{"id":"https://openalex.org/W2919615971","doi":"https://doi.org/10.1186/s13054-019-2329-5","title":"The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study","display_name":"The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study","publication_year":2019,"publication_date":"2019-02-08","ids":{"openalex":"https://openalex.org/W2919615971","doi":"https://doi.org/10.1186/s13054-019-2329-5","mag":"2919615971","pmid":"https://pubmed.ncbi.nlm.nih.gov/30736862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6368690"},"language":"en","primary_location":{"id":"doi:10.1186/s13054-019-2329-5","doi":"https://doi.org/10.1186/s13054-019-2329-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-019-2329-5","pdf_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2329-5","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2329-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031735144","display_name":"Kordo B. A. Saeed","orcid":"https://orcid.org/0000-0003-0123-0302","observed_orcids":["https://orcid.org/0000-0003-0123-0302"]},"institutions":[{"id":"https://openalex.org/I312843336","display_name":"Hampshire Hospitals NHS Foundation Trust","ror":"https://ror.org/04shzs249","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I312843336"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kordo Saeed","raw_affiliation_strings":["Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK. kordosaeed@nhs.net","University of Southampton, School of Medicine, Southampton, UK. kordosaeed@nhs.net","Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK. kordosaeed@nhs.net","institution_ids":["https://openalex.org/I312843336"]},{"raw_affiliation_string":"University of Southampton, School of Medicine, Southampton, UK. kordosaeed@nhs.net","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","institution_ids":["https://openalex.org/I312843336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075267547","display_name":"Darius Cameron Wilson","orcid":"https://orcid.org/0000-0001-9225-7185","observed_orcids":["https://orcid.org/0000-0001-9225-7185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darius Cameron Wilson","raw_affiliation_strings":["B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, Hennigsdorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00b7R\u00b7A\u00b7H\u00b7M\u00b7S GmbH, Hennigsdorf, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021420921","display_name":"Frank Bloos","orcid":"https://orcid.org/0000-0002-0767-7941","observed_orcids":["https://orcid.org/0000-0002-0767-7941"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I4405270327","display_name":"Center for Sepsis Control and Care","ror":"https://ror.org/00g364847","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405270327"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Bloos","raw_affiliation_strings":["Center for Sepsis Control & Care (CSCC), Jena University Hospital, Jena, Germany","Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Sepsis Control & Care (CSCC), Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I4405270327"]},{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037540908","display_name":"Philipp Sch\u00fcetz","orcid":"https://orcid.org/0000-0001-6400-4949","observed_orcids":["https://orcid.org/0000-0001-6400-4949","https://orcid.org/0000-0002-4191-7603","https://orcid.org/0000-0001-7564-1468"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philipp Schuetz","raw_affiliation_strings":["Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Switzerland","Medical Faculty of the University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]},{"raw_affiliation_string":"Medical Faculty of the University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067996181","display_name":"Yuri van der Does","orcid":"https://orcid.org/0000-0002-6303-3083","observed_orcids":["https://orcid.org/0000-0002-6303-3083"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yuri van der Does","raw_affiliation_strings":["Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086839394","display_name":"Olle Melander","orcid":"https://orcid.org/0000-0002-2581-484X","observed_orcids":["https://orcid.org/0000-0002-2581-484X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olle Melander","raw_affiliation_strings":["Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden","Department of Internal Medicine, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Internal Medicine, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029385529","display_name":"Pierre Hausfater","orcid":"https://orcid.org/0000-0002-7716-6354","observed_orcids":["https://orcid.org/0000-0002-7716-6354"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210154657","display_name":"Fondation pour l\u2019innovation en Cadiom\u00e9tabolisme et Nutrition","ror":"https://ror.org/050c3pq49","country_code":"FR","type":"other","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210154657"]},{"id":"https://openalex.org/I4389425476","display_name":"Biomarqueurs d\u2019urgence et de r\u00e9animation","ror":"https://ror.org/01jnrzt83","country_code":"FR","type":"facility","lineage":["https://openalex.org/I39804081","https://openalex.org/I4389425476"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Hausfater","raw_affiliation_strings":["Emergency Department