{"id":"https://openalex.org/W2920786147","doi":"https://doi.org/10.1161/res.123.suppl_1.249","title":"Abstract 249: Cortical-bone Derived Stem Cells Improve Cardiac Outcomes After Myocardial Infarction by Modulating the Inflammatory Response","display_name":"Abstract 249: Cortical-bone Derived Stem Cells Improve Cardiac Outcomes After Myocardial Infarction by Modulating the Inflammatory Response","publication_year":2018,"publication_date":"2018-08-03","ids":{"openalex":"https://openalex.org/W2920786147","doi":"https://doi.org/10.1161/res.123.suppl_1.249","mag":"2920786147"},"language":"en","primary_location":{"id":"doi:10.1161/res.123.suppl_1.249","doi":"https://doi.org/10.1161/res.123.suppl_1.249","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.249","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044261867","display_name":"Alexander R. H. Hobby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander R Hobby","raw_affiliation_strings":["Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","Alexander R Hobby"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Alexander R Hobby","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075449965","display_name":"Thomas E. Sharp","orcid":"https://orcid.org/0000-0001-8706-9825","observed_orcids":["https://orcid.org/0000-0001-8706-9825"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E Sharp","raw_affiliation_strings":["Louisiana State Univ Health Science Cntr, Cardiovascular Rsch Cntr, New Orleans, LA","Thomas E Sharp, III"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State Univ Health Science Cntr, Cardiovascular Rsch Cntr, New Orleans, LA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Thomas E Sharp, III","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064014104","display_name":"Eric A. Feldsott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Feldsott","raw_affiliation_strings":["Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","Eric Feldsott"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Eric Feldsott","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017026968","display_name":"Sadia Mohsin","orcid":"https://orcid.org/0000-0002-2106-1094","observed_orcids":["https://orcid.org/0000-0002-2106-1094"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadia Mohsin","raw_affiliation_strings":["Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","Sadia Mohsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Sadia Mohsin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103190679","display_name":"Hajime Kubo","orcid":"https://orcid.org/0000-0001-5729-1994","observed_orcids":["https://orcid.org/0000-0001-5729-1994"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hajime Kubo","raw_affiliation_strings":["Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","Hajime Kubo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Hajime Kubo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074296319","display_name":"Remus M. Berretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remus Berretta","raw_affiliation_strings":["Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","Remus Berretta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Remus Berretta","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067892109","display_name":"Steven R. Houser","orcid":"https://orcid.org/0000-0001-6359-5425","observed_orcids":["https://orcid.org/0000-0001-6359-5425"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R Houser","raw_affiliation_strings":["Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","Steven R Houser"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ Sch of Medicine - Cardiovascular Rsch Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Steven R Houser","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.24789999425411224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9309999942779541},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9369999766349792},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.925000011920929},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9089999794960022},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cardiac-wound-healing","display_name":"cardiac wound