{"id":"https://openalex.org/W29184072","doi":"https://doi.org/10.18926/amo/31651","title":"The impact of propylthiouracil therapy on lipid peroxidation and antioxidant status parameters in hyperthyroid patients.","display_name":"The impact of propylthiouracil therapy on lipid peroxidation and antioxidant status parameters in hyperthyroid patients.","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W29184072","doi":"https://doi.org/10.18926/amo/31651","mag":"29184072","pmid":"https://pubmed.ncbi.nlm.nih.gov/10096735"},"language":"en","primary_location":{"id":"pmid:10096735","doi":"https://doi.org/10.18926/amo/31651","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10096735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/31651/20160528024112418494/fulltext.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074669250","display_name":"Arzu Seven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A Seven","raw_affiliation_strings":["Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041077493","display_name":"Ertu\u011frul Ta\u015fan","orcid":"https://orcid.org/0000-0003-2944-0272","observed_orcids":["https://orcid.org/0000-0003-2944-0272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tasan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111544396","display_name":"Hasan H\u00fcsrev Hatemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hatemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088575597","display_name":"G\u00fclden Bur\u00e7ak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Burcak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6102,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64636783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"53","issue":"1","first_page":"27","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.996999979019165},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8659999966621399},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.9779999852180481},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.9340000152587891},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cu-zn-superoxide-dismutase","display_name":"Cu/Zn superoxide dismutase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.9490228295326233},{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.8319027423858643},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.7159574627876282},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7109497785568237},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.707025945186615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7001246809959412},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6309607625007629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6307384371757507},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.604475736618042},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.52614426612854},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.4912559390068054},{"id":"https://openalex.org/C2776606491","wikidata":"https://www.wikidata.org/wiki/Q1365501","display_name":"Antithyroid agent","level":4,"score":0.4747886061668396},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.45737481117248535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3136560320854187},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.31009218096733093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2672663927078247},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22437676787376404},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.19502779841423035},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19113034009933472}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011441","descriptor_name":"Propylthiouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10096735","doi":"https://doi.org/10.18926/amo/31651","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10096735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Clinical Trial"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000647066","doi":"https://doi.org/10.18926/amo/31651","is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/31651","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/31651/20160528024112418494/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:31651","doi":"https://doi.org/10.18926/amo/31651","is_oa":false,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/31651","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"Journal Article"},{"id":"mag:29184072","doi":"https://doi.org/10.18926/amo/31651","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10096735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000647066","doi":"https://doi.org/10.18926/amo/31651","is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/31651","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/31651/20160528024112418494/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W29184072.pdf"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2237033277"],"related_works":["https://openalex.org/W1990847242","https://openalex.org/W2197242379","https://openalex.org/W2035489160","https://openalex.org/W2031593935","https://openalex.org/W1977264349","https://openalex.org/W2787012647","https://openalex.org/W1998841568","https://openalex.org/W2079815303","https://openalex.org/W7052917169","https://openalex.org/W7160226010"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2],"performed":[3],"on":[4,37],"17":[5],"hyperthyroid":[6],"patients":[7,13,75],"and":[8,36,59,68,84,118,131,138],"15":[9],"healthy":[10],"controls.":[11],"The":[12],"were":[14,43,76],"under":[15],"propylthiouracil":[16],"(PTU)":[17],"therapy":[18,101],"at":[19,33],"a":[20,103,119,139,152],"dosage":[21],"of":[22,41,155],"3":[23],"x":[24],"100":[25],"mg/day":[26],"for":[27,45],"one":[28],"month.":[29],"Blood":[30],"samples,":[31],"taken":[32],"the":[34,38,123,156],"beginning":[35],"30th":[39],"day":[40],"therapy,":[42],"analyzed":[44],"hormonal":[46],"parameters":[47],"(T3,":[48],"T4,":[49],"TSH),":[50],"lipid":[51],"peroxidation":[52],"endproduct":[53],"[thiobarbituric":[54],"acid":[55],"reactive":[56],"substances":[57],"(TBARS)]":[58],"antioxidant":[60,124],"status":[61,125],"parameters:":[62,126],"glutathione":[63,65],"(GSH),":[64],"peroxidase":[66],"(GSH-Px)":[67],"CuZn":[69,85,132],"superoxide":[70],"dismutase":[71],"(CuZn":[72],"SOD).":[73],"Hyperthyroid":[74],"observed":[77],"to":[78,173],"have":[79],"significantly":[80,111],"higher":[81],"TBARS,":[82],"GSH":[83,130,143],"SOD":[86,133],"levels":[87,114,134],"than":[88],"controls":[89],"(P":[90,115,135,145],"<":[91,94,97,116,136,146],"0.05,":[92],"P":[93,96],"0.001,":[95,98],"respectively).":[99],"PTU":[100,161],"caused":[102],"relief":[104],"in":[105,122,129,142,159,168,171],"oxidative":[106],"stress":[107],"as":[108,166],"reflected":[109],"by":[110],"decreased":[112],"TBARS":[113],"0.001)":[117,137],"selective":[120,153],"modification":[121,154],"significant":[127,140],"decreases":[128],"increase":[141],"Px":[144],"0.01)":[147],"activity.":[148],"Our":[149],"findings":[150],"suggest":[151],"antioxidative":[157],"profile":[158],"hyperthyroidism.":[160],"should":[162],"also":[163],"be":[164],"considered":[165],"an":[167],"vivo":[169],"antioxidant,":[170],"addition":[172],"its":[174],"antithyroid":[175],"action.":[176]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}