{"id":"https://openalex.org/W2919476398","doi":"https://doi.org/10.1161/res.123.suppl_1.465","title":"Abstract 465: Short Term Hypoxia Can Induce Adult Feline Cardiomyocytes to Re-enter the Cell Cycle and Divide","display_name":"Abstract 465: Short Term Hypoxia Can Induce Adult Feline Cardiomyocytes to Re-enter the Cell Cycle and Divide","publication_year":2018,"publication_date":"2018-08-03","ids":{"openalex":"https://openalex.org/W2919476398","doi":"https://doi.org/10.1161/res.123.suppl_1.465","mag":"2919476398"},"language":"en","primary_location":{"id":"doi:10.1161/res.123.suppl_1.465","doi":"https://doi.org/10.1161/res.123.suppl_1.465","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.465","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089535581","display_name":"Jaslyn P. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaslyn Johnson","raw_affiliation_strings":["Lewis Katz Sch of Medicine, Philadelphia, PA","Jaslyn Johnson Lewis Katz Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]},{"raw_affiliation_string":"Jaslyn Johnson Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019068197","display_name":"Polina Gross","orcid":"https://orcid.org/0000-0002-8997-659X","observed_orcids":["https://orcid.org/0000-0002-8997-659X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Polina Gross","raw_affiliation_strings":["Lewis Katz Sch of Medicine, Philadelphia, PA","Polina Gross Lewis Katz Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]},{"raw_affiliation_string":"Polina Gross Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074296319","display_name":"Remus M. Berretta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Remus Berretta","raw_affiliation_strings":["Lewis Katz Sch of Medicine, Philadelphia, PA","Remus Berretta Lewis Katz Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]},{"raw_affiliation_string":"Remus Berretta Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103190679","display_name":"Hajime Kubo","orcid":"https://orcid.org/0000-0001-5729-1994","observed_orcids":["https://orcid.org/0000-0001-5729-1994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Kubo","raw_affiliation_strings":["Lewis Katz Sch of Medicine, Philadelphia, PA","Hajime Kubo Lewis Katz Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]},{"raw_affiliation_string":"Hajime Kubo Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017026968","display_name":"Sadia Mohsin","orcid":"https://orcid.org/0000-0002-2106-1094","observed_orcids":["https://orcid.org/0000-0002-2106-1094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadia Mohsin","raw_affiliation_strings":["Lewis Katz Sch of Medicine, Philadelphia, PA","Sadia Mohsin Lewis Katz Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]},{"raw_affiliation_string":"Sadia Mohsin Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067892109","display_name":"Steven R. Houser","orcid":"https://orcid.org/0000-0001-6359-5425","observed_orcids":["https://orcid.org/0000-0001-6359-5425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven R Houser","raw_affiliation_strings":["Lewis Katz Sch of Medicine, Philadelphia, PA","Steven R Houser Lewis Katz Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]},{"raw_affiliation_string":"Steven R Houser Lewis Katz Sch of Medicine, Philadelphia, PA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/adult-cardiomyocytes","display_name":"adult cardiomyocytes","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.8479999899864197},{"id":"https://openalex.org/keywords/acute-hypoxia","display_name":"acute hypoxia","score":0.6200000047683716},{"id":"https://openalex.org/keywords/chronic-hypoxia","display_name":"chronic hypoxia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.5989999771118164},{"id":"https://openalex.org/keywords/edu-labeling","display_name":"EdU labeling","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.8429434299468994},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.7367327213287354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5266734957695007},{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.42482835054397583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4199541211128235},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4138393998146057},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.4124016761779785},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39033740758895874},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34935152530670166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33092695474624634},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3243888020515442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1827012002468109},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.08516135811805725},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.123.suppl_1.465","doi":"https://doi.org/10.1161/res.123.suppl_1.465","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.123.suppl_1.465","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3217577530","https://openalex.org/W2542943305","https://openalex.org/W7006113174","https://openalex.org/W36799218","https://openalex.org/W2562435026","https://openalex.org/W2556234583","https://openalex.org/W3172539846","https://openalex.org/W1877749691","https://openalex.org/W3026766086","https://openalex.org/W1917974736"],"abstract_inverted_index":{"Rationale:":[0],"The":[1],"mammalian":[2],"adult":[3,45,66,85,99,149,254],"heart":[4],"has":[5],"a":[6,112],"very":[7],"limited":[8],"capacity":[9],"to":[10,69,88,128,153,186,194,204,223,242,257,264],"regenerate":[11],"cardiomyocytes":[12,68,87,95,150,256],"that":[13,22,41],"die":[14],"from":[15,32,98],"pathological":[16],"damage.":[17],"Most":[18],"recent":[19,36],"studies":[20],"suggest":[21,40],"those":[23],"few":[24],"new":[25,196],"myocytes":[26,210],"found":[27],"after":[28,170],"injury":[29,265],"are":[30],"derived":[31],"pre-existing":[33],"cardiomyocytes.":[34,199],"A":[35],"study":[37],"in":[38,44,76,103,111,198,208,236],"mice":[39],"systemic":[42],"hypoxemia":[43],"animals":[46],"can":[47,252],"induce":[48,253],"cardiac":[49,209],"myocyte":[50,55],"cell":[51,72,206,234],"cycle":[52,73],"reentry":[53],"and":[54,74,91,101,126,137,172,232,244,266],"proliferation.":[56],"In":[57],"the":[58,63,71,138,162],"present":[59],"experiments":[60],"we":[61],"evaluate":[62],"ability":[64],"of":[65,164],"feline":[67,86,255],"reenter":[70],"proliferate":[75],"hypoxic":[77,113],"environments.":[78],"Hypothesis:":[79],"To":[80],"determine":[81],"if":[82],"hypoxia":[83,176,201,228,246,251],"induces":[84],"regenerate.":[89],"Methods":[90],"results:":[92],"Adult":[93],"ventricular":[94],"were":[96,109,151,189],"isolated":[97],"felines":[100],"maintained":[102],"culture.":[104],"For":[105,146],"acute":[106,245],"hypoxia,":[107,148,187],"cultures":[108],"placed":[110],"chamber":[114],"on":[115],"day":[116,168,217],"1,":[117],"3,":[118,178],"5,":[119,179],"7,":[120,180],"10,":[121,181],"or":[122,182],"14":[123,183],"following":[124],"isolation":[125,171,220],"subjected":[127,152],"1%":[129,154],"O":[130,155],"2":[131,135,142,156,160,166],",":[132,136,157],"5%":[133,158],"CO":[134,159],"balance":[139,163],"was":[140,202],"N":[141,165],"for":[143,177],"24":[144],"hours.":[145],"chronic":[147,227],"with":[161,191],"at":[167,174,211,216],"1":[169,218],"kept":[173],"continuous":[175],"days.":[184],"Prior":[185],"cells":[188],"treated":[190],"10uM":[192],"EdU":[193],"identify":[195],"DNA":[197],"Acute":[200],"shown":[203],"promote":[205],"division":[207],"all":[212,237],"time":[213,238],"points":[214,239],"except":[215],"post":[219],"when":[221],"compared":[222,241],"control":[224,243],"cultures.":[225,247],"However,":[226],"caused":[229],"cardiomyocyte":[230],"damage":[231],"increased":[233],"death":[235],"as":[240],"Conclusion:":[248],"Short":[249],"term":[250,261],"proliferate,":[258],"while":[259],"long":[260],"exposure":[262],"leads":[263],"apoptosis.":[267]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-03-11T00:00:00"}
