{"id":"https://openalex.org/W2921117033","doi":"https://doi.org/10.1002/marc.201800917","title":"pH\u2010Responsive Polymer Nanoparticles for Drug Delivery","display_name":"pH\u2010Responsive Polymer Nanoparticles for Drug Delivery","publication_year":2019,"publication_date":"2019-03-05","ids":{"openalex":"https://openalex.org/W2921117033","doi":"https://doi.org/10.1002/marc.201800917","mag":"2921117033","pmid":"https://pubmed.ncbi.nlm.nih.gov/30835923"},"language":"en","primary_location":{"id":"doi:10.1002/marc.201800917","doi":"https://doi.org/10.1002/marc.201800917","is_oa":true,"landing_page_url":"https://doi.org/10.1002/marc.201800917","pdf_url":"https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/marc.201800917","source":{"id":"https://openalex.org/S130615878","display_name":"Macromolecular Rapid Communications","issn_l":"1022-1336","issn":["1022-1336","1521-3927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Rapid Communications","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/marc.201800917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021558836","display_name":"Nayeleh Deirram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nayeleh Deirram","raw_affiliation_strings":["School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101439250","display_name":"Changhe Zhang","orcid":"https://orcid.org/0000-0002-9774-7981","observed_orcids":["https://orcid.org/0000-0002-9774-7981"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Changhe Zhang","raw_affiliation_strings":["School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030641193","display_name":"Sarah S. Kermaniyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah S. Kermaniyan","raw_affiliation_strings":["School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086995353","display_name":"Angus P. R. Johnston","orcid":"https://orcid.org/0000-0001-5611-4515","observed_orcids":["https://orcid.org/0000-0001-5611-4515"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Angus P. R. Johnston","raw_affiliation_strings":["Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052 Australia"],"raw_orcid":"https://orcid.org/0000-0001-5611-4515","affiliations":[{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052 Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080650707","display_name":"Georgina K. Such","orcid":"https://orcid.org/0000-0002-2868-5799","observed_orcids":["https://orcid.org/0000-0002-2868-5799"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Georgina K. Such","raw_affiliation_strings":["School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia"],"raw_orcid":"https://orcid.org/0000-0002-2868-5799","affiliations":[{"raw_affiliation_string":"School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080650707"],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":3.3471,"has_fulltext":true,"cited_by_count":545,"citation_normalized_percentile":{"value":0.95740741,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"40","issue":"10","first_page":"e1800917","last_page":"e1800917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensitive-nanoparticles","display_name":"pH-responsive nanoparticles","score":0.9559999704360962},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-delivery","display_name":"stimuli-responsive drug delivery","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-acidosis","display_name":"tumor acidosis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/endosomal-acidification","display_name":"endosomal acidification","score":0.6930000185966492},{"id":"https://openalex.org/keywords/targeted-drug-release","display_name":"targeted drug release","score":0.5680000185966492},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.7813024520874023},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.643082857131958},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5988160967826843},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5771069526672363},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5452315807342529},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5408490300178528},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.4578380584716797},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3364368677139282},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3097676932811737},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1434837281703949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06546637415885925}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/marc.201800917","doi":"https://doi.org/10.1002/marc.201800917","is_oa":true,"landing_page_url":"https://doi.org/10.1002/marc.201800917","pdf_url":"https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/marc.201800917","source":{"id":"https://openalex.org/S130615878","display_name":"Macromolecular