{"id":"https://openalex.org/W2917834883","doi":"https://doi.org/10.1117/12.2507048","title":"Imaging neural activity in zebrafish larvae with adaptive optics and structured illumination light sheet microscopy","display_name":"Imaging neural activity in zebrafish larvae with adaptive optics and structured illumination light sheet microscopy","publication_year":2019,"publication_date":"2019-02-20","ids":{"openalex":"https://openalex.org/W2917834883","doi":"https://doi.org/10.1117/12.2507048","mag":"2917834883"},"language":"en","primary_location":{"id":"doi:10.1117/12.2507048","doi":"https://doi.org/10.1117/12.2507048","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2507048","pdf_url":null,"source":{"id":"https://openalex.org/S7407113914","display_name":"Adaptive Optics and Wavefront Control for Biological Systems","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adaptive Optics and Wavefront Control for Biological Systems V","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028181118","display_name":"Peter Kner","orcid":"https://orcid.org/0000-0001-7555-5180","observed_orcids":["https://orcid.org/0000-0001-7555-5180"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kner","raw_affiliation_strings":["The Univ. of Georgia (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Georgia (United States)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026060643","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-8168-5421","observed_orcids":["https://orcid.org/0000-0002-8168-5421"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["The Univ. of Georgia (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Georgia (United States)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102662061","display_name":"Aqsa Malik","orcid":"https://orcid.org/0009-0003-5127-1273","observed_orcids":["https://orcid.org/0009-0003-5127-1273"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aqsa Malik","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046460008","display_name":"Keelan Lawrence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keelan Lawrence","raw_affiliation_strings":["The Univ. of Georgia (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Georgia (United States)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097759653","display_name":"Chelsea E. Gunderson","orcid":"https://orcid.org/0000-0003-0007-7289","observed_orcids":["https://orcid.org/0000-0003-0007-7289"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea E. Gunderson","raw_affiliation_strings":["The Univ. of Georgia (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Georgia (United States)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rebecca Ball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Ball","raw_affiliation_strings":["The Univ. of Georgia (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Georgia (United States)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069049550","display_name":"James D. Lauderdale","orcid":"https://orcid.org/0000-0001-7503-0528","observed_orcids":["https://orcid.org/0000-0001-7503-0528"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Lauderdale","raw_affiliation_strings":["The Univ. of Georgia (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Georgia (United States)","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1101,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.86854742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"10499","issue":null,"first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish-larvae","display_name":"zebrafish larvae","score":0.9340000152587891},{"id":"https://openalex.org/keywords/neuronal-activity-imaging","display_name":"neuronal activity imaging","score":0.7739999890327454},{"id":"https://openalex.org/keywords/adaptive-optics","display_name":"adaptive optics","score":0.718999981880188},{"id":"https://openalex.org/keywords/structured-illumination","display_name":"structured illumination","score":0.7940000295639038},{"id":"https://openalex.org/keywords/light-sheet-microscopy","display_name":"light-sheet microscopy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/seizure-like-activity","display_name":"seizure-like activity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/refractive-index-change","display_name":"refractive index change","score":0.6600000262260437},{"id":"https://openalex.org/keywords/optical-aberration-correction","display_name":"optical aberration correction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/deep-tissue-imaging","display_name":"deep tissue imaging","score":0.5950000286102295},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C113976765","wikidata":"https://www.wikidata.org/wiki/Q1823502","display_name":"Light sheet fluorescence