{"id":"https://openalex.org/W2921149595","doi":"https://doi.org/10.1136/bmjopen-2018-026797","title":"The COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial: a phase III randomised controlled clinical trial for low-risk ductal carcinoma in situ (DCIS)","display_name":"The COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial: a phase III randomised controlled clinical trial for low-risk ductal carcinoma in situ (DCIS)","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2921149595","doi":"https://doi.org/10.1136/bmjopen-2018-026797","mag":"2921149595","pmid":"https://pubmed.ncbi.nlm.nih.gov/30862637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6429899"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2018-026797","doi":"https://doi.org/10.1136/bmjopen-2018-026797","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2018-026797","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/9/3/e026797.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/9/3/e026797.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103862948","display_name":"E. Shelley Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Shelley Hwang","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061721402","display_name":"Terry Hyslop","orcid":"https://orcid.org/0000-0002-3930-8876","observed_orcids":["https://orcid.org/0000-0002-3930-8876"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry Hyslop","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Lynch","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022943610","display_name":"Elizabeth S. Frank","orcid":"https://orcid.org/0000-0001-9268-5104","observed_orcids":["https://orcid.org/0000-0001-9268-5104"]},"institutions":[{"id":"https://openalex.org/I4210147017","display_name":"Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics","ror":"https://ror.org/047d2d387","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I130828816","https://openalex.org/I139290333","https://openalex.org/I141816643","https://openalex.org/I146655781","https://openalex.org/I190082696","https://openalex.org/I241749","https://openalex.org/I36234482","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210147017","https://openalex.org/I45129253","https://openalex.org/I71052956","https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Frank","raw_affiliation_strings":["Patient Leadership Team, COMET Study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient Leadership Team, COMET Study","institution_ids":["https://openalex.org/I4210147017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112612802","display_name":"Donna Pinto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147017","display_name":"Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics","ror":"https://ror.org/047d2d387","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I130828816","https://openalex.org/I139290333","https://openalex.org/I141816643","https://openalex.org/I146655781","https://openalex.org/I190082696","https://openalex.org/I241749","https://openalex.org/I36234482","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210147017","https://openalex.org/I45129253","https://openalex.org/I71052956","https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Donna Pinto","raw_affiliation_strings":["Patient Leadership Team, COMET Study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient Leadership Team, COMET Study","institution_ids":["https://openalex.org/I4210147017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111330651","display_name":"Desiree Basila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147017","display_name":"Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics","ror":"https://ror.org/047d2d387","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I130828816","https://openalex.org/I139290333","https://openalex.org/I141816643","https://openalex.org/I146655781","https://openalex.org/I190082696","https://openalex.org/I241749","https://openalex.org/I36234482","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210147017","https://openalex.org/I45129253","https://openalex.org/I71052956","https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Desiree Basila","raw_affiliation_strings":["Patient Leadership Team, COMET Study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient Leadership Team, COMET Study","institution_ids":["https://openalex.org/I4210147017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079171882","display_name":"Deborah E. Collyar","orcid":"https://orcid.org/0000-0003-0886-0964","observed_orcids":["https://orcid.org/0000-0003-0886-0964"]},"institutions":[{"id":"https://openalex.org/I4210147017","display_name":"Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics","ror":"https://ror.org/047d2d387","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I130828816","https://openalex.org/I139290333","https://openalex.org/I141816643","https://openalex.org/I146655781","https://openalex.org/I190082696","https://openalex.org/I241749","https://openalex.org/I36234482","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210147017","https://openalex.org/I45129253","https://openalex.org/I71052956","https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deborah Collyar","raw_affiliation_strings":["Patient Leadership Team, COMET Study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient Leadership Team, COMET Study","institution_ids":["https://openalex.org/I4210147017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045265283","display_name":"Antonia Vickery Bennett","orcid":"https://orcid.org/0000-0002-8968-4511","observed_orcids":["https://orcid.org/0000-0002-8968-4511"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonia Bennett","raw_affiliation_strings":["Department of Health Policy and Management, University of North Carolina, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Policy and Management, University of North Carolina, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005336770","display_name":"Celia Patricia