{"id":"https://openalex.org/W2919083801","doi":"https://doi.org/10.1016/j.jsps.2019.02.008","title":"The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer","display_name":"The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2919083801","doi":"https://doi.org/10.1016/j.jsps.2019.02.008","mag":"2919083801","pmid":"https://pubmed.ncbi.nlm.nih.gov/31297013","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6598218"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsps.2019.02.008","doi":"https://doi.org/10.1016/j.jsps.2019.02.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsps.2019.02.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319016419300374/pdf","source":{"id":"https://openalex.org/S34003737","display_name":"Saudi Pharmaceutical Journal","issn_l":"1319-0164","issn":["1319-0164","2213-7475"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharmaceutical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1319016419300374/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035093830","display_name":"Abdullah H. Alomrani","orcid":"https://orcid.org/0000-0003-1524-4828","observed_orcids":["https://orcid.org/0000-0003-1524-4828"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Alomrani","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010919056","display_name":"Mohamed M. Badran","orcid":"https://orcid.org/0000-0003-1814-0215","observed_orcids":["https://orcid.org/0000-0003-1814-0215"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Mohamed Badran","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Nasr City Cairo, Egypt","Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Nasr City Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015730372","display_name":"Gamaleldin I. Harisa","orcid":"https://orcid.org/0000-0002-7988-4421","observed_orcids":["https://orcid.org/0000-0002-7988-4421"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Gamaleldin I. Harisa","raw_affiliation_strings":["Department of Biochemistry, College of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt","Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031656212","display_name":"Mohamed ALshehry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed ALshehry","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049996386","display_name":"Moayed Alhariri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185203018","display_name":"King Saud bin Abdulaziz University for Health Sciences","ror":"https://ror.org/0149jvn88","country_code":"SA","type":"education","lineage":["https://openalex.org/I185203018"]},{"id":"https://openalex.org/I4210095597","display_name":"King Abdullah International Medical Research Center","ror":"https://ror.org/009p8zv69","country_code":"SA","type":"facility","lineage":["https://openalex.org/I4210095597"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Moayed Alhariri","raw_affiliation_strings":["King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I185203018","https://openalex.org/I4210095597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041382792","display_name":"Aws Alshamsan","orcid":"https://orcid.org/0000-0002-8950-6571","observed_orcids":["https://orcid.org/0000-0002-8950-6571"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Aws Alshamsan","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-8950-6571","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024423250","display_name":"Musaed A. Alkholief","orcid":"https://orcid.org/0000-0002-7204-3910","observed_orcids":["https://orcid.org/0000-0002-7204-3910"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Musaed Alkholief","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041382792"],"corresponding_institution_ids":["https://openalex.org/I28022161"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.0791,"has_fulltext":true,"cited_by_count":143,"citation_normalized_percentile":{"value":0.93143647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"27","issue":"5","first_page":"603","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan-coated-liposomes","display_name":"chitosan-coated liposomes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chitosomes","display_name":"chitosomes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/drug-delivery-nanocarriers","display_name":"drug delivery nanocarriers","score":0.824999988079071},{"id":"https://openalex.org/keywords/electrostatic-deposition","display_name":"electrostatic deposition","score":0.7099999785423279},{"id":"https://openalex.org/keywords/film-hydration","display_name":"film hydration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.815330982208252},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.8015210628509521},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7957072257995605},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7460490465164185},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7242943644523621},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.5679693818092346},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.48584863543510437},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4685457944869995},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.454187273979187},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.41784483194351196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4122990667819977},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4012480676174164},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.33961519598960876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2848432660102844},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.27044710516929626},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.18618085980415344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16181305050849915},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14140814542770386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0919460654258728},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.06481772661209106},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jsps.2019.02.008","doi":"https://doi.org/10.1016/j.jsps.2019.02.