{"id":"https://openalex.org/W2921343344","doi":null,"title":"CHARACTERIZATION OF PORCINE NLRP3 INFLAMMASOME-MEDIATED INTERLEUKIN-1 BETA PRODUCTION IN RESPONSE TO INFLUENZA A VIRUSES","display_name":"CHARACTERIZATION OF PORCINE NLRP3 INFLAMMASOME-MEDIATED INTERLEUKIN-1 BETA PRODUCTION IN RESPONSE TO INFLUENZA A VIRUSES","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2921343344","mag":"2921343344"},"language":"en","primary_location":{"id":"pmh:oai:harvest.usask.ca:10388/11674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/11674","pdf_url":"http://hdl.handle.net/10388/11674","source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10388/11674","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061998268","display_name":"Hong-su Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hong-su Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061998268"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.949999988079071},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/swine-influenza-virus","display_name":"swine influenza virus","score":0.8080000281333923},{"id":"https://openalex.org/keywords/porcine-alveolar-macrophages","display_name":"porcine alveolar macrophages","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ns1-protein","display_name":"NS1 protein","score":0.7269999980926514},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.7429999709129333},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.8119999766349792},{"id":"https://openalex.org/keywords/viral-pathogenicity","display_name":"viral pathogenicity","score":0.37400001287460327},{"id":"https://openalex.org/keywords/h3n2","display_name":"H3N2","score":0.5929999947547913},{"id":"https://openalex.org/keywords/h5n1","display_name":"H5N1","score":0.7149999737739563},{"id":"https://openalex.org/keywords/h7n9","display_name":"H7N9","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8255510330200195},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.7542599439620972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6695089340209961},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.6433920860290527},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5747082829475403},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.555833637714386},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5267495512962341},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49627190828323364},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4768213629722595},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.42155951261520386},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3779764771461487}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:harvest.usask.ca:10388/11674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/11674","pdf_url":"http://hdl.handle.net/10388/11674","source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2921343344","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/handle/10388/11674","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:harvest.usask.ca:10388/11674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/11674","pdf_url":"http://hdl.handle.net/10388/11674","source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320332907","display_name":"Medical Center, University of Rochester","ror":"https://ror.org/00trqv719"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921343344.pdf","grobid_xml":"https://content.openalex.org/works/W2921343344.grobid-xml"},"referenced_works_count":515,"referenced_works":["https://openalex.org/W38265209","https://openalex.org/W39486818","https://openalex.org/W48032740","https://openalex.org/W67730157","https://openalex.org/W187072071","https://openalex.org/W208933311","https://openalex.org/W220223675","https://openalex.org/W1483301458","https://openalex.org/W1500843579","https://openalex.org/W1513095566","https://openalex.org/W1517475862","https://openalex.org/W1524848610","https://openalex.org/W1526531594","https://openalex.org/W1529149321","https://openalex.org/W1529674879","https://openalex.org/W1533910363","https://openalex.org/W1536422556","https://