h\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique - H\u00f4pitaux de Paris and Sorbonne Universit\u00e9s GRC-14 BIOSFAST and INSERM UMR-S 1166, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department h\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique - H\u00f4pitaux de Paris and Sorbonne Universit\u00e9s GRC-14 BIOSFAST and INSERM UMR-S 1166, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210154657","https://openalex.org/I4389425476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054446009","display_name":"Jacopo M. Legramante","orcid":"https://orcid.org/0000-0001-9762-9902","observed_orcids":["https://orcid.org/0000-0001-9762-9902"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jacopo M. Legramante","raw_affiliation_strings":["Department of Medical Systems, Universita di Tor Vergata, Rome, Italy","Emergency Department, Policlinico Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Systems, Universita di Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Emergency Department, Policlinico Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867837","display_name":"Yann-\u00c9rick Claessens","orcid":"https://orcid.org/0000-0001-7506-3063","observed_orcids":["https://orcid.org/0000-0001-7506-3063"]},"institutions":[{"id":"https://openalex.org/I2801035888","display_name":"Princess Grace Hospital Centre","ror":"https://ror.org/03x1jt541","country_code":"MC","type":"healthcare","lineage":["https://openalex.org/I2801035888"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"Yann-Erick Claessens","raw_affiliation_strings":["Department of Emergency Medicine, Monaco Princess Grace Hospital, Monaco, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Monaco Princess Grace Hospital, Monaco, France","institution_ids":["https://openalex.org/I2801035888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113862854","display_name":"Deveendra Amin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800075908","display_name":"Morton Plant Hospital","ror":"https://ror.org/05s0ee237","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800075908","https://openalex.org/I4210104814"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deveendra Amin","raw_affiliation_strings":["Department of Critical Care, Morton Plant Hospital, 300 Pinellas Street, Clearwater, FL, 33756, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care, Morton Plant Hospital, 300 Pinellas Street, Clearwater, FL, 33756, USA","institution_ids":["https://openalex.org/I2800075908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111384037","display_name":"Mari Rosenqvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mari Rosenqvist","raw_affiliation_strings":["Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden","Infectious Disease Unit, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Infectious Disease Unit, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Graham White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I312843336","display_name":"Hampshire Hospitals NHS Foundation Trust","ror":"https://ror.org/04shzs249","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I312843336"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham White","raw_affiliation_strings":["Department of Blood Sciences, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Sciences, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","institution_ids":["https://openalex.org/I312843336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037001275","display_name":"Beat M\u00fceller","orcid":"https://orcid.org/0000-0002-1986-2511","observed_orcids":["https://orcid.org/0000-0002-1986-2511"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Beat Mueller","raw_affiliation_strings":["Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Switzerland","Medical Faculty of the University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]},{"raw_affiliation_string":"Medical Faculty of the University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086576456","display_name":"Maarten Limper","orcid":"https://orcid.org/0000-0002-4859-3250","observed_orcids":["https://orcid.org/0000-0002-4859-3250"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maarten Limper","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht University, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht University, Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043553394","display_name":"Carlota Clemente-Callejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlota Clemente Callejo","raw_affiliation_strings":["Emergency Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043721188","display_name":"Antonella Brandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Brandi","raw_affiliation_strings":["Emergency Department, Policlinico Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Policlinico Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064297274","display_name":"Marc-Alexis Macchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801035888","display_name":"Princess Grace Hospital Centre","ror":"https://ror.org/03x1jt541","country_code":"MC","type":"healthcare","lineage":["https://openalex.org/I2801035888"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"Marc-Alexis Macchi","raw_affiliation_strings":["Department of Emergency