{"id":"https://openalex.org/W2918729264","doi":"https://doi.org/10.1161/circ.136.suppl_1.21413","title":"Abstract 21413: Molecular Basis of Maternal Obesity Induced Fetal Cardiac Contractile Dysfunction","display_name":"Abstract 21413: Molecular Basis of Maternal Obesity Induced Fetal Cardiac Contractile Dysfunction","publication_year":2017,"publication_date":"2017-11-14","ids":{"openalex":"https://openalex.org/W2918729264","doi":"https://doi.org/10.1161/circ.136.suppl_1.21413","mag":"2918729264"},"language":"en","primary_location":{"id":"doi:10.1161/circ.136.suppl_1.21413","doi":"https://doi.org/10.1161/circ.136.suppl_1.21413","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.136.suppl_1.21413","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035024037","display_name":"Qiurong Wang","orcid":"https://orcid.org/0000-0001-9654-9126","observed_orcids":["https://orcid.org/0000-0001-9654-9126"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiurong Wang","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","Qiurong Wang Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Qiurong Wang Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010258524","display_name":"John F. Odhiambo","orcid":"https://orcid.org/0000-0002-1005-3486","observed_orcids":["https://orcid.org/0000-0002-1005-3486"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F Odhiambo","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","John F Odhiambo Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"John F Odhiambo Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047804500","display_name":"Christopher L. Pankey","orcid":"https://orcid.org/0000-0001-6538-5843","observed_orcids":["https://orcid.org/0000-0001-6538-5843"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Pankey","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","Chris Pankey Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Chris Pankey Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018687396","display_name":"Adel B. Ghnenis","orcid":"https://orcid.org/0000-0001-6352-1821","observed_orcids":["https://orcid.org/0000-0001-6352-1821"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adel Ghnenis","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","Adel Ghnenis Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Adel Ghnenis Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069145317","display_name":"Peter W. Nathanielsz","orcid":"https://orcid.org/0000-0001-8410-6280","observed_orcids":["https://orcid.org/0000-0001-8410-6280","https://orcid.org/0000-0003-0802-0084"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W Nathanielsz","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","Peter W Nathanielsz Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Peter W Nathanielsz Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110510646","display_name":"Stephen P. Ford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P Ford","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","Stephen P Ford Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Stephen P Ford Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054901137","display_name":"Wei Guo","orcid":"https://orcid.org/0000-0002-9158-8107","observed_orcids":["https://orcid.org/0000-0002-9158-8107"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":["Dept of Animal Science, Univ of Wyoming, Laramie, WY","Wei Guo Dept of Animal Science, Univ of Wyoming, Laramie, WY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Wei Guo Dept of Animal Science, Univ of Wyoming, Laramie, WY","institution_ids":["https://openalex.org/I12834331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12834331"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.25200000405311584,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-obesity","display_name":"maternal obesity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fetal-cardiomyocytes","display_name":"fetal cardiomyocytes","score":0.7699999809265137},{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.8320000171661377},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.7239999771118164},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9580000042915344},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-leak","display_name":"sarcoplasmic reticulum calcium leak","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fkbp12-6","display_name":"FKBP12.6","score":0.8830000162124634},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.9470000267028809},{"id":"https://openalex.org/keywords/troponin","display_name":"troponin","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7703620791435242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7446858882904053},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7407758235931396},{"id":"https://openalex.org/C190712762","wikidata":"https://www.wikidata.org/wiki/Q18031341","display_name":"Ryanodine receptor 