{"id":"https://openalex.org/W2921140967","doi":"https://doi.org/10.1161/atvb.38.suppl_1.007","title":"Abstract 007: Athero-protective Flow Regulation of ITPR3: an Epigenetic Approach","display_name":"Abstract 007: Athero-protective Flow Regulation of ITPR3: an Epigenetic Approach","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2921140967","doi":"https://doi.org/10.1161/atvb.38.suppl_1.007","mag":"2921140967"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.38.suppl_1.007","doi":"https://doi.org/10.1161/atvb.38.suppl_1.007","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.38.suppl_1.007","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074511839","display_name":"Ming He","orcid":"https://orcid.org/0000-0001-8867-1826","observed_orcids":["https://orcid.org/0000-0001-8867-1826"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming He","raw_affiliation_strings":["Univ of California, San Diego, La Jolla, CA","Ming He Univ of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Ming He Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037945748","display_name":"Tse-Shun Huang","orcid":"https://orcid.org/0000-0001-8902-5439","observed_orcids":["https://orcid.org/0000-0001-8902-5439"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tse-Shun Huang","raw_affiliation_strings":["Univ of California, San Diego, La Jolla, CA","Tse-Shun Huang Univ of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Tse-Shun Huang Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036507250","display_name":"Marcy Martin","orcid":"https://orcid.org/0000-0003-0035-0185","observed_orcids":["https://orcid.org/0000-0003-0035-0185"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcy Martin","raw_affiliation_strings":["Univ of California, San Diego, La Jolla, CA","Marcy Martin Univ of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Marcy Martin Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X","observed_orcids":["https://orcid.org/0000-0003-0332-285X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Chien","raw_affiliation_strings":["Univ of California, San Diego, La Jolla, CA","Shu Chien Univ of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Shu Chien Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":null,"display_name":"John Shyy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Shyy","raw_affiliation_strings":["Univ of California, San Diego, La Jolla, CA","John Shyy Univ of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"John Shyy Univ of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.18930000066757202,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itpr3","display_name":"ITPR3","score":0.968999981880188},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oscillatory-shear","display_name":"oscillatory shear","score":0.9829999804496765},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.8880000114440918},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9490000009536743},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.8159999847412109},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7580000162124634},{"id":"https://openalex.org/keywords/atheroprotection","display_name":"atheroprotection","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.6802694797515869},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5286087393760681},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5211724638938904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46214449405670166},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.430146187543869},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4284001290798187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41870760917663574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41645893454551697},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36641925573349},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3480314016342163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32527855038642883},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.12917304039001465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.38.suppl_1.007","doi":"https://doi.org/10.1161/atvb.38.suppl_1.007","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