{"id":"https://openalex.org/W2919862009","doi":"https://doi.org/10.1093/ofid/ofz107","title":"Safety and Immunogenicity of MF59-Adjuvanted Cell Culture\u2013Derived A/H5N1 Subunit Influenza Virus Vaccine: Dose-Finding Clinical Trials in Adults and the Elderly","display_name":"Safety and Immunogenicity of MF59-Adjuvanted Cell Culture\u2013Derived A/H5N1 Subunit Influenza Virus Vaccine: Dose-Finding Clinical Trials in Adults and the Elderly","publication_year":2019,"publication_date":"2019-02-28","ids":{"openalex":"https://openalex.org/W2919862009","doi":"https://doi.org/10.1093/ofid/ofz107","mag":"2919862009","pmid":"https://pubmed.ncbi.nlm.nih.gov/30968056","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6446137"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofz107","doi":"https://doi.org/10.1093/ofid/ofz107","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofz107","pdf_url":"https://academic.oup.com/ofid/article-pdf/6/4/ofz107/28267069/ofz107.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/6/4/ofz107/28267069/ofz107.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078714130","display_name":"Sharon E. Frey","orcid":"https://orcid.org/0009-0008-6313-4053","observed_orcids":["https://orcid.org/0009-0008-6313-4053"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E Frey","raw_affiliation_strings":["School of Medicine, Saint Louis University, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Saint Louis University, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033973551","display_name":"Sepehr Shakib","orcid":"https://orcid.org/0000-0002-7199-5733","observed_orcids":["https://orcid.org/0000-0002-7199-5733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sepehr Shakib","raw_affiliation_strings":["CMAX Clinical Research Pty Ltd., Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CMAX Clinical Research Pty Ltd., Adelaide, SA, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032430662","display_name":"Pornthep Chanthavanich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pornthep Chanthavanich","raw_affiliation_strings":["Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030667842","display_name":"Peter Richmond","orcid":"https://orcid.org/0000-0001-7562-7228","observed_orcids":["https://orcid.org/0000-0001-7562-7228"]},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Richmond","raw_affiliation_strings":["Division of Paediatrics, School of Medicine, University of Western Australia, and Vaccine Trials Group, Telethon Kids Institute, Subiaco, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Paediatrics, School of Medicine, University of Western Australia, and Vaccine Trials Group, Telethon Kids Institute, Subiaco, WA, Australia","institution_ids":["https://openalex.org/I175234967","https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102876753","display_name":"Timothy R. Smith","orcid":"https://orcid.org/0009-0003-0691-7530","observed_orcids":["https://orcid.org/0009-0003-0691-7530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Smith","raw_affiliation_strings":["Mercy Health Research, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercy Health Research, St. Louis, Missouri","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019706094","display_name":"Terapong Tantawichien","orcid":"https://orcid.org/0000-0003-1970-5118","observed_orcids":["https://orcid.org/0000-0003-1970-5118"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I19949148","display_name":"Queen Saovabha Memorial Institute","ror":"https://ror.org/00akhwn95","country_code":"TH","type":"facility","lineage":["https://openalex.org/I19949148"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Terapong Tantawichien","raw_affiliation_strings":["Department of Medicine, Faculty of Medicine, Chulalongkorn University and Queen Saovabha Memorial Institute, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Chulalongkorn University and Queen Saovabha Memorial Institute, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052","https://openalex.org/I19949148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081852695","display_name":"Claudia Kittel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148983","display_name":"GlaxoSmithKline (Germany)","ror":"https://ror.org/05gedqb32","country_code":"DE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210148983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Kittel","raw_affiliation_strings":["GlaxoSmithKline Vaccines GmbH, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Vaccines GmbH, Marburg, Germany","institution_ids":["https://openalex.org/I4210148983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065099159","display_name":"Peter Jaehnig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148983","display_name":"GlaxoSmithKline (Germany)","ror":"https://ror.org/05gedqb32","country_code":"DE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210148983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Jaehnig","raw_affiliation_strings":["GlaxoSmithKline Vaccines GmbH, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Vaccines