Kaplan","orcid":"https://orcid.org/0009-0008-8376-6656","observed_orcids":["https://orcid.org/0009-0008-8376-6656"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celia Kaplan","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024392666","display_name":"Shoshana M. Rosenberg","orcid":"https://orcid.org/0000-0002-0074-6385","observed_orcids":["https://orcid.org/0000-0002-0074-6385"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoshana Rosenberg","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027846283","display_name":"Alastair Mark Thompson","orcid":"https://orcid.org/0000-0003-0604-7267","observed_orcids":["https://orcid.org/0000-0003-0604-7267"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alastair Thompson","raw_affiliation_strings":["Department of Breast Surgery, Division of Surgical Oncology, Baylor College of Medicine, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Division of Surgical Oncology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089573340","display_name":"Anna Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091146","display_name":"Alliance Foundation Trials","ror":"https://ror.org/00fztf021","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210091146"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Weiss","raw_affiliation_strings":["Alliance Foundation Trials, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alliance Foundation Trials, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210091146"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039694693","display_name":"Ann H. Partridge","orcid":"https://orcid.org/0000-0002-4722-4824","observed_orcids":["https://orcid.org/0000-0002-4722-4824"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Partridge","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":12.2243,"has_fulltext":true,"cited_by_count":303,"citation_normalized_percentile":{"value":0.99596064,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"e026797","last_page":"e026797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9990000128746033},{"id":"https://openalex.org/keywords/low-risk-dcis","display_name":"low-risk DCIS","score":0.9340000152587891},{"id":"https://openalex.org/keywords/active-surveillance","display_name":"active surveillance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/breast-cancer-surgery","display_name":"breast cancer surgery","score":0.5720000267028809},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7120000123977661},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.7269999980926514},{"id":"https://openalex.org/keywords/breast-cancer-treatment","display_name":"breast cancer treatment","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9735405445098877},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.7985249757766724},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4933148920536041},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47712087631225586},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4233127534389496},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41984492540359497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41482430696487427},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.27158796787261963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26877325773239136},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06774485111236572}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057832","descriptor_name":"Watchful Waiting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063868","descriptor_name":"Patient Outcome Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1136/bmjopen-2018-026797","doi":"https://doi.org/10.1136/bmjopen-2018-026797","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2018-026797","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/9/3/e026797.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5434800","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6429899","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6429899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6429899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:30862637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30862637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Clinical Trial Protocol"},{"id":"pmh:cdr.lib.unc.edu:zc77t1207","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/68rt-h486","pdf_url":"https://doi.org/10.17615/68rt-h486","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, 9(3)","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:bmjopen:9/3/e026797","doi":null,"is_oa":false,"landing_page_url":"http://bmjopen.bmj.com/cgi/content/short/9/3/e026797","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"doi:10.17615/68rt-h486","doi":"https://doi.org/10.17615/68rt-h486","is_oa":true,"landing_page_url":"https://doi.org/10.17615/68rt-h486","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2018-026797","doi":"https://doi.org/10.1136/bmjopen-2018-026797","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2018-026797","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/9/3/e026797.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[{"id":"https://openalex.org/G9000894312","display_name":"Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK056350","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000914840","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014236","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320308927","display_name":"Patient-Centered Outcomes Research Institute","ror":"https://ror.org/014q65q44"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921149595.pdf","grobid_xml":"https://content.openalex.org/works/W2921149595.