Medicine, Monaco Princess Grace Hospital, Monaco, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Monaco Princess Grace Hospital, Monaco, France","institution_ids":["https://openalex.org/I2801035888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085501051","display_name":"Nicholas Cortes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I312843336","display_name":"Hampshire Hospitals NHS Foundation Trust","ror":"https://ror.org/04shzs249","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I312843336"]},{"id":"https://openalex.org/I4210105295","display_name":"St Bernard's Hospital","ror":"https://ror.org/01npwa559","country_code":"GI","type":"healthcare","lineage":["https://openalex.org/I4210105295","https://openalex.org/I4210124692"]},{"id":"https://openalex.org/I4210124692","display_name":"Gibraltar Health Authority","ror":"https://ror.org/02srfgm34","country_code":"GI","type":"government","lineage":["https://openalex.org/I4210124692"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB","GI"],"is_corresponding":false,"raw_author_name":"Nicholas Cortes","raw_affiliation_strings":["Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","Gibraltar Health Authority, St Bernard's Hospital, Gibraltar, Spain","University of Southampton, School of Medicine, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","institution_ids":["https://openalex.org/I312843336"]},{"raw_affiliation_string":"Gibraltar Health Authority, St Bernard's Hospital, Gibraltar, Spain","institution_ids":["https://openalex.org/I4210105295","https://openalex.org/I4210124692"]},{"raw_affiliation_string":"University of Southampton, School of Medicine, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057116885","display_name":"Alexander Kutz","orcid":"https://orcid.org/0000-0002-7549-5648","observed_orcids":["https://orcid.org/0000-0002-7549-5648"]},"institutions":[{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander Kutz","raw_affiliation_strings":["Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051511977","display_name":"Peter Patka","orcid":"https://orcid.org/0000-0003-4381-7187","observed_orcids":["https://orcid.org/0000-0003-4381-7187"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter Patka","raw_affiliation_strings":["Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055523740","display_name":"Mar\u00eda Cecilia Ya\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Cecilia Ya\u00f1ez","raw_affiliation_strings":["Emergency Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006082027","display_name":"Sergio Bernardini","orcid":"https://orcid.org/0000-0003-1984-6834","observed_orcids":["https://orcid.org/0000-0003-1984-6834"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Bernardini","raw_affiliation_strings":["Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy","Department of Laboratory Medicine, Policlinico Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Policlinico Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086424753","display_name":"Nathalie Beau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801035888","display_name":"Princess Grace Hospital Centre","ror":"https://ror.org/03x1jt541","country_code":"MC","type":"healthcare","lineage":["https://openalex.org/I2801035888"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"Nathalie Beau","raw_affiliation_strings":["Department of Emergency Medicine, Monaco Princess Grace Hospital, Monaco, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Monaco Princess Grace Hospital, Monaco, France","institution_ids":["https://openalex.org/I2801035888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010679786","display_name":"Matthew Dryden","orcid":"https://orcid.org/0000-0002-8967-169X","observed_orcids":["https://orcid.org/0000-0002-8967-169X"]},"institutions":[{"id":"https://openalex.org/I312843336","display_name":"Hampshire Hospitals NHS Foundation Trust","ror":"https://ror.org/04shzs249","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I312843336"]},{"id":"https://openalex.org/I348769827","display_name":"Public Health England","ror":"https://ror.org/00vbvha87","country_code":"GB","type":"government","lineage":["https://openalex.org/I1311074006","https://openalex.org/I348769827"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew Dryden","raw_affiliation_strings":["Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","Rare and Imported Pathogen Laboratories, Public Health England, Porton Down, UK","University of Southampton, School of Medicine, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","institution_ids":["https://openalex.org/I312843336"]},{"raw_affiliation_string":"Rare and Imported Pathogen Laboratories, Public Health England, Porton Down, UK","institution_ids":["https://openalex.org/I348769827"]},{"raw_affiliation_string":"University of Southampton, School of Medicine, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038465935","display_name":"Eric C. M. Van Gorp","orcid":"https://orcid.org/0000-0001-6415-6678","observed_orcids":["https://orcid.org/0000-0001-6415-6678"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eric C. M. van Gorp","raw_affiliation_strings":["Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands","Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068801085","display_name":"Marilena