healing","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.657322108745575},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6537126302719116},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6385775804519653},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6152583360671997},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5684614181518555},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.4903740882873535},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.48135906457901},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4806748330593109},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4732644855976105},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.45364874601364136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3689686059951782},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.363353431224823},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3537377119064331},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.21451109647750854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18955525755882263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1814993917942047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17791825532913208}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.123.suppl_1.249","doi":"https://doi.org/10.1161/res.123.suppl_1.249","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.249","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981297599","https://openalex.org/W3215632718","https://openalex.org/W3094701958","https://openalex.org/W7070470466","https://openalex.org/W3193965254","https://openalex.org/W2980552844","https://openalex.org/W2914947292","https://openalex.org/W2919064916","https://openalex.org/W3037472634","https://openalex.org/W3173248084"],"abstract_inverted_index":{"Rationale:":[0],"Cortical-bone":[1],"derived":[2],"stem":[3],"cells":[4,163,273],"(CBSCs)":[5],"improve":[6,66],"cardiac":[7,94,290,307],"pump":[8],"function":[9],"and":[10,21,86,96,100,115,152,168,190,199,276,309],"reduce":[11],"scar":[12],"size":[13],"after":[14,293],"myocardial":[15],"infarction":[16],"(MI)":[17],"compared":[18,58,220],"to":[19,47,59,117,145,192,204,221,260,300,305],"Cardiac-Derived":[20],"Mesenchymal":[22],"Stem":[23],"Cells.":[24],"However,":[25],"the":[26,48,72,77,80,88,128,146,171,175,194,202,209,212,256,269,284,302],"mechanism":[27,251,282],"for":[28,283],"these":[29,91,244],"improved":[30],"outcomes":[31],"is":[32],"not":[33],"known.":[34],"Recent":[35],"data":[36,225,245],"in":[37,54,79,93,122,155,181,237,274,277],"a":[38,178,227,249],"swine":[39,239],"model":[40],"of":[41,71,83,90,127,211,229,271,287],"MI":[42,53,230,294],"has":[43],"demonstrated":[44],"acute":[45],"changes":[46,78,92],"immune":[49,73,81,272],"response":[50,82,258,304],"elicited":[51,196],"by":[52,69,197,266],"CBSC":[55,118,157],"treated":[56,164],"animals":[57,85],"vehicle":[60],"controls,":[61,133,222],"suggesting":[62],"that":[63,108,231],"CBSCs":[64,254,267,288],"may":[65,295],"post-MI":[67],"remodeling":[68],"modulation":[70],"response.":[74],"Objective:":[75],"Identify":[76],"CBSC-treated":[84,238],"determine":[87],"role":[89],"healing":[95,292],"wound":[97,291],"repair.":[98],"Methods":[99],"Results:":[101],"Using":[102],"multi-color":[103],"flow":[104],"cytometry,":[105],"we":[106],"found":[107],"murine":[109],"bone":[110],"marrow-derived":[111],"macrophages":[112],"(BMDMs)":[113],"cultured":[114],"exposed":[116,144],"conditioned":[119,156,182,205],"culture":[120],"medium":[121],"vitro":[123,275],"express":[124],"higher":[125],"levels":[126,236],"mannose":[129],"receptor":[130,173,216],"CD206":[131,185],"than":[132,162],"indicating":[134],"alternative":[135],"\u201cM2\u201d":[136],"activation.":[137],"In":[138],"addition,":[139],"CD86":[140,188],"expression":[141],"on":[142,174,289],"BMDMs":[143,176,203],"classical":[147],"(M1)":[148],"activators":[149],"interferon-\u03b3":[150],"(INF-\u03b3)":[151],"lipopolysaccharide":[153],"(LPS)":[154],"media":[158,183,206],"was":[159],"significantly":[160],"lower":[161],"only":[165],"with":[166,177],"INF-\u03b3":[167,198],"LPS.":[169,200],"Blocking":[170],"IL-4":[172,247],"monoclonal":[179],"antibody":[180],"decreased":[184],"expression,":[186,189],"increased":[187,208,233],"failed":[191],"mitigate":[193],"activation":[195],"Exposing":[201],"also":[207],"amount":[210],"anti-inflammatory":[213],"cytokine":[214],"IL-1":[215],"antagonist":[217],"(IL1-RA)":[218],"released":[219],"matching":[223],"previous":[224],"from":[226,297],"swine-model":[228],"showed":[232],"IL-1RA":[234],"blood":[235],"72":[240],"hours":[241],"post-MI.":[242],"Together":[243],"implicate":[246],"as":[248],"possible":[250,281],"through":[252],"which":[253],"influence":[255],"inflammatory":[257],"raised":[259],"MI.":[261],"Conclusion:":[262],"Soluble":[263],"factors":[264],"secreted":[265],"change":[268],"phenotype":[270],"vivo":[278],".":[279],"A":[280],"beneficial":[285],"effects":[286],"come":[296],"their":[298],"ability":[299],"modulate":[301],"monocyte/macrophage":[303],"preserve":[306],"structure":[308],"function.":[310]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-03-11T00:00:00"}