openalex.org/W1550983053","https://openalex.org/W1561041814","https://openalex.org/W1564755100","https://openalex.org/W1567772680","https://openalex.org/W1574330564","https://openalex.org/W1586591061","https://openalex.org/W1587650589","https://openalex.org/W1588939300","https://openalex.org/W1604969938","https://openalex.org/W1680053970","https://openalex.org/W1689514240","https://openalex.org/W1695062097","https://openalex.org/W1743744546","https://openalex.org/W1756461615","https://openalex.org/W1770945399","https://openalex.org/W1776031695","https://openalex.org/W1778352924","https://openalex.org/W1802558161","https://openalex.org/W1804579058","https://openalex.org/W1820249097","https://openalex.org/W1825604636","https://openalex.org/W1833270844","https://openalex.org/W1859128422","https://openalex.org/W1864325817","https://openalex.org/W1893318402","https://openalex.org/W1915332119","https://openalex.org/W1934419416","https://openalex.org/W1939312397","https://openalex.org/W1952767463","https://openalex.org/W1963987860","https://openalex.org/W1964454875","https://openalex.org/W1964541540","https://openalex.org/W1965105151","https://openalex.org/W1966390603","https://openalex.org/W1966914633","https://openalex.org/W1967139098","https://openalex.org/W1967280262","https://openalex.org/W1968987342","https://openalex.org/W1969430178","https://openalex.org/W1969603232","https://openalex.org/W1970436087","https://openalex.org/W1970560893","https://openalex.org/W1972126235","https://openalex.org/W1972483153","https://openalex.org/W1972745528","https://openalex.org/W1974412717","https://openalex.org/W1974495821","https://openalex.org/W1975032025","https://openalex.org/W1975145629","https://openalex.org/W1975296966","https://openalex.org/W1975921445","https://openalex.org/W1976990823","https://openalex.org/W1977457899","https://openalex.org/W1978008054","https://openalex.org/W1978274182","https://openalex.org/W1978525572","https://openalex.org/W1979032223","https://openalex.org/W1979035564","https://openalex.org/W1979231045","https://openalex.org/W1979275431","https://openalex.org/W1979513695","https://openalex.org/W1979991507","https://openalex.org/W1980086230","https://openalex.org/W1980109413","https://openalex.org/W1981237612","https://openalex.org/W1981837371","https://openalex.org/W1983963026","https://openalex.org/W1984520240","https://openalex.org/W1985538633","https://openalex.org/W1985831101","https://openalex.org/W1987329700","https://openalex.org/W1988197452","https://openalex.org/W1989061093","https://openalex.org/W1989249407","https://openalex.org/W1990545448","https://openalex.org/W1993102001","https://openalex.org/W1993271324","https://openalex.org/W1993728991","https://openalex.org/W1993808715","https://openalex.org/W1994167951","https://openalex.org/W1994566041","https://openalex.org/W1995003146","https://openalex.org/W1996338676","https://openalex.org/W1997572777","https://openalex.org/W1997839876","https://openalex.org/W1997892691","https://openalex.org/W1998639445","https://openalex.org/W1998722122","https://openalex.org/W1999352184","https://openalex.org/W1999542797","https://openalex.org/W2000134546","https://openalex.org/W2000451599","https://openalex.org/W2001166572","https://openalex.org/W2001788095","https://openalex.org/W2002223631","https://openalex.org/W2003778885","https://openalex.org/W2004586645","https://openalex.org/W2005359428","https://openalex.org/W2005529950","https://openalex.org/W2007283920","https://openalex.org/W2007508922","https://openalex.org/W2008202400","https://openalex.org/W2008332711","https://openalex.org/W2009004909","https://openalex.org/W2009127910","https://openalex.org/W2010508038","https://openalex.org/W2010836377","https://openalex.org/W2012156061","https://openalex.org/W2012270515","https://openalex.org/W2012680181","https://openalex.org/W2013053777","https://openalex.org/W2013601771","https://openalex.org/W2013999310","https://openalex.org/W2014602273","https://openalex.org/W2015449243","https://openalex.org/W2015650354","https://openalex.org/W2015879727","https://openalex