{"id":"https://openalex.org/W2920684346","doi":"https://doi.org/10.1161/res.123.suppl_1.366","title":"Abstract 366: The Role of Mitochondrial Calcium Uniporter Complex in Cardiac Contractility and Function","display_name":"Abstract 366: The Role of Mitochondrial Calcium Uniporter Complex in Cardiac Contractility and Function","publication_year":2018,"publication_date":"2018-08-03","ids":{"openalex":"https://openalex.org/W2920684346","doi":"https://doi.org/10.1161/res.123.suppl_1.366","mag":"2920684346"},"language":"en","primary_location":{"id":"doi:10.1161/res.123.suppl_1.366","doi":"https://doi.org/10.1161/res.123.suppl_1.366","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.366","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002199234","display_name":"Dhanendra Tomar","orcid":"https://orcid.org/0000-0002-3144-7257","observed_orcids":["https://orcid.org/0000-0002-3144-7257"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhanendra Tomar","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Dhanendra Tomar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Dhanendra Tomar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067518055","display_name":"Santhanam Shanmughapriya","orcid":"https://orcid.org/0000-0003-1041-8198","observed_orcids":["https://orcid.org/0000-0003-1041-8198"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santhanam Shanmughapriya","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Santhanam Shanmughapriya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Santhanam Shanmughapriya","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023999167","display_name":"Rajika Roy","orcid":"https://orcid.org/0000-0001-9394-3224","observed_orcids":["https://orcid.org/0000-0001-9394-3224"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajika Roy","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Rajika Roy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Rajika Roy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101724741","display_name":"Xueqian Zhang","orcid":"https://orcid.org/0000-0003-1566-1138","observed_orcids":["https://orcid.org/0000-0003-1566-1138"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueqian Zhang","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Xueqian Zhang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Xueqian Zhang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112697910","display_name":"Jianliang Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianliang Song","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Jianliang Song"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Jianliang Song","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086366787","display_name":"Sarah M. Schumacher","orcid":"https://orcid.org/0000-0002-4941-7267","observed_orcids":["https://orcid.org/0000-0002-4941-7267"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M Schumacher","raw_affiliation_strings":["Lerner Rsch Institute, Cleveland, OH","Sarah M Schumacher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lerner Rsch Institute, Cleveland, OH","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Sarah M Schumacher","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011101977","display_name":"Muniswamy Madesh","orcid":"https://orcid.org/0000-0001-6745-9092","observed_orcids":["https://orcid.org/0000-0001-6745-9092"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muniswamy Madesh","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Muniswamy Madesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Muniswamy Madesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085167135","display_name":"Joseph Y. Cheung","orcid":"https://orcid.org/0000-0002-8024-9177","observed_orcids":["https://orcid.org/0000-0002-8024-9177"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Y Cheung","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Joseph Y Cheung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Joseph Y Cheung","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075648082","display_name":"Walter J. Koch","orcid":"https://orcid.org/0000-0002-8522-530X","observed_orcids":["https://orcid.org/0000-0002-8522-530X","https://orcid.org/0000-0002-0609-8649"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter J Koch","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Walter J Koch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Walter J Koch","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047939416","display_name":"Sudarsan Rajan","orcid":"https://orcid.org/0000-0003-4096-0586","observed_orcids":["https://orcid.org/0000-0003-4096-0586"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudarsan Rajan","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Sudarsan Rajan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Sudarsan Rajan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.26440000534057617,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-calcium-uniporter","display_name":"mitochondrial calcium uniporter","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uptake","display_name":"mitochondrial calcium uptake","score":0.8050000071525574},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.9580000042915344},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/adrenergic-stimulation","display_name":"adrenergic