microscopy","level":4,"score":0.9294962286949158},{"id":"https://openalex.org/C20446124","wikidata":"https://www.wikidata.org/wiki/Q7098895","display_name":"Optical sectioning","level":3,"score":0.6557010412216187},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6444593667984009},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6329045295715332},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.6235073804855347},{"id":"https://openalex.org/C132771110","wikidata":"https://www.wikidata.org/wiki/Q506922","display_name":"Adaptive optics","level":2,"score":0.5944981575012207},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.465353786945343},{"id":"https://openalex.org/C42067758","wikidata":"https://www.wikidata.org/wiki/Q174102","display_name":"Refractive index","level":2,"score":0.44204437732696533},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4173605442047119},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.4167150557041168},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19681715965270996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1935102641582489},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17124760150909424},{"id":"https://openalex.org/C187921700","wikidata":"https://www.wikidata.org/wiki/Q7430074","display_name":"Scanning confocal electron microscopy","level":3,"score":0.1497608721256256},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1416603922843933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2507048","doi":"https://doi.org/10.1117/12.2507048","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2507048","pdf_url":null,"source":{"id":"https://openalex.org/S7407113914","display_name":"Adaptive Optics and Wavefront Control for Biological Systems","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adaptive Optics and Wavefront Control for Biological Systems V","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1856708139","https://openalex.org/W2006796899","https://openalex.org/W2017252663","https://openalex.org/W2020556902","https://openalex.org/W2026619291","https://openalex.org/W2031312855","https://openalex.org/W2039173702","https://openalex.org/W2050721997","https://openalex.org/W2056942342","https://openalex.org/W2057071627","https://openalex.org/W2059157514","https://openalex.org/W2083793763","https://openalex.org/W2087809363","https://openalex.org/W2091815433","https://openalex.org/W2103016955","https://openalex.org/W2109576877","https://openalex.org/W2114169008","https://openalex.org/W2144613560","https://openalex.org/W2167390012","https://openalex.org/W2426164422","https://openalex.org/W2535030769","https://openalex.org/W2598427385","https://openalex.org/W2602293332","https://openalex.org/W2765313388","https://openalex.org/W2784692733","https://openalex.org/W2793462084","https://openalex.org/W2794191694","https://openalex.org/W3101566021","https://openalex.org/W4235848594"],"related_works":["https://openalex.org/W2794191694","https://openalex.org/W4392682199","https://openalex.org/W7165800245","https://openalex.org/W2920056980","https://openalex.org/W3134198466","https://openalex.org/W3118972044","https://openalex.org/W3111120923","https://openalex.org/W2576404407","https://openalex.org/W3014626789","https://openalex.org/W2727646402"],"abstract_inverted_index":{"Zebrafish":[0],"are":[1,24],"an":[2,25],"important":[3],"vertebrate":[4],"model":[5,27],"used":[6],"to":[7,15,30,72,96,121,128],"view":[8,31],"the":[9,32,56,62,69,93,102,108,133],"mechanisms":[10],"underlying":[11],"seizure":[12,123],"disorders.":[13],"Due":[14],"their":[16],"relatively":[17],"small":[18],"size":[19],"and":[20,53,58,100,125],"transparency,":[21],"larval":[22],"zebrafish":[23],"excellent":[26],"through":[28],"which":[29],"occurence":[33],"of":[34],"seizure-like":[35],"neural":[36,117],"activity":[37,118],"in":[38,92],"vivo":[39],"using":[40],"light":[41,86],"sheet":[42,87],"fluorescence":[43],"microscopy":[44],"(LSFM).":[45],"Although":[46],"LSFM":[47],"possesses":[48],"good":[49],"optical":[50,98,130],"sectioning":[51],"capability":[52],"high":[54],"speed,":[55],"resolution":[57,103],"contrast":[59],"degrade":[60],"as":[61],"imaging":[63,105],"plane":[64],"is":[65,126],"moved":[66],"deeper":[67],"into":[68,107],"sample":[70],"due":[71],"refractive":[73],"index":[74],"variations.":[75],"We":[76,110],"have":[77],"developed":[78],"a":[79,83],"system":[80,114],"that":[81,112],"combines":[82],"structured":[84],"illumination":[85],"microscope":[88],"with":[89],"adaptive":[90],"optics":[91],"emission":[94],"path":[95],"correct":[97,129],"aberrations":[99,131],"increase":[101],"when":[104],"deep":[106],"sample.":[109,134],"show":[111],"our":[113],"can":[115],"record":[116],"fast":[119],"enough":[120],"capture":[122],"events,":[124],"able":[127],"throughout":[132]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-03-02T00:00:00"}