.org/W2016540525","https://openalex.org/W2017275974","https://openalex.org/W2017309788","https://openalex.org/W2018234381","https://openalex.org/W2018563185","https://openalex.org/W2018607502","https://openalex.org/W2019073610","https://openalex.org/W2019407752","https://openalex.org/W2020908160","https://openalex.org/W2021064333","https://openalex.org/W2022078450","https://openalex.org/W2023283007","https://openalex.org/W2025673880","https://openalex.org/W2026400708","https://openalex.org/W2026500006","https://openalex.org/W2027732533","https://openalex.org/W2028145763","https://openalex.org/W2028571879","https://openalex.org/W2028642580","https://openalex.org/W2028792773","https://openalex.org/W2029456306","https://openalex.org/W2029465014","https://openalex.org/W2030362470","https://openalex.org/W2032370476","https://openalex.org/W2032725983","https://openalex.org/W2033003569","https://openalex.org/W2034453538","https://openalex.org/W2034649150","https://openalex.org/W2034679941","https://openalex.org/W2035232303","https://openalex.org/W2036146926","https://openalex.org/W2037600884","https://openalex.org/W2038165924","https://openalex.org/W2038312874","https://openalex.org/W2038698914","https://openalex.org/W2039440227","https://openalex.org/W2039483481","https://openalex.org/W2041753380","https://openalex.org/W2042196311","https://openalex.org/W2042288276","https://openalex.org/W2042433863","https://openalex.org/W2042767581","https://openalex.org/W2042816890","https://openalex.org/W2042876447","https://openalex.org/W2043661964","https://openalex.org/W2043992563","https://openalex.org/W2044210137","https://openalex.org/W2045278877","https://openalex.org/W2045969462","https://openalex.org/W2046714103","https://openalex.org/W2047073144","https://openalex.org/W2047837196","https://openalex.org/W2048676149","https://openalex.org/W2051874642","https://openalex.org/W2052798287","https://openalex.org/W2052874989","https://openalex.org/W2053089001","https://openalex.org/W2053476949","https://openalex.org/W2053847949","https://openalex.org/W2054400909","https://openalex.org/W2056036445","https://openalex.org/W2056080643","https://openalex.org/W2056145969","https://openalex.org/W2056161765","https://openalex.org/W2056165940","https://openalex.org/W2056732680","https://openalex.org/W2058015620","https://openalex.org/W2059009119","https://openalex.org/W2059395206","https://openalex.org/W2059924886","https://openalex.org/W2060377782","https://openalex.org/W2061578670","https://openalex.org/W2061600879","https://openalex.org/W2061868430","https://openalex.org/W2062383102","https://openalex.org/W2062490839","https://openalex.org/W2064882706","https://openalex.org/W2064955349","https://openalex.org/W2065139062","https://openalex.org/W2065470422","https://openalex.org/W2066904343","https://openalex.org/W2067262890","https://openalex.org/W2067406680","https://openalex.org/W2067436737","https://openalex.org/W2067622131","https://openalex.org/W2067706259","https://openalex.org/W2068353535","https://openalex.org/W2069277514","https://openalex.org/W2069360787","https://openalex.org/W2069509021","https://openalex.org/W2070000205","https://openalex.org/W2071496192","https://openalex.org/W2071517838","https://openalex.org/W2071688420","https://openalex.org/W2072237100","https://openalex.org/W2073625279","https://openalex.org/W2073743133","https://openalex.org/W2074061005","https://openalex.org/W2074535746","https://openalex.org/W2074833392","https://openalex.org/W2076062022","https://openalex.org/W2078288243","https://openalex.org/W2079440368","https://openalex.org/W2079882002","https://openalex.org/W2080657634","https://openalex.org/W2081240341","https://openalex.org/W2082413189","https://openalex.org/W2082857443","https://openalex.org/W2083084591","https://openalex.org/W2083124439","https://openalex.org/W2083392874","https://openalex.org/W2083427357","https://openalex.org/W2084158898","https://openalex.org/W2084998907","https://openalex.org/W2085006185","https://openalex.org/W2087239120","https://openalex.org/W2087976242","https://openalex.org/W2