{"id":"https://openalex.org/W2916574153","doi":"https://doi.org/10.1158/1078-0432.ccr-18-2206","title":"Effects of Age and Immune Landscape on Outcome in HER2-Positive Breast Cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) Trials","display_name":"Effects of Age and Immune Landscape on Outcome in HER2-Positive Breast Cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) Trials","publication_year":2019,"publication_date":"2019-02-26","ids":{"openalex":"https://openalex.org/W2916574153","doi":"https://doi.org/10.1158/1078-0432.ccr-18-2206","mag":"2916574153","pmid":"https://pubmed.ncbi.nlm.nih.gov/30808774","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634998"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-18-2206","doi":"https://doi.org/10.1158/1078-0432.ccr-18-2206","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-18-2206","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052187738","display_name":"Saranya Chumsri","orcid":"https://orcid.org/0000-0001-7117-1446","observed_orcids":["https://orcid.org/0000-0001-7117-1446"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saranya Chumsri","raw_affiliation_strings":["1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033771723","display_name":"Daniel Serie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Serie","raw_affiliation_strings":["2Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642999","display_name":"Zhuo Li","orcid":"https://orcid.org/0000-0003-0839-7236","observed_orcids":["https://orcid.org/0000-0003-0839-7236"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo Li","raw_affiliation_strings":["2Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079315515","display_name":"Katherine L. Pogue\u2013Geile","orcid":"https://orcid.org/0000-