{"id":"https://openalex.org/W2921336638","doi":"https://doi.org/10.1093/nar/gkz153","title":"Sequence specific suppression of androgen receptor\u2013DNA binding in vivo by a Py-Im polyamide","display_name":"Sequence specific suppression of androgen receptor\u2013DNA binding in vivo by a Py-Im polyamide","publication_year":2019,"publication_date":"2019-02-22","ids":{"openalex":"https://openalex.org/W2921336638","doi":"https://doi.org/10.1093/nar/gkz153","mag":"2921336638","pmid":"https://pubmed.ncbi.nlm.nih.gov/30838415","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486638"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz153","doi":"https://doi.org/10.1093/nar/gkz153","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz153","pdf_url":"https://academic.oup.com/nar/article-pdf/47/8/3828/28535020/gkz153.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/47/8/3828/28535020/gkz153.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023919307","display_name":"Alexis A. Kurmis","orcid":"https://orcid.org/0000-0002-8427-2198","observed_orcids":["https://orcid.org/0000-0002-8427-2198"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis A Kurmis","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076578241","display_name":"Peter B. Dervan","orcid":"https://orcid.org/0000-0001-8852-7306","observed_orcids":["https://orcid.org/0000-0001-8852-7306"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter B Dervan","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076578241"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.0538,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.69703992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"8","first_page":"3828","last_page":"3835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":1.0},{"id":"https://openalex.org/keywords/pyrrole-imidazole-polyamides","display_name":"pyrrole-imidazole polyamides","score":0.9169999957084656},{"id":"https://openalex.org/keywords/minor-groove-binding","display_name":"minor groove binding","score":0.7020000219345093},{"id":"https://openalex.org/keywords/androgen-response-element","display_name":"androgen response element","score":0.8640000224113464},{"id":"https://openalex.org/keywords/sequence-specific-dna-binding","display_name":"sequence-specific DNA binding","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cistrome","display_name":"cistrome","score":0.6480000019073486},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6570000052452087},{"id":"https://openalex.org/keywords/sequence-specificity","display_name":"sequence specificity","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8375597596168518},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6929194331169128},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6825193762779236},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5002007484436035},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4889017641544342},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4698939323425293},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46274900436401367},{"id":"https://openalex.org/C96739231","wikidata":"https://www.wikidata.org/wiki/Q4914025","display_name":"Binding selectivity","level":2,"score":0.45611143112182617},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.44856923818588257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40507960319519043},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36340177059173584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31968921422958374},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13141462206840515}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkz153","doi":"https://doi.org/10.1093/nar/gkz153","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz153","pdf_url":"https://academic.oup.com/nar/article-pdf/47/8/3828/28535020/gkz153.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5477868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486638","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30838415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30838415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6486638","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6486638/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:93737","doi":null,"is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20190312-134021657","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz153","doi":"https://doi.org/10.1093/nar/gkz153","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz153","pdf_url":"https://academic.oup.com/nar/article-pdf/47/8/3828/28535020/gkz153.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G260839292","display_name":"PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRY","funder_award_id":"T32GM007616","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7174699068","display_name":"Programmable DNA Binding Oligomers for Control of Transcription","funder_award_id":"R01GM027681","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8000866915","display_name":null,"funder_award_id":"T32GM761637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000311505","display_name":null,"funder_award_id":"GM027681","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306472","display_name":"Ralph M. Parsons Foundation","ror":"https://ror.org/04mchsp40"},{"id":"https://openalex.org/F4320309398","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921336638.pdf","grobid_xml":"https://content.openalex.org/works/W2921336638.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W283594982","https://openalex.org/W1974433420","https://openalex.org/W1989701451","https://openalex.org/W1994708868","https://openalex.org/W2003955264","https://openalex.org/W2008549629","https://openalex.org/W2014677321","https://openalex.org/W2017764099","https://openalex.org/W2018902871","https://openalex.org/W2037700362","https://openalex.org/W2037932659","https://openalex.org/W2055636531","https://openalex.org/W2064293531","https://openalex.org/W2065597622","https://openalex.org/W2072994395","https://openalex.org/W2079523259","https://openalex.org/W2081942683","https://openalex.org/W2084637523","https://openalex.org/W2085820867","https://openalex.org/W2099199578","https://openalex.org/W2102619694","https://openalex.org/W2105245583","https://openalex.org/W2108234281","https://openalex.org/W2108955823","https://openalex.org/W2119038558","https://openalex.org/W2119504728","https://openalex.org/W2120649027","https://openalex.org/W2124985265","https://openalex.org/W2130189600","https://openalex.org/W2136344158","https://openalex.org/W2142609387","https://openalex.org/W2157009395","https://openalex.org/W2157952888","https://openalex.org/W2161282696","https://openalex.org/W2164443538","https://openalex.org/W2170830174","https://openalex.org/W2171808845","https://openalex.org/W2181570564","https://openalex.org/W2338595937","https://openalex.org/W2555285448","https://openalex.org/W2587844368","https://openalex.org/W2599160831","https://openalex.org/W2905512551","https://openalex.org/W3015143116","https://openalex.org/W3104066961","https://openalex.org/W6652705693"],"related_works":["https://openalex.org/W2944747649","https://openalex.org/W7099399774","https://openalex.org/W2037932659","https://openalex.org/W201134421","https://openalex.org/W2182870000","https://openalex.org/W2435767721","https://openalex.org/W7100338614","https://openalex.org/W2599160831","https://openalex.org/W2038114355","https://openalex.org/W2269576017"],"abstract_inverted_index":{"The":[0],"crucial":[1],"role":[2],"of":[3,20,51,70,97],"androgen":[4,52],"receptor":[5],"(AR)":[6],"in":[7,48,67,73,93,120,133,138],"prostate":[8,21],"cancer":[9,22],"development":[10],"is":[11,17,41],"well":[12],"documented,":[13],"and":[14],"its":[15,68,132],"inhibition":[16],"a":[18,35,45,49,126],"mainstay":[19],"treatment.":[23],"Here,":[24],"we":[25],"analyze":[26],"the":[27,30,87,98,107,119],"perturbations":[28],"to":[29,43,106],"AR":[31,71],"cistrome":[32],"caused":[33,124],"by":[34,125],"minor":[36],"groove":[37],"binding":[38,72,90,110,135],"molecule":[39],"that":[40,85,118],"designed":[42],"target":[44],"sequence":[46,65,111,127],"found":[47],"subset":[50],"response":[53],"elements":[54],"(ARE).":[55],"We":[56],"find":[57],"treatment":[58],"with":[59,131],"this":[60],"pyrrole-imidazole":[61],"(Py-Im)":[62],"polyamide":[63,89,109,129],"exhibits":[64],"selectivity":[66],"repression":[69],"vivo.":[74],"Differentially":[75],"changed":[76],"loci":[77],"are":[78,112],"enriched":[79],"for":[80],"sequences":[81],"resembling":[82],"ARE":[83,99],"half-sites":[84],"match":[86],"Py-Im":[88,108],"preferences":[91],"determined":[92],"vitro.":[94],"Comparatively,":[95],"permutations":[96],"half-site":[100],"bearing":[101],"single":[102],"or":[103],"double":[104],"mismatches":[105],"not":[113],"enriched.":[114],"This":[115],"study":[116],"confirms":[117],"vivo":[121],"perturbation":[122],"pattern":[123],"specific":[128],"correlates":[130],"vitro":[134],"preference":[136],"genome-wide":[137],"an":[139],"unbiased":[140],"manner.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-03-22T00:00:00"}
