{"id":"https://openalex.org/W292110951","doi":null,"title":"CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies.","display_name":"CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies.","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W292110951","mag":"292110951","pmid":"https://pubmed.ncbi.nlm.nih.gov/1691593","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877648"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1544981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T J Kipps","raw_affiliation_strings":["Department of Molecular, Research Institute of Scripps Clinic, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Research Institute of Scripps Clinic, La Jolla, California","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210859","display_name":"Bruce A. Robbins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Robbins","raw_affiliation_strings":["Dept. Mol./Experimental Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Mol./Experimental Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016216479","display_name":"Ayalew Tefferi","orcid":"https://orcid.org/0000-0003-4605-3821","observed_orcids":["https://orcid.org/0000-0003-4605-3821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tefferi","raw_affiliation_strings":["Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069458091","display_name":"Grant W. Meisenholder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Meisenholder","raw_affiliation_strings":["Dept. Mol./Experimental Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Mol./Experimental Med","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P M Banks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Banks","raw_affiliation_strings":["Dept. Mol./Experimental Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Mol./Experimental Med","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086448751","display_name":"Dennis Anthony Carson","orcid":"https://orcid.org/0000-0001-5273-0804","observed_orcids":["https://orcid.org/0000-0001-5273-0804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Carson","raw_affiliation_strings":["Dept. Mol./Experimental Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Mol./Experimental Med","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1153,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.95928913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"4","first_page":"809","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.16519999504089355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cross-reactive-idiotype","display_name":"cross-reactive idiotype","score":0.968999981880188},{"id":"https://openalex.org/keywords/igm-autoantibodies","display_name":"IgM autoantibodies","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.8379999995231628},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6970000267028809},{"id":"https://openalex.org/keywords/follicular-center-cell-lymphoma","display_name":"follicular center cell lymphoma","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C113067387","wikidata":"https://www.wikidata.org/wiki/Q14912836","display_name":"CD5","level":3,"score":0.7726350426673889},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7376836538314819},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6798505783081055},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.6482095718383789},{"id":"https://openalex.org/C2780126324","wikidata":"https://www.wikidata.org/wiki/Q612345","display_name":"Lymphocytosis","level":2,"score":0.5864536762237549},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.5403082966804504},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.5269982218742371},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5210413336753845},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4760555922985077},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.474608838558197},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4738728702068329},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4613097012042999},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.4264809191226959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41542863845825195},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.4137866497039795},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39872488379478455},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3912837505340576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3908997178077698},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3299293518066406},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.24956941604614258}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018956","descriptor_name":"CD5 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1544981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1877648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877648","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1691593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1691593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:292110951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1691593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1544981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7830645845","display_name":"HUMAN