{"id":"https://openalex.org/W2920145783","doi":"https://doi.org/10.1182/blood-2018-99-115129","title":"Long-Term Efficacy and Safety (5 Years) in RESPONSE, a Phase 3 Study Comparing Ruxolitinib (rux) with Best Available Therapy (BAT) in Hydroxyurea (HU)-Resistant/Intolerant Patients (pts) with Polycythemia Vera (PV)","display_name":"Long-Term Efficacy and Safety (5 Years) in RESPONSE, a Phase 3 Study Comparing Ruxolitinib (rux) with Best Available Therapy (BAT) in Hydroxyurea (HU)-Resistant/Intolerant Patients (pts) with Polycythemia Vera (PV)","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2920145783","doi":"https://doi.org/10.1182/blood-2018-99-115129","mag":"2920145783"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-115129","doi":"https://doi.org/10.1182/blood-2018-99-115129","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-115129","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008609620","display_name":"Jean\u2010Jacques Kiladjian","orcid":"https://orcid.org/0000-0002-8121-438X","observed_orcids":["https://orcid.org/0000-0002-8121-438X"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Jacques Kiladjian","raw_affiliation_strings":["Centre d'Investigations Cliniques, H\u00f4pital Saint-Louis, Universit\u00e9 Paris Diderot, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre d'Investigations Cliniques, H\u00f4pital Saint-Louis, Universit\u00e9 Paris Diderot, Paris, France","institution_ids":["https://openalex.org/I4210144610","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036582191","display_name":"Pierre Zach\u00e9e","orcid":"https://orcid.org/0000-0002-2275-5143","observed_orcids":["https://orcid.org/0000-0002-2275-5143"]},"institutions":[{"id":"https://openalex.org/I4210150429","display_name":"Ziekenhuisnetwerk Antwerpen Stuivenberg","ror":"https://ror.org/05dpzfc16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210150429","https://openalex.org/I4405261247"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Pierre Zach\u00e9e","raw_affiliation_strings":["Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerpen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerpen, Belgium","institution_ids":["https://openalex.org/I4210150429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001816724","display_name":"Masayuki Hino","orcid":"https://orcid.org/0000-0002-9128-7750","observed_orcids":["https://orcid.org/0000-0002-9128-7750"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Hino","raw_affiliation_strings":["Department of Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057084037","display_name":"Fabrizio Pane","orcid":"https://orcid.org/0000-0003-2563-4125","observed_orcids":["https://orcid.org/0000-0003-2563-4125"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Pane","raw_affiliation_strings":["Hematology - Departments of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology - Departments of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087934925","display_name":"Tam\u00e1s Masszi","orcid":"https://orcid.org/0000-0003-2322-9863","observed_orcids":["https://orcid.org/0000-0003-2322-9863"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tamas Masszi","raw_affiliation_strings":["3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046827092","display_name":"Claire N. Harrison","orcid":"https://orcid.org/0000-0002-3212-920X","observed_orcids":["https://orcid.org/0000-0002-3212-920X"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire N. Harrison","raw_affiliation_strings":["Department of Haematology, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039057642","display_name":"Ruben A. Mesa","orcid":"https://orcid.org/0000-0001-5880-7972","observed_orcids":["https://orcid.org/0000-0001-5880-7972"]},"institutions":[{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben A. Mesa","raw_affiliation_strings":["UT Health San Antonio Cancer Center, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health San Antonio Cancer Center, San Antonio, TX","institution_ids":["https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109288290","display_name":"Carole