.38.suppl_1.007","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2929552001","https://openalex.org/W6990745876","https://openalex.org/W2036593131","https://openalex.org/W2931401907","https://openalex.org/W2528918941","https://openalex.org/W2912031349","https://openalex.org/W4220819948","https://openalex.org/W4408695079","https://openalex.org/W97856865","https://openalex.org/W2009521038"],"abstract_inverted_index":{"Background:":[0],"The":[1],"topographic":[2],"distribution":[3],"of":[4,12,28,44,97,161,212,230,289],"atherosclerosis":[5,262],"in":[6,15,21,26,62,66,93,120,142,155,194,208,235,241,260,291],"human":[7],"vasculature":[8],"underscores":[9],"the":[10,22,42,48,54,121,134,162,190,209,213,281,286],"role":[11],"shear":[13,37,69,78,82],"stress":[14],"regulating":[16],"gene":[17,39,91,215],"expression":[18,92,193],"and":[19,46,59,72,80,138,175,202,226,248,303],"function":[20],"endothelium.":[23],"Recent":[24],"advances":[25],"understanding":[27],"mechanotransduction":[29],"reveal":[30],"that":[31,76,111,128,182,216,276,284],"epigenetic":[32],"regulation":[33,61],"is":[34,278],"integral":[35],"to":[36,52,68,264,297],"stress-mediated":[38],"expression.":[40],"With":[41],"use":[43],"ChIP-seq":[45],"ATAC-seq,":[47],"current":[49],"study":[50],"aims":[51],"demonstrate":[53],"link":[55],"between":[56],"histone":[57,282],"modifications":[58,283],"transcriptional":[60,287],"endothelial":[63],"cells":[64],"(ECs)":[65],"response":[67],"stress.":[70],"Methods":[71],"Results:":[73],"We":[74],"found":[75,181],"pulsatile":[77],"(PS)-":[79],"oscillatory":[81],"(OS)-induced":[83],"differential":[84],"H3K27ac":[85,123,141,222],"enrichments":[86],"were":[87,118],"associated":[88],"with":[89,198],"adjacent":[90],"ECs,":[94,179],"approximately":[95],"30%":[96],"which":[98],"showed":[99],"significant":[100],"positive":[101],"correlation":[102,104],"(Pearson\u2019s":[103],"coefficient":[105],">0.7).":[106],"In":[107],"silico":[108],"prediction":[109],"revealed":[110],"Kr\u00fcppel-like":[112],"factor":[113],"4":[114],"(KLF4)":[115],"binding":[116,136,233],"motifs":[117],"enriched":[119],"PS-enhanced":[122],"regions.":[124],"By":[125],"integrating":[126],"genes":[127],"are":[129],"induced":[130],"by":[131,237,306],"PS,":[132],"have":[133,274],"KLF4":[135,220,232,277],"loci,":[137],"contain":[139],"PS-associated":[140],"their":[143],"promoter":[144,210],"regions,":[145],"we":[146,180,273],"identified":[147],"18":[148],"novel":[149,294],"PS-upregulated":[150],"genes.":[151],"Validating":[152],"these":[153,199],"results":[154],"mouse":[156],"ECs":[157,169,236],"isolated":[158],"from":[159,170],"intima":[160],"thoracic":[163],"aorta":[164],"vs":[165,172,177],"aortic":[166],"arch,":[167],"lung":[168],"EC-KLF4-TG":[171],"EC-KLF4-KO":[173],"mice,":[174],"atorvastatin-treated":[176],"control":[178],"Inositol":[183],"1,4,5-trisphosphate":[184],"receptor":[185],"type":[186],"3":[187],"(ITPR3)":[188],"had":[189],"most":[191],"robust":[192],"multiple":[195],"systems.":[196],"Consistent":[197],"findings,":[200],"ATAC-seq":[201],"ChIP-qPCR":[203],"demonstrated":[204,275],"a":[205,269],"specific":[206],"locus":[207,234],"region":[211],"ITPR3":[214,227,290],"was":[217],"essential":[218],"for":[219,280],"binding,":[221],"enrichment,":[223],"chromatin":[224],"accessibility,":[225],"transcription.":[228],"Deletion":[229],"this":[231],"using":[238],"CRISPR-Cas9":[239],"resulted":[240,259],"blunted":[242],"calcium":[243],"influx,":[244],"reduced":[245],"eNOS":[246,301],"expression,":[247],"diminished":[249],"NO":[250],"bioavailability.":[251],"Furthermore,":[252],"ITPR-KO":[253],"mice":[254],"fed":[255],"an":[256,308],"atherogenic":[257],"diet":[258],"exacerbated":[261],"compared":[263],"wildtype":[265],"littermates.":[266],"Conclusions:":[267],"Using":[268],"multi-layer":[270],"systems":[271],"approach,":[272],"crucial":[279],"allow":[285],"activation":[288,302],"ECs.":[292],"This":[293],"mechanism":[295],"contributes":[296],"Ca2":[298],"+":[299],"-dependent":[300],"EC":[304],"homeostasis":[305],"maintaining":[307],"athero-protective":[309],"phenotype.":[310]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2019-03-22T00:00:00"}
