{"id":"https://openalex.org/W2921151663","doi":"https://doi.org/10.3164/jcbn.18-81","title":"High-glucose administration induces glucose intolerance in mice: a critical role of toll-like receptor 4","display_name":"High-glucose administration induces glucose intolerance in mice: a critical role of toll-like receptor 4","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2921151663","doi":"https://doi.org/10.3164/jcbn.18-81","mag":"2921151663","pmid":"https://pubmed.ncbi.nlm.nih.gov/31138952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6529706"},"language":"en","primary_location":{"id":"doi:10.3164/jcbn.18-81","doi":"https://doi.org/10.3164/jcbn.18-81","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.18-81","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/64/3/64_18-81/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2921151663"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jcbn/64/3/64_18-81/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035284772","display_name":"Xiandong Zhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiandong Zhan","raw_affiliation_strings":["Department of Endocrinology, the First Affiliated Hospital of North University of Hebei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, the First Affiliated Hospital of North University of Hebei","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436541","display_name":"Lijuan Wang","orcid":"https://orcid.org/0000-0003-1727-2670","observed_orcids":["https://orcid.org/0000-0003-1727-2670","https://orcid.org/0009-0008-4226-1184"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Wang","raw_affiliation_strings":["Institute of Pathogen Biology and Immunology, North University of Hebei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogen Biology and Immunology, North University of Hebei","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526343","display_name":"Zhenhui Wang","orcid":"https://orcid.org/0000-0002-7424-9322","observed_orcids":["https://orcid.org/0000-0002-7424-9322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenhui Wang","raw_affiliation_strings":["Department of Nuclear Medicine, the 251st Hospital of PLA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, the 251st Hospital of PLA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067653665","display_name":"Shiping Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiping Chai","raw_affiliation_strings":["Department of Medicine, North University of Hebei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, North University of Hebei","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040610716","display_name":"Xiaobo Zhu","orcid":"https://orcid.org/0000-0002-4735-3183","observed_orcids":["https://orcid.org/0000-0002-4735-3183"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaobo Zhu","raw_affiliation_strings":["Institute of Pathogen Biology and Immunology, North University of Hebei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogen Biology and Immunology, North University of Hebei","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101955816","display_name":"Weidong Ren","orcid":"https://orcid.org/0009-0004-4306-0676","observed_orcids":["https://orcid.org/0009-0004-4306-0676"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Weidong Ren","raw_affiliation_strings":["Department of Endocrinology, the First Affiliated Hospital of North University of Hebei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, the First Affiliated Hospital of North University of Hebei","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044565033","display_name":"Xiaotong Chang","orcid":"https://orcid.org/0000-0002-4658-4297","observed_orcids":["https://orcid.org/0000-0002-4658-4297"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaotong Chang","raw_affiliation_strings":["Institute of Pathogen Biology and Immunology, North University of Hebei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathogen Biology and Immunology, North University of Hebei","institution_ids":["https://openalex.org/I169071405"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040610716","https://openalex.org/A5044565033","https://openalex.org/A5101955816"],"corresponding_institution_ids":["https://openalex.org/I169071405"],"apc_list":null,"apc_paid":null,"fwci":0.3945,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.66386156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"64","issue":"3","first_page":"194","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.15710000693798065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.1459999978542328,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9440000057220459},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1-secretion","display_name":"glucagon-like peptide-1 secretion","score":0.9350000023841858},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.925000011920929},{"id":"https://openalex.org/keywords/insulinogenic-index","display_name":"insulinogenic index","score":0.6549999713897705},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tlr4-knockout-mice","display_name":"TLR4 knockout