Brennan Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310298795","display_name":"Saint Agnes Hospital","ror":"https://ror.org/0011azt19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310298795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carole B. Miller","raw_affiliation_strings":["St. Agnes Healthcare Cancer Institute, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Agnes Healthcare Cancer Institute, Baltimore, MD","institution_ids":["https://openalex.org/I1310298795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009381933","display_name":"Francesco Passamonti","orcid":"https://orcid.org/0000-0001-8068-5289","observed_orcids":["https://orcid.org/0000-0001-8068-5289"]},"institutions":[{"id":"https://openalex.org/I2801668426","display_name":"Ospedale di Circolo e Fondazione Macchi","ror":"https://ror.org/02s6h0431","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801668426"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Passamonti","raw_affiliation_strings":["University Hospital Ospedale Di Circolo E Fondazione Macchi, Varese, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Ospedale Di Circolo E Fondazione Macchi, Varese, Italy","institution_ids":["https://openalex.org/I2801668426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028552390","display_name":"Simon Durrant","orcid":"https://orcid.org/0000-0003-3659-179X","observed_orcids":["https://orcid.org/0000-0003-3659-179X"]},"institutions":[{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon Durrant","raw_affiliation_strings":["Royal Brisbane & Women's Hospital, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Brisbane & Women's Hospital, Brisbane, Australia","institution_ids":["https://openalex.org/I2799393793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006360930","display_name":"Martin Grie\u00dfhammer","orcid":"https://orcid.org/0000-0001-8718-7004","observed_orcids":["https://orcid.org/0000-0001-8718-7004"]},"institutions":[{"id":"https://openalex.org/I4210162969","display_name":"Johannes Wesling Klinikum Minden","ror":"https://ror.org/05d89kr76","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210162969"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Griesshammer","raw_affiliation_strings":["Department of Hematology, Oncology, Hemostaseology and Palliative Care, Johannes Wesling Clinic, Minden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology, Hemostaseology and Palliative Care, Johannes Wesling Clinic, Minden, Germany","institution_ids":["https://openalex.org/I4210162969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090470146","display_name":"Keita Kirito","orcid":"https://orcid.org/0000-0001-5682-2132","observed_orcids":["https://orcid.org/0000-0001-5682-2132"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita Kirito","raw_affiliation_strings":["Department of Hematology and Oncology, University of Yamanashi, Chuo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University of Yamanashi, Chuo, Japan","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020155090","display_name":"Carlos Besses","orcid":"https://orcid.org/0000-0003-1806-3440","observed_orcids":["https://orcid.org/0000-0003-1806-3440"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Carles Besses","raw_affiliation_strings":["Hematology Department, Hospital del Mar-IMIM (Institut Hospital del Mar d'Investigacions M\u00e8diques), Universidad Aut\u00f3noma de Barcelona., Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital del Mar-IMIM (Institut Hospital del Mar d'Investigacions M\u00e8diques), Universidad Aut\u00f3noma de Barcelona., Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051359342","display_name":"Beatriz Moiraghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103251","display_name":"Hospital Ramos Mej\u00eda","ror":"https://ror.org/01bnyxq20","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210103251"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Beatriz Moiraghi","raw_affiliation_strings":["Hospital Jose Maria Ramos Mej\u00eda, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Jose