{"id":"https://openalex.org/W2918488283","doi":"https://doi.org/10.1002/jbmr.3683","title":"DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture","display_name":"DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture","publication_year":2019,"publication_date":"2019-03-03","ids":{"openalex":"https://openalex.org/W2918488283","doi":"https://doi.org/10.1002/jbmr.3683","mag":"2918488283","pmid":"https://pubmed.ncbi.nlm.nih.gov/30827034"},"language":"en","primary_location":{"id":"doi:10.1002/jbmr.3683","doi":"https://doi.org/10.1002/jbmr.3683","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.3683","pdf_url":"https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3683","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3683","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085219619","display_name":"Tingjun Liu","orcid":"https://orcid.org/0000-0002-9553-8510","observed_orcids":["https://orcid.org/0000-0002-9553-8510"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingjun Liu","raw_affiliation_strings":["Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":["Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039964552","display_name":"Xudong Xie","orcid":"https://orcid.org/0000-0002-5932-1496","observed_orcids":["https://orcid.org/0000-0002-5932-1496"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xudong Xie","raw_affiliation_strings":["Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360107","display_name":"Ke Wang","orcid":"https://orcid.org/0000-0002-1866-0678","observed_orcids":["https://orcid.org/0000-0002-1866-0678"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Wang","raw_affiliation_strings":["Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101940117","display_name":"Tingting Sui","orcid":"https://orcid.org/0000-0002-8865-0862","observed_orcids":["https://orcid.org/0000-0002-8865-0862"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Sui","raw_affiliation_strings":["Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108133981","display_name":"Di Liu","orcid":"https://orcid.org/0000-0003-3693-2726","observed_orcids":["https://orcid.org/0000-0003-3693-2726"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Liu","raw_affiliation_strings":["Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109635888","display_name":"Liangxue Lai","orcid":"https://orcid.org/0000-0002-1793-9618","observed_orcids":["https://orcid.org/0000-0002-1793-9618","https://orcid.org/0000-0002-5256-6802"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangxue Lai","raw_affiliation_strings":["Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042903123","display_name":"Hu Zhao","orcid":"https://orcid.org/0000-0002-2961-0086","observed_orcids":["https://orcid.org/0000-0002-2961-0086"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hu Zhao","raw_affiliation_strings":["Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008990095","display_name":"Zhanjun Li","orcid":"https://orcid.org/0000-0001-6914-8589","observed_orcids":["https://orcid.org/0000-0001-6914-8589"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhanjun Li","raw_affiliation_strings":["Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035291764","display_name":"Jian Q. Feng","orcid":"https://orcid.org/0000-0003-1508-5038","observed_orcids":["https://orcid.org/0000-0003-1508-5038"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian Q Feng","raw_affiliation_strings":["Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5008990095","https://openalex.org/A5035291764"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I91045830"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":4.4363,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94547935,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"6","first_page":"1115","last_page":"1128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.430400013923645,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.430400013923645,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.15530000627040863,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dmp1","display_name":"DMP1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bone-mineralization-defect","display_name":"bone mineralization defect","score":0.6740000247955322},{"id":"https://openalex.org/keywords/haversian-canals","display_name":"Haversian canals","score":0.6919999718666077},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.8640000224113464},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2777267240","wikidata":"https://www.wikidata.org/wiki/Q17914022","display_name":"DMP1","level":4,"score":0.9444481134414673},{"id":"https://openalex.org/C2777909254","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Osteon","level":3,"score":0.8360571265220642},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.73734050989151},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.7328771948814392},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.7104917764663696},{"id":"https://openalex.org/C81880429","wikidata":"https://www.wikidata.org/wiki/Q2035067","display_name":"Osteoid","level":2,"score":0.6401709318161011},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.478071928024292},{"id":"https://openalex.org/C2779782008","wikidata":"https://www.wikidata.org/wiki/Q1632552","display_name":"Hyperostosis","level":2,"score":0.45183855295181274},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.4242153763771057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38457149267196655},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37212902307510376},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3423355221748352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3030926585197449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.243238627910614},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.19906291365623474},{"id":"https://openalex.org/C68434959","wikidata":"https://www.wikidata.org/wiki/Q1908996","display_name":"Viral matrix