Minieri","orcid":"https://orcid.org/0000-0002-2512-4793","observed_orcids":["https://orcid.org/0000-0002-2512-4793"]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marilena Minieri","raw_affiliation_strings":["Department of Laboratory Medicine, Policlinico Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Policlinico Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Louisa Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I312843336","display_name":"Hampshire Hospitals NHS Foundation Trust","ror":"https://ror.org/04shzs249","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I312843336"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louisa Chan","raw_affiliation_strings":["Department of accident and emergency, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of accident and emergency, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK","institution_ids":["https://openalex.org/I312843336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113605756","display_name":"Pleunie P. M. Rood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pleunie P. M. Rood","raw_affiliation_strings":["Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086843846","display_name":"Juan Mar\u00eda Gonz\u00e1lez del Castillo","orcid":"https://orcid.org/0000-0002-4329-9802","observed_orcids":["https://orcid.org/0000-0002-4329-9802","https://orcid.org/0009-0009-0608-9951"]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210097846","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/014v12a39","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210097846"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Gonzalez del Castillo","raw_affiliation_strings":["Emergency Department, Instituto de Investigaci\u00f3n Sanitaria (IdISSC), Hospital Cl\u00ednico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Instituto de Investigaci\u00f3n Sanitaria (IdISSC), Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182","https://openalex.org/I4210097846"]}]}],"institutions":[],"countries_distinct_count":11,"institutions_distinct_count":24,"corresponding_author_ids":["https://openalex.org/A5031735144"],"corresponding_institution_ids":["https://openalex.org/I312843336","https://openalex.org/I43439940"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":17.0752,"has_fulltext":true,"cited_by_count":131,"citation_normalized_percentile":{"value":0.99569877,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"255","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11095","display_name":"Emergency and Acute Care Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proadrenomedullin","display_name":"proadrenomedullin","score":0.722000002861023},{"id":"https://openalex.org/keywords/disease-progression-prediction","display_name":"disease progression prediction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/suspected-infection","display_name":"suspected infection","score":0.9150000214576721},{"id":"https://openalex.org/keywords/emergency-department","display_name":"emergency department","score":0.7680000066757202},{"id":"https://openalex.org/keywords/28-day-mortality","display_name":"28-day mortality","score":0.843999981880188},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7509999871253967},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.8840000033378601},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/clinical-scoring-systems","display_name":"clinical scoring systems","score":0.6809999942779541},{"id":"https://openalex.org/keywords/qsofa","display_name":"qSOFA","score":0.6859999895095825},{"id":"https://openalex.org/keywords/sofa","display_name":"SOFA","score":0.7139999866485596},{"id":"https://openalex.org/keywords/crb-65","display_name":"CRB-65","score":0.9710000157356262},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.718999981880188},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9290000200271606},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hospital-readmission","display_name":"hospital readmission","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9500141143798828},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.8172702789306641},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6762750744819641},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6697526574134827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6165311932563782},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.569933295249939},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5149527192115784},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4754083752632141},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.45614051818847656},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4357123076915741},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4133642911911011},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.4111706614494324},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.09037986397743225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004636","descriptor_name":"Emergency Service, Hospital","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D004636","descriptor_name":"Emergency