Maria Ramos Mej\u00eda, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210103251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072484806","display_name":"Elisa Rumi","orcid":"https://orcid.org/0000-0002-7572-9504","observed_orcids":["https://orcid.org/0000-0002-7572-9504"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Elisa Rumi","raw_affiliation_strings":["Department of Hematology Oncology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Oncology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy","institution_ids":["https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019241495","display_name":"Vittorio Rosti","orcid":"https://orcid.org/0000-0003-4195-2289","observed_orcids":["https://orcid.org/0000-0003-4195-2289"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Rosti","raw_affiliation_strings":["Center for the Study of Myelofibrosis, Laboratory of Biochemistry Biotecnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Myelofibrosis, Laboratory of Biochemistry Biotecnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy","institution_ids":["https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060295441","display_name":"Igor Wolfgang Blau","orcid":"https://orcid.org/0000-0003-1416-819X","observed_orcids":["https://orcid.org/0000-0003-1416-819X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Igor W. Blau","raw_affiliation_strings":["Department of Hematology, Charit\u00e9 University School of Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Charit\u00e9 University School of Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047003547","display_name":"Nathalie Francillard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nathalie Francillard","raw_affiliation_strings":["Novartis Pharma S.A.S, Rueil Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma S.A.S, Rueil Malmaison, France","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113264458","display_name":"Tuochuan Dong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tuochuan Dong","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046878445","display_name":"Monika Wroclawska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Monika Wroclawska","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046772202","display_name":"Alessandro Maria Vannucchi","orcid":"https://orcid.org/0000-0001-5755-0730","observed_orcids":["https://orcid.org/0000-0001-5755-0730"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro M. Vannucchi","raw_affiliation_strings":["CRIMM; Center Research and Innovation of Myeloproliferative Neoplasms, AOUC, University of Florence, Firenze, Italy","CRIMM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIMM; Center Research and Innovation of Myeloproliferative Neoplasms, AOUC, University of Florence, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393","https://openalex.org/I45084792"]},{"raw_affiliation_string":"CRIMM","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085521139","display_name":"Sr\u0111an Verstov\u0161ek","orcid":"https://orcid.org/0000-0002-6912-8569","observed_orcids":["https://orcid.org/0000-0002-6912-8569"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srdan Verstovsek","raw_affiliation_strings":["Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":12,"institutions_distinct_count":25,"corresponding_author_ids":["https://openalex.org/A5006360930","https://openalex.org/A5009381933","https://openalex.org/A5020155090","https://openalex.org/A5036582191","https://openalex.org/A5046878445","https://openalex.org/A5047003547","https://openalex.org/A5051359342","https://openalex.org/A5060295441","https://openalex.org/A5072484806","https://openalex.org/A5109288290","https://openalex.org/A5113264458"],"corresponding_institution_ids":["https://openalex.org/I123044942","https://openalex.org/I1283582996","https://openalex.org/I1310298795","https://openalex.org/I2801668426","https://openalex.org/I4210092929","https://openalex.org/I4210103251","https://openalex.org/I4210130874","https://openalex.org/I4210150429","https://openalex.org/I4210151645","https://openalex.org/I4210156109","https://openalex.org/I4210162969","https://openalex.org/I7877124"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"1753","last_page":"1753"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hydroxyurea-resistance","display_name":"hydroxyurea