{"id":"https://openalex.org/W2918530465","doi":"https://doi.org/10.1016/j.omtn.2019.02.021","title":"MicroRNA-134-5p Regulates Media Degeneration through Inhibiting VSMC Phenotypic Switch and Migration in Thoracic Aortic Dissection","display_name":"MicroRNA-134-5p Regulates Media Degeneration through Inhibiting VSMC Phenotypic Switch and Migration in Thoracic Aortic Dissection","publication_year":2019,"publication_date":"2019-02-28","ids":{"openalex":"https://openalex.org/W2918530465","doi":"https://doi.org/10.1016/j.omtn.2019.02.021","mag":"2918530465","pmid":"https://pubmed.ncbi.nlm.nih.gov/30951965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6446055"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2019.02.021","doi":"https://doi.org/10.1016/j.omtn.2019.02.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2019.02.021","pdf_url":"http://www.cell.com/article/S2162253119300526/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2162253119300526/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347150","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-7852-386X","observed_orcids":["https://orcid.org/0000-0002-7852-386X","https://orcid.org/0000-0001-8941-0484"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100931090","display_name":"Changqing Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Qing Dong","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014646309","display_name":"Guang-Yin Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Yin Peng","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101407665","display_name":"Haoyue Huang","orcid":"https://orcid.org/0000-0002-2986-5097","observed_orcids":["https://orcid.org/0000-0002-2986-5097"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao-yue Huang","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058506630","display_name":"Yun-Sheng Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-sheng Yu","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065408776","display_name":"Zhenchun Ji","orcid":"https://orcid.org/0000-0002-9482-6457","observed_orcids":["https://orcid.org/0000-0002-9482-6457"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Chun Ji","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054398168","display_name":"Zhenya Shen","orcid":"https://orcid.org/0000-0002-7042-7929","observed_orcids":["https://orcid.org/0000-0002-7042-7929"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen-Ya Shen","raw_affiliation_strings":["Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China. Electronic address: uuzyshen@aliyun.com","Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China. Electronic address: uuzyshen@aliyun.com","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054398168"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":5.6991,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.96910653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"284","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.11069999635219574,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-134-5p","display_name":"miR-134-5p","score":0.9879999756813049},{"id":"https://openalex.org/keywords/thoracic-aortic-dissection","display_name":"thoracic aortic dissection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/vsmc-migration","display_name":"VSMC migration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/stat5b","display_name":"STAT5B","score":0.9399999976158142},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.9039999842643738},{"id":"https://openalex.org/keywords/aortic-dilation","display_name":"aortic dilatation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8218095898628235},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.625807523727417},{"id":"https://openalex.org/C2779993142","wikidata":"https://www.wikidata.org/wiki/Q594660","display_name":"Aortic dissection","level":3,"score":0.5719783902168274},{"id":"https://openalex.org/C2994150672","wikidata":"https://www.wikidata.org/wiki/Q17143044","display_name":"Aortic repair","level":3,"score":0.4540073573589325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42462843656539917},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.4141913056373596},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3520362377166748},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26100796461105347},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.23548796772956848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22155031561851501},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2176525890827179},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10679861903190613}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.omtn.2019.02.021","doi":"https://doi.org/10.1016/j.omtn.2019.02.