Service, Hospital","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D004739","descriptor_name":"England","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053607","descriptor_name":"Adrenomedullin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053607","descriptor_name":"Adrenomedullin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054928","descriptor_name":"Validation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063305","descriptor_name":"Organ Dysfunction Scores","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":19,"locations":[{"id":"doi:10.1186/s13054-019-2329-5","doi":"https://doi.org/10.1186/s13054-019-2329-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-019-2329-5","pdf_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2329-5","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5363478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6368690","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30736862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30736862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmid:31307526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31307526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6368690","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6368690/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6628495","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6628495/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmh:oai:pure.eur.nl:openaire/4d8a8bef-a0ac-4e4c-8ecd-e13c4561f5d8","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/4d8a8bef-a0ac-4e4c-8ecd-e13c4561f5d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.soton.ac.uk:428272","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1186/s13054-019-2329-5>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.soton.ac.uk:432848","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1186/s13054-019-2536-0>).","pdf_url":"https://eprints.soton.ac.uk/432848/1/s13054_019_2536_0.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Letter"},{"id":"pmh:eur:oai:pure.eur.nl:publications/4d8a8bef-a0ac-4e4c-8ecd-e13c4561f5d8","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/4d8a8bef-a0ac-4e4c-8ecd-e13c4561f5d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, 23:40. BioMed Central Ltd.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:115186","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/115186","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02049226v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-02049226","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, 2019, 23, pp.40. &#x27E8;10.1186/s13054-019-2329-5&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:art.torvergata.it:2108/217982","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2108/217982","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9199435d707f41d1a5a3ce217b21ada6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9199435d707f41d1a5a3ce217b21ada6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, Vol 23, Iss 1, Pp 1-15 (2019)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/457348","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/457348","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:lup.lub.lu.se:36922e33-cd05-405b-b3a7-b15b44297ae7","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/36922e33-cd05-405b-b3a7-b15b44297ae7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1364-8535","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:datasets/a0c3852b-63c6-44d1-95cc-e898ed472ba0","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/datasets/a0c3852b-63c6-44d1-95cc-e898ed472ba0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.eur.nl:datasets/b45b4b95-455c-4833-88ef-805a28555417","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/datasets/b45b4b95-455c-4833-88ef-805a28555417","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:repub.eur.nl:115186","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/115186","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care vol. 23","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13054-019-2329-5","doi":"https://doi.org/10.1186/s13054-019-2329-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-019-2329-5","pdf_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2329-5","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3803372573","display_name":null,"funder_award_id":"NNF14OC0009819","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2919615971.pdf","grobid_xml":"https://content.openalex.org/works/W2919615971.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W97018936","https://openalex.org/W191064394","https://openalex.org/W1938931195","https://openalex.org/W1981692128","https://openalex.org/W1993397663","https://openalex.org/W2004689339","https://openalex.org/W2011462556","https://openalex.org/W2019274588","https://openalex.org/W2044142824","https://openalex.org/W2052100013","https://openalex.org/W2061679651","https://openalex.org/W2087203965","https://openalex.org/W2088817713","https://openalex.org/W2109068302","https://openalex.org/W2109308366","https://openalex.org/W2132959667","https://openalex.org/W2135709454","https://openalex.org/W2150137339","https://openalex.org/W2161838725","https://openalex.org/W2164990391","https://openalex.org/W2165960214","https://openalex.org/W2188214922","https://openalex.org/W2255691977","https://openalex.org/W2280404143","https://openalex.org/W2281541573","https