088240440","https://openalex.org/W2088322976","https://openalex.org/W2088941584","https://openalex.org/W2089578585","https://openalex.org/W2090859543","https://openalex.org/W2091080506","https://openalex.org/W2091527885","https://openalex.org/W2091978007","https://openalex.org/W2093588907","https://openalex.org/W2093785176","https://openalex.org/W2094184533","https://openalex.org/W2097721907","https://openalex.org/W2098855274","https://openalex.org/W2099533608","https://openalex.org/W2101039718","https://openalex.org/W2101043191","https://openalex.org/W2101096291","https://openalex.org/W2101663219","https://openalex.org/W2104028914","https://openalex.org/W2104195963","https://openalex.org/W2104221775","https://openalex.org/W2104934425","https://openalex.org/W2105926865","https://openalex.org/W2106120955","https://openalex.org/W2107237397","https://openalex.org/W2107513655","https://openalex.org/W2108100953","https://openalex.org/W2109678731","https://openalex.org/W2110214166","https://openalex.org/W2110590976","https://openalex.org/W2111058723","https://openalex.org/W2111642458","https://openalex.org/W2112499131","https://openalex.org/W2113010696","https://openalex.org/W2113162618","https://openalex.org/W2114142573","https://openalex.org/W2114315853","https://openalex.org/W2114443908","https://openalex.org/W2114884151","https://openalex.org/W2114906848","https://openalex.org/W2115612309","https://openalex.org/W2115617484","https://openalex.org/W2116990699","https://openalex.org/W2117047064","https://openalex.org/W2117916089","https://openalex.org/W2117964520","https://openalex.org/W2118275084","https://openalex.org/W2118694630","https://openalex.org/W2119828139","https://openalex.org/W2120090099","https://openalex.org/W2120096887","https://openalex.org/W2120815988","https://openalex.org/W2121260217","https://openalex.org/W2123749436","https://openalex.org/W2124803334","https://openalex.org/W2125501515","https://openalex.org/W2126303830","https://openalex.org/W2126384811","https://openalex.org/W2126604656","https://openalex.org/W2126623340","https://openalex.org/W2127245371","https://openalex.org/W2127567432","https://openalex.org/W2127780670","https://openalex.org/W2128175717","https://openalex.org/W2129237135","https://openalex.org/W2130180391","https://openalex.org/W2131235825","https://openalex.org/W2131497083","https://openalex.org/W2132233942","https://openalex.org/W2132482634","https://openalex.org/W2132490889","https://openalex.org/W2133006561","https://openalex.org/W2133053859","https://openalex.org/W2133318493","https://openalex.org/W2133377721","https://openalex.org/W2133449490","https://openalex.org/W2133936786","https://openalex.org/W2134219545","https://openalex.org/W2134735862","https://openalex.org/W2134784093","https://openalex.org/W2134928825","https://openalex.org/W2135343017","https://openalex.org/W2135344338","https://openalex.org/W2135437517","https://openalex.org/W2137160332","https://openalex.org/W2137303998","https://openalex.org/W2137594178","https://openalex.org/W2137949247","https://openalex.org/W2138660104","https://openalex.org/W2138694950","https://openalex.org/W2138760860","https://openalex.org/W2138996282","https://openalex.org/W2139206194","https://openalex.org/W2141331384","https://openalex.org/W2141475236","https://openalex.org/W2141826291","https://openalex.org/W2141871826","https://openalex.org/W2141998683","https://openalex.org/W2143119237","https://openalex.org/W2144147369","https://openalex.org/W2145144950","https://openalex.org/W2145866317","https://openalex.org/W2147100898","https://openalex.org/W2147546596","https://openalex.org/W2147901189","https://openalex.org/W2148229843","https://openalex.org/W2148624953","https://openalex.org/W2148695635","https://openalex.org/W2148748985","https://openalex.org/W2151071187","https://openalex.org/W2151287868","https://openalex.org/W2151778974","https://openalex.org/W2152892875","https://openalex.org/W2154322581","https://openalex.org/W2154907719","https://openalex.org/W2154970420","https://openalex.org/W2155102822","https://openalex.org/W2155518363