{"id":"https://openalex.org/W2919978558","doi":null,"title":"PSMA, a marker for prostate cancer: Molecular signalling and transport mechanisms in humans and their transferability to dogs","display_name":"PSMA, a marker for prostate cancer: Molecular signalling and transport mechanisms in humans and their transferability to dogs","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2919978558","mag":"2919978558"},"language":"en","primary_location":{"id":"mag:2919978558","doi":null,"is_oa":false,"landing_page_url":"https://elib.tiho-hannover.de/dissertations/schmidts_ws12","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088069272","display_name":"Sonja K. Schmidt","orcid":"https://orcid.org/0009-0003-7150-3123","observed_orcids":["https://orcid.org/0009-0003-7150-3123"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sonja Schmidt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7150-3123","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088069272"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.19709999859333038,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prostate-cancer-biomarkers","display_name":"prostate cancer biomarkers","score":0.9269999861717224},{"id":"https://openalex.org/keywords/detergent-resistant-membranes","display_name":"detergent-resistant membranes","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/homodimerization","display_name":"homodimerization","score":0.8629999756813049},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.906000018119812},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.8169999718666077},{"id":"https://openalex.org/keywords/basement-membrane-adhesion","display_name":"basement membrane adhesion","score":0.6779999732971191},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/antibody-based-therapy","display_name":"antibody-based therapy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.4169999957084656},{"id":"https://openalex.org/keywords/transgenic-rats","display_name":"transgenic rats","score":0.3610000014305115},{"id":"https://openalex.org/keywords/transgenic-zebrafish","display_name":"transgenic zebrafish","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.8210031986236572},{"id":"https://openalex.org/C20417620","wikidata":"https://www.wikidata.org/wiki/Q4140229","display_name":"Glutamate carboxypeptidase II","level":4,"score":0.7780215740203857},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6781648397445679},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.5453668236732483},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.507820188999176},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5053446888923645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5034977793693542},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4627874195575714},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4441734254360199},{"id":"https://openalex.org/C2776243700","wikidata":"https://www.wikidata.org/wiki/Q7252869","display_name":"Proximity ligation assay","level":3,"score":0.44401922821998596},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.442491352558136},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4293524920940399},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3261207342147827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3081052601337433},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28627485036849976},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26806315779685974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20026835799217224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19957810640335083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09487593173980713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2919978558","doi":null,"is_oa":false,"landing_page_url":"https://elib.tiho-hannover.de/dissertations/schmidts_ws12","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W84626747","https://openalex.org/W200081977","https://openalex.org/W1480342093","https://openalex.org/W1484811165","https://openalex.org/W1491459594","https://openalex.org/W1495043122","https://openalex.org/W1506033718","https://openalex.org/W1558144205","https://openalex.org/W1564861448","https://openalex.org/W1581642890","https://openalex.org/W1583154040","https://openalex.org/W1630241876","https://openalex.org/W1835922802","https://openalex.org/W1845375977","https://openalex.org/W1849365998","https://openalex.org/W1908565627","https://openalex.org/W1916477575","https://openalex.org/W1966110715","https://openalex.org/W1967223868","https://openalex.org/W1967363104","https://openalex.org/W1967796382","https://openalex.org/W1969461041","https://openalex.org/W1971926635","https://openalex.org/W1973596992","