{"id":"https://openalex.org/W292015718","doi":null,"title":"Changes in serum eotaxin and eosinophil cationic protein levels, and eosinophil count during treatment of childhood asthma.","display_name":"Changes in serum eotaxin and eosinophil cationic protein levels, and eosinophil count during treatment of childhood asthma.","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W292015718","mag":"292015718","pmid":"https://pubmed.ncbi.nlm.nih.gov/17446966"},"language":"en","primary_location":{"id":"pmid:17446966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17446966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111915284","display_name":"Yu Te Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu Te Chu","raw_affiliation_strings":["Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I2802587341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109397840","display_name":"Wen Chin Chiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Chiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086542533","display_name":"Tsu\u2010Nai Wang","orcid":"https://orcid.org/0000-0002-0278-289X","observed_orcids":["https://orcid.org/0000-0002-0278-289X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsu Nai Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111439059","display_name":"Chih Hsing Hung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chih Hsing Hung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109095405","display_name":"Yuh Jyh Jong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuh Jyh Jong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112421242","display_name":"Jiunn Ren Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiunn Ren Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8094,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.7667527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"2","first_page":"162","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eotaxin","display_name":"eotaxin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/eosinophil-cationic-protein","display_name":"eosinophil cationic protein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/eosinophil-count","display_name":"eosinophil count","score":0.8029999732971191},{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oral-prednisolone","display_name":"oral prednisolone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.8790000081062317},{"id":"https://openalex.org/keywords/fluticasone","display_name":"fluticasone","score":0.9649999737739563},{"id":"https://openalex.org/keywords/salmeterol","display_name":"salmeterol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.878000020980835},{"id":"https://openalex.org/keywords/peak-expiratory-flow","display_name":"peak expiratory flow","score":0.8619999885559082},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5049999952316284},{"id":"https://openalex.org/keywords/asthma-treatment-response","display_name":"asthma treatment response","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8824646472930908},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.7734935283660889},{"id":"https://openalex.org/C2781212218","wikidata":"https://www.wikidata.org/wiki/Q1002165","display_name":"Fluticasone","level":3,"score":0.7295069694519043},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.7133317589759827},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6967191696166992},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6960495114326477},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.5842834711074829},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5740196108818054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5541370511054993},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.5402601957321167},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.4827782213687897},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4541087746620178},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42252862453460693},{"id":"https://openalex.org/C2776719499","wikidata":"https://www.wikidata.org/wiki/Q424333","display_name":"Salmeterol","level":3,"score":0.42094194889068604},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2365739345550537}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010366","descriptor_name":"Peak Expiratory Flow Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D047150","descriptor_name":"Eosinophil Cationic Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054413","descriptor_name":"Chemokine CCL11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17446966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17446966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","raw_type":"Journal Article"},{"id":"mag:292015718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17446966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1975280365","https://openalex.org/W1979346304","https://openalex.org/W1980330913","https://openalex.org/W1981343823","https://openalex.org/W1987108574","https://openalex.org/W1989859315","https://openalex.org/W2002885211","https://openalex.org/W2015925421","https://openalex.org/W2019026856","https://openalex.org/W2023520187","https://openalex.org/W2030685975","https://openalex.org/W2056292800","https://openalex.org/W2056640102","https://openalex.org/W2058385347","https://openalex.org/W2067714902","https://openalex.org/W2082070605","https://openalex.org/W2135152690","https://openalex.org/W2144118944","https://openalex.org/W2144839092","https://openalex.org/W2149742688","https://openalex.org/W2158648379","https://openalex.org/W2166132450","https://openalex.org/W2169673841","https://openalex.org/W2280477331","https://openalex.org/W2323128871","https://openalex.org/W2585717783"],"related_works":["https://openalex.org/W1966618506","https://openalex.org/W2015925421","https://openalex.org/W2368657353","https://openalex.org/W2099224023","https://openalex.org/W2123478982","https://openalex.org/W2017751469","https://openalex.org/W2073169593","https://openalex.org/W2388428719","https://openalex.org/W2284986385","https://openalex.org/W2743519976"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Increased":[3],"serum":[4,32,60,159,215,223],"levels":[5,33,61,125,161,171,204],"of":[6,13,24,34,85,99,107,143,240],"eotaxin":[7,35,57,124,203,216],"are":[8,18],"related":[9],"to":[10,169],"the":[11,22,54,119,127,141,184,214],"severity":[12],"asthma":[14,49,91],"in":[15,47,56,79,177,186,202,246],"adults.":[16],"There":[17,196],"limited":[19],"data":[20,211],"on":[21,31],"effects":[23],"oral":[25,68,100,130,144,165,189],"corticosteroids":[26,69,73],"and":[27,36,41,58,62,70,103,158,205,233],"inhaled":[28,72,108,228],"corticosteroid":[29],"therapy":[30],"eosinophil":[37,44],"cationic":[38],"protein":[39],"(ECP)":[40],"peripheral":[42,63,219],"blood":[43,64,220],"counts":[45],"(ECs)":[46],"pediatric":[48,80,87,247],"patients.":[50,81],"We":[51],"investigated":[52],"prospectively":[53],"changes":[55,201],"ECP":[59,160,178,224],"ECs":[65,187],"after":[66,96,104,129,135,164],"administering":[67],"then":[71],"plus":[74,110,230],"long-acting":[75],"beta2":[76],"agonist":[77],"treatment":[78,138,146,191,232],"METHODS:":[82],"Serum":[83,123],"samples":[84],"20":[86],"patients":[88],"with":[89,140,183,188],"mild-to-moderate":[90],"were":[92],"collected":[93],"before":[94],"treatment,":[95,102,132,167],"5-7":[97],"days":[98],"prednisolone":[101,131],"1-2":[105],"months":[106],"fluticasone":[109,229],"salmeterol":[111,231],"treatment.":[112,174],"Peak":[113],"expiratory":[114,207],"flow":[115],"was":[116,180,197],"used":[117],"as":[118,236],"outcome":[120],"index.":[121],"RESULTS:":[122],"remained":[126],"same":[128],"but":[133],"decreased":[134],"subsequent":[136],"inhalation":[137,173],"compared":[139],"end":[142],"steroid":[145,166,190],"(64.7":[147],"+/-":[148,152],"22.6":[149],"vs":[150],"85.7":[151],"36.8":[153],"pg/mL,":[154],"p<0.001).":[155],"The":[156,175],"EC":[157,221],"declined":[162],"soon":[163],"rebounding":[168],"initial":[170],"during":[172,227],"decrease":[176,185],"level":[179],"positively":[181],"correlated":[182],"(r(2)":[192],"=":[193],"0.28,":[194],"p=0.016).":[195],"no":[198],"correlation":[199],"between":[200],"peak":[206],"flow.":[208],"CONCLUSIONS:":[209],"Our":[210],"suggest":[212],"that":[213],"level,":[217,225],"not":[218],"or":[222],"declines":[226],"might":[234],"serve":[235],"a":[237],"surrogate":[238],"marker":[239],"T":[241],"helper":[242],"2":[243],"residual":[244],"activity":[245],"asthma.":[248]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