","https://openalex.org/W2155521955","https://openalex.org/W2155706758","https://openalex.org/W2155734592","https://openalex.org/W2156354476","https://openalex.org/W2157381917","https://openalex.org/W2157861528","https://openalex.org/W2158662692","https://openalex.org/W2158939742","https://openalex.org/W2160085982","https://openalex.org/W2160898409","https://openalex.org/W2161743104","https://openalex.org/W2161995310","https://openalex.org/W2162098634","https://openalex.org/W2162759549","https://openalex.org/W2163351493","https://openalex.org/W2163853272","https://openalex.org/W2163878817","https://openalex.org/W2165275387","https://openalex.org/W2166193532","https://openalex.org/W2166343003","https://openalex.org/W2166682453","https://openalex.org/W2166865493","https://openalex.org/W2167350263","https://openalex.org/W2168935492","https://openalex.org/W2169905292","https://openalex.org/W2170472829","https://openalex.org/W2170605026","https://openalex.org/W2170740154","https://openalex.org/W2171369029","https://openalex.org/W2172184476","https://openalex.org/W2172200039","https://openalex.org/W2174186223","https://openalex.org/W2176443454","https://openalex.org/W2176524527","https://openalex.org/W2191498919","https://openalex.org/W2197062280","https://openalex.org/W2202883779","https://openalex.org/W2253297363","https://openalex.org/W2254807163","https://openalex.org/W2256645120","https://openalex.org/W2261748232","https://openalex.org/W2262759738","https://openalex.org/W2268958665","https://openalex.org/W2276614885","https://openalex.org/W2279656743","https://openalex.org/W2296449512","https://openalex.org/W2300023009","https://openalex.org/W2317197905","https://openalex.org/W2318238011","https://openalex.org/W2320348279","https://openalex.org/W2338241371","https://openalex.org/W2340659327","https://openalex.org/W2346294312","https://openalex.org/W2395416726","https://openalex.org/W2395808966","https://openalex.org/W2410171354","https://openalex.org/W2412727661","https://openalex.org/W2428504347","https://openalex.org/W2461967493","https://openalex.org/W2464242197","https://openalex.org/W2467178923","https://openalex.org/W2473253004","https://openalex.org/W2476599418","https://openalex.org/W2481913431","https://openalex.org/W2507605260","https://openalex.org/W2510523315","https://openalex.org/W2522054313","https://openalex.org/W2523977787","https://openalex.org/W2525002693","https://openalex.org/W2525973507","https://openalex.org/W2528889330","https://openalex.org/W2530130883","https://openalex.org/W2538561584","https://openalex.org/W2538612363","https://openalex.org/W2541799514","https://openalex.org/W2546079450","https://openalex.org/W2547386153","https://openalex.org/W2547513157","https://openalex.org/W2553460399","https://openalex.org/W2553620755","https://openalex.org/W2558814382","https://openalex.org/W2560356992","https://openalex.org/W2567835140","https://openalex.org/W2570221933","https://openalex.org/W2572603768","https://openalex.org/W2574376450","https://openalex.org/W2576878971","https://openalex.org/W2577806521","https://openalex.org/W2581861531","https://openalex.org/W2582702421","https://openalex.org/W2584234181","https://openalex.org/W2586088194","https://openalex.org/W2592390176","https://openalex.org/W2592752673","https://openalex.org/W2593435098","https://openalex.org/W2600098707","https://openalex.org/W2607339157","https://openalex.org/W2607501063","https://openalex.org/W2610487582","https://openalex.org/W2611631307","https://openalex.org/W2613074324","https://openalex.org/W2623286853","https://openalex.org/W2691961655","https://openalex.org/W2726849276","https://openalex.org/W2730923948","https://openalex.org/W2734590870","https://openalex.org/W2735084243","https://openalex.org/W2736148366","https://openalex.org/W2740959450","https://openalex.org/W2746618668","https://openalex.org/W2752263458","https://openalex.org/W2755373925","https://openalex.org/W2759295689","https://openalex.org/W2760769671","https://openalex.org/W2762477198","https://openalex.org/W2762703589","https://openalex.org/W2766512429","https