{"id":"https://openalex.org/W2919628656","doi":null,"title":"Rat Model of Pre-Motor Parkinson's Disease: Behavioral and MRI Characterization.","display_name":"Rat Model of Pre-Motor Parkinson's Disease: Behavioral and MRI Characterization.","publication_year":2011,"publication_date":"2011-04-14","ids":{"openalex":"https://openalex.org/W2919628656","mag":"2919628656"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wpi.edu:etd-dissertations-1113","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1113&context=etd-dissertations","pdf_url":"https://digitalcommons.wpi.edu/etd-dissertations/114","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations (All Dissertations, All Years)","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wpi.edu/etd-dissertations/114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019591565","display_name":"Pallavi Rane","orcid":"https://orcid.org/0000-0002-8720-6807","observed_orcids":["https://orcid.org/0000-0002-8720-6807"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pallavi Rane","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8720-6807","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019591565"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.7409999966621399},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/striatal-lesions","display_name":"striatal lesions","score":0.7149999737739563},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.9639999866485596},{"id":"https://openalex.org/keywords/non-motor-symptoms","display_name":"non-motor symptoms","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7369999885559082},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.9070000052452087},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.824999988079071},{"id":"https://openalex.org/keywords/brain-networks","display_name":"brain networks","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9710000157356262},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.906000018119812},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6510000228881836},{"id":"https://openalex.org/keywords/behavioral-phenotyping","display_name":"behavioral phenotyping","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4974968731403351},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4922555983066559},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.48575881123542786},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4262579083442688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4009351134300232},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39497578144073486},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19870677590370178}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wpi.edu:etd-dissertations-1113","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1113&context=etd-dissertations","pdf_url":"https://digitalcommons.wpi.edu/etd-dissertations/114","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations (All Dissertations, All Years)","raw_type":"text"},{"id":"mag:2919628656","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1113&context=etd-dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wpi.edu:etd-dissertations-1113","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1113&context=etd-dissertations","pdf_url":"https://digitalcommons.wpi.edu/etd-dissertations/114","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations (All Dissertations, All Years)","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2919628656.pdf","grobid_xml":"https://content.openalex.org/works/W2919628656.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W8260265","https://openalex.org/W39507232","https://openalex.org/W49830623","https://openalex.org/W62865870","https://openalex.org/W104577931","https://openalex.org/W199354732","https://openalex.org/W204757329","https://openalex.org/W1226827050","https://openalex.org/W1503018677","https://openalex.org/W1527671059","https://openalex.org/W1647158246","https://openalex.org/W1766888123","https://openalex.org/W1821906452","https://openalex.org/W1863422003","https://openalex.org/W1964044507","https://openalex.org/W1964204618","https://openalex.org/W1964372470","https://openalex.org/W1966293926","https://openalex.org/W1971842245","https://openalex.org/W1976063687","https://openalex.org/W1976679890","https://openalex.org/W1977266070","https://openalex.org/W1978078858","https://openalex.org/W1978262170","https://openalex.org/W1978618011","https://openalex.org/W1979581929","https://openalex.org/W1979837953","https://openalex.org/W1985091985","https://openalex.org/W1985597770","https://openalex.org/W1986009431","https://openalex.org/W1986779034","https://openalex.org/W1988794652","https://openalex.org/W1991575782","https://openalex.org/W1992483894","https://openalex.org/W1993303421","https://openalex.org/W1995416216","https://openalex.org/W1995605620","https://openalex.org/W1996040347","https://openalex.org/W2001003591","https://openalex.org/W2001381028","https://openalex.org/W2002660165","https://openalex.org/W2002748828","https://openalex.org/W2003244414","https://openalex.org/W2003883601","https://openalex.org/W2007037349","https://openalex.org/W2007682117","https://openalex.org/W2008024137","https://openalex.org/W2008560062","https://openalex.org/W2009494091","https://openalex.org/W2009740169","https://openalex.org/W2010478807","https://openalex.org/W2010626656","https://openalex.org/W2011660168","https://openalex.org/W2012557172","https://openalex.org/W2013141834","https://openalex.org/W2013982195","https://openalex.org/W2015615781","https://openalex.org/W2016621535","https://openalex.org/W2017091618","https://openalex.org/W2018211893","https://openalex.org/W2019038353","https://openalex.org/W2019954466","https://openalex.org/W2020304716","https://openalex.org/W2020394405","https://openalex.org/W2020623316","https://openalex.org/W2022349962","https://openalex.org/W2022469447","https://openalex.org/W2022533807","https://openalex.org/W2022607137","https://openalex.org/W2023847682","https://openalex.org/W2024330937","https://openalex.org/W2027096397","https://openalex.org/W2030431065","https://openalex.org/W2032981828","https://openalex.org/W2033109865","https://openalex.org/W2035678379","https://openalex.org/W2036724733","https://openalex.org/W2037643842","https://openalex.org/W2038168220","https://openalex.org/W2040447574","https://openalex.org/W2043988673","https://openalex.org/W2044839034","https://openalex.org/W2046189898","https://openalex.org/W2046198995","https://openalex.org/W2046632451","https://openalex.org/W2046690778","https://openalex.org/W2046746252","https://openalex.org/W2048815938","https://openalex.org/W2049061136","https://openalex.org/W2049863502","https://openalex.org/W2054647536","https://openalex.org/W2056081184","https://openalex.org/W2057023399","https://openalex.org/W2057451803","https://openalex.org/W2062142540","https://openalex.org/W2062147269","https://openalex.org/W2062605045","https://openalex.org/W2062656862","https://openalex.org/W2064025985","https://openalex.org/W2064996887","https://openalex.org/W2065000444","https://openalex.org/W2065719677","https://openalex.org/W2065978481","https://openalex.org/W2066350882","https://openalex.org/W2067050766","https://openalex.org/W2068013068","https://openalex.org/W2068829020","https://openalex.org/W2070069429","https://openalex.org/W2070428399","https://openalex.org/W2071714163","https://openalex.org/W2071970488","https://openalex.org/W2072212361","https://openalex.org/W2073279428","https://openalex.org/W2073449985","https://openalex.org/W2074560876","https://openalex.org/W2075278002","https://openalex.org/W2076100769","https://openalex.org/W2078968907","https://openalex.org/W2080902873","https://openalex.org/W2080949995","https://openalex.org/W2081302124","https://openalex.org/W2081355012","https://openalex.org/W2082893764","https://openalex.org/W2083497145","https://openalex.org/W2083505668","https://openalex.org/W2085203306","https://openalex.org/W2086483799","https://openalex.org/W2088962120","https://openalex.org/W2089669016","https://openalex.org/W2090054406","https://openalex.org/W2090450195","https://openalex.org/W2092173254","https://openalex.org/W2092462980","https://openalex.org/W2096462474","https://openalex.org/W2099652807","https://openalex.org/W2103681669","https://openalex.org/W2104825387","https://openalex.org/W2105098269","https://openalex.org/W2105180380","https://openalex.org/W2105396029","https://openalex.org/W2105440094","https://openalex.org/W2105580240","https://openalex.org/W2106089606","https://openalex.org/W2106396500","https://openalex.org/W2107240361","https://openalex.org/W2107370783","https://openalex.org/W2111682630","https://openalex.org/W2111843532","https://openalex.org/W2113959942","https://openalex.org/W2117535122","https://openalex.org/W2119370314","