{"id":"https://openalex.org/W2916889802","doi":"https://doi.org/10.1021/acs.biochem.9b00068","title":"A Shared Mechanism for the Folding of Voltage-Gated K+ Channels","display_name":"A Shared Mechanism for the Folding of Voltage-Gated K+ Channels","publication_year":2019,"publication_date":"2019-02-22","ids":{"openalex":"https://openalex.org/W2916889802","doi":"https://doi.org/10.1021/acs.biochem.9b00068","mag":"2916889802","pmid":"https://pubmed.ncbi.nlm.nih.gov/30793887","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6588284"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.9b00068","doi":"https://doi.org/10.1021/acs.biochem.9b00068","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00068","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6588284","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076094088","display_name":"Sarah K. McDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah K. McDonald","raw_affiliation_strings":["Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066071787","display_name":"Talya S. Levitz","orcid":"https://orcid.org/0000-0001-9938-7580","observed_orcids":["https://orcid.org/0000-0001-9938-7580"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talya S. Levitz","raw_affiliation_strings":["Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030012812","display_name":"Francis I. Valiyaveetil","orcid":"https://orcid.org/0000-0002-3387-8018","observed_orcids":["https://orcid.org/0000-0002-3387-8018"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francis I. Valiyaveetil","raw_affiliation_strings":["Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, United States"],"raw_orcid":"https://orcid.org/0000-0002-3387-8018","affiliations":[{"raw_affiliation_string":"Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030012812"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.3308,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.50907579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"12","first_page":"1660","last_page":"1671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8769999742507935},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6209999918937683},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tetramerization","display_name":"tetramerization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.7300000190734863},{"id":"https://openalex.org/keywords/dimer-of-dimers","display_name":"dimer of dimers","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.8029999732971191},{"id":"https://openalex.org/keywords/folding-pathways","display_name":"folding pathways","score":0.4339999854564667},{"id":"https://openalex.org/keywords/channel-assembly","display_name":"channel assembly","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6302089691162109},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5845718383789062},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5764486193656921},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5661265254020691},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.500032901763916},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4938862919807434},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.4766553044319153},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.42545393109321594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2977863550186157},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.19140487909317017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11433100700378418},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D041522","descriptor_name":"Aeropyrum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.biochem.9b00068","doi":"https://doi.org/10.1021/acs.biochem.9b00068","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00068","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:30793887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30793887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6588284","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6588284","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6588284","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6588284","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3150305461","display_name":"Probing functional mechanisms in K+ channels using unnatural