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2019.02.021","pdf_url":"http://www.cell.com/article/S2162253119300526/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5443709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6446055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6446055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6446055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:30951965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30951965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:89e7506f9fe74e46b4ac1d4826cc7414","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/89e7506f9fe74e46b4ac1d4826cc7414","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 284-294 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2019.02.021","doi":"https://doi.org/10.1016/j.omtn.2019.02.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2019.02.021","pdf_url":"http://www.cell.com/article/S2162253119300526/pdf","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2918530465.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W9129716","https://openalex.org/W1873506300","https://openalex.org/W1899869666","https://openalex.org/W1935519166","https://openalex.org/W1963906441","https://openalex.org/W1966034684","https://openalex.org/W1976795428","https://openalex.org/W1982711630","https://openalex.org/W1996630410","https://openalex.org/W1999474558","https://openalex.org/W2010510784","https://openalex.org/W2018621592","https://openalex.org/W2031769009","https://openalex.org/W2039068212","https://openalex.org/W2044682394","https://openalex.org/W2058498186","https://openalex.org/W2062930407","https://openalex.org/W2101579992","https://openalex.org/W2108661174","https://openalex.org/W2120243513","https://openalex.org/W2121822802","https://openalex.org/W2132665343","https://openalex.org/W2167125089","https://openalex.org/W2276896312","https://openalex.org/W2290959418","https://openalex.org/W2331757605","https://openalex.org/W2548599454","https://openalex.org/W2736555309","https://openalex.org/W2762002459","https://openalex.org/W2772945804","https://openalex.org/W2773009193","https://openalex.org/W2786281724","https://openalex.org/W2888940757"],"related_works":["https://openalex.org/W2917474839","https://openalex.org/W2972157170","https://openalex.org/W4283466757","https://openalex.org/W4283078640","https://openalex.org/W4396670526","https://openalex.org/W2726871304","https://openalex.org/W2986640280","https://openalex.org/W4398147484","https://openalex.org/W3020018702","https://openalex.org/W3214269928"],"abstract_inverted_index":{"Abnormal":[0],"phenotypic":[1,35,111,137],"switch,":[2],"migration,":[3],"and":[4,37,47,60,95,104,113,119,129,139,150,178],"proliferation":[5],"of":[6,16,49,54,89,97,124,141,181,202],"vascular":[7,151,160,176],"smooth":[8],"muscle":[9],"cells":[10],"(VSMCs)":[11],"are":[12],"hallmarks":[13],"for":[14],"pathogenesis":[15],"thoracic":[17],"aortic":[18],"dissection":[19],"(TAD).":[20],"In":[21],"the":[22,147],"current":[23],"study,":[24],"we":[25,63,76],"identified":[26,64,117],"miR-134-5p":[27,42,79,90,106,125,170,188],"as":[28,101,121],"a":[29,172],"critical":[30],"regulator":[31,174],"controlling":[32],"human":[33,44,85,127],"VSMC":[34,45,93,110,136],"switch":[36,112,138],"migration":[38],"to":[39,132],"investigate":[40],"whether":[41],"affects":[43],"functions":[46],"development":[48],"TAD.":[50,142,203],"Using":[51],"miRNA":[52],"microarray":[53],"aorta":[55,148],"specimens":[56],"from":[57],"12":[58,61],"TAD":[59,71,157,182],"controls,":[62],"miR-134-5p,":[65],"which":[66],"was":[67,80,171],"significantly":[68],"downregulated":[69],"in":[70,84,126,135,156,175,193,199],"tissues.":[72],"With":[73],"qPCR":[74],"detection,":[75],"found":[77],"that":[78,169],"also":[81],"evidently":[82],"decreased":[83],"AoSMCs.":[86],"Ectopic":[87],"expression":[88,96],"obviously":[91,145],"promoted":[92],"differentiation":[94],"contractile":[98],"markers,":[99],"such":[100],"\u03b1-SMA,":[102],"SM22\u03b1,":[103],"MYH11.":[105],"potently":[107],"inhibited":[108],"PDGF-BB-induced":[109],"migration.":[114],"We":[115],"further":[116],"STAT5B":[118],"ITGB1":[120],"downstream":[122,191],"targets":[123],"VSMCs":[128,194],"proved":[130],"them":[131],"be":[133],"mediators":[134],"progression":[140],"Finally,":[143],"Ad-miR-134-5p":[144],"suppressed":[146],"dilatation":[149],"media":[152],"degeneration":[153],"by":[154,163],"39%":[155],"mice":[158],"after":[159],"injury":[161],"induced":[162],"Ang":[164],"II.":[165],"Our":[166],"findings":[167],"revealed":[168],"novel":[173],"remodeling":[177],"pathological":[179],"progress":[180],"via":[183],"targeting":[184],"STAT5B/ITGB1":[185],"expression.":[186],"Targeting":[187],"or":[189],"its":[190],"molecules":[192],"might":[195],"develop":[196],"new":[197],"avenues":[198],"clinical":[200],"treatment":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-03-11T00:00:00"}