mice","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8611965775489807},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8383976221084595},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6529914140701294},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5227875113487244},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.5191416144371033},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4748245179653168},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4700913429260254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4559533894062042},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.45530882477760315},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4146847128868103},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.4101426601409912},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3888131380081177}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3164/jcbn.18-81","doi":"https://doi.org/10.3164/jcbn.18-81","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.18-81","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/64/3/64_18-81/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},{"id":"pmid:31138952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31138952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical biochemistry and nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6529706","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6529706/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Biochem Nutr","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3164/jcbn.18-81","doi":"https://doi.org/10.3164/jcbn.18-81","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.18-81","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/64/3/64_18-81/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309170","display_name":"Florida State University","ror":"https://ror.org/05g3dte14"},{"id":"https://openalex.org/F4320318556","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921151663.pdf","grobid_xml":"https://content.openalex.org/works/W2921151663.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1764140709","https://openalex.org/W1864489464","https://openalex.org/W1973416470","https://openalex.org/W1992770268","https://openalex.org/W1996669620","https://openalex.org/W2001656396","https://openalex.org/W2002472794","https://openalex.org/W2013878695","https://openalex.org/W2039784479","https://openalex.org/W2040322192","https://openalex.org/W2041469860","https://openalex.org/W2045359670","https://openalex.org/W2052187157","https://openalex.org/W2052882363","https://openalex.org/W2062756785","https://openalex.org/W2072224686","https://openalex.org/W2089851317","https://openalex.org/W2105153491","https://openalex.org/W2114360920","https://openalex.org/W2116241217","https://openalex.org/W2116369874","https://openalex.org/W2120282627","https://openalex.org/W2121976341","https://openalex.org/W2130078845","https://openalex.org/W2130926103","https://openalex.org/W2149411404","https://openalex.org/W2156769836","https://openalex.org/W2160234571","https://openalex.org/W2167790121","https://openalex.org/W2190310508","https://openalex.org/W2266900399","https://openalex.org/W2304466936","https://openalex.org/W2528840879","https://openalex.org/W2550668182","https://openalex.org/W2554228598","https://openalex.org/W2594257536","https://openalex.org/W2607031541","https://openalex.org/W2619338750","https://openalex.org/W2620991346","https://openalex.org/W2624760510","https://openalex.org/W2753688296","https://openalex.org/W2769630295","https://openalex.org/W2797466742","https://openalex.org/W4252900768"],"related_works":["https://openalex.org/W2909884569","https://openalex.org/W3002724127","https://openalex.org/W2149411404","https://openalex.org/W2185900964","https://openalex.org/W2301393895","https://openalex.org/W2950144459","https://openalex.org/W2342315515","https://openalex.org/W1864489464","https://openalex.org/W4322775396"],"abstract_inverted_index":{"Glucose":[0],"converted":[1],"from":[2],"a":[3,8],"diet":[4],"has":[5],"been":[6],"considered":[7],"high-risk":[9],"factor":[10],"of":[11,27,34,57,81,128,179,183,193],"type":[12],"2":[13],"diabetes":[14],"mellitus":[15],"(T2DM).":[16],"However,":[17],"it":[18,23],"is":[19],"not":[20,143],"clear":[21],"how":[22],"increases":[24],"the":[25,32,126],"risk":[26],"T2DM.":[28],"Here,":[29],"we":[30,84],"investigated":[31],"effect":[33],"high-glucose":[35,100,168],"administration":[36],"on":[37],"glucose":[38,64,82,108,112,124,151,172,185],"tolerence":[39],"in":[40,118,139,144,158,197],"wild-type":[41,119,140,159],"and":[42,62,68,71,91,115,132,160,190,195],"toll-like":[43],"receptor":[44],"4":[45],"(TLR4)":[46],"knockout":[47,146,162],"mice.":[48,120,147,163,198],"Mice":[49],"were":[50,66,73],"intragastrically":[51],"administered":[52],"with":[53,174],"high-glucose.":[54],"The":[55],"level":[56],"fasting":[58],"blood":[59,87,184],"glucose,":[60,88],"insulin":[61,116,175],"intraperitoneal":[63],"tolerance":[65,113],"measured,":[67],"insulinogenic":[69],"index":[70],"HOMA-IR":[72],"calculated":[74],"at":[75,95],"1":[76],"week.":[77],"To":[78],"understand":[79],"mechanism":[80],"action,":[83],"also":[85,153],"assessed":[86],"glucagon-like":[89],"peptide-1":[90],"inflammatory":[92],"cytokines":[93],"levels":[94,127,186,192],"different":[96],"time":[97],"windows":[98],"following":[99],"load.":[101],"Our":[102,164],"results":[103,165],"show":[104],"that":[105,167],"20":[106,122,149],"g/kg":[107,123,150],"load":[109,152,169],"leads":[110,170],"to":[111,171],"impairment":[114,178],"resistance":[117,176],"Following":[121],"load,":[125],"plasma":[129],"interlukin-6":[130],"(IL-6)":[131],"tumor":[133],"necrosis":[134],"factor-\u03b1":[135],"(TNF-\u03b1)":[136],"increased":[137],"significantly":[138],"mice,":[141],"but":[142],"TLR4":[145,161,189],"Moreover,":[148],"impaired":[154],"glucose-induced":[155],"GLP-1":[156,180],"secretion":[157],"indicate":[166],"intolerance":[173],"through":[177],"secretion,":[181],"increase":[182],"via":[187],"activating":[188],"increasing":[191],"IL-6":[194],"TNF-\u03b1":[196]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2019-03-22T00:00:00"}
