{"id":"https://openalex.org/W2919217142","doi":"https://doi.org/10.1186/s13046-019-1026-1","title":"MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma","display_name":"MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma","publication_year":2019,"publication_date":"2019-01-25","ids":{"openalex":"https://openalex.org/W2919217142","doi":"https://doi.org/10.1186/s13046-019-1026-1","mag":"2919217142","pmid":"https://pubmed.ncbi.nlm.nih.gov/30683134","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6347789"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-019-1026-1","doi":"https://doi.org/10.1186/s13046-019-1026-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-019-1026-1","pdf_url":null,"source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13046-019-1026-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048718447","display_name":"Yun Zhao","orcid":"https://orcid.org/0000-0001-6109-4520","observed_orcids":["https://orcid.org/0000-0001-6109-4520"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yun Zhao","raw_affiliation_strings":["Department of Chemotherapy, Tumor Hospital of Guangxi Medical University, No.2, Nanning, Guangxi, China","Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemotherapy, Tumor Hospital of Guangxi Medical University, No.2, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101467791","display_name":"Wei Huang","orcid":"https://orcid.org/0000-0003-3865-2576","observed_orcids":["https://orcid.org/0000-0003-3865-2576"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Huang","raw_affiliation_strings":["Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719073","display_name":"Tae\u2010Min Kim","orcid":"https://orcid.org/0000-0002-7993-9701","observed_orcids":["https://orcid.org/0000-0002-7993-9701"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae-Min Kim","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102938183","display_name":"Yuchae Jung","orcid":"https://orcid.org/0000-0003-2202-7303","observed_orcids":["https://orcid.org/0000-0003-2202-7303"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuchae Jung","raw_affiliation_strings":["Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055359281","display_name":"Lata G. Menon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lata G. Menon","raw_affiliation_strings":["Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongyan Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyan Xing","raw_affiliation_strings":["Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongwei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongwei Li","raw_affiliation_strings":["Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084911592","display_name":"Rona Stephanie Carroll","orcid":"https://orcid.org/0000-0002-6804-7177","observed_orcids":["https://orcid.org/0000-0002-6804-7177"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rona S. Carroll","raw_affiliation_strings":["Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA","Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022028438","display_name":"Peter J. Park","orcid":"https://orcid.org/0000-0001-9378-960X","observed_orcids":["https://orcid.org/0000-0001-9378-960X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Park","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101769917","display_name":"Hong Wei Yang","orcid":"https://orcid.org/0000-0003-2367-4692","observed_orcids":["https://orcid.org/0000-0003-2367-4692"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hong Wei Yang","raw_affiliation_strings":["Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA. Hongwei.yang@umassmed.edu","Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Hongwei.yang@umassmed.edu","Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA","Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA. Hongwei.yang@umassmed.edu","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Hongwei.yang@umassmed.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101616645","display_name":"Mark D. Johnson","orcid":"https://orcid.org/0000-0002-4010-2605","observed_orcids":["https://orcid.org/0000-0002-4010-2605"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1303243448","display_name":"UMass Memorial Health Care","ror":"https://ror.org/00pq96s96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark D. Johnson","raw_affiliation_strings":["Department of Neurological Surgery, UMass Memorial Healthcare, University of Massachusetts Medical School, 55 Lake Avenue North, S2-855, Worcester, MA, 01655, USA. mark.johnson3@umassmemorial.org","Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA. mark.johnson3@umassmemorial.org","Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mark.johnson3@umassmemorial.org","Program in Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA. mark.johnson3@umassmemorial.org","Department of Neurological Surgery, UMass Memorial Healthcare, University of Massachusetts Medical School, 55 Lake Avenue North, S2-855, Worcester, MA, 01655, USA","Program in Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, UMass Memorial Healthcare, University of Massachusetts Medical School, 55 Lake Avenue North, S2-855, Worcester, MA, 