://openalex.org/W2766654922","https://openalex.org/W2766996538","https://openalex.org/W2768967928","https://openalex.org/W2769013758","https://openalex.org/W2769095663","https://openalex.org/W2771968994","https://openalex.org/W2773048783","https://openalex.org/W2773560724","https://openalex.org/W2775569101","https://openalex.org/W2778820157","https://openalex.org/W2778962949","https://openalex.org/W2781555529","https://openalex.org/W2782887521","https://openalex.org/W2783051373","https://openalex.org/W2783326957","https://openalex.org/W2790886260","https://openalex.org/W2792061260","https://openalex.org/W2792195687","https://openalex.org/W2793541038","https://openalex.org/W2794509477","https://openalex.org/W2800469433","https://openalex.org/W2800642540","https://openalex.org/W2801310804","https://openalex.org/W2806319892","https://openalex.org/W2807669630","https://openalex.org/W2883031503","https://openalex.org/W2883561311","https://openalex.org/W2885679300","https://openalex.org/W2886925656"],"related_works":["https://openalex.org/W2787024316","https://openalex.org/W3097022634","https://openalex.org/W3212903297","https://openalex.org/W1915149056","https://openalex.org/W2094184533","https://openalex.org/W7098948454","https://openalex.org/W4220654676","https://openalex.org/W1979035564","https://openalex.org/W2943019001","https://openalex.org/W2885218986"],"abstract_inverted_index":{"Influenza":[0],"A":[1],"virus":[2,19,78,88,364,484],"(IAV)":[3],"causes":[4],"respiratory":[5],"infections":[6,157],"in":[7,59,158,163,246,280,285,296,302,336,342,358,479,568,648,656,701],"humans":[8],"and":[9,25,66,90,94,140,190,208,228,232,250,326,409,450,473,620,675],"animals.":[10],"Pigs":[11,29],"are":[12,169,334],"infected":[13],"not":[14,382,546],"only":[15,547],"by":[16,23,47,118,146,199,253,315,507,534,666],"swine":[17,248,287,703],"influenza":[18,27],"(SIV),":[20],"but":[21,381,564],"also":[22,437,565,579],"human":[24,52,362],"avian":[26],"viruses.":[28],"serve":[30],"as":[31,45,99,101,457],"the":[32,36,48,75,87,107,110,123,133,141,166,205,238,247,251,259,272,275,286,293,312,321,330,361,376,389,393,399,405,414,439,458,469,476,482,486,494,504,508,516,520,530,582,593,604,607,617,621,644,650,664,677,683,695,702],"mixing":[33],"vessel":[34],"for":[35,150,171,388,413,558,616,634],"generation":[37],"of":[38,50,77,132,220,274,307,379,384,392,402,424,429,435,441,463,471,497,519,549,562,606,610,623,643,694],"novel":[39],"reassortant":[40],"viruses":[41],"with":[42,485,625],"pandemic":[43,53],"potential":[44],"evidenced":[46],"emergence":[49],"2009":[51],"IAV":[54,57,138,147,156,175,244,255,283,340,699],"(pdm09).":[55],"Therefore,":[56],"infection":[58,89,139,245,284,341,544,700],"pigs":[60],"poses":[61],"both":[62],"an":[63,421,599,631,640],"economic":[64],"concern":[65],"a":[67,129,151,200,411,427],"threat":[68],"to":[69,96,102,137,154,282,304,420,481,502,514,581,598,681,698],"public":[70],"health.":[71],"Virus-host":[72],"interplay":[73],"dictates":[74],"outcome":[76],"infection.":[79,176],"The":[80,215,234,570,687],"host":[81,111,172,684],"innate":[82,112,135,142,685,696],"immune":[83,113,143,161,188,505],"system":[84],"can":[85,115],"sense":[86],"produce":[91,178],"multiple":[92],"cytokines":[93,180],"chemokines":[95],"control":[97],"inflammation":[98],"well":[100],"mount":[103],"antiviral":[104],"responses.":[105],"On":[106],"other":[108,187],"hand,":[109],"response":[114,262,281,303,480],"be":[116],"antagonized":[117],"IAV-encoded":[119],"proteins,":[120],"one":[121],"being":[122],"non-structural":[124],"protein":[125,211,224,257,319,536,612],"1":[126,537,614],"(NS1).":[127],"Thus,":[128],"better":[130],"understanding":[131],"porcine":[134,260,298,322,442,453,651,670],"immunity":[136,697],"evasion":[144,506],"strategies":[145,678],"is":[148,196,218,556,630],"required":[149,557],"rational":[152],"design":[153],"combat":[155],"pigs.":[159],"Innate":[160],"cells":[162,189],"lungs,":[164],"particularly":[165],"alveolar":[167,299],"macrophages,":[168],"indispensable":[170],"protection":[173],"against":[174],"They":[177],"pro-inflammatory":[179],