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W866117870","https://openalex.org/W1602301969","https://openalex.org/W1910439551","https://openalex.org/W1964710140","https://openalex.org/W1971289412","https://openalex.org/W1974427392","https://openalex.org/W1977873493","https://openalex.org/W1981701335","https://openalex.org/W1982345758","https://openalex.org/W1987612077","https://openalex.org/W1988486380","https://openalex.org/W1992575472","https://openalex.org/W1994684666","https://openalex.org/W1999428403","https://openalex.org/W2008448411","https://openalex.org/W2016725888","https://openalex.org/W2017955940","https://openalex.org/W2020340122","https://openalex.org/W2021349245","https://openalex.org/W2028370051","https://openalex.org/W2030993903","https://openalex.org/W2037377025","https://openalex.org/W2042472927","https://openalex.org/W2045095129","https://openalex.org/W2057806081","https://openalex.org/W2060319312","https://openalex.org/W2061278678","https://openalex.org/W2065701291","https://openalex.org/W2066739760","https://openalex.org/W2071726232","https://openalex.org/W2075091924","https://openalex.org/W2080743918","https://openalex.org/W2081059976","https://openalex.org/W2081943263","https://openalex.org/W2091476544","https://openalex.org/W2094030123","https://openalex.org/W2101210666","https://openalex.org/W2112311640","https://openalex.org/W2112778345","https://openalex.org/W2113622720","https://openalex.org/W2114841681","https://openalex.org/W2122704890","https://openalex.org/W2134470147","https://openalex.org/W2134710391","https://openalex.org/W2135271710","https://openalex.org/W2138301087","https://openalex.org/W2143558286","https://openalex.org/W2146322264","https://openalex.org/W2147790392","https://openalex.org/W2148959816","https://openalex.org/W2152740900","https://openalex.org/W2159846010","https://openalex.org/W2161865034","https://openalex.org/W2162189690","https://openalex.org/W2168133848","https://openalex.org/W2173607665","https://openalex.org/W2207029559","https://openalex.org/W2255857942","https://openalex.org/W2479717569","https://openalex.org/W2523396458","https://openalex.org/W2599915045","https://openalex.org/W2692274695","https://openalex.org/W2745023080","https://openalex.org/W2783472631","https://openalex.org/W2791835582","https://openalex.org/W2891045514","https://openalex.org/W2911883240","https://openalex.org/W4231959353","https://openalex.org/W4292806894","https://openalex.org/W6721329182"],"related_works":["https://openalex.org/W2807114123","https://openalex.org/W4281911844","https://openalex.org/W3132690118","https://openalex.org/W3156153285","https://openalex.org/W4411291935","https://openalex.org/W2984407092","https://openalex.org/W7140216331","https://openalex.org/W2947106325","https://openalex.org/W3024928385","https://openalex.org/W2793122087"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Ductal":[1],"carcinoma":[2],"in":[3,56,187,221,239],"situ":[4],"(DCIS)":[5],"is":[6,43,77,128,165,181,258],"a":[7,44,166],"non-invasive":[8],"non-obligate":[9],"precursor":[10],"of":[11,46,62,66,88,155,234,250,296],"invasive":[12,183,235],"breast":[13,184,236],"cancer.":[14,237],"With":[15],"guideline":[16],"concordant":[17],"care":[18,47],"(GCC),":[19],"DCIS":[20,76],"outcomes":[21],"are":[22],"at":[23,274],"least":[24],"as":[25,27,35,214,216],"favourable":[26],"some":[28,107],"other":[29],"early":[30],"stage":[31],"cancer":[32,185],"types":[33],"such":[34],"prostate":[36],"cancer,":[37],"for":[38,74,91,150,173,285,301],"which":[39],"active":[40],"surveillance":[41],"(AS)":[42],"standard":[45,95],"option.":[48],"However,":[49],"AS":[50,223,244],"has":[51],"not":[52,111],"yet":[53],"been":[54],"tested":[55],"relation":[57],"to":[58,78,81,97,141,198,207,270],"DCIS.":[59,177],"The":[60,99,178,253,264],"goal":[61,257],"the":[63,86,153,156,208,222,241,248,275],"COMET":[64,164,265],"(Comparison":[65],"Operative":[67],"versus":[68],"Monitoring":[69,280],"and":[70,117,202,243],"Endocrine":[71],"Therapy)":[72],"trial":[73,100,172,266],"low-risk":[75,92,176],"gather":[79],"evidence":[80],"help":[82],"future":[83,135],"patients":[84,174],"consider":[85],"range":[87],"treatment":[89],"choices":[90],"DCIS,":[93],"from":[94,114],"therapies":[96],"AS.":[98,125,193],"will":[101,138,196,211,225,246,267,287],"determine":[102],"whether":[103],"there":[104],"may":[105],"be":[106,121,139,197,226,268,288],"women":[108,188],"who":[109,118],"do":[110],"substantially":[112],"benefit":[113],"current":[115],"GCC":[116,190,209,242],"could":[119],"thus":[120],"safely":[122],"managed":[123],"with":[124,175,192,229,291],"This":[126],"protocol":[127,136],"version":[129],"5":[130],"(11":[131],"July":[132],"2018).":[133],"Any":[134],"amendments":[137],"submitted":[140],"Quorum":[142],"Centralised":[143],"Institutional":[144],"Review":[145],"Board/local":[146],"institutional":[147],"review":[148,273],"boards":[149],"approval":[151],"via":[152],"sponsor":[154],"study":[157],"(Alliance":[158],"Foundation":[159,277],"Trials).":[160],"METHODS":[161],"AND":[162,262],"ANALYSIS:":[163],"phase":[167],"III,":[168],"randomised":[169,206],"controlled":[170],"clinical":[171],"primary":[179],"outcome":[180],"ipsilateral":[182],"rate":[186],"undergoing":[189],"compared":[191],"Secondary":[194],"objectives":[195],"compare":[199],"surgical,":[200],"oncological":[201],"patient-reported":[203],"outcomes.":[204],"Patients":[205,238],"group":[210,224],"undergo":[212],"surgery":[213,230],"well":[215],"radiotherapy":[217],"when":[218],"appropriate;":[219],"those":[220],"monitored":[227],"closely":[228],"only":[231],"on":[232],"identification":[233],"both":[240],"groups":[245],"have":[247],"option":[249],"endocrine":[251],"therapy.":[252],"total":[254],"planned":[255],"accrual":[256],"1200":[259],"patients.":[260],"ETHICS":[261],"DISSEMINATION:":[263],"subject":[269],"biannual":[271],"formal":[272],"Alliance":[276],"Data":[278],"Safety":[279],"Board":[281],"meetings.":[282],"Interim":[283],"analyses":[284],"futility/safety":[286],"completed":[289],"annually,":[290],"reporting":[292],"following":[293],"Consolidated":[294],"Standards":[295],"Reporting":[297],"Trials":[298],"(CONSORT)":[299],"guidelines":[300],"non-inferiority":[302],"trials.":[303],"TRIAL":[304],"REGISTRATION":[305],"NUMBER:":[306],"NCT02926911;":[307],"Pre-results.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":46},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":43},{"year":2020,"cited_by_count":50},{"year":2019,"cited_by_count":10},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-03-22T00:00:00"}