01655, USA. mark.johnson3@umassmemorial.org","institution_ids":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"raw_affiliation_string":"Department of Neurological Surgery, University of Massachusetts Medical School, Albert Sherman Center AS6-1001, 368 Plantation Street, Worcester, MA, 01605, USA. mark.johnson3@umassmemorial.org","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mark.johnson3@umassmemorial.org","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA. mark.johnson3@umassmemorial.org","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Neurological Surgery, UMass Memorial Healthcare, University of Massachusetts Medical School, 55 Lake Avenue North, S2-855, Worcester, MA, 01655, USA","institution_ids":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]},{"raw_affiliation_string":"Program in Neuro-Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101616645","https://openalex.org/A5101769917"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1303243448","https://openalex.org/I136199984","https://openalex.org/I166722992","https://openalex.org/I4210117453","https://openalex.org/I4210162397"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":1.3549,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.76797728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"1","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-29a","display_name":"miR-29a","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ephb3","display_name":"EphB3","score":0.949999988079071},{"id":"https://openalex.org/keywords/sox4","display_name":"SOX4","score":0.875},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.6589999794960022},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5239999890327454},{"id":"https://openalex.org/keywords/metastasis-suppressor","display_name":"metastasis suppressor","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8855093717575073},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7546546459197998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6927592754364014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6817524433135986},{"id":"https://openalex.org/C128473837","wikidata":"https://www.wikidata.org/wiki/Q7863603","display_name":"U87","level":3,"score":0.6215900182723999},{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.5142126083374023},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5025880336761475},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.47824373841285706},{"id":"https://openalex.org/C139259183","wikidata":"https://www.wikidata.org/wiki/Q18031651","display_name":"SOX4","level":5,"score":0.47085779905319214},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3233204483985901},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.31489163637161255},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28176409006118774},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2520369291305542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18174037337303162},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1192534863948822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10175114870071411},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.057349205017089844},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13046-019-1026-1","doi":"https://doi.org/10.1186/s13046-019-1026-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-019-1026-1","pdf_url":null,"source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5331649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6347789","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30683134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30683134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6347789","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6347789/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4748","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3734","pdf_url":"https://escholarship.umassmed.edu/oapubs/3734","source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMMS Authors","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:82a40154e96e4676825139fff83676d4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/82a40154e96e4676825139fff83676d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-019-1026-1","doi":"https://doi.org/10.1186/s13046-019-1026-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-019-1026-1","pdf_url":null,"source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4902574485","display_name":"MicroRNA Biogenesis and the Cancer Proteome","funder_award_id":"1dp2od002319-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G821994617","display_name":"Preventing Glioma Cancer Stem Cell Dispersal Using Cdc2 Kinase Inhibitors","funder_award_id":"R01NS062219","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000859758","display_name":"A Chemosensory-Mechanotransduction System Regulating Ventricular Size and Brain Function","funder_award_id":"R01NS106985","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320313301","display_name":"Brain Science Foundation","ror":"https://ror.org/02r89bf73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2919217142.pdf","grobid_xml":"https://content.openalex.org/works/W2919217142.