protein","level":3,"score":0.1931876242160797},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.14984795451164246},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.1472676396369934},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1403351128101349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09431576728820801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbmr.3683","doi":"https://doi.org/10.1002/jbmr.3683","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.3683","pdf_url":"https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3683","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:30827034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30827034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jbmr.3683","doi":"https://doi.org/10.1002/jbmr.3683","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.3683","pdf_url":"https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3683","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2817196195","display_name":"Chondrocyte-derived bone cells determine the overall pattern of TMJ condyle and contribute to bone remodeling","funder_award_id":"R01DE025659","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2882962825","display_name":null,"funder_award_id":"81700980","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4588469700","display_name":"Biphasic Roles of OSX-WNT-B-Catenin Signaling Pathway in Tooth Root Formation","funder_award_id":"R01DE025014","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6033669475","display_name":null,"funder_award_id":"2017M623048","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7399214459","display_name":null,"funder_award_id":"2017YFA010501","funder_id":"https://openalex.org/F4320336026","funder_display_name":"National Key Research and Development Program of China Stem Cell and Translational Research"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336026","display_name":"National Key Research and Development Program of China Stem Cell and Translational Research","ror":null},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2918488283.pdf","grobid_xml":"https://content.openalex.org/works/W2918488283.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1749100053","https://openalex.org/W1895827429","https://openalex.org/W1964062633","https://openalex.org/W1964148458","https://openalex.org/W1970864109","https://openalex.org/W1982395713","https://openalex.org/W1994611947","https://openalex.org/W2003621498","https://openalex.org/W2011371855","https://openalex.org/W2019744993","https://openalex.org/W2026748077","https://openalex.org/W2051959338","https://openalex.org/W2055683188","https://openalex.org/W2061807047","https://openalex.org/W2061991539","https://openalex.org/W2064815984","https://openalex.org/W2066749771","https://openalex.org/W2072288858","https://openalex.org/W2078883007","https://openalex.org/W2079273064","https://openalex.org/W2086360835","https://openalex.org/W2087394924","https://openalex.org/W2087665466","https://openalex.org/W2096425957","https://openalex.org/W2129904461","https://openalex.org/W2141783706","https://openalex.org/W2152842423","https://openalex.org/W2171100097","https://openalex.org/W2265756380","https://openalex.org/W2343489211","https://openalex.org/W2520790269","https://openalex.org/W2565471228","https://openalex.org/W2569064980","https://openalex.org/W2591055995","https://openalex.org/W2748969320","https://openalex.org/W2772673497","https://openalex.org/W2782662381","https://openalex.org/W4210657902","https://openalex.org/W4211024055"],"related_works":["https://openalex.org/W1970585207","https://openalex.org/W3086475500","https://openalex.org/W2054480264","https://openalex.org/W4234925757","https://openalex.org/W2051959338","https://openalex.org/W2169454115","https://openalex.org/W2586121632","https://openalex.org/W2342045898","https://openalex.org/W2077144474","https://openalex.org/W2151408020"],"abstract_inverted_index":{"DMP1":[0,36,99,146,211,234],"(dentin":[1],"matrix":[2,8,180],"protein":[3,9],"1)":[4],"is":[5,191],"an":[6],"extracellular":[7],"highly":[10],"expressed":[11],"in":[12,61,75,86,101,141,164,183,199,205,226],"bones.":[13],"Studies":[14],"of":[15,24,30,53,67,81,111,120,169,175,196,210,241],"Dmp1":[16],"knockout":[17],"(KO)":[18],"mice":[19],"led":[20],"to":[21,47,223],"the":[22,98,116,121,126,165,242],"discovery":[23],"a":[25,51,78,156,161,186,194,197,203,208,238],"rare":[26,94],"autosomal":[27],"recessive":[28],"form":[29],"hypophosphatemic":[31],"rickets":[32,190],"(ARHR)":[33],"caused":[34,192],"by":[35,150,193],"mutations.":[37],"However,":[38],"there":[39],"are":[40],"limitations":[41],"for":[42,250],"using":[43,103],"this":[44,93],"mouse":[45],"model":[46,107],"study":[48,209],"ARHR,":[49,113],"including":[50],"lack":[52],"Haversian":[54],"canals":[55],"and":[56,73,83,132,202,252],"osteons":[57],"(that":[58],"occurs":[59],"only":[60],"large":[62],"mammalian":[63],"bones),":[64],"high":[65],"levels":[66],"fibroblast":[68],"growth":[69],"factor":[70],"23":[71],"(FGF23),":[72],"PTH,":[74],"comparison":[76],"with":[77,172,231],"moderate":[79],"elevation":[80],"FGF23":[82],"unchanged":[84],"PTH":[85,134],"human":[87,112],"ARHR":[88,218],"patients.":[89],"To":[90],"better":[91],"understand":[92],"disease,":[95],"we":[96],"deleted":[97],"gene":[100],"rabbit":[102,106],"CRISPR/Cas9.":[104],"This":[105],"recapitulated":[108],"many":[109],"features":[110],"such":[114],"as":[115,136,138],"rachitic":[117],"rosary":[118],"(expansion":[119],"anterior":[122],"rib":[123],"ends":[124],"at":[125],"costochondral":[127],"junctions),":[128],"moderately":[129],"increased":[130],"FGF23,":[131],"normal":[133],"levels,":[135],"well":[137],"severe":[139,157],"defects":[140],"bone":[142,158,179,200],"mineralization.":[143,206],"Unexpectedly,":[144],"all":[145,178],"KO":[147,212,235],"rabbits":[148,236],"died":[149],"postnatal":[151],"week":[152],"8.":[153],"They":[154],"developed":[155,233],"microarchitecture":[159,201],"defect:":[160],"major":[162],"increase":[163],"central":[166],"canal":[167],"areas":[168],"osteons,":[170],"concurrent":[171],"massive":[173],"accumulation":[174],"osteoid":[176],"throughout":[177],"(a":[181],"defect":[182,198],"mineralization),":[184],"suggesting":[185],"new":[187],"paradigm,":[188],"where":[189],"combination":[195],"failure":[204],"Furthermore,":[207],"bones":[213],"found":[214],"accelerated":[215],"chondrogenesis,":[216],"whereas":[217],"has":[219],"commonly":[220],"been":[221],"thought":[222],"be":[224],"involved":[225],"reduced":[227],"chondrogenesis.":[228],"Our":[229],"findings":[230],"newly":[232],"suggest":[237],"revised":[239],"understanding":[240],"mechanism":[243],"underlying":[244],"ARHR.":[245],"\u00a9":[246],"2019":[247],"American":[248],"Society":[249],"Bone":[251],"Mineral":[253],"Research.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-03-11T00:00:00"}