GmbH, Marburg, Germany","institution_ids":["https://openalex.org/I4210148983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032223866","display_name":"Zenaida Reynoso Mojares","orcid":"https://orcid.org/0000-0003-1632-9268","observed_orcids":["https://orcid.org/0000-0003-1632-9268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zenaida Mojares","raw_affiliation_strings":["GlaxoSmithKline Pte Ltd., Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Pte Ltd., Singapore, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014131291","display_name":"Bikash Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bikash Verma","raw_affiliation_strings":["GlaxoSmithKline Vaccines LLC, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Vaccines LLC, Rockville, Maryland","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032741988","display_name":"Niranjan Kanesa-thasan","orcid":"https://orcid.org/0000-0002-9346-5485","observed_orcids":["https://orcid.org/0000-0002-9346-5485"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niranjan Kanesa-thasan","raw_affiliation_strings":["GlaxoSmithKline Vaccines LLC, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Vaccines LLC, Rockville, Maryland","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109915296","display_name":"Matthew J. Hohenboken","orcid":"https://orcid.org/0000-0003-0453-1418","observed_orcids":["https://orcid.org/0000-0003-0453-1418"]},"institutions":[{"id":"https://openalex.org/I4210129217","display_name":"Seqirus (United States)","ror":"https://ror.org/03k879d12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129217"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew Hohenboken","raw_affiliation_strings":["Seqirus Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seqirus Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4210129217"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5109915296"],"corresponding_institution_ids":["https://openalex.org/I4210129217"],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":1.3321,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78985084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"ofz107","last_page":"ofz107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h5n1-influenza-vaccine","display_name":"H5N1 influenza vaccine","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mf59-adjuvant","display_name":"MF59 adjuvant","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-culture-derived-vaccine","display_name":"cell culture-derived vaccine","score":0.7609999775886536},{"id":"https://openalex.org/keywords/subunit-influenza-vaccine","display_name":"subunit influenza vaccine","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dose-finding","display_name":"dose-finding","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dose-sparing","display_name":"dose sparing","score":0.6629999876022339},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.972000002861023},{"id":"https://openalex.org/keywords/hemagglutination-titer","display_name":"hemagglutination titer","score":0.859000027179718},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.9559999704360962},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5550000071525574},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pandemic-influenza-preparedness","display_name":"pandemic influenza preparedness","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.9105485677719116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8972656726837158},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.6546860337257385},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6022027730941772},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5412802696228027},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.5060021281242371},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.477017879486084},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47113674879074097},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41114920377731323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22852769494056702},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2247278094291687}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1093/ofid/ofz107","doi":"https://doi.org/10.1093/ofid/ofz107","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofz107","pdf_url":"https://academic.oup.com/ofid/article-pdf/6/4/ofz107/28267069/ofz107.