resistance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hydroxyurea-intolerance","display_name":"hydroxyurea intolerance","score":0.9210000038146973},{"id":"https://openalex.org/keywords/long-term-efficacy","display_name":"long-term efficacy","score":0.800000011920929},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hematocrit-control","display_name":"hematocrit control","score":0.8109999895095825},{"id":"https://openalex.org/keywords/phlebotomy","display_name":"phlebotomy","score":0.777999997138977},{"id":"https://openalex.org/keywords/spleen-volume-reduction","display_name":"spleen volume reduction","score":0.8429999947547913},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.8799999952316284},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.652999997138977},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.4300000071525574},{"id":"https://openalex.org/keywords/durability-of-response","display_name":"durability of response","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8367817401885986},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.7655115127563477},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6596832871437073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.564862072467804},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.5395869612693787},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5031268000602722},{"id":"https://openalex.org/C2777357209","wikidata":"https://www.wikidata.org/wiki/Q3595842","display_name":"Phlebotomy","level":2,"score":0.48564258217811584},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.48404330015182495},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4817628860473633},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4390721917152405},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3651723265647888},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.3288726806640625},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32450753450393677},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0916396975517273}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-115129","doi":"https://doi.org/10.1182/blood-2018-99-115129","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-115129","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2783012969","https://openalex.org/W3095758083","https://openalex.org/W2326125048","https://openalex.org/W2912061124","https://openalex.org/W2803381821","https://openalex.org/W2551573304","https://openalex.org/W2603736070","https://openalex.org/W2987230910","https://openalex.org/W2981576356","https://openalex.org/W2616508561"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"RESPONSE":[2],"is":[3],"a":[4,39,144,181,772],"randomized":[5,127,233,248,269,308],"(1:1),":[6],"open-label,":[7],"phase":[8],"3":[9],"study":[10,322,432,537,548],"of":[11,22,98,112,148,195,291,333,346,359,400,431,436,466,577,586,643,666,681,693,740,775,795,808,821,945,980,991,1006],"rux":[12,48,73,129,241,250,271,329,387,413,492,523,598,703,741,776],"vs":[13,53,285,302,672,675,686,689],"BAT":[14,51,134,235,255,283,309,342,355,494,659,729],"in":[15,43,106,327,353,385,411,490,521,584,596,648,701,718,728],"pts":[16,28,110,268,325,336,455,555,650,660],"with":[17,47,71,81,118,165,453,749,783],"PV":[18,109,736],"who":[19,338,456],"are":[20,760],"resistant/intolerant":[21,111,735],"HU.":[23],"In":[24,475,550,733],"RESPONSE,":[25],"significantly":[26],"more":[27,167],"achieved":[29,457],"the":[30,72,76,87,196,328,334,354,386,396,412,429,476,491,522,551,597,653,702,754,765],"primary":[31,64,141,197,402,424,467],"composite":[32,145],"end":[33,146,230],"point":[34,147],"(hematocrit":[35],"control":[36,125,152,202,744],"[Hct]":[37],"and":[38,65,75,90,180,221,254,288,314,331,366,371,374,378,389,468,493,502,539,600,606,610,614,619,623,627,631,633,637,652,697,707,713,721,723,745