stimulation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9390000104904175},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7972104549407959},{"id":"https://openalex.org/C35341161","wikidata":"https://www.wikidata.org/wiki/Q289992","display_name":"Uniporter","level":4,"score":0.7433814406394958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5575806498527527},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5238668322563171},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4799652099609375},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.47631606459617615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47250425815582275},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4244271218776703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3855011761188507},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.3599205017089844},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3394075632095337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32397469878196716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21401172876358032},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18497002124786377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1148844063282013},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.11032727360725403},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.123.suppl_1.366","doi":"https://doi.org/10.1161/res.123.suppl_1.366","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.366","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3097068019","https://openalex.org/W1622243645","https://openalex.org/W3177403459","https://openalex.org/W2981111748","https://openalex.org/W4366335342","https://openalex.org/W2750879765","https://openalex.org/W2731496086","https://openalex.org/W3163934168","https://openalex.org/W1523821352","https://openalex.org/W3022098300"],"abstract_inverted_index":{"Cardiac":[0],"contractility":[1,87],"is":[2,23,67,88,95],"regulated":[3,96,220],"by":[4,14,97,177,186,285],"the":[5,24,33,39,45,75,82,109,113,133,141,163,242,283,287,293,297,300,307],"intracellular":[6],"Ca":[7,27,35,59,63,79,136,149,211,222,244,304],"2+":[8,28,36,60,64,80,137,150,212,223,245,305],"concentration":[9],"fluxes":[10],"which":[11,286],"are":[12],"maintained":[13],"multiple":[15],"channels":[16],"and":[17,50,157,169,193,203,237,262,299,309],"transporters.":[18],"Mitochondrial":[19],"Calcium":[20],"Uniporter":[21],"(MCU)":[22],"highly":[25,89],"selective":[26],"ion":[29],"channel":[30,93,289],"responsible":[31],"for":[32,69],"electrophoretic":[34],"uptake":[37],"into":[38,282],"mitochondrial":[40,58],"matrix.":[41],"Earlier":[42],"studies":[43,119],"on":[44],"cardiac-specific":[46,165],"acute":[47],"MCU":[48,53,92,115,125,145,172,263,288],"knockout":[49,167],"transgenic":[51],"dominant-negative":[52],"mice":[54,266],"have":[55,120,161],"demonstrated":[56,121],"that":[57,122,209,253],"(":[61],"m":[62,78,135,210,221,303],")":[65],"signaling":[66],"necessary":[68],"cardiac":[70,86,158,191,199,260],"\u2018\u2018fight-or-flight\u2019\u2019":[71],"contractile":[72,294],"response,":[73],"however,":[74],"role":[76,143,301],"of":[77,85,112,124,144,190,296,302,311],"in":[81,129,132,146,187,194,216,225,234,240,291,306],"beat-to-beat":[83],"regulation":[84],"debated.":[90],"The":[91],"function":[94,295],"varied":[98],"molecular":[99],"regulatory":[100],"components":[101],"as":[102,104],"well":[103],"ROS":[105],"mediated":[106],"modification":[107],"at":[108,273],"Cys-96":[110],"residue":[111],"core":[114],"protein.":[116],"Our":[117,250],"earlier":[118],"loss":[123],"Regulator":[126],"1":[127],"(MCUR1)":[128],"cardiomyocytes":[130,298],"results":[131,278],"impaired":[134],"uptake.":[138],"To":[139],"dissect":[140],"precise":[142],"regulating":[147,241,292],"cytosolic":[148],"transients":[151,246],"associated":[152],"with":[153],"excitation-contraction":[154],"(E-C)":[155],"coupling":[156],"functions,":[159],"we":[160],"employed":[162],"loss-of-function,":[164],"MCUR1":[166,254],"mouse":[168,175,183],"a":[170],"gain-of-function":[171],"C96A":[173,264],"knockin":[174],"generated":[176],"CRISPR/Cas9":[178],"approach.":[179],"Using":[180],"these":[181],"novel":[182],"models,":[184],"both":[185],"vivo":[188],"analyses":[189],"physiology":[192],"vitro":[195],"experiments":[196],"including":[197],"single-cell":[198],"contractility,":[200],"calcium":[201],"transients,":[202],"electrophysiology":[204],"measurements,":[205],"our":[206,277],"study":[207],"demonstrates":[208],"buffering":[213,224],"actively":[214,238],"participates":[215,239],"E-C":[217],"coupling.":[218],"MCUR1/MCU":[219],"cardiomyocytes,":[226],"although":[227],"insignificant":[228],"under":[229],"basal":[230],"condition,":[231],"becomes":[232],"critical":[233,280],"stress-induced":[235],"conditions":[236],"c":[243],"during":[247],"adrenergic":[248],"stimulation.":[249],"data":[251],"indicate":[252],"ablation":[255],"offers":[256],"protection":[257],"against":[258],"pressure-overload":[259],"hypertrophy":[261],"KI":[265],"exhibit":[267],"significantly":[268],"decreased":[269],"LV":[270],"ejection":[271],"fraction":[272],"baseline.":[274],"In":[275],"summary,":[276],"provide":[279],"insights":[281],"mechanisms":[284],"contributes":[290],"development":[308],"progression":[310],"heart":[312],"failure.":[313]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-03-11T00:00:00"}