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5438552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6446137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6446137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6446137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"},{"id":"pmid:30968056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30968056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open forum infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/2bd6a395-0b29-44d4-8963-ca9991cbcb24","doi":null,"is_oa":true,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/2bd6a395-0b29-44d4-8963-ca9991cbcb24","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frey, S E, Shakib, S, Chanthavanich, P, Richmond, P, Smith, T, Tantawichien, T, Kittel, C, Jaehnig, P, Mojares, Z, Verma, B, Kanesa-Thasan, N & Hohenboken, M 2019, 'Safety and immunogenicity of MF59-adjuvanted cell culture-derived A/H5N1 subunit influenza virus vaccine : Dose-finding clinical trials in adults and the elderly', Open Forum Infectious Diseases, vol. 6, no. 4, ofz107. https://doi.org/10.1093/ofid/ofz107","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/121954","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/121954","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1093/ofid/ofz107","raw_type":"Journal article"},{"id":"doi:10.60692/dk5y2-8js92","doi":"https://doi.org/10.60692/dk5y2-8js92","is_oa":true,"landing_page_url":"https://doi.org/10.60692/dk5y2-8js92","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/f9qdz-txh53","doi":"https://doi.org/10.60692/f9qdz-txh53","is_oa":true,"landing_page_url":"https://doi.org/10.60692/f9qdz-txh53","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofz107","doi":"https://doi.org/10.1093/ofid/ofz107","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofz107","pdf_url":"https://academic.oup.com/ofid/article-pdf/6/4/ofz107/28267069/ofz107.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2919862009.pdf","grobid_xml":"https://content.openalex.org/works/W2919862009.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1968334717","https://openalex.org/W1969987339","https://openalex.org/W1971015537","https://openalex.org/W1982019229","https://openalex.org/W1982855609","https://openalex.org/W1990289558","https://openalex.org/W1991761489","https://openalex.org/W2011879952","https://openalex.org/W2015174103","https://openalex.org/W2016910674","https://openalex.org/W2018151048","https://openalex.org/W2021941809","https://openalex.org/W2024412478","https://openalex.org/W2028238051","https://openalex.org/W2048092342","https://openalex.org/W2057647944","https://openalex.org/W2081582947","https://openalex.org/W2084560434","https://openalex.org/W2084773445","https://openalex.org/W2103758376","https://openalex.org/W2114960492","https://openalex.org/W2116470688","https://openalex.org/W2166346258","https://openalex.org/W6677555462"],"related_works":["https://openalex.org/W2944195142","https://openalex.org/W1971015537","https://openalex.org/W7212034117","https://openalex.org/W4220657810","https://openalex.org/W1982019229","https://openalex.org/W2015174103","https://openalex.org/W4200519296","https://openalex.org/W6943278045","https://openalex.org/W7098892222","https://openalex.org/W2169482835"],"abstract_inverted_index":{"BACKGROUND:":[0],"A/H5N1":[1,51],"influenza":[2],"viruses":[3],"have":[4],"high":[5],"pandemic":[6,199],"potential;":[7],"consequently,":[8],"vaccines":[9],"need":[10],"to":[11,40,71,157,168],"be":[12,158],"produced":[13],"rapidly.":[14],"MF59\u00ae":[15],"adjuvant":[16],"reduces":[17],"the":[18,42,150,161,183],"antigen":[19,79],"required":[20],"per":[21,80],"dose,":[22],"allowing":[23],"for":[24,95,104,107,144,149,198],"dose":[25],"sparing":[26],"and":[27,44,60,99,102,115,122,129,133,164,180,191,194],"more":[28],"rapid":[29],"vaccine":[30,52,186],"availability.":[31],"METHODS:":[32],"Two":[33],"multicenter,":[34],"phase":[35],"II":[36],"trials":[37],"were":[38,68,91,125,136,147,165],"conducted":[39],"evaluate":[41],"safety":[43],"immunogenicity":[45],"of":[46,77,166],"an":[47],"MF59-adjuvanted,":[48],"cell":[49],"culture-derived,":[50],"(aH5N1c)":[53],"among":[54],"979":[55],"adult":[56,179],"(18-64":[57],"years":[58,64],"old)":[59,65],"1393":[61],"elderly":[62,181],"(\u226565":[63],"subjects.":[66],"Participants":[67],"equally":[69],"randomized":[70],"receive":[72],"2":[73,83],"full-dose":[74,151,162,184],"(7.5":[75],"\u03bcg":[76],"hemagglutinin":[78],"dose)":[81],"or":[82],"half-dose":[84],"aH5N1c":[85,185],"vaccinations":[86],"3":[87],"weeks":[88],"apart.":[89],"Outcomes":[90],"based":[92],"on":[93,117],"Center":[94],"Biologics":[96],"Evaluation":[97],"Research":[98],"Review":[100],"(CBER)":[101],"Committee":[103],"Medicinal":[105],"Products":[106],"Human":[108],"Use":[109],"(CHMP)":[110],"licensure":[111,196],"criteria":[112,135,143,197],"(titers":[113],"\u22651:40":[114],"seroconversions":[116],"day":[118],"43).":[119],"Solicited":[120,153],"reactions":[121],"adverse":[123,174],"events":[124,175],"assessed":[126],"(www.clinicaltrials.gov:":[127],"NCT01776541":[128],"NCT01766921).":[130],"RESULTS:":[131],"CBER":[132,142],"CHMP":[134],"met":[137,148,192],"by":[138],"both":[139],"age":[140],"groups.":[141],"hemagglutination":[145],"titers":[146],"formulation.":[152],"reaction":[154],"frequencies":[155],"tended":[156],"higher":[159],"in":[160],"group":[163],"mild":[167],"moderate":[169],"intensity.":[170],"No":[171],"vaccine-related":[172],"serious":[173],"occurred.":[176],"CONCLUSIONS:":[177],"In":[178],"participants,":[182],"formulation":[187],"was":[188],"well":[189],"tolerated":[190],"US":[193],"European":[195],"vaccines.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-03-11T00:00:00"}