://openalex.org/W2282181907","https://openalex.org/W2321237103","https://openalex.org/W2323977282","https://openalex.org/W2522105146","https://openalex.org/W2550498515","https://openalex.org/W2587277154","https://openalex.org/W2587973613","https://openalex.org/W2588806320","https://openalex.org/W2593799432","https://openalex.org/W2610730883","https://openalex.org/W2620241325","https://openalex.org/W2620296299","https://openalex.org/W2724851251","https://openalex.org/W2745333029","https://openalex.org/W2749122064","https://openalex.org/W2763141616","https://openalex.org/W2766172131","https://openalex.org/W2775986198","https://openalex.org/W2790554811","https://openalex.org/W2797283758","https://openalex.org/W2804805254","https://openalex.org/W2806728633","https://openalex.org/W2806759722","https://openalex.org/W2886310164","https://openalex.org/W2899563698","https://openalex.org/W2901495711","https://openalex.org/W2982360623","https://openalex.org/W3005450232","https://openalex.org/W3008819550","https://openalex.org/W3019637436","https://openalex.org/W3033683066","https://openalex.org/W4255620235"],"related_works":["https://openalex.org/W6921077695","https://openalex.org/W2982360623","https://openalex.org/W3005450232","https://openalex.org/W4390114786","https://openalex.org/W4410776136","https://openalex.org/W2901495711","https://openalex.org/W3141161604","https://openalex.org/W4415531232","https://openalex.org/W2885425382","https://openalex.org/W1938931195"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2],"a":[3,25,95,200,235,266,292],"lack":[4],"of":[5,98,126,133,204,210,238,270,305],"validated":[6,62],"tools":[7],"to":[8,19,31,50,87,246,288,323],"assess":[9,88],"potential":[10],"disease":[11,239,307],"progression":[12,91,240],"and":[13,39,48,72,82,103,115,128,130,135,145,160,222,230,234,275,281],"hospitalisation":[14,104,131,146,205],"decisions":[15],"in":[16,141,321],"patients":[17,118,286,334],"presenting":[18,287],"the":[20,77,289,295,303],"emergency":[21],"department":[22],"(ED)":[23],"with":[24,121,153,249,277,291],"suspected":[26,293],"infection.":[27],"This":[28],"study":[29],"aimed":[30],"identify":[32,302,333],"suitable":[33,335],"blood":[34,296],"biomarkers":[35],"(MR-proADM,":[36],"PCT,":[37],"lactate":[38,167],"CRP)":[40],"or":[41,171,176,191,327,332],"clinical":[42,54,177],"scores":[43],"(SIRS,":[44],"SOFA,":[45,220],"qSOFA,":[46],"NEWS":[47,187,223],"CRB-65)":[49],"fulfil":[51],"this":[52],"unmet":[53],"need.":[55],"METHODS:":[56],"An":[57],"observational":[58],"derivation":[59,114],"patient":[60],"cohort":[61],"by":[63,199],"an":[64,311],"independent":[65],"secondary":[66],"analysis":[67],"across":[68,148,259],"nine":[69],"EDs.":[70],"Logistic":[71],"Cox":[73],"regression,":[74],"area":[75],"under":[76],"receiver":[78],"operating":[79],"characteristic":[80],"(AUROC)":[81],"Kaplan-Meier":[83],"curves":[84],"were":[85,119,197],"used":[86],"performance.":[89],"Disease":[90],"was":[92],"identified":[93],"using":[94,265],"composite":[96],"endpoint":[97],"28-day":[99,123,143],"mortality,":[100],"ICU":[101,211],"admission":[102,212],">":[105],"10":[106],"days.":[107],"RESULTS:":[108],"One":[109],"thousand":[110],"one":[111],"hundred":[112],"seventy-five":[113],"896":[116],"validation":[117],"analysed":[120],"respective":[122],"mortality":[124,144,217],"rates":[125,132,280],"7.1%":[127],"5.0%,":[129],"77.9%":[134],"76.2%.":[136],"MR-proADM":[137,155,251,268,298],"showed":[138],"greatest":[139],"accuracy":[140],"predicting":[142],"requirement":[147],"both":[149,260],"cohorts.":[150],"Patient":[151],"subgroups":[152,248],"high":[154],"concentrations":[156,252],"(\u2265":[157],"1.54":[158,254],"nmol/L)":[159],"low":[161,250],"biomarker":[162,297],"(PCT":[163],"<":[164,168,173,180,184,188,193,207,214,243,271],"0.25":[165],"ng/mL,":[166],"2.0":[169],"mmol/L":[170],"CRP":[172],"67":[174],"mg/L)":[175],"score":[178],"(SOFA":[179],"2":[181,185,194],"points,":[182,186],"qSOFA":[183,221],"4":[189],"points":[190],"CRB-65":[192],"points)":[195],"values":[196],"characterised":[198],"significantly":[201],"longer":[202],"length":[203],"(p":[206,213,242],"0.001),":[208,215,244],"rate":[209],"elevated":[216],"risk":[218],"(e.g.":[219],"HR":[224],"[95%CI],":[225],"45.5":[226],"[10.0-207.6],":[227],"23.4":[228],"[11.1-49.3]":[229],"32.6":[231],"[9.4-113.6],":[232],"respectively)":[233],"greater":[236],"number":[237],"events":[241],"compared":[245],"similar":[247],"(<":[253],"nmol/L).":[255],"Increased":[256],"out-patient":[257,338],"treatment":[258,330],"cohorts":[261],"could":[262,299],"be":[263],"facilitated":[264],"derivation-derived":[267],"cut-off":[269],"0.87":[272],"nmol/L":[273],"(15.0%":[274],"16.6%),":[276],"decreased":[278],"readmission":[279],"no":[282],"mortalities.":[283],"CONCLUSIONS:":[284],"In":[285],"ED":[290],"infection,":[294],"most":[300],"accurately":[301],"likelihood":[304],"further":[306],"progression.":[308],"Incorporation":[309],"into":[310],"early":[312,329],"sepsis":[313],"management":[314],"protocol":[315],"may":[316],"therefore":[317],"aid":[318],"rapid":[319],"decision-making":[320],"order":[322],"either":[324],"initiate,":[325],"escalate":[326],"intensify":[328],"strategies,":[331],"for":[336],"safe":[337],"treatment.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-03-11T00:00:00"}