https://openalex.org/W2120061154","https://openalex.org/W2120800380","https://openalex.org/W2121264285","https://openalex.org/W2123817334","https://openalex.org/W2124141514","https://openalex.org/W2124680543","https://openalex.org/W2125300928","https://openalex.org/W2125463914","https://openalex.org/W2125652750","https://openalex.org/W2125879914","https://openalex.org/W2127817386","https://openalex.org/W2128624570","https://openalex.org/W2129698492","https://openalex.org/W2130685024","https://openalex.org/W2131153484","https://openalex.org/W2131168315","https://openalex.org/W2131236995","https://openalex.org/W2131624282","https://openalex.org/W2136838610","https://openalex.org/W2136980191","https://openalex.org/W2138825607","https://openalex.org/W2141042796","https://openalex.org/W2142794733","https://openalex.org/W2142830252","https://openalex.org/W2144183062","https://openalex.org/W2144476134","https://openalex.org/W2144623340","https://openalex.org/W2145490055","https://openalex.org/W2146061719","https://openalex.org/W2152921016","https://openalex.org/W2153154672","https://openalex.org/W2154761807","https://openalex.org/W2155175950","https://openalex.org/W2155369114","https://openalex.org/W2155456336","https://openalex.org/W2156026942","https://openalex.org/W2158052449","https://openalex.org/W2158817049","https://openalex.org/W2159929956","https://openalex.org/W2160681852","https://openalex.org/W2161325655","https://openalex.org/W2162010696","https://openalex.org/W2162054698","https://openalex.org/W2170117095","https://openalex.org/W2170276695","https://openalex.org/W2170965445","https://openalex.org/W2171213068","https://openalex.org/W2171456544","https://openalex.org/W2336893408","https://openalex.org/W2398779696","https://openalex.org/W2416871384","https://openalex.org/W2433836463","https://openalex.org/W2525550930","https://openalex.org/W2539842147","https://openalex.org/W2938065217","https://openalex.org/W3004772456","https://openalex.org/W3039083618","https://openalex.org/W3118412182"],"related_works":["https://openalex.org/W2617889983","https://openalex.org/W203382294","https://openalex.org/W2208683632","https://openalex.org/W1960565658","https://openalex.org/W7099652036","https://openalex.org/W2800378135","https://openalex.org/W2752602007","https://openalex.org/W6980536600","https://openalex.org/W3172534900","https://openalex.org/W4230691336"],"abstract_inverted_index":{"Background:":[0],"Parkinson's":[1,53],"disease":[2,96],"(PD)":[3],"is":[4,36,84,97,120,128,161,609],"a":[5,17,125,201,248,275,338,353,362,459,610,660],"chronic,":[6],"progressive,":[7],"neurodegenerative":[8],"disorder":[9],"with":[10,94,245,253,325,422,440,515,644],"currently":[11],"no":[12],"known":[13],"cure.":[14],"PD":[15,72,83,195,252,483,538,604],"has":[16],"significant":[18,491],"impact":[19],"on":[20,132,287],"quality":[21],"of":[22,24,42,71,80,82,110,115,123,157,174,194,218,226,247,251,257,261,380,390,424,462,507,601,617,648,653,668],"life":[23],"the":[25,30,37,62,104,108,113,116,147,155,165,169,175,214,223,227,268,282,303,320,326,344,356,399,407,441,450,463,475,494,508,523,528,533,567,575,588,599,634,645,665],"patients,":[26],"as":[27,124,138,337,361,550],"well":[28],"as,":[29],"caregivers":[31],"and":[32,48,65,112,127,140,171,212,216,266,281,293,343,415,511,520,547,650],"family":[33],"members.":[34],"It":[35],"second":[38,280],"most":[39],"common":[40],"cause":[41],"chronic":[43],"neurological":[44],"disability":[45],"in":[46,61,103,164,168,183,196,271,298,369,412,417,435,474,482,493,522,535,552,559,566,581,638],"US":[47],"Europe.":[49],"According":[50],"to":[51,67,86,99,145,189,206,318,349,479,498,527,573,632],"National":[52],"Foundation,":[54],"there":[55,160],"are":[56,73,143],"almost":[57,151],"1":[58],"million":[59],"patients":[60],"Unites":[63],"States":[64],"50,000":[66],"60,000":[68],"new":[69],"cases":[70,81],"diagnosed":[74,130],"each":[75],"year.":[76],"The":[77,90,180,240,279,313,341,372,429,437,453,485],"total":[78],"number":[79],"predicted":[85],"double":[87],"by":[88,150,395],"2030.":[89],"annual":[91],"cost":[92,109,114],"associated":[93,324],"this":[95,184,237,272,299,385,582,607,654],"estimated":[98],"be":[100],"$10.8":[101],"billion":[102],"United":[105],"States,":[106],"including":[107],"treatment":[111,220,364,585,662],"disability.":[117],"Although":[118],"it":[119],"primarily":[121],"thought":[122,144],"movement-disorder":[126],"clinically":