2","level":4,"score":0.6138916015625},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5710334777832031},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5285108685493469},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.49073469638824463},{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.46236541867256165},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4461181163787842},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.4222540557384491},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.41767457127571106},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3589403033256531},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.20097649097442627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19565847516059875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.136.suppl_1.21413","doi":"https://doi.org/10.1161/circ.136.suppl_1.21413","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.136.suppl_1.21413","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2894798854","https://openalex.org/W2898926016","https://openalex.org/W2139836380","https://openalex.org/W2768075647","https://openalex.org/W2795824202","https://openalex.org/W2100072681","https://openalex.org/W4280503593","https://openalex.org/W2956026953","https://openalex.org/W4409696956","https://openalex.org/W7205205285"],"abstract_inverted_index":{"One":[0],"third":[1],"of":[2,35,68,73,101,126,171,181,194,207,231,258,275,284,304,317,335],"the":[3,66,69,99,121,130,141,155,159,169,179,225,239,256,282,299,315],"women":[4],"at":[5,200],"reproductive":[6],"age":[7],"are":[8],"overweight":[9],"or":[10],"obese":[11],"in":[12,16,38,54,60,78,144,158,220,235,250,261,281,291,301,323],"US.":[13],"Epidemiological":[14],"studies":[15,19,328],"humans":[17],"and":[18,48,62,71,124,128,153,202,243,272,308,312,320],"on":[20,103],"animals":[21],"have":[22,110,329],"shown":[23],"that":[24,112,138,166,269,298],"obesity":[25],"during":[26],"pregnancy":[27],"(":[28],"i.e.":[29],"maternal":[30],"obesity,":[31],"MO)":[32],"increases":[33],"incidences":[34],"cardiovascular":[36,58,75],"diseases":[37],"offspring.":[39,64],"Uterus":[40],"environment":[41],"is":[42,314],"essential":[43],"for":[44,215],"fetal":[45,104,115,145,222,236,262,292,325],"cardiac":[46,240],"development":[47,72,283],"MO":[49,102,113,139,167,221,228,251,254,324,336],"as":[50,94,176,178],"a":[51,95,209,278,331],"stress":[52],"condition":[53],"uterus":[55],"could":[56],"program":[57],"disease":[59,76],"prenatal":[61],"postnatal":[63],"However,":[65],"mechanisms":[67],"origin":[70],"MO-induced":[74,285],"later":[77],"life":[79],"remain":[80],"unclear.":[81],"For":[82],"this":[83],"purpose,":[84],"we":[85,109,164],"use":[86],"sheep":[87,116],"(sharing":[88],"many":[89],"similarities":[90],"with":[91,213],"human":[92],"pregnancy)":[93],"model":[96],"to":[97,132],"study":[98],"impact":[100],"heart":[105,338],"contractile":[106,321],"function.":[107],"Previously,":[108],"demonstrated":[111],"impaired":[114],"cardiomyocyte":[117],"contractility":[118],"by":[119,147],"reducing":[120],"peak":[122,133],"shortening":[123],"velocity":[125],"shortening/relengthening":[127],"prolonged":[129],"time":[131],"shortening/relengthening.":[134],"We":[135],"also":[136],"found":[137,165],"disrupted":[140],"calcium":[142,156,216,318],"homeostasis":[143],"cardiomyocytes":[146],"increasing":[148],"intracellular":[149],"Ca":[150,182,288],"2+":[151,183,289],"level":[152,193,206,247],"inducing":[154],"insensitivity":[157,319],"cell.":[160],"In":[161],"current":[162],"study,":[163],"increased":[168,270],"phosphorylation":[170,180,192,274],"protein":[172,185,211],"kinase":[173,186],"A":[174],"(PKA)":[175],"well":[177],"/calmodulin-dependent":[184],"II":[187],"(CaMKII),":[188],"which":[189],"further":[190],"promoted":[191],"ryanodine":[195],"receptor":[196],"type":[197],"2":[198],"(Ryr2)":[199],"Ser2808":[201],"Ser2814":[203],"respectively.":[204],"Expression":[205],"FKBP12.6,":[208],"key":[210],"interacting":[212],"Ryr2":[214,276],"releasing,":[217],"was":[218,248],"upregulated":[219,249],"myocardium.":[223,237,263],"On":[224],"other":[226],"hand,":[227],"reduced":[229],"expression":[230,246,257,302],"myosin":[232,305],"heavy":[233,306],"chain":[234,307],"Moreover,":[238],"troponin":[241,244,259,309],"T":[242,313],"I":[245,311],"fetuses,":[252],"whereas":[253],"downregulated":[255],"C":[260],"Taken":[264],"together,":[265],"our":[266,295],"findings":[267],"suggest":[268],"CaMKII":[271],"PKA":[273],"plays":[277],"critical":[279],"role":[280],"sarcoplasmic":[286],"reticulum":[287],"leak":[290],"cardiomyocytes.":[293,326],"Furthermore,":[294],"data":[296],"indicate":[297],"change":[300],"levels":[303],"C,":[310],"cause":[316],"dysfunction":[322],"Our":[327],"provided":[330],"fundamental":[332],"molecular":[333],"basis":[334],"programmed":[337],"disease.":[339]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-03-11T00:00:00"}