{"id":"https://openalex.org/W2920280845","doi":"https://doi.org/10.3389/fmicb.2019.00545","title":"The Capsule Depolymerase Dpo48 Rescues Galleria mellonella and Mice From Acinetobacter baumannii Systemic Infections","display_name":"The Capsule Depolymerase Dpo48 Rescues Galleria mellonella and Mice From Acinetobacter baumannii Systemic Infections","publication_year":2019,"publication_date":"2019-03-18","ids":{"openalex":"https://openalex.org/W2920280845","doi":"https://doi.org/10.3389/fmicb.2019.00545","mag":"2920280845","pmid":"https://pubmed.ncbi.nlm.nih.gov/30936862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6431613"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2019.00545","doi":"https://doi.org/10.3389/fmicb.2019.00545","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.00545","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.00545/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.00545/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101662386","display_name":"Yannan Liu","orcid":"https://orcid.org/0000-0002-9583-079X","observed_orcids":["https://orcid.org/0000-0002-9583-079X"]},"institutions":[{"id":"https://openalex.org/I4210096476","display_name":"307th Hospital of Chinese People\u2019s Liberation Army","ror":"https://ror.org/00vrd0936","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096476"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yannan Liu","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China","Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China","institution_ids":["https://openalex.org/I4210096476"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050840890","display_name":"Sharon Shui Yee Leung","orcid":"https://orcid.org/0000-0002-0194-7058","observed_orcids":["https://orcid.org/0000-0002-0194-7058"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Sharon Shui Yee Leung","raw_affiliation_strings":["School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104274945","display_name":"Yatao Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yatao Guo","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101949538","display_name":"Lili Zhao","orcid":"https://orcid.org/0000-0002-7605-641X","observed_orcids":["https://orcid.org/0000-0002-7605-641X"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Zhao","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ning Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Jiang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112410210","display_name":"Liyuan Mi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Mi","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011523309","display_name":"Puyuan Li","orcid":"https://orcid.org/0009-0006-3610-2617","observed_orcids":["https://orcid.org/0009-0006-3610-2617"]},"institutions":[{"id":"https://openalex.org/I4210096476","display_name":"307th Hospital of Chinese People\u2019s Liberation Army","ror":"https://ror.org/00vrd0936","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Puyuan Li","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China","institution_ids":["https://openalex.org/I4210096476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428568","display_name":"Can Wang","orcid":"https://orcid.org/0000-0002-2157-9889","observed_orcids":["https://orcid.org/0000-0002-2157-9889"]},"institutions":[{"id":"https://openalex.org/I4210096476","display_name":"307th Hospital of Chinese People\u2019s Liberation Army","ror":"https://ror.org/00vrd0936","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Can Wang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China","institution_ids":["https://openalex.org/I4210096476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101500213","display_name":"Yanhong Qin","orcid":"https://orcid.org/0000-0002-8354-5860","observed_orcids":["https://orcid.org/0000-0002-8354-5860"]},"institutions":[{"id":"https://openalex.org/I4210096476","display_name":"307th Hospital of Chinese People\u2019s Liberation Army","ror":"https://ror.org/00vrd0936","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhong Qin","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China","institution_ids":["https://openalex.org/I4210096476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067123137","display_name":"Zhiqiang Mi","orcid":"https://orcid.org/0000-0002-7491-5073","observed_orcids":["https://orcid.org/0000-0002-7491-5073"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiqiang Mi","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102602018","display_name":"Changqing Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096476","display_name":"307th Hospital of Chinese People\u2019s Liberation Army","ror":"https://ror.org/00vrd0936","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changqing Bai","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, 307th Hospital of Chinese People's