],"\u2265":[40,182,594],"35%":[41,183],"reduction":[42],"spleen":[44],"volume":[45],"[SVR])":[46],"compared":[49,281,657],"to":[50,128,163,174,234,240,249,270,274,279,282,382,533,536,547,560,566,658,695],"(23%":[52],"1%;":[54],"P":[55],"\u02c2":[56],".0001).":[57],"The":[58,140,434,588,662,678,778],"4-year":[59],"(y)":[60],"follow-up":[61],"confirmed":[62],"that":[63,753],"clinicohematologic":[66],"(CLHM)":[67],"responses":[68,470],"were":[69,126,193,247,261,272,496,517,603,646,669,705,747],"sustained":[70],"treatment,":[74],"safety":[77,91,780],"profile":[78],"was":[79,143,227,318,357,415,447,580,683,781],"consistent":[80,782],"previous":[82,784],"reports.":[83],"Here,":[84],"we":[85],"report":[86],"long-term":[88,222,750,779],"efficacy":[89,360],"after":[92,242,311],"5":[93,344,488],"ys":[94,345,489],"(256":[95],"weeks":[96],"[wks])":[97],"treatment":[99,104,310,383,742],"(after":[100],"last":[101],"pt":[102,305,375,569],"first":[103],"visit)":[105],"RESPONSE.":[107],"Methods":[108],"HU":[113,280,734],"(per":[114,640],"modified":[115],"ELN":[116],"criteria)":[117],"splenomegaly":[119],"requiring":[120],"phlebotomy":[121],"(PBT)":[122],"for":[123,351,404,440,481,485],"Hct":[124,151],"10":[130,214],"mg":[131],"BID":[132],"or":[133,297,797,810,823,947,982,993,1008],"(selected":[135],"based":[136],"on":[137,307,572,791,804,817,941,976,987,1002],"investigator's":[138],"choice).":[139],"response":[142,403,439],"achieving":[149],"both":[150],"without":[153,203],"PBT":[154,158,170],"(defined":[155],"as":[156],"no":[157,166,581],"eligibility":[159,171],"between":[160,264],"wks":[161,406,442],"8":[162],"32":[164,179,461],"than":[168],"1":[169],"from":[172,341,408,444,757,768],"randomization":[173],"wk":[175,178,188,243,312,409,445,460],"8)":[176],"through":[177],"SVR":[184,217],"by":[185,219,428,762],"imaging":[186],"at":[187,459,487],"32.":[189,244],"Key":[190],"secondary":[191],"endpoints":[192],"durability":[194],"response,":[198],"overall":[199],"CLHM":[200,438,458,469],"(Hct":[201,743],"PBT,":[204],"platelet":[205],"count":[206,212],"\u2264":[207,213],"400":[208],"\u00d7":[209,215],"109/L,":[210,216],"WBC":[211],"\u226535%":[218],"imaging),":[220],"safety.":[223],"Overall":[224],"survival":[225],"(OS)":[226],"an":[228,792,805,818,942,977,988,1003],"exploratory":[229],"point.":[231],"Pts":[232,246],"could":[236],"cross":[237],"over":[238,340],"(CO)":[239,674,688],"Results":[245],"(n":[251,256],"=":[252,257,510,528,543],"110)":[253],"112).":[258],"Baseline":[259],"characteristics":[260],"mostly":[262],"balanced":[263],"arms.":[265],"At":[266,321,393],"baseline,":[267],"reported":[273],"have":[275],"longer":[276,575],"prior":[277,292],"exposure":[278,576,663],"(162.9":[284],"145.6":[286],"wks)":[287],"higher":[289],"frequency":[290],"nonmelanoma":[293],"skin":[294,299],"cancer":[295],"(NMSC)":[296],"pre-cancerous":[298],"conditions":[300],"(10.9":[301],"6.3%).":[303],"No":[304,568],"remained":[306],"80":[313],"median":[315],"CO":[316,390,552,601,654,719],"time":[317,430],"34.7":[319],"wks.":[320],"completion,":[323],"72":[324],"(66%)":[326],"arm":[330,356,388,414,524,599,704],"64":[332],"98":[335],"(65%)":[337],"crossed":[339],"completed":[343],"on-study":[347],"treatment.":[348],"Main":[349],"reason":[350],"discontinuation":[352],"lack":[358],"(89%).":[361],"Adverse":[362],"events":[363,645],"(AEs;":[364],"15%":[365],"16%),":[367],"disease":[368],"progression":[369],"(11%":[370],"9%":[372],")":[373],"decision":[376],"(6%":[377],"6%)":[379],"primarily":[380],"led":[381],"discontinuations":[384],"population,":[391,553,720],"respectively.":[392,731],"final":[394],"analysis,":[395],"KM":[397,483],"estimated":[398],"probability":[399,435],"maintaining":[401,437],"224":[405,441],"(starting":[407,443],"32)":[410,446],"0.74":[416],"(95%":[417,449,498,504],"CI:":[418,450,499,505,513],"0.51,":[419],"0.88)":[420],"(Figure":[421],"1);":[422],"6/25":[423],"responders":[425],"had":[426,462,471,556],"progressed":[427],"completion.":[433],"0.67":[448],"0.54,":[451],"0.77)":[452],"21/70":[454],"progressed.":[463],"Median":[464],"duration":[465],"not":