{"id":"https://openalex.org/W2919985407","doi":"https://doi.org/10.1161/res.123.suppl_1.361","title":"Abstract 361: Analysis of Cardiotoxic Mechanisms Associated With Tyrosine Kinase Inhibitor Ponatinib","display_name":"Abstract 361: Analysis of Cardiotoxic Mechanisms Associated With Tyrosine Kinase Inhibitor Ponatinib","publication_year":2018,"publication_date":"2018-08-03","ids":{"openalex":"https://openalex.org/W2919985407","doi":"https://doi.org/10.1161/res.123.suppl_1.361","mag":"2919985407"},"language":"en","primary_location":{"id":"doi:10.1161/res.123.suppl_1.361","doi":"https://doi.org/10.1161/res.123.suppl_1.361","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.361","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088135964","display_name":"Anand Prakash Singh","orcid":"https://orcid.org/0000-0002-9409-1366","observed_orcids":["https://orcid.org/0000-0002-9409-1366"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand P Singh","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Anand P Singh Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Anand P Singh Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076509487","display_name":"Michael S. Glennon","orcid":"https://orcid.org/0009-0006-2898-6731","observed_orcids":["https://orcid.org/0009-0006-2898-6731"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S Glennon","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Michael S Glennon Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Michael S Glennon Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033362734","display_name":"Prachi Umbarkar","orcid":"https://orcid.org/0000-0002-7989-577X","observed_orcids":["https://orcid.org/0000-0002-7989-577X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prachi P Umbarkar","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Prachi P Umbarkar Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Prachi P Umbarkar Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108235341","display_name":"Manisha Gupte","orcid":"https://orcid.org/0009-0000-9014-139X","observed_orcids":["https://orcid.org/0009-0000-9014-139X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manisha Gupte","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Manisha Gupte Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Manisha Gupte Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024831931","display_name":"Cristi Lara Galindo","orcid":"https://orcid.org/0000-0001-9002-4572","observed_orcids":["https://orcid.org/0000-0001-9002-4572"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristi L Galindo","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Cristi L Galindo Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Cristi L Galindo Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059427088","display_name":"Qinkun Zhang","orcid":"https://orcid.org/0000-0002-0876-609X","observed_orcids":["https://orcid.org/0000-0002-0876-609X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinkun Zhang","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Qinkun Zhang Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Qinkun Zhang Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017332459","display_name":"Thomas L. Force","orcid":"https://orcid.org/0000-0002-0450-8659","observed_orcids":["https://orcid.org/0000-0002-0450-8659"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Force","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Thomas Force Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Thomas Force Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065796273","display_name":"Jason R. Becker","orcid":"https://orcid.org/0000-0002-2107-8179","observed_orcids":["https://orcid.org/0000-0002-2107-8179"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R Becker","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Jason R Becker Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Jason R Becker Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004233469","display_name":"Hind Lal","orcid":"https://orcid.org/0000-0001-8980-9874","observed_orcids":["https://orcid.org/0000-0001-8980-9874"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hind Lal","raw_affiliation_strings":["Vanderbilt Univ Med. Cntr, Nashville, TN","Hind Lal Vanderbilt Univ Med. Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Hind Lal Vanderbilt Univ Med. Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuregulin-1beta","display_name":"neuregulin-1\u03b2","score":0.890999972820282},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/asciminib","display_name":"asciminib","score":0.9490000009536743},{"id":"https://openalex.org/keywords/t315i-mutation","display_name":"T315I mutation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neonatal-rat-ventricular-myocytes","display_name":"neonatal rat ventricular myocytes","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.9813761711120605},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.918510913848877},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.621904730796814},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5544407963752747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5266100168228149},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.47943538427352905},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4759528338909149},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.43474486470222473},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.30921638011932373},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2739790678024292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25897830724716187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2238999903202057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15925952792167664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13940206170082092},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12333926558494568},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12068614363670349},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.09466195106506348}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.123.suppl_1.361","doi":"https://doi.org/10.1161/res.123.suppl_1.361","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.361","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2908998660","https://openalex.org/W3029527842","https://openalex.org/W2980630547","https://openalex.org/W4392282821","https://openalex.org/W7162821608","https://openalex.org/W7154713731","https://openalex.org/W4312975199","https://openalex.org/W4283695000","https://openalex.org/W3215580358","https://openalex.org/W4313908390"],"abstract_inverted_index":{"Background:":[0],"Ponatinib,":[1],"a":[2,28],"potent":[3],"pan-BCR-ABL":[4],"tyrosine":[5,194],"kinase":[6,195],"inhibitor":[7,196],"(TKI)":[8],"holds":[9],"significant":[10],"promise":[11],"in":[12,80,84,116,120,130,133,205],"the":[13,21,53,59,69,87,145,152,167,184,192,220,229],"treatment":[14,177,240],"of":[15,24,38,52,89,170,216,222],"chronic":[16],"myelogenous":[17],"leukemia":[18],"(CML),":[19],"although":[20],"potential":[22,43,70],"cardiotoxicity":[23,65,181],"this":[25,75,233],"agent":[26],"remains":[27],"concern.":[29],"In":[30,74],"order":[31],"to":[32,57,67,99,112,127,161,172,225],"overcome":[33],"ponatinib":[34,110,137,150,174,204,243],"associated":[35,103],"cardiotoxicity,":[36,218],"delineation":[37],"linked":[39],"cardiotoxic":[40,101,201],"mechanisms":[41,61],"and":[42,66,123,156,227],"rescue":[44,71,228],"methods":[45],"are":[46],"urgently":[47],"warranted.":[48],"Objectives:":[49],"The":[50],"objectives":[51],"present":[54],"study":[55,210,234],"were":[56],"delineate":[58],"signaling":[60,158,189],"responsible":[62],"for":[63,86,244],"ponatinib-induced":[64,180,217,230],"identify":[68],"strategies.":[72],"Methods:":[73],"study,":[76],"we":[77,165],"employed":[78],"direct":[79],"vivo":[81],"drug":[82,142],"screening":[83],"zebrafish":[85],"prediction":[88],"cardiotoxicity.":[90,231],"We":[91,107],"also":[92],"exploited":[93],"neonatal":[94],"rat":[95,135],"ventricular":[96],"myocytes":[97],"(NRVMs)":[98],"explore":[100],"mechanism":[102],"with":[104,249],"ponatinib.":[105],"Results:":[106],"observed":[108],"that":[109],"leads":[111],"cardiomyocyte":[113,162,186],"apoptosis,":[114],"elevation":[115],"BNP":[117],"level,":[118],"decrease":[119],"heart":[121],"rate":[122],"fractional":[124],"shortening":[125],"leading":[126],"cardiac":[128],"dysfunction":[129],"Zebrafish.":[131],"Consistently,":[132],"cultured":[134],"cardiomyocytes,":[136],"was":[138],"found":[139],"most":[140],"cytotoxic":[141],"among":[143],"all":[144],"approved":[146],"CML":[147,248],"TKIs.":[148],"Mechanistically,":[149],"inhibits":[151],"essential":[153,185],"prosurvival":[154,187],"AKT":[155],"ERK":[157],"pathway,":[159],"resulting":[160],"apoptosis.":[163],"Interestingly,":[164],"evaluated":[166],"cardioprotective":[168,223],"effects":[169,202],"Neuregulin-1\u03b2":[171,176],"limit":[173],"toxicity.":[175],"significantly":[178],"protects":[179],"by":[182],"supplementing":[183],"AKT/ERK":[188],"pathways.":[190],"Additionally,":[191],"allosteric":[193],"asciminib":[197,236],"depicts":[198],"less":[199],"pronounced":[200],"than":[203,242],"similar":[206],"settings.":[207],"Conclusions:":[208],"This":[209],"will":[211],"advance":[212],"our":[213],"mechanistic":[214],"understanding":[215],"accelerate":[219],"discovery":[221],"strategies":[224],"prevent":[226],"Furthermore,":[232],"suggests":[235],"as":[237],"an":[238],"alternate":[239],"option":[241],"patients":[245],"suffering":[246],"from":[247],"T315I":[250],"\u201cgatekeeper\u201d":[251],"mutation.":[252]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-03-11T00:00:00"}