[129],"based":[131,375],"motor":[133,258,427,509],"symptoms,":[134],"non-motor":[135,224,666],"symptoms":[136,225,394],"such":[137],"cognitive":[139,294,367,568,635],"emotional":[141,290],"deficits":[142,292,297,368,456,636,667],"precede":[146],"clinical":[148,158],"diagnosis":[149],"20":[152],"years.":[153],"By":[154],"time":[156],"diagnosis,":[159],"80%":[162],"loss":[163],"dopamine":[166,178,269,374,414,420],"content":[167],"striatum":[170],"50%":[172],"degeneration":[173],"substantia":[176,418],"nigra":[177,419],"cells.":[179],"research":[181,608],"presented":[182],"thesis":[185],"was":[186,317,348,557,571,630],"an":[187,191,469],"attempt":[188],"develop":[190,207],"animal":[192],"model":[193,202,250,273,301,332,379,600,616],"its":[197],"pre-motor":[198,276,381,602],"stages.":[199],"Such":[200],"would":[203],"allow":[204],"us":[205],"pre-clinical":[208],"markers":[209],"for":[210,222,236,263,289,366,664],"PD,":[211,382],"facilitate":[213],"development":[215,246],"testing":[217,288],"potential":[219,363],"strategies":[221],"disorder.":[228],"Specific":[229],"Aims:":[230],"There":[231],"were":[232],"five":[233],"specific":[234,242,284,309,315,346],"aims":[235,285],"research:":[238],"*":[239,278,312,340],"first":[241],"aim":[243,310,316,347],"dealt":[244],"rat":[249,300,331,460,615,640],"slow,":[254],"progressive":[255],"onset":[256,389],"deficits,":[259],"determination":[260],"timeline":[262],"future":[264],"studies,":[265],"quantification":[267],"depletion":[270],"at":[274,302],"stage.":[277],"third":[283],"focused":[286],"(aversion)":[291],"(executive":[295],"functioning)":[296],"3":[304,402,626],"week":[305,396],"timepoint":[306],"determined":[307],"during":[308,384,606],"1.":[311],"fourth":[314],"determine":[319],"brain":[321],"network":[322],"changes":[323,328,434,492],"behavioral":[327],"observed":[329,503,542,580,637],"our":[330,595,639,656],"using":[333,458],"resting":[334,486],"state":[335,487],"connectivity":[336,488,506,514],"measure.":[339],"fifth":[342],"final":[345],"test":[350],"sodium":[351],"butyrate,":[352],"drug":[354],"from":[355],"histone":[357],"deacetylase":[358],"inhibitor":[359],"family,":[360],"option":[365],"PD.":[370,627,669],"Results:":[371],"6-hydroxy":[373],"stepwise":[376],"striatal":[377,413],"lesion":[378,405],"developed":[383,605],"research,":[386],"exhibits":[387],"delayed":[388],"Parkinsonian":[391],"gait":[392],"like":[393],"4":[397],"after":[398],"lesions.":[400],"At":[401],"weeks":[403],"post":[404],"(3WKPD),":[406],"rats":[408,431,477,496,525],"exhibit":[409],"27%":[410],"reduction":[411],"23%reduction":[416],"cells,":[421],"lack":[423],"any":[425],"apparent":[426],"deficits.":[428,452],"3WKPD":[430,476,495,524,560],"also":[432,541,586],"exhibited":[433],"aversion.":[436],"fMRI":[438],"study":[439,489],"aversive":[442],"scent":[443],"pointed":[444],"towards":[445,659],"possible":[446,661],"amygdala":[447,546],"dysfunction":[448],"sub-serving":[449],"aversion":[451],"executive":[454],"function":[455],"tested":[457,565],"analog":[461],"Wisconsin":[464],"card":[465],"sorting":[466],"test,":[467],"divulged":[468],"extra-dimensional":[470,576],"set":[471,577,590],"shifting":[472,578],"deficit":[473,569,579],"similar":[478],"those":[480],"reported":[481,551],"patients.":[484,539],"indicated":[490],"compared":[497,526],"age":[499],"matched":[500],"controls.":[501,529],"We":[502,540],"increased":[504,512],"overall":[505],"cortex":[510,549],"CPu":[513],"prefrontal":[516,548],"cortex,":[517,519],"cingulate":[518],"hypothalamus":[521],"These":[530],"observations":[531,534,596],"parallel":[532],"unmedicated":[536],"early-stage":[537],"negative":[543,555],"correlation":[544,556],"between":[545],"humans.":[553],"This":[554,584],"lost":[558],"rats.":[561],"Sodium":[562,628],"butyrate":[563,629],"treatment,":[564],"study,":[570],"able":[572,631],"ameliorate":[574],"model.":[583,641],"improved":[587],"attentional":[589],"formation.":[591],"Conclusion:":[592],"Taken":[593],"together,":[594],"indicate":[597],"that,":[598],"stage":[603,620,625],"very":[611],"high":[612],"face":[613],"validity":[614],"late":[618],"Braak":[619,624],"2":[621],"or":[622],"early":[623],"alleviate":[633],"Hence,":[642],"along":[643],"prior":[646],"reports":[647],"anti-depressant":[649],"neuroprotective":[651],"effects":[652],"drug,":[655],"results":[657],"point":[658],"strategy":[663]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-11T00:00:00"}
