{"id":"https://openalex.org/W2918429960","doi":"https://doi.org/10.1158/1055-9965.epi-19-0086","title":"A Prospective Analysis of Red Blood Cell Trans Fatty Acid Levels and Risk of Non-Hodgkin Lymphoma","display_name":"A Prospective Analysis of Red Blood Cell Trans Fatty Acid Levels and Risk of Non-Hodgkin Lymphoma","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2918429960","doi":"https://doi.org/10.1158/1055-9965.epi-19-0086","mag":"2918429960"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-19-0086","doi":"https://doi.org/10.1158/1055-9965.epi-19-0086","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-19-0086","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051972536","display_name":"Korat AV Ardisson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Korat AV Ardisson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113801274","display_name":"Y\u2010H Chiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YH Chiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072226926","display_name":"Kimberly A. Bertrand","orcid":"https://orcid.org/0000-0002-4565-7618","observed_orcids":["https://orcid.org/0000-0002-4565-7618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KS Bertrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025538658","display_name":"S Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024488327","display_name":"Francine Laden","orcid":"https://orcid.org/0000-0002-2813-2174","observed_orcids":["https://orcid.org/0000-0002-2813-2174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Laden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088528540","display_name":"MM Epstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MM Epstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089191285","display_name":"BERNARD A. ROSNER","orcid":"https://orcid.org/0000-0001-6907-0056","observed_orcids":["https://orcid.org/0000-0001-6907-0056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BA Rosner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046838165","display_name":"Stephanie E. Chiuve","orcid":"https://orcid.org/0000-0002-3524-8917","observed_orcids":["https://orcid.org/0000-0002-3524-8917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Chiuve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074249857","display_name":"Hannia Campos","orcid":"https://orcid.org/0000-0001-9964-6802","observed_orcids":["https://orcid.org/0000-0001-9964-6802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Campos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038373228","display_name":"Edward L. Giovannucci","orcid":"https://orcid.org/0000-0002-6123-0219","observed_orcids":["https://orcid.org/0000-0002-6123-0219","https://orcid.org/0009-0003-9117-569X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EL Giovannucci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075236631","display_name":"Jorge E. Chavarro","orcid":"https://orcid.org/0000-0002-4436-9630","observed_orcids":["https://orcid.org/0000-0002-4436-9630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JE Chavarro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023428946","display_name":"Brenda M. Birmann","orcid":"https://orcid.org/0000-0002-7550-5498","observed_orcids":["https://orcid.org/0000-0002-7550-5498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BM Birmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01668929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"3","first_page":"621","last_page":"621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.1354999989271164,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dietary-trans-fatty-acids","display_name":"dietary trans fatty acids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/elaidic-acid","display_name":"elaidic acid","score":0.8379999995231628},{"id":"https://openalex.org/keywords/lymphoma-subtypes","display_name":"lymphoma subtypes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lymphoma-risk","display_name":"lymphoma risk","score":0.4699999988079071},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.8050000071525574},{"id":"https://openalex.org/keywords/health-professionals-follow-up-study","display_name":"Health Professionals Follow-up Study","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nutritional-biomarkers","display_name":"dietary biomarkers","score":0.6389999985694885},{"id":"https://openalex.org/keywords/saturated-fatty-acids","display_name":"saturated fatty acids","score":0.5239999890327454},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8003891110420227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6431382298469543},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6227109432220459},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5687042474746704},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5622018575668335},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5464455485343933},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.500359296798706},{"id":"https://openalex.org/C2778476748","wikidata":"https://www.wikidata.org/wiki/Q1138590","display_name":"Non-Hodgkin's