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsps.2019.02.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319016419300374/pdf","source":{"id":"https://openalex.org/S34003737","display_name":"Saudi Pharmaceutical Journal","issn_l":"1319-0164","issn":["1319-0164","2213-7475"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharmaceutical Journal","raw_type":"journal-article"},{"id":"pmid:31297013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31297013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6598218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6598218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharm J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5ac4556d9e1b42d2a7dd0c84ab63adab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ac4556d9e1b42d2a7dd0c84ab63adab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Saudi Pharmaceutical Journal, Vol 27, Iss 5, Pp 603-611 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jsps.2019.02.008","doi":"https://doi.org/10.1016/j.jsps.2019.02.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsps.2019.02.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319016419300374/pdf","source":{"id":"https://openalex.org/S34003737","display_name":"Saudi Pharmaceutical Journal","issn_l":"1319-0164","issn":["1319-0164","2213-7475"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharmaceutical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2919083801.pdf","grobid_xml":"https://content.openalex.org/works/W2919083801.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1129784260","https://openalex.org/W1170748232","https://openalex.org/W1862714180","https://openalex.org/W1963830953","https://openalex.org/W1971762652","https://openalex.org/W1974129846","https://openalex.org/W2016756429","https://openalex.org/W2034587896","https://openalex.org/W2047784903","https://openalex.org/W2053911682","https://openalex.org/W2054692285","https://openalex.org/W2059761734","https://openalex.org/W2080014602","https://openalex.org/W2086889742","https://openalex.org/W2087564090","https://openalex.org/W2090491437","https://openalex.org/W2100809064","https://openalex.org/W2106376916","https://openalex.org/W2110233014","https://openalex.org/W2132258159","https://openalex.org/W2138785892","https://openalex.org/W2152291391","https://openalex.org/W2165215951","https://openalex.org/W2165543012","https://openalex.org/W2184330631","https://openalex.org/W2277365960","https://openalex.org/W2307645079","https://openalex.org/W2318707663","https://openalex.org/W2327420883","https://openalex.org/W2346306482","https://openalex.org/W2395109033","https://openalex.org/W2525304625","https://openalex.org/W2528151165","https://openalex.org/W2536698167","https://openalex.org/W2555505930","https://openalex.org/W2592701528","https://openalex.org/W2648095064","https://openalex.org/W2801891672","https://openalex.org/W2810136225"],"related_works":["https://openalex.org/W4390751286","https://openalex.org/W2911072234","https://openalex.org/W4386913555","https://openalex.org/W2559715734","https://openalex.org/W4398164615","https://openalex.org/W2056300960","https://openalex.org/W4322746407","https://openalex.org/W4280543331","https://openalex.org/W7151934822","https://openalex.org/W4378894912"],"abstract_inverted_index":{"Surface-coated":[0],"nanocarriers":[1,206],"have":[2],"been":[3],"extensively":[4],"used":[5],"to":[6,39,104,114,126,135,163],"enhance":[7],"the":[8,89,97,118,164,197],"delivery":[9],"of":[10,88,99,112,121,133,207],"anticancer":[11],"drugs":[12],"and":[13,31,49,51,56,63,80,86,138,167,196],"improve":[14],"their":[15],"therapeutic":[16],"index.":[17],"In":[18],"this":[19],"study,":[20],"chitosan":[21],"(CS)-coated":[22],"flexible":[23,45],"liposomes":[24,46,122,195],"(chitosomes)":[25],"containing":[26],"5-fluorouracil":[27],"(5-FU)":[28],"were":[29,58,91,183,201],"designed":[30],"characterized":[32],"for":[33,212],"use":[34],"as":[35,161,205],"a":[36,108,141,145,173,191],"novel":[37],"approach":[38],"target":[40],"colon":[41,174],"cancer":[42,175,188,214],"cells.":[43,215],"5-FU-loaded":[44,52,181],"(F1,":[47],"F2,":[48],"F3)":[50],"chitosomes":[53,100,157,182],"(F4,":[54],"F5,":[55],"F6)":[57],"prepared":[59],"using":[60,172],"film":[61],"hydration":[62],"electrostatic":[64],"deposition":[65],"techniques,":[66],"respectively.":[67],"The":[68,93,149,169],"particle":[69,119],"size,":[70],"polydispersity":[71],"index":[72],"(PDI),":[73],"zeta":[74],"potential,":[75],"entrapment":[76],"efficiency":[77],"(EE%),":[78],"morphology,":[79],"in":[81,150,186,190],"vitro":[82,151],"drug":[83,152],"release":[84,153,160],"ability,":[85],"cytotoxicity":[87,170,211],"formulations":[90],"determined.":[92],"results":[94],"revealed":[95,155],"that":[96,156,180],"size":[98,120],"ranged":[101,123],"from":[102,124],"212":[103],"271":[105],"nm":[106,128],"with":[107,129,144,209],"positive":[109],"surface":[110,131,147],"charge":[111],"6.1":[113],"14.7":[115],"mV,":[116],"whereas":[117],"108":[125],"234":[127],"negative":[130],"charges":[132],"\u22122.3":[134],"\u221216.3.":[136],"F3":[137],"F6":[139],"had":[140],"spherical":[142],"shape":[143],"rough":[146],"structure.":[148],"study":[154,171],"retard":[158],"5-FU":[159,165,198],"opposed":[162],"solution":[166],"liposomes.":[168],"cell":[176],"line":[177],"(HT-29)":[178],"showed":[179],"more":[184],"effective":[185],"killing":[187],"cells":[189],"sustained":[192],"manner":[193],"than":[194],"solution.":[199],"Chitosomes":[200],"therefore":[202],"successfully":[203],"developed":[204],"5-FU,":[208],"potential":[210],"colorectal":[213]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-03-11T00:00:00"}