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W94490837","https://openalex.org/W206698969","https://openalex.org/W1574653524","https://openalex.org/W1714595722","https://openalex.org/W1971623350","https://openalex.org/W1971661261","https://openalex.org/W1972626324","https://openalex.org/W1974402829","https://openalex.org/W1983922487","https://openalex.org/W1997643107","https://openalex.org/W2002168324","https://openalex.org/W2016233862","https://openalex.org/W2019199449","https://openalex.org/W2021369237","https://openalex.org/W2025183726","https://openalex.org/W2034143104","https://openalex.org/W2038796494","https://openalex.org/W2041580366","https://openalex.org/W2059943377","https://openalex.org/W2065284473","https://openalex.org/W2066497759","https://openalex.org/W2067884710","https://openalex.org/W2070196854","https://openalex.org/W2085674255","https://openalex.org/W2086120407","https://openalex.org/W2093281361","https://openalex.org/W2093963603","https://openalex.org/W2104610341","https://openalex.org/W2104915842","https://openalex.org/W2105528101","https://openalex.org/W2111471857","https://openalex.org/W2112005444","https://openalex.org/W2113942802","https://openalex.org/W2118327319","https://openalex.org/W2119609551","https://openalex.org/W2127034758","https://openalex.org/W2129282939","https://openalex.org/W2135020535","https://openalex.org/W2145896028","https://openalex.org/W2147587303","https://openalex.org/W2149784145","https://openalex.org/W2154406133","https://openalex.org/W2158388175","https://openalex.org/W2160102037","https://openalex.org/W2161289668","https://openalex.org/W2164202885","https://openalex.org/W2169034821","https://openalex.org/W2516445915","https://openalex.org/W2624752673","https://openalex.org/W2734097006","https://openalex.org/W2761342778","https://openalex.org/W2782614891","https://openalex.org/W2799538301","https://openalex.org/W2807477070","https://openalex.org/W2807870374","https://openalex.org/W2890027638","https://openalex.org/W2911315351","https://openalex.org/W4235498863"],"related_works":["https://openalex.org/W6939621778","https://openalex.org/W2275972315","https://openalex.org/W2013005452","https://openalex.org/W2076723438","https://openalex.org/W2971482366","https://openalex.org/W2580055986","https://openalex.org/W2887593961","https://openalex.org/W2523013096","https://openalex.org/W2766615514","https://openalex.org/W3085852786"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"is":[2,119],"a":[3,52,235],"malignant":[4],"brain":[5],"tumor":[6],"characterized":[7],"by":[8,143,155,171],"rapid":[9],"growth,":[10],"diffuse":[11],"invasion":[12,56,140,166,209],"and":[13,28,32,38,55,91,113,133,139,179,208,212,215,241],"therapeutic":[14],"resistance.":[15],"We":[16,115],"recently":[17],"used":[18],"microRNA":[19,63],"expression":[20,64,102,218],"profiles":[21,65],"to":[22,40,71,79],"subclassify":[23],"glioblastoma":[24,60,80,106,137,148,169,206,220,239],"into":[25],"five":[26],"genetically":[27],"clinically":[29],"distinct":[30],"subclasses,":[31],"showed":[33],"that":[34,49,58,76,117,123,134],"microRNAs":[35,122],"both":[36],"define":[37],"contribute":[39],"the":[41,73,97,104,109,121,157,175,182,191],"phenotypes":[42],"of":[43,96,174,196,202,238],"these":[44,230],"subclasses.":[45],"Here":[46],"we":[47,187],"show":[48],"miR-29a":[50,118,135,151,163,197,204,217,233],"activates":[51,153],"multi-faceted":[53],"growth":[54,138,207,240],"program":[57],"promotes":[59,136,165],"aggressiveness.":[61,81],"METHODS:":[62],"from":[66],"197":[67],"glioblastomas":[68],"were":[69],"analyzed":[70],"identify":[72,232],"candidate":[74,83],"miRNAs":[75],"are":[77,124],"correlated":[78],"The":[82],"miRNA,":[84],"miR-29a,":[85],"was":[86],"further":[87],"studied":[88],"in":[89,92,103,131,141,167,198,210,213,219],"vitro":[90,211],"vivo.":[93],"RESULTS:":[94],"Members":[95],"miR-29":[98],"subfamily":[99],"display":[100],"increased":[101,216],"two":[105],"subclasses":[107],"with":[108,127,223],"worst":[110],"prognoses":[111],"(astrocytic":[112],"neural).":[114],"observed":[116],"among":[120],"most":[125,192],"positively-correlated":[126],"PTEN":[128],"copy":[129],"number":[130],"glioblastoma,":[132],"part":[142],"targeting":[144],"PTEN.":[145],"In":[146,161],"PTEN-deficient":[147,168],"cells,":[149],"however,":[150],"nevertheless":[152],"AKT":[154],"downregulating":[156],"metastasis":[158],"suppressor,":[159],"EphB3.":[160],"addition,":[162],"robustly":[164],"cells":[170],"repressing":[172],"translation":[173],"Sox4":[176,189],"transcription":[177],"factor,":[178],"this":[180],"upregulates":[181],"invasion-promoting":[183],"protein,":[184],"HIC5.":[185],"Indeed,":[186],"identified":[188],"as":[190,234],"anti-correlated":[193],"predicted":[194],"target":[195],"glioblastoma.":[199],"Importantly,":[200],"inhibition":[201],"endogenous":[203],"decreases":[205],"vivo,":[214],"specimens":[221],"correlates":[222],"decreased":[224],"patient":[225],"survival.":[226],"CONCLUSIONS:":[227],"Taken":[228],"together,":[229],"data":[231],"master":[236],"regulator":[237],"invasion.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-03-11T00:00:00"}