ANTIBODY DIVERSITY IN HEALTH &AUTOIMMUNITY","funder_award_id":"R29AR038475","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W85552500","https://openalex.org/W85952294","https://openalex.org/W154103547","https://openalex.org/W194705401","https://openalex.org/W1490930162","https://openalex.org/W1495301772","https://openalex.org/W1506425197","https://openalex.org/W1529904888","https://openalex.org/W1550554916","https://openalex.org/W1559976558","https://openalex.org/W1568921590","https://openalex.org/W1585252350","https://openalex.org/W1597557271","https://openalex.org/W1650504690","https://openalex.org/W1658761436","https://openalex.org/W1675863586","https://openalex.org/W1966844155","https://openalex.org/W1971451354","https://openalex.org/W1974884008","https://openalex.org/W1992707199","https://openalex.org/W2001161625","https://openalex.org/W2006781361","https://openalex.org/W2011940682","https://openalex.org/W2013483011","https://openalex.org/W2019168095","https://openalex.org/W2021672579","https://openalex.org/W2021916493","https://openalex.org/W2031824271","https://openalex.org/W2032742929","https://openalex.org/W2034477072","https://openalex.org/W2039979639","https://openalex.org/W2042796954","https://openalex.org/W2043863020","https://openalex.org/W2048872477","https://openalex.org/W2052154101","https://openalex.org/W2082990384","https://openalex.org/W2088600764","https://openalex.org/W2092000913","https://openalex.org/W2108067576","https://openalex.org/W2114146017","https://openalex.org/W2123354475","https://openalex.org/W2124184968","https://openalex.org/W2129077978","https://openalex.org/W2134721677","https://openalex.org/W2135151085","https://openalex.org/W2164503950"],"related_works":["https://openalex.org/W2413988244","https://openalex.org/W194705401","https://openalex.org/W2415824781","https://openalex.org/W2054040503","https://openalex.org/W1880155747","https://openalex.org/W2039979639","https://openalex.org/W2047490934","https://openalex.org/W2028245339","https://openalex.org/W1994883887","https://openalex.org/W343224492"],"abstract_inverted_index":{"Using":[0],"monoclonal":[1,12],"antibodies":[2],"(MAb)":[3],"specific":[4,67,99,115,151,175],"for":[5,68,100,116,152,176],"cross-reactive":[6],"idiotypes":[7],"(CRIs)":[8],"associated":[9],"with":[10,47,63,147,207,218,234],"human":[11],"IgM":[13],"autoantibodies,":[14],"we":[15],"examined":[16],"57":[17],"biopsy":[18],"specimens":[19,40,93],"that":[20,121,227,250],"previously":[21],"had":[22],"been":[23],"noted":[24,42,204],"to":[25,43],"have":[26,251],"immunohistologic":[27],"features":[28],"of":[29,53,83,105,134,189,220,232,246],"CD5-positive":[30,236],"B-cell":[31,237],"small":[32],"lymphocytic":[33,49],"(SL)":[34],"non-Hodgkin's":[35],"lymphoma":[36,39],"(NHL).":[37],"Twenty-five":[38],"were":[41,94,210],"be":[44],"from":[45,202,255],"patients":[46,195,206,217,233],"chronic":[48],"leukemia":[50],"(CLL).":[51],"Eight":[52],"thirty-four":[54],"(24%)":[55],"immunoglobulin":[56],"(Ig)":[57],"kappa":[58,77],"light-chain":[59],"expressing":[60],"lymphomas":[61,141],"reacted":[62,146],"17.109,":[64],"a":[65,69,74,113,125,153,172,243],"MAb":[66,98,114,150,174],"major":[70],"CRI":[71,120],"encoded":[72,123],"by":[73,96,124,166],"conserved":[75,126],"Ig":[76,247],"variable":[78,130],"region":[79,131],"gene":[80],"(Vk":[81],"gene)":[82],"the":[84,135,228,256],"VkIIIb":[85,101],"sub-subgroup.":[86],"All":[87,138],"17.109-reactive":[88],"tissues":[89],"and":[90,142],"two":[91,143,183],"17.109-negative":[92],"recognized":[95],"another":[97,149],"framework":[102],"determinant(s).":[103],"Seven":[104],"all":[106],"fifty-six":[107],"(13%)":[108,168],"Ig-expressing":[109],"tumors":[110,145],"bound":[111],"G6,":[112],"an":[117],"autoantibody":[118],"heavy-chain-associated":[119,156,178],"is":[122],"antibody":[127],"heavy":[128],"chain":[129],"gene(s)":[132],"(VHgene)":[133],"VH1":[136],"subgroup.":[137],"seven":[139,167],"G6-positive":[140],"G6-negative":[144],"Cc1,":[148],"rheumatoid":[154],"factor":[155],"CRI.":[157],"A":[158],"third":[159],"autoantibody-heavy-chain-associated":[160],"CRI,":[161,179],"termed":[162],"Lc1,":[163],"was":[164],"expressed":[165],"other":[169],"lymphomas.":[170],"Finally,":[171],"fourth":[173],"RF":[177],"named":[180],"B6,":[181],"detected":[182],"additional":[184],"tumors.":[185],"The":[186],"expression":[187],"frequencies":[188],"autoantibody-associated":[190],"CRIs":[191],"among":[192,205,216],"SL":[193,238],"NHL":[194,219,239],"without":[196],"peripheral":[197],"lymphocytosis":[198],"did":[199],"not":[200,252],"differ":[201],"those":[203,214],"CLL":[208,241],"but":[209],"significantly":[211],"higher":[212],"than":[213],"observed":[215],"follicular":[221],"center-cell":[222],"origin.":[223],"These":[224],"data":[225],"imply":[226],"malignant":[229],"B":[230],"cells":[231],"either":[235],"or":[240],"express":[242],"restricted":[244],"set":[245],"V":[248],"genes":[249],"substantially":[253],"diversified":[254],"germline":[257],"DNA.":[258]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