lymphoma","level":3,"score":0.417765736579895},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3995285928249359},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.379886656999588}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.epi-19-0086","doi":"https://doi.org/10.1158/1055-9965.epi-19-0086","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-19-0086","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3092334855","https://openalex.org/W2979800100","https://openalex.org/W4306728706","https://openalex.org/W2803244791","https://openalex.org/W2119643885","https://openalex.org/W2734097870","https://openalex.org/W2561150745","https://openalex.org/W1973529900","https://openalex.org/W2172190939","https://openalex.org/W2020839430"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"confirm":[2],"previous":[3,291],"reports":[4],"of":[5,14,26,36,86,136,205,215,286,311,320,338,342],"increased":[6],"non-Hodgkin":[7],"lymphoma":[8,46],"(NHL)":[9],"risk":[10,35,163,202,204,221,337],"with":[11,79,199,219,276,283,309],"higher":[12],"intake":[13,332],"dietary":[15],"trans":[16,253,300],"fatty":[17,138],"acids":[18],"(TFA),":[19],"we":[20,210,247],"conducted":[21,62],"the":[22,147,185,317],"first":[23],"prospective":[24],"study":[25,66],"pre-diagnosis":[27],"red":[28],"blood":[29,118],"cell":[30,45],"(RBC)":[31],"TFA":[32,129,172,218,245,274,288,296,331],"levels":[33,130,275,297],"and":[34,38,72,83,108,117,155,192,313,325,340],"NHL":[37,40,98,162,201],"common":[39],"histologic":[41,207],"subtypes":[42,187],"(diffuse":[43],"large-B":[44],"(DLBCL),":[47],"follicular":[48],"lymphoma,":[49],"chronic":[50],"lymphocytic":[51,53],"lymphoma/small":[52],"leukemia,":[54],"other":[55,264],"B-cell":[56],"NHL,":[57,339],"T-cell":[58],"NHL).":[59],"Methods:":[60],"We":[61,95,121,140,174,267],"a":[63,134,212,249],"nested":[64],"case-control":[65],"in":[67,102,106,171],"Nurses'":[68],"Health":[69,73],"Study":[70,76],"(NHS)":[71],"Professionals":[74],"Follow-Up":[75],"(HPFS)":[77],"participants":[78],"archived":[80],"RBC":[81,123,194,217,273],"specimens":[82],"no":[84],"history":[85],"cancer":[87],"at":[88],"sample":[89],"collection":[90],"(NHS:":[91],"1989\u201390;":[92],"HPFS:":[93],"1994\u20135).":[94],"confirmed":[96],"583":[97,110],"cases":[99],"(332":[100],"women":[101],"NHS,":[103],"251":[104],"men":[105],"HPFS)":[107],"matched":[109],"controls":[111],"by":[112,237],"cohort":[113],"(sex),":[114],"age,":[115],"race/ethnicity":[116],"draw":[119],"date/time.":[120],"analyzed":[122],"TFAs":[124,195,239],"using":[125],"gas-liquid":[126],"chromatography;":[127],"individual":[128,193],"were":[131,196],"expressed":[132],"as":[133],"percentage":[135],"total":[137,216],"acids.":[139],"used":[141],"unconditional":[142],"logistic":[143,178],"regression,":[144],"adjusted":[145],"for":[146,160,184,252,263,272],"matching":[148],"factors,":[149],"to":[150,181,329,335],"estimate":[151],"odds":[152],"ratios":[153],"(OR)":[154],"95%":[156],"confidence":[157],"intervals":[158],"(CI)":[159],"overall":[161,200],"per":[164,229],"1":[165,230],"standard":[166],"deviation":[167],"(SD)":[168],"unit":[169],"increase":[170],"level.":[173],"fitted":[175],"multivariate":[176],"polytomous":[177],"regression":[179],"models":[180],"assess":[182],"associations":[183,271],"specific":[186],"listed":[188],"above.":[189],"Results:":[190],"Total":[191],"not":[197,262],"associated":[198],"or":[203],"most":[206],"subtypes.":[208],"However,":[209],"observed":[211,268],"positive":[213,250,270],"association":[214,251],"DLBCL":[220,277],"(n":[222],"=":[223],"86":[224],"cases;":[225],"OR":[226],"[95%":[227],"CI]":[228],"SD:":[231],"1.29":[232],"[1.02,":[233],"1.64]),":[234],"driven":[235],"primarily":[236],"18:1":[238,244,254],"(1.35":[240],"[1.07,":[241],"1.72]).":[242],"Among":[243],"isomers,":[246],"found":[248],"n-9":[255],"(elaidic":[256],"acid;":[257],"1.33":[258],"[1.05,":[259],"1.68])":[260],"but":[261],"isomers.":[265],"Conclusions:":[266],"significant":[269],"risk.":[278],"These":[279],"findings":[280],"are":[281,306],"consistent":[282],"published":[284],"studies":[285,292],"self-reported":[287],"intake;":[289],"further,":[290],"have":[293],"shown":[294],"that":[295],"\u2013":[298,305],"particularly":[299,341],"18:1n-9,":[301],"which":[302],"is":[303],"industrially-derived":[304],"positively":[307],"correlated":[308],"biomarkers":[310],"inflammation":[312],"immune":[314],"activation,":[315],"supporting":[316],"biologic":[318],"plausibility":[319],"our":[321],"findings.":[322],"Food":[323],"industry":[324],"public":[326],"health":[327],"measures":[328],"diminish":[330],"may":[333],"help":[334],"reduce":[336],"DLBCL.":[343]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-03-11T00:00:00"}