Liberation Army, Beijing, China","institution_ids":["https://openalex.org/I4210096476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102845974","display_name":"Zhancheng Gao","orcid":"https://orcid.org/0000-0002-8589-9339","observed_orcids":["https://orcid.org/0000-0002-8589-9339"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhancheng Gao","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210124809"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067123137","https://openalex.org/A5102602018","https://openalex.org/A5102845974"],"corresponding_institution_ids":["https://openalex.org/I4210096476","https://openalex.org/I4210124809","https://openalex.org/I4405260518"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.7351,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.90504223,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"545","last_page":"545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5327000021934509,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5327000021934509,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.15230000019073486,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.08139999955892563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bacterial-capsule","display_name":"bacterial capsule","score":0.7039999961853027},{"id":"https://openalex.org/keywords/anti-virulence-therapy","display_name":"anti-virulence therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/extensively-drug-resistant-bacteria","display_name":"extensively drug-resistant bacteria","score":0.8529999852180481},{"id":"https://openalex.org/keywords/systemic-infection","display_name":"systemic infection","score":0.6629999876022339},{"id":"https://openalex.org/keywords/peritoneal-sepsis","display_name":"peritoneal sepsis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/galleria-mellonella-infection-model","display_name":"Galleria mellonella infection model","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.45899999141693115},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.8579999804496765},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.414000004529953},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.8035528659820557},{"id":"https://openalex.org/C2779032433","wikidata":"https://www.wikidata.org/wiki/Q761648","display_name":"Galleria mellonella","level":4,"score":0.722432553768158},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6653559803962708},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6286790370941162},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.6210378408432007},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5181859135627747},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.512484073638916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49638229608535767},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4133101999759674},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37428760528564453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3582894802093506},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23100462555885315},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.22138947248458862},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.14353927969932556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fmicb.2019.00545","doi":"https://doi.org/10.3389/fmicb.2019.00545","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.00545","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.00545/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5425828","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6431613","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30936862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30936862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6431613","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6431613/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5c89063f135444d9bdeaf8adac2ee3db","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5c89063f135444d9bdeaf8adac2ee3db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2019.00545","doi":"https://doi.org/10.3389/fmicb.2019.00545","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.00545","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.00545/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2090092199","display_name":null,"funder_award_id":"No. 81572045","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6219045488","display_name":null,"funder_award_id":"81572045","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8294964749","display_name":"\u57fa\u4e8eCRISPR-Cas9\u57fa\u56e0\u7f16\u8f91\u53ca\u5fae\u6d41\u63a7\u82af\u7247\u7cfb\u7edf\u7814\u7a76\u566c\u83cc\u4f53\u4ecb\u5bfc\u7684\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u8010\u836f\u6027\u6c89\u9ed8\u673a\u5236","funder_award_id":"81870010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2920280845.pdf","grobid_xml":"https://content.openalex.org/works/W2920280845.