"including":[181],"interleukin-1":[182],"beta":[183],"(IL-1\u03b2)":[184],"that":[185,333,347,375,383,493,542,555,628],"recruits":[186],"promotes":[191],"phagocytic":[192],"activities.":[193],"IL-1\u03b2":[194,241,261,278,294,356,368,396,477,523,583,601,618,654,673],"production":[195,242,279,295,357,478,524,619,655,674],"tightly":[197],"regulated":[198,533],"cytosolic":[201],"multiprotein":[202],"complex":[203],"called":[204],"nucleotide-binding":[206],"domain":[207,230],"leucine-rich":[209],"repeat-containing":[210],"3":[212],"(NLRP3)":[213],"inflammasome.":[214],"NLRP3":[216,239,276,323,354,394,408,415,430,521,594,652,671],"inflammasome":[217,324,337,416,431,595],"comprised":[219],"NLRP3,":[221],"apoptosis-associated":[222],"speck-like":[223],"containing":[225],"caspase":[226],"activation":[227,338],"recruitment":[229],"(ASC),":[231],"pro-caspase-1.":[233],"molecular":[235,313,331],"mechanism":[236,252,518,665],"underlying":[237],"inflammasome-mediated":[240,277,355,395,522,653,672],"upon":[243,339,525],"host,":[249],"which":[254,316,667],"NS1":[256,318,377,400,433,487,495],"counteracts":[258],"remain":[263],"largely":[264],"unknown.":[265],"This":[266,344,539],"PhD":[267],"project":[268],"was":[269,386,578],"centered":[270],"on":[271,452,529,589],"characterization":[273],"host;":[288],"specifically,":[289],"I":[290,310,328],"first":[291],"characterized":[292],"primary":[297,359],"macrophages":[300],"(PAMs)":[301],"different":[305],"isolates":[306],"IAV.":[308],"Next,":[309],"investigated":[311],"mechanisms":[314],"viral":[317],"modulates":[320],"activity,":[325,596],"finally":[327],"examined":[329],"pathways":[332],"involved":[335],"PAMs.":[343,569,658],"study":[345,540,662],"showed":[346,541],"while":[348],"various":[349],"SIV":[350,526,543,668],"strains":[351],"could":[352,591],"induce":[353],"PAMs,":[360],"pdm09":[363,403,436,483,498,679],"induced":[365,545],"much":[366],"less":[367],"than":[369],"did":[370],"SIVs.":[371],"Subsequent":[372],"analyses":[373],"revealed":[374,492],"C-terminus":[378,401,434,496],"pdm09,":[380],"SIV,":[385],"responsible":[387],"significant":[390],"inhibition":[391],"production.":[397,584,602],"Mechanistically,":[398],"disrupted":[404],"interaction":[406],"between":[407],"ASC,":[410],"prerequisite":[412],"assembly;":[417],"this":[418,661],"led":[419],"impaired":[422],"formation":[423],"ASC":[425,454,472,500],"specks,":[426],"hallmark":[428],"activation.":[432],"suppressed":[438],"ubiquitination":[440,459,470,501],"ASC.":[443],"Furthermore,":[444,603],"two":[445,465],"lysine":[446,466],"(K)":[447],"residues,":[448],"K110":[449],"K140,":[451],"were":[455,512],"identified":[456],"acceptor":[460],"sites;":[461],"mutation":[462,586],"these":[464],"residues":[467],"diminished":[468],"significantly":[474],"reduced":[475],"C-terminal":[488],"deletion.":[489],"These":[490,637],"results":[491,638],"suppresses":[499],"support":[503],"virus.":[509],"Further":[510],"attempts":[511],"made":[513],"dissect":[515],"upstream":[517,632],"infection,":[527],"focusing":[528],"mitochondrial":[531,559,566,576],"dynamics":[532],"dynamin-related":[535],"(DRP1).":[538],"phosphorylation":[548],"DRP1":[550,590,626,635],"at":[551,587],"serine":[552],"579":[553],"(S579)":[554],"fission":[560,567,577],"activity":[561,609],"DRP1,":[563],"reactive":[571],"oxygen":[572],"species":[573],"produced":[574],"from":[575],"related":[580],"Phospho-mimetic":[585],"S579":[588],"upreguate":[592],"leading":[597],"increased":[600],"requirement":[605],"kinase":[608,613,633],"receptor-interacting":[611],"(RIPK1)":[615],"association":[622],"RIPK1":[624,629],"suggested":[627],"phosphorylation.":[636],"indicated":[639],"integral":[641],"role":[642],"RIPK1/DRP1":[645],"signaling":[646],"axis":[647],"modulating":[649],"SIV-infected":[657],"Taken":[659],"together,":[660],"defined":[663],"induces":[669],"elucidated":[676],"employs":[680],"circumvent":[682],"immunity.":[686],"obtained":[688],"information":[689],"will":[690],"enhance":[691],"our":[692],"knowledge":[693],"host.":[704]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-22T00:00:00"}