mutagenesis","funder_award_id":"R01GM087546","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W6949998","https://openalex.org/W95681726","https://openalex.org/W1524723825","https://openalex.org/W1540419168","https://openalex.org/W1565093592","https://openalex.org/W1850795218","https://openalex.org/W1969129798","https://openalex.org/W1969549030","https://openalex.org/W1971293653","https://openalex.org/W1976455693","https://openalex.org/W1978052549","https://openalex.org/W1980573183","https://openalex.org/W1983178254","https://openalex.org/W1987313471","https://openalex.org/W1990792736","https://openalex.org/W1991594572","https://openalex.org/W1992864587","https://openalex.org/W2005496553","https://openalex.org/W2011565078","https://openalex.org/W2024141394","https://openalex.org/W2027711565","https://openalex.org/W2029667189","https://openalex.org/W2032734987","https://openalex.org/W2033242114","https://openalex.org/W2039849471","https://openalex.org/W2043557479","https://openalex.org/W2049520220","https://openalex.org/W2049821301","https://openalex.org/W2055043387","https://openalex.org/W2056072103","https://openalex.org/W2057653477","https://openalex.org/W2065197175","https://openalex.org/W2070504376","https://openalex.org/W2080434522","https://openalex.org/W2082362903","https://openalex.org/W2085794233","https://openalex.org/W2094122978","https://openalex.org/W2106670341","https://openalex.org/W2107008091","https://openalex.org/W2107537025","https://openalex.org/W2108022643","https://openalex.org/W2112680381","https://openalex.org/W2116391487","https://openalex.org/W2131816541","https://openalex.org/W2135946423","https://openalex.org/W2139553445","https://openalex.org/W2142660615","https://openalex.org/W2152197489","https://openalex.org/W2158697417","https://openalex.org/W2165499430","https://openalex.org/W2265567744","https://openalex.org/W2273299625","https://openalex.org/W2314225431","https://openalex.org/W2328349784","https://openalex.org/W2331638543","https://openalex.org/W2339750916","https://openalex.org/W2346822460","https://openalex.org/W2521315420","https://openalex.org/W2524821347","https://openalex.org/W2587906106","https://openalex.org/W2981516656","https://openalex.org/W2990430151","https://openalex.org/W3031949211"],"related_works":["https://openalex.org/W3031949211","https://openalex.org/W2051881490","https://openalex.org/W126082365","https://openalex.org/W2287948079","https://openalex.org/W6939342305","https://openalex.org/W2911393077","https://openalex.org/W3169960006","https://openalex.org/W2029259174","https://openalex.org/W3194898706","https://openalex.org/W2912452525"],"abstract_inverted_index":{"In":[0],"this":[1,151,236],"study,":[2],"we":[3],"probe":[4],"the":[5,41,60,72,80,84,114,123,135,143,159,162,165,181,186,194,220,242,252,264],"folding":[6,61,113,184,215,221,265],"of":[7,25,40,71,142,164,174,185,193,224,230,244,267],"K":[8,13,20,35,42,73,115,144,166,187,200,209,226,253,268],"v":[9,16,21,36,43,74,116,145,167,188,210,227,254,269],"AP,":[10],"a":[11,94,103,127,132,155,172,213,225],"voltage-gated":[12,199],"+":[14,201],"(K":[15],")":[17],"channel.":[18,147],"The":[19,217],"AP":[22,44,75,117,146,168,189,255],"channel,":[23],"though":[24],"archaebacterial":[26],"origin,":[27],"is":[28,46,119,138,229],"structurally":[29],"and":[30,59,83,102,203,222],"functionally":[31],"similar":[32],"to":[33,77,98,106],"eukaryotic":[34],"channels.":[37,270],"An":[38],"advantage":[39],"channel":[45,76,169,190,228,256],"that":[47,111,137,150,161,180,206,251],"it":[48],"can":[49,62],"be":[50,63],"folded":[51],"in":[52,182,235,241],"vitro":[53,183],"from":[54],"an":[55,258],"extensively":[56],"unfolded":[57],"state":[58],"controlled":[64],"by":[65],"temperature.":[66],"We":[67,89,109,130,148],"utilize":[68],"these":[69],"properties":[70],"separately":[78],"study":[79],"membrane":[81,100],"insertion":[82,101],"tetramerization":[85,163],"stages":[86],"during":[87,112],"folding.":[88],"use":[90],"two":[91],"quantitative":[92],"assays:":[93],"Cys":[95],"PEGylation":[96],"assay":[97,105],"monitor":[99,107],"cross-linking":[104],"tetramerization.":[108],"show":[110,149,179],"polypeptide":[118],"rapidly":[120],"inserted":[121],"into":[122],"lipid":[124],"bilayer":[125],"with":[126],"\u201cnative-like\u201d":[128],"topology.":[129],"identify":[131],"segment":[133],"at":[134],"C-terminus":[136],"important":[139],"for":[140,198,219,262],"multimerization":[141],"C-terminal":[152],"domain":[153],"forms":[154],"dimer,":[156],"which":[157],"raises":[158],"possibility":[160],"proceeds":[170],"through":[171],"dimer":[173],"dimers":[175],"pathway.":[176,216],"Our":[177,248],"studies":[178,249],"mirrors":[191],"aspects":[192],"cellular":[195],"assembly":[196,223],"pathway":[197,218,237],"channels":[202,211],"therefore":[204],"suggest":[205],"evolutionarily":[207],"distinct":[208],"share":[212],"common":[214],"central":[231],"importance":[232],"as":[233],"defects":[234],"have":[238],"been":[239],"implicated":[240],"etiology":[243],"several":[245],"disease":[246],"states.":[247],"indicate":[250],"provides":[257],"experimentally":[259],"tractable":[260],"system":[261],"elucidating":[263],"mechanism":[266]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-03-02T00:00:00"}