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1513764702","https://openalex.org/W1974348924","https://openalex.org/W2000443479","https://openalex.org/W2031437556","https://openalex.org/W2040274090","https://openalex.org/W2051765619","https://openalex.org/W2095077206","https://openalex.org/W2102257721","https://openalex.org/W2102749349","https://openalex.org/W2104664744","https://openalex.org/W2108773674","https://openalex.org/W2113997975","https://openalex.org/W2119445362","https://openalex.org/W2154984047","https://openalex.org/W2178055262","https://openalex.org/W2262970286","https://openalex.org/W2288748065","https://openalex.org/W2320966985","https://openalex.org/W2336495737","https://openalex.org/W2414786145","https://openalex.org/W2419479251","https://openalex.org/W2467410187","https://openalex.org/W2558551622","https://openalex.org/W2561373402","https://openalex.org/W2578361705","https://openalex.org/W2588286059","https://openalex.org/W2588769001","https://openalex.org/W2731127457","https://openalex.org/W2734851808","https://openalex.org/W2740654307","https://openalex.org/W2747615902","https://openalex.org/W2748956562","https://openalex.org/W2759499811","https://openalex.org/W2766461528","https://openalex.org/W2769071465","https://openalex.org/W2782347958","https://openalex.org/W2807703896","https://openalex.org/W2897531714","https://openalex.org/W2900910034","https://openalex.org/W2910139188","https://openalex.org/W3197137935","https://openalex.org/W6800920323"],"related_works":["https://openalex.org/W2910139188","https://openalex.org/W2967762554","https://openalex.org/W4409346889","https://openalex.org/W3043690282","https://openalex.org/W4389991542","https://openalex.org/W3145408552","https://openalex.org/W2724650960","https://openalex.org/W7008597365","https://openalex.org/W7027302139","https://openalex.org/W4361277964"],"abstract_inverted_index":{"The":[0,138],"emergence":[1],"of":[2,29,63,95,108,132,147,165,241],"multidrug-":[3],"and":[4,15,52,129,154,169,177,193,210,223,229],"extensively":[5,84],"drug-resistant":[6,85],"Acinetobacter":[7],"baumannii":[8,32,56,251],"has":[9],"made":[10],"it":[11],"difficult":[12],"to":[13,24,89,119,134,218,225,247],"treat":[14],"control":[16],"infections":[17,33,81],"caused":[18,82],"by":[19,83,197],"this":[20],"bacterium.":[21],"Thus,":[22],"alternatives":[23],"conventional":[25],"antibiotics":[26],"for":[27,78],"management":[28],"severe":[30],"A.":[31,55,86,250],"is":[34],"urgently":[35],"needed.":[36],"In":[37],"our":[38],"previous":[39],"study,":[40],"we":[41,69],"found":[42],"that":[43,214],"a":[44,75,101],"capsule":[45,242],"depolymerase":[46],"Dpo48":[47,96,112,133,142,173,215],"could":[48,174],"strip":[49],"bacterial":[50,186],"capsules,":[51],"the":[53,61,92,120,127,185,208,234,238],"noncapsuled":[54],"were":[57,136,161],"significantly":[58,116,195],"decreased":[59],"in":[60,66,100,163,188],"presence":[62],"serum":[64,145],"complement":[65],"vitro.":[67],"Here,":[68],"further":[70],"explored":[71],"its":[72],"potential":[73,240],"as":[74,244],"therapeutic":[76,130,245],"agent":[77],"controlling":[79],"systemic":[80],"baumannii.":[87],"Prior":[88],"mammalian":[90],"studies,":[91],"anti-virulence":[93],"efficacy":[94,131],"was":[97,115,216],"first":[98],"tested":[99],"Galleria":[102],"mellonella":[103,123],"infection":[104],"model.":[105],"Survival":[106],"rate":[107],"Dpo48-pretreated":[109],"bacteria":[110],"or":[111],"treatment":[113],"group":[114],"increased":[117],"compared":[118],"infective":[121],"G.":[122],"without":[124],"treatment.":[125,206],"Furthermore,":[126],"safety":[128],"mice":[135,139,179],"evaluated.":[137],"treated":[140],"with":[141,172,184],"displayed":[143],"normal":[144,176],"levels":[146],"TBIL,":[148],"AST,":[149],"ALT,":[150],"ALP,":[151],"Cr,":[152],"BUN":[153],"LDH,":[155],"while":[156],"no":[157],"significant":[158],"histopathology":[159],"changes":[160],"observed":[162],"tissues":[164],"liver,":[166,190],"spleen,":[167,191],"lung":[168,192],"kidney.":[170],"Treatment":[171],"rescue":[175],"immunocompromised":[178],"from":[180],"lethal":[181],"peritoneal":[182],"sepsis,":[183],"counts":[187],"blood,":[189],"kidney":[194,230],"reduced":[196],"1.4\u20133.3":[198],"log":[199],"colony-forming":[200],"units":[201],"at":[202],"4":[203],"h":[204],"post":[205],"Besides,":[207],"hemolysis":[209],"cytotoxicity":[211],"assays":[212],"showed":[213],"non-homolytic":[217],"human":[219,226],"red":[220],"blood":[221],"cells":[222],"non-toxic":[224],"lung,":[227],"liver":[228],"cell":[231],"lines.":[232],"Overall,":[233],"present":[235],"study":[236],"demonstrated":[237],"promising":[239],"depolymerases":[243],"agents":[246],"prevent":[248],"antibiotic-resisitant":[249],"infections.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-03-11T00:00:00"}