{"id":"https://openalex.org/W2921152183","doi":"https://doi.org/10.1155/2019/9394615","title":"Ovarian Cancer Stem Cells with High ROR1 Expression Serve as a New Prophylactic Vaccine for Ovarian Cancer","display_name":"Ovarian Cancer Stem Cells with High ROR1 Expression Serve as a New Prophylactic Vaccine for Ovarian Cancer","publication_year":2019,"publication_date":"2019-03-17","ids":{"openalex":"https://openalex.org/W2921152183","doi":"https://doi.org/10.1155/2019/9394615","mag":"2921152183","pmid":"https://pubmed.ncbi.nlm.nih.gov/31008116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6441513"},"language":"en","primary_location":{"id":"doi:10.1155/2019/9394615","doi":"https://doi.org/10.1155/2019/9394615","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9394615","pdf_url":"https://downloads.hindawi.com/journals/jir/2019/9394615.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jir/2019/9394615.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102817467","display_name":"Di Wu","orcid":"https://orcid.org/0000-0002-5151-6010","observed_orcids":["https://orcid.org/0000-0002-5151-6010"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0002-5151-6010","affiliations":[{"raw_affiliation_string":"Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101946288","display_name":"Xiaoyu Yu","orcid":"https://orcid.org/0000-0002-8686-8251","observed_orcids":["https://orcid.org/0000-0002-8686-8251"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Yu","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090496446","display_name":"Hui Xu","orcid":"https://orcid.org/0000-0002-2888-1490","observed_orcids":["https://orcid.org/0000-0002-2888-1490"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Hui","raw_affiliation_strings":["Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0002-2888-1490","affiliations":[{"raw_affiliation_string":"Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690374","display_name":"Yunxia Zhang","orcid":"https://orcid.org/0000-0003-1708-686X","observed_orcids":["https://orcid.org/0000-0003-1708-686X"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunxia Zhang","raw_affiliation_strings":["Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032358575","display_name":"Yunlang Cai","orcid":"https://orcid.org/0000-0002-4143-1785","observed_orcids":["https://orcid.org/0000-0002-4143-1785"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunlang Cai","raw_affiliation_strings":["Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102360239","display_name":"Mulan Ren","orcid":"https://orcid.org/0000-0002-6492-753X","observed_orcids":["https://orcid.org/0000-0002-6492-753X"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mulan Ren","raw_affiliation_strings":["Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology & Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101453137","display_name":"Mei Guo","orcid":"https://orcid.org/0000-0002-8653-8180","observed_orcids":["https://orcid.org/0000-0002-8653-8180"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Guo","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0002-8653-8180","affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101835771","display_name":"Fengshu Zhao","orcid":"https://orcid.org/0000-0002-9722-0055","observed_orcids":["https://orcid.org/0000-0002-9722-0055"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengshu Zhao","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0002-9722-0055","affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065009308","display_name":"Jun Dou","orcid":"https://orcid.org/0000-0001-6944-5874","observed_orcids":["https://orcid.org/0000-0001-6944-5874"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Dou","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China"],"raw_orcid":"https://orcid.org/0000-0001-6944-5874","affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065009308"],"corresponding_institution_ids":["https://openalex.org/I76569877"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":1.357,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78067042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2019","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.6100000143051147},{"id":"https://openalex.org/keywords/immunoprophylaxis","display_name":"immunoprophylaxis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7948933839797974},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5017807483673096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49118301272392273},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4858560264110565},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4843205511569977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4439646005630493},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42901164293289185},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.42799896001815796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35109901428222656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12585505843162537}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057050","descriptor_name":"Receptor Tyrosine Kinase-like Orphan Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1155/2019/9394615","doi":"https://doi.org/10.1155/2019/9394615","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9394615","pdf_url":"https://downloads.hindawi.com/journals/jir/2019/9394615.