Rapid Communications","issn_l":"1022-1336","issn":["1022-1336","1521-3927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Rapid Communications","raw_type":"journal-article"},{"id":"pmid:30835923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30835923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular rapid communications","raw_type":"Journal Article"},{"id":"pmh:oai:monash.edu:openaire/dd9f40f5-0a3a-4f32-8677-5821726a7fba","doi":null,"is_oa":true,"landing_page_url":"https://research.monash.edu/files/281702588/281702458_oa.pdf","pdf_url":"https://researchmgt.monash.edu/ws/files/281702588/281702458_oa.pdf","source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deirram, N, Zhang, C, Kermaniyan, S S, Johnston, A P R & Such, G K 2019, 'pH-Responsive Polymer Nanoparticles for Drug Delivery', Macromolecular Rapid Communications, vol. 40, no. 10, 1800917. https://doi.org/10.1002/marc.201800917","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/285518","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/285518","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/marc.201800917","doi":"https://doi.org/10.1002/marc.201800917","is_oa":true,"landing_page_url":"https://doi.org/10.1002/marc.201800917","pdf_url":"https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/marc.201800917","source":{"id":"https://openalex.org/S130615878","display_name":"Macromolecular Rapid Communications","issn_l":"1022-1336","issn":["1022-1336","1521-3927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Rapid Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2958460889","display_name":null,"funder_award_id":"APP1129672","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G554274409","display_name":"Engineering the trafficking of nanoparticles within cells","funder_award_id":"DP180100844","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G7460944943","display_name":"Improving Therapeutic Delivery by Understanding Nanoparticle Interactions with Cells","funder_award_id":"1129672","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2921117033.pdf","grobid_xml":"https://content.openalex.org/works/W2921117033.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W324171879","https://openalex.org/W328453650","https://openalex.org/W1597092954","https://openalex.org/W1602020336","https://openalex.org/W1809393544","https://openalex.org/W1863418049","https://openalex.org/W1914981819","https://openalex.org/W1919306097","https://openalex.org/W1932774860","https://openalex.org/W1956617916","https://openalex.org/W1965857736","https://openalex.org/W1966791520","https://openalex.org/W1968646764","https://openalex.org/W1971031921","https://openalex.org/W1972133529","https://openalex.org/W1972141585","https://openalex.org/W1979335059","https://openalex.org/W1981853312","https://openalex.org/W1982144070","https://openalex.org/W1983979770","https://openalex.org/W1986960592","https://openalex.org/W1987988449","https://openalex.org/W1991706084","https://openalex.org/W1999092226","https://openalex.org/W2004349712","https://openalex.org/W2004616019","https://openalex.org/W2005813454","https://openalex.org/W2007072758","https://openalex.org/W2009069733","https://openalex.org/W2009174913","https://openalex.org/W2011569859","https://openalex.org/W2012240787","https://openalex.org/W2012286388","https://openalex.org/W2016488018","https://openalex.org/W2017653397","https://openalex.org/W2021196541","https://openalex.org/W2025372180","https://openalex.org/W2029041094","https://openalex.org/W2037128514","https://openalex.org/W2038443207","https://openalex.org/W2039013575","https://openalex.org/W2040273584","https://openalex.org/W2040728588","https://openalex.org/W2042359340","https://openalex.org/W2042769575","https://openalex.org/W2042940583","https://openalex.org/W2043359917","https://openalex.org/W2044556787","https://openalex.org/W2045501299","https://openalex.org/W2049753441","https://openalex.org/W2050165248","https://openalex.org/W2050559479","https://openalex.org/W2054770710","https://openalex.org/W2058109807","https://openalex.org/W2058417598","https://openalex.org/W2058983562","https://openalex.org/W2062549413","https://openalex.org/W2063682682","https://openalex.org/W2064115046","https://openalex.org/W2064796179","https://openalex.org/W2065044954","https://openalex.org/W2070143261","https://openalex.org/W2080300304","https://openalex.org/W2085752004","https://openalex.org/W2086583202","https://openalex.org/W2086770409","https://openalex.org/W2087138396","https://openalex.org/W2088245347","https://openalex.org/W2093480017","https://openalex.org/W2096921917","https://openalex.org/W2099487519","https://