https://openalex.org/W1974911723","https://openalex.org/W1975286848","https://openalex.org/W1975672381","https://openalex.org/W1977149059","https://openalex.org/W1978281474","https://openalex.org/W1979043529","https://openalex.org/W1980334501","https://openalex.org/W1981761488","https://openalex.org/W1981862236","https://openalex.org/W1983760836","https://openalex.org/W1986324420","https://openalex.org/W1988020128","https://openalex.org/W1991655565","https://openalex.org/W1992119878","https://openalex.org/W1993352932","https://openalex.org/W1995374771","https://openalex.org/W1997156303","https://openalex.org/W1998083136","https://openalex.org/W2000638372","https://openalex.org/W2003630286","https://openalex.org/W2003727692","https://openalex.org/W2005888725","https://openalex.org/W2008602052","https://openalex.org/W2008676629","https://openalex.org/W2013824417","https://openalex.org/W2015704490","https://openalex.org/W2015741145","https://openalex.org/W2016894006","https://openalex.org/W2016973566","https://openalex.org/W2017430299","https://openalex.org/W2018088003","https://openalex.org/W2019498266","https://openalex.org/W2019869547","https://openalex.org/W2021211941","https://openalex.org/W2023965621","https://openalex.org/W2024811115","https://openalex.org/W2025529482","https://openalex.org/W2028415754","https://openalex.org/W2037735248","https://openalex.org/W2037923640","https://openalex.org/W2038899098","https://openalex.org/W2039185164","https://openalex.org/W2039469316","https://openalex.org/W2041064090","https://openalex.org/W2043017963","https://openalex.org/W2043103956","https://openalex.org/W2043851505","https://openalex.org/W2055066655","https://openalex.org/W2059703954","https://openalex.org/W2061306848","https://openalex.org/W2064399682","https://openalex.org/W2064952123","https://openalex.org/W2065918262","https://openalex.org/W2066015352","https://openalex.org/W2067356373","https://openalex.org/W2068504553","https://openalex.org/W2069568296","https://openalex.org/W2069986720","https://openalex.org/W2070307339","https://openalex.org/W2073117151","https://openalex.org/W2079515412","https://openalex.org/W2080494149","https://openalex.org/W2080644669","https://openalex.org/W2082013215","https://openalex.org/W2083754827","https://openalex.org/W2086358590","https://openalex.org/W2087443831","https://openalex.org/W2092776013","https://openalex.org/W2093847817","https://openalex.org/W2095761465","https://openalex.org/W2097629605","https://openalex.org/W2101103881","https://openalex.org/W2104148175","https://openalex.org/W2105276867","https://openalex.org/W2116008044","https://openalex.org/W2116422958","https://openalex.org/W2116511683","https://openalex.org/W2117334458","https://openalex.org/W2121936687","https://openalex.org/W2124023027","https://openalex.org/W2125225672","https://openalex.org/W2127901889","https://openalex.org/W2129044698","https://openalex.org/W2129244120","https://openalex.org/W2129399870","https://openalex.org/W2131974710","https://openalex.org/W2132109283","https://openalex.org/W2132905193","https://openalex.org/W2133388060","https://openalex.org/W2134344512","https://openalex.org/W2136220787","https://openalex.org/W2137541551","https://openalex.org/W2137870598","https://openalex.org/W2138743737","https://openalex.org/W2139846514","https://openalex.org/W2140900740","https://openalex.org/W2141367941","https://openalex.org/W2142061382","https://openalex.org/W2144298794","https://openalex.org/W2147465611","https://openalex.org/W2153905340","https://openalex.org/W2156819631","https://openalex.org/W2157788428","https://openalex.org/W2158603948","https://openalex.org/W2158757486","https://openalex.org/W2159719571","https://openalex.org/W2160069559","https://openalex.org/W2161715331","https://openalex.org/W2163380421","https://openalex.org/W2165199733","https://openalex.org/W2167019990","https://openalex.org/W2175665183","https://openalex.org/W2188635754","https://openalex.org/W2402202970"],"related_works":["https://openalex.org/W159527917","https://openalex.org/W2090443751","https://openalex.org/W1967363104","https://openalex.org/W100527194","https://openalex.org/W7208835327","https://openalex.org/W1502167250","https://openalex.org/W2155421560","https://openalex.org/W7131671024","https://openalex.org/W2157788428","https://openalex.org/W2170337253"],"abstract_inverted_index":{"Prostate-specific":[0],"membrane":[1,285,322],"antigen":[2,493],"(PSMA)":[3],"is\n":[4],"a":[6,75,188,232,338,407,435,484],"type-II-transmembrane-glycoprotein":[7],"with":[8,89,157,301,460],"folate":[9],"hydrolase":[10],"and":[11,25,42,59,74,94,136,140,218,262,286,328,356,362,380,387,434,457,467,477,491],"carboxypeptidase":[12],"activity.