[472,479,545],"been":[473],"reached.":[474],"intent-to-treat":[477],"analysis":[478,759,770],"accounting":[480],"CO,":[482,764],"estimates":[484],"OS":[486,755],"arms":[495],"91.9%":[497],"84.4,":[500],"95.9)":[501],"91.0%":[503],"82.8,":[506],"95.4),":[507],"respectively":[508],"(HR":[509],"0.95":[511],"[95%":[512],"0.38,":[514],"2.41]).":[515],"There":[516],"2":[518],"on-treatment":[519,562],"deaths":[520,563],"(adenocarcinoma":[525],"gastric":[526],"[n":[527,542],"1,":[529,544],"investigator":[530],"suspected":[531],"event":[532],"be":[534],"related":[535,546,565],"drug]":[538],"neoplasm":[540],"malignant":[541],"drug]).":[549],"4":[554,561],"fatal":[557],"AEs":[558,591],"leading":[559],"(not":[564],"rux).":[567],"died":[570],"while":[571],"BAT.":[573],"With":[574],"rux,":[578],"there":[579],"notable":[582],"increase":[583],"rate":[585,593,680],"AEs.":[587],"most":[589],"common":[590],"(exposure-adjusted":[592],"5)":[595],"population":[602,655],"anemia":[604],"(8.9":[605],"8.8),":[607],"pruritus":[608],"(7.0":[609,613],"6.1),":[611],"diarrhea":[612],"3.6),":[615],"weight":[616],"increased":[617],"(6.1":[618],"4.2),":[620],"headache":[621],"(5.8":[622],"5.2),":[624],"arthralgia":[625],"(5.6":[626],"3.3),":[628],"fatigue":[629],"(5.1":[630,636],"3.9)":[632],"muscle":[634],"spasms":[635],"3.3).":[638],"Rates":[639,692],"100":[641,710,716,726],"pt-y)":[642],"thromboembolic":[644],"lower":[647],"rux-treated":[649],"(1.2)":[651],"(2.7)":[656],"(8.2).":[661],"adjusted":[664],"rates":[665],"second":[667],"malignancies":[668],"7.0":[670],"(rux)":[671,685],"4.5":[673],"4.1":[676],"(BAT).":[677,691],"exposure-adjusted":[679],"NMSC":[682],"5.1":[684],"2.7":[687,690],"transformation":[694],"myelofibrosis":[696],"acute":[698],"myeloid":[699],"leukeimia":[700],"2.1":[706],"0.2":[708],"per":[709,715,725],"pt-y,":[711],"1.8":[712],"0.6":[714],"pt-y":[717,727],"1.4":[722],"0.0":[724],"arm,":[730],"Conclusion":[732],"pts,":[737],"clinical":[738],"benefits":[739],"CLHM)":[746],"durable":[748],"therapy.":[751],"Considering":[752],"findings":[756],"this":[758,769],"confounded":[761],"extensive":[763],"observed":[766],"HR":[767],"represents":[771],"conservative":[773],"estimate":[774],"benefit.":[777],"findings.":[785],"Disclosures":[786],"Kiladjian:":[787],"AOP":[788],"Orphan:":[789],"Membership":[790,803,816,940,975,986,1001],"entity's":[793,806,819,943,978,989,1004],"Board":[794,807,820,944,979,990,1005],"Directors":[796,809,822,946,981,992,1007],"advisory":[798,811,824,948,983,994,1009],"committees,":[799,812,949,995],"Research":[800,813,830,833,836,877,882,885,888,891,894,904,909,914,958,996],"Funding;":[801,814,831,883,886,889,892,895,905,915,959],"Novartis:":[802,832,854,874,900,916,928,985],"Celgene:":[815,887,924,1000],"committees.":[825,1010],"Hino:Otsuka":[826],"Pharmaceutical":[827],"Co.,":[828],"Ltd.:":[829],"Funding.":[834],"Pane:Novartis:":[835],"Funding,":[837,878,910,997],"Speakers":[838,841,844,861,872,879,911,918,922,926,931,937,950,998],"Bureau;":[839,842,862,873,912,923,927,932,999],"BMS:":[840,848],"AMGEN:":[843],"Bureau.":[845,880,919,938,951],"Masszi:Pfizer:":[846],"Consultancy;":[847,849,851,853,855,897,899,973],"AbbVie:":[850],"Janssen-Cilag:":[852],"Takeda:":[856],"Consultancy.":[857,901,934],"Harrison:Celgene:":[858],"Consultancy,":[859,864,868,875,907,921,925,929],"Honoraria,":[860,871,876,903,908,917,930,936,957],"Roche:":[863,933],"Honoraria;":[865,869],"CTI":[866],"BioPharma:":[867],"Gilead:":[870,893],"Mesa:CTI:":[881],"Promedior:":[884],"Incyte:":[890,906],"Galena:":[896],"Ariad:":[898],"Miller:Gilead:":[902],"CTI:":[913],"Passamonti:Janssen:":[920],"Durrant:Novartis:":[935],"Griesshammer:Novartis:":[939],"Kirito:Novartis":[952],"Pharma":[953],"KK:":[954],"Honoraria.":[955,961],"Besses:Novartis:":[956],"Shire:":[960],"Francillard:Novartis:":[962],"Employment.":[963],"Dong:Novartis:":[964],"Employment,":[965,969],"Equity":[966,970],"Ownership.":[967,971],"Wroclawska:Novartis:":[968],"Verstovsek:Incyte:":[972],"Italfarmaco:":[974],"committees;":[984]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-11T00:00:00"}