openalex.org/W2107214272","https://openalex.org/W2110075452","https://openalex.org/W2112607530","https://openalex.org/W2114567522","https://openalex.org/W2115026910","https://openalex.org/W2118213449","https://openalex.org/W2121583497","https://openalex.org/W2125666008","https://openalex.org/W2126331122","https://openalex.org/W2126497597","https://openalex.org/W2130435963","https://openalex.org/W2133728860","https://openalex.org/W2138853132","https://openalex.org/W2140558679","https://openalex.org/W2140726391","https://openalex.org/W2144118351","https://openalex.org/W2149801291","https://openalex.org/W2153940157","https://openalex.org/W2156545114","https://openalex.org/W2158479359","https://openalex.org/W2167263245","https://openalex.org/W2167357429","https://openalex.org/W2183914927","https://openalex.org/W2200680635","https://openalex.org/W2231337032","https://openalex.org/W2233432152","https://openalex.org/W2266962357","https://openalex.org/W2270023069","https://openalex.org/W2284013896","https://openalex.org/W2291172546","https://openalex.org/W2293130530","https://openalex.org/W2299144098","https://openalex.org/W2316294126","https://openalex.org/W2319065582","https://openalex.org/W2321135349","https://openalex.org/W2322703943","https://openalex.org/W2327337032","https://openalex.org/W2328113874","https://openalex.org/W2338968912","https://openalex.org/W2339139143","https://openalex.org/W2345674378","https://openalex.org/W2400386150","https://openalex.org/W2409932367","https://openalex.org/W2421275313","https://openalex.org/W2466110658","https://openalex.org/W2474008740","https://openalex.org/W2511655585","https://openalex.org/W2522857603","https://openalex.org/W2526661709","https://openalex.org/W2535849056","https://openalex.org/W2561224580","https://openalex.org/W2561271695","https://openalex.org/W2563295566","https://openalex.org/W2587114059","https://openalex.org/W2594451304","https://openalex.org/W2596582407","https://openalex.org/W2597588061","https://openalex.org/W2602351147","https://openalex.org/W2606608340","https://openalex.org/W2612723996","https://openalex.org/W2623158620","https://openalex.org/W2747732435","https://openalex.org/W2748818568","https://openalex.org/W2749381722","https://openalex.org/W2751955879","https://openalex.org/W2755935639","https://openalex.org/W2766788410","https://openalex.org/W2786695047","https://openalex.org/W2789603074","https://openalex.org/W2796246859","https://openalex.org/W2805107459","https://openalex.org/W2805331379","https://openalex.org/W2809536582","https://openalex.org/W2811501377","https://openalex.org/W2883796578","https://openalex.org/W2884870215","https://openalex.org/W2885145446","https://openalex.org/W2885185081","https://openalex.org/W2888795254","https://openalex.org/W2893746099","https://openalex.org/W2898784359"],"related_works":["https://openalex.org/W4312362870","https://openalex.org/W4214486368","https://openalex.org/W2410631057","https://openalex.org/W7160850127","https://openalex.org/W4229449460","https://openalex.org/W1997787046","https://openalex.org/W2803819767","https://openalex.org/W2310127226","https://openalex.org/W2994156102","https://openalex.org/W4414304575"],"abstract_inverted_index":{"Stimuli-responsive":[0],"nanoparticles":[1,55,57,90],"have":[2,25,74],"the":[3,7,18,40,51,68,79,95],"potential":[4,27],"to":[5,11,73,87],"improve":[6],"delivery":[8],"of":[9,31,35,42,53,97],"therapeutics":[10],"a":[12,75],"specific":[13,29],"cell":[14],"or":[15,39],"region":[16],"within":[17],"body.":[19],"There":[20],"are":[21,58,65,91],"many":[22],"stimuli":[23],"that":[24,64],"shown":[26],"for":[28,50],"release":[30],"cargo,":[32],"including":[33],"variation":[34,45],"pH,":[36],"redox":[37],"potential,":[38],"presence":[41],"enzymes.":[43],"pH":[44,77],"has":[46],"generated":[47],"significant":[48],"interest":[49],"synthesis":[52],"stimuli-responsive":[54],"because":[56],"internalized":[59],"into":[60],"cells":[61],"via":[62],"vesicles":[63],"acidified.":[66],"Additionally,":[67],"tumor":[69],"microenvironment":[70],"is":[71],"known":[72],"lower":[76],"than":[78],"surrounding":[80],"tissue.":[81],"In":[82],"this":[83],"review,":[84],"different":[85],"strategies":[86],"design":[88],"pH-responsive":[89],"discussed,":[92],"focusing":[93],"on":[94],"use":[96],"charge-shifting":[98],"polymers,":[99],"acid":[100],"labile":[101],"linkages,":[102],"and":[103],"crosslinking.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":65},{"year":2025,"cited_by_count":77},{"year":2024,"cited_by_count":82},{"year":2023,"cited_by_count":102},{"year":2022,"cited_by_count":87},{"year":2021,"cited_by_count":76},{"year":2020,"cited_by_count":53},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-03-22T00:00:00"}