":[13],"PSMA":[14,29,86,145,164,182,223,243,351,382,392,414,453,469,479],"is":[15,62,87,216,224,244,406,458],"mainly":[16,147],"expressed":[17],"in\n":[18,32],"epithelial":[20],"cells":[21,36,370],"of":[22,28,45,50,71,111,124,132,144,163,169,172,181,200,208,234,242,289,294,305,321,346,412],"the":[23,69,100,109,129,178,209,283,295,310,349,363,403],"prostate":[24,34,72,489],"elevated":[26],"levels":[27,49,199],"are":[30,40,53,123,146,470],"detected":[31],"cancer":[35,73,490],"including":[37],"those":[38],"that":[39,122,222,376],"metastatic,":[41],"in":[43,68,83,117,128,149,187,195,203,213,237,278,325,367,474,499],"neovasculature":[44],"further":[46],"tumours.":[47],"Thereby":[48],"PSMA\n":[51],"directly":[54],"proportional":[55],"to":[56,166,183,398,416,422,427,449,482],"disease":[57],"grade":[58],"stage.":[60],"It":[61,374],"therefore":[63],"a\n":[64,256,444],"promising":[66],"biomarker":[67],"diagnosis":[70],"potential\n":[76],"target":[78,340],"for":[79,318,341,488,494],"antibody-based":[80],"therapeutic":[81],"strategies":[82],"men.\n":[84],"associated":[88,300,459],"detergent-resistant\n":[90],"membranes":[92],"(DRMs)":[93],"transported":[95],"via":[96,227],"different":[97,319],"DRMs":[98],"along":[99],"secretory\n":[101],"pathway.":[103],"In":[104,420,443],"this":[105,219],"study":[106,220],"we":[107],"addressed":[108],"role":[110,277,317],"DRMs\n":[112],"or":[114,371],"lipid":[115,462],"rafts":[116],"two":[118],"major":[119,404],"physiological":[120],"events":[121],"pivotal\n":[125],"importance":[127],"life":[130],"cycle":[131],"PSMA,":[133,170,451],"homodimerization\n":[134],"internalization.":[137],"The":[138],"mature":[139],"homodimeric\n":[141],"forms":[143,455],"insoluble":[148],"Lubrol":[150],"WX,\n":[151],"but":[153],"do":[154],"not":[155],"associate":[156],"Triton":[158,214,238],"X-100-DRMs.":[159],"Antibody-induced":[160],"cross-linking\n":[161],"leads":[165],"increased":[167,303],"internalization":[168,327],"activation":[171,241],"different\n":[173],"signalling":[175],"cascades":[176],"like":[177],"MAPK-pathway,":[179],"redistribution":[180],"Triton\n":[184],"X-100-DRMs":[186,215,239],"time-dependent":[189],"manner":[190],"as":[191,193],"well":[192],"alterations":[194],"the\n":[196,377],"expression":[198,288],"several":[201],"proteins":[202,210,383],"these":[204],"DRMs.\n":[205],"One":[207],"also":[211,454],"clustering":[212],"\u03b1-tubulin,":[217],"shows":[221,393],"internalized\n":[225],"microtubules.":[228],"Another":[229],"protein":[230,352],"showing":[231],"trend":[233],"downregulation\n":[235],"upon":[240],"laminin\n":[245],"receptor-1":[247],"(67LR).":[248],"Indirect":[249],"immunofluorescence":[250],"and\n":[251],"co-immunoprecipitation":[253],"experiments":[254],"revealed":[255],"direct":[258],"interaction":[259,265],"between":[260],"67LR":[261,273,290],"YFP-PSMA.":[263],"This":[264],"might":[266,298],"be":[267,299,483],"of\n":[268],"particular":[270],"interest,":[271],"because":[272],"plays":[274],"an":[275,302,315,423],"important":[276],"cell":[279,296],"adhesion":[280],"to\n":[281],"basement":[284],"less":[287],"within":[291],"microdomains\n":[292,323],"surface":[297],"risk":[304],"metastasis.\n":[306],"Taken":[308],"together,":[309],"results":[311],"strongly":[312],"propose\n":[313],"essential":[316],"types":[320],"homodimerization,":[326],"signalling\n":[329],"pathways":[331],"involving":[332],"PSMA.\n":[333],"As":[337],"potential":[339],"animal":[342],"preclinical\n":[343],"studies":[345,498],"antibody":[347],"based-therapies,":[348],"canine":[350,379,413,452,468,478],"was":[353],"identified\n":[354],"investigated":[357],"regarding":[358],"its":[359,417],"cellular":[360,428],"distribution":[361,426],"biochemical\n":[364],"characteristics":[366],"either":[368],"COS-1":[369],"MDCK":[372],"cells.":[373],"appears":[375],"human":[381,399,418,450,466],"share":[384],"many":[385],"biochemical":[386],"cellular\n":[388],"characteristics.":[390],"Canine":[391],"91%":[394],"amino":[395],"acid":[396],"homology":[397],"PSMA,\n":[400],"whereas":[402],"difference":[405],"longer":[408],"cytoplasmic\n":[409],"tail":[411],"compared":[415],"counterpart.":[419],"addition":[421],"equal\n":[424],"compartments,":[429],"similar":[430,448,473],"glycosylation\n":[431],"pattern":[433,440],"slightly":[436],"more":[437],"rapid":[438],"trafficking":[439],"were":[441],"revealed.":[442],"fashion":[446],"almost":[447],"homodimers":[456],"distinct":[461],"microdomains.\n":[463],"Therefore":[465],"very\n":[471],"their":[475],"behaviour":[476],"turned":[480],"out":[481],"useful\n":[485],"model-protein":[487],"suitable":[492],"targeted":[495],"therapy\n":[496],"dogs.":[500]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-03-11T00:00:00"}
