mRNAs,":[115,152],"17":[116,157],"associated":[118],"46":[123],"miRNAs,":[124],"comprising":[125],"116":[126],"interactions:":[127],"16":[128],"overall,":[131],"one":[132],"MSS":[134],"tumors":[135],"only.":[136],"Twenty":[137],"the":[139],"29":[140],"interactions":[141],"beta":[144,186],"coefficients":[145,187],"involved":[146],"seed":[148],"sequence":[149],"matches":[150],"supporting":[153],"miRNA-mediated":[154],"mRNA":[155],"repression;":[156],"encode":[161],"receptor":[163],"molecules.":[164],"Receptor":[165],"molecule":[166],"degradation":[167],"is":[168],"an":[169],"established":[170],"control":[173],"mechanism;":[174],"our":[175],"results":[176],"suggest":[177],"that":[178],"facilitate":[180],"this":[181],"process.":[182],"Interactions":[183],"involving":[184],"positive":[185],"may":[188],"illustrate":[189],"disrupted":[193],"STAT":[194],"activity,":[195],"subsequent":[197],"upregulation.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-03-22T00:00:00"}