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5457133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6441513","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31008116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31008116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6441513","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6441513/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunol Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:588d73c9e81b4d25b84cc3062c597a3f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/588d73c9e81b4d25b84cc3062c597a3f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunology Research, Vol 2019 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2019/9394615","doi":"https://doi.org/10.1155/2019/9394615","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9394615","pdf_url":"https://downloads.hindawi.com/journals/jir/2019/9394615.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5004149383","display_name":null,"funder_award_id":"81572887","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6869815489","display_name":null,"funder_award_id":"81202372","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921152183.pdf","grobid_xml":"https://content.openalex.org/works/W2921152183.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1524586235","https://openalex.org/W1842632875","https://openalex.org/W1966178502","https://openalex.org/W1972700706","https://openalex.org/W1978639844","https://openalex.org/W1998181914","https://openalex.org/W2007046259","https://openalex.org/W2010317454","https://openalex.org/W2023316892","https://openalex.org/W2023427658","https://openalex.org/W2029739605","https://openalex.org/W2061373541","https://openalex.org/W2061662618","https://openalex.org/W2066166771","https://openalex.org/W2068368560","https://openalex.org/W2092864627","https://openalex.org/W2093424661","https://openalex.org/W2103018035","https://openalex.org/W2106532478","https://openalex.org/W2128627710","https://openalex.org/W2129209894","https://openalex.org/W2164114377","https://openalex.org/W2166584906","https://openalex.org/W2193549693","https://openalex.org/W2200740615","https://openalex.org/W2319403512","https://openalex.org/W2321085269","https://openalex.org/W2344919561","https://openalex.org/W2345394027","https://openalex.org/W2404756654","https://openalex.org/W2492412617","https://openalex.org/W2514069796","https://openalex.org/W2521102102","https://openalex.org/W2603744382","https://openalex.org/W2607501294","https://openalex.org/W2611006672","https://openalex.org/W2611877356","https://openalex.org/W2626688702","https://openalex.org/W2739567284","https://openalex.org/W2746357202","https://openalex.org/W2748819860","https://openalex.org/W2765237233","https://openalex.org/W2766516868","https://openalex.org/W2766591622","https://openalex.org/W2773771998"],"related_works":["https://openalex.org/W4327545252","https://openalex.org/W1842632875","https://openalex.org/W4389039258","https://openalex.org/W2092864627","https://openalex.org/W2014152111","https://openalex.org/W2771339222","https://openalex.org/W2098681953","https://openalex.org/W2565648216","https://openalex.org/W2200740615","https://openalex.org/W7130517615"],"abstract_inverted_index":{"Tumor":[0],"vaccines":[1,197],"offer":[2],"a":[3,36,62,112],"number":[4],"of":[5,23,96,143],"advantages":[6],"for":[7,39,220],"cancer":[8,16,78,106],"treatment.":[9],"In":[10],"the":[11,13,24,40,93,129,141,147,167,171,179,192],"study,":[12],"vaccination":[14,131],"with":[15,20,92,114,151,198],"stem":[17],"cells":[18,118],"(CSCs)":[19],"high":[21,199],"expression":[22,181,201],"type":[25],"I":[26],"receptor":[27,31],"tyrosine":[28],"kinase-like":[29],"orphan":[30],"(ROR1)":[32],"was":[33,176,182],"evaluated":[34],"in":[35,146,166,186,205,210],"murine":[37,67],"model":[38],"vaccine\u2019s":[41],"immunogenicity":[42],"and":[43,98,104,138,161,213],"protective":[44,172],"efficacy":[45,173],"against":[46,135,174,208],"epithelial":[47],"ovarian":[48],"carcinoma":[49],"(EOC).":[50],"CD117+CD44+":[51,102],"CSCs":[52,103],"were":[53,81,89,202],"isolated":[54],"from":[55,83,191],"human":[56],"EOC":[57,69,136,175,209,221],"HO8910":[58,101,115],"cell":[59,64],"line":[60],"using":[61],"magnetic-activated":[63],"sorting":[65],"system;":[66],"ID8":[68,105,117],"suspension":[70,85],"sphere":[71],"cells,":[72,80,108],"which":[73],"are":[74],"collectively":[75],"known":[76],"as":[77,216],"stem-like":[79,107],"acquired":[82],"serum-free":[84],"sphere-forming":[86],"culture.":[87],"Mice":[88],"subcutaneously":[90],"immunized":[91],"repeat":[94],"cycles":[95],"freezing":[97],"thawing":[99],"whole":[100],"respectively,":[109],"followed":[110],"by":[111,184],"challenge":[113],"or":[116],"at":[119],"one":[120],"week":[121],"after":[122],"final":[123],"vaccination.":[124,153],"The":[125,189],"results":[126],"showed":[127,156],"that":[128,195],"CSC":[130,164,187,196],"significantly":[132,157],"induced":[133],"immunity":[134,207],"growth":[137],"markedly":[139],"prolonged":[140],"survival":[142],"EOC-bearing":[144],"mice":[145,212],"prophylactic":[148],"setting":[149],"compared":[150],"non-CSC":[152],"Flow":[154],"cytometry":[155],"increased":[158],"immunocyte":[159],"cytotoxicities":[160],"remarkably":[162],"reduced":[163],"counts":[165],"CSC-vaccinated":[168],"mice.":[169],"Moreover,":[170],"decreased":[177],"when":[178],"ROR1":[180,200],"downregulated":[183],"shRNA":[185],"vaccines.":[188],"findings":[190],"study":[193],"suggest":[194],"highly":[203],"effective":[204,218],"triggering":[206],"vaccinated":[211],"may":[214],"serve":[215],"an":[217],"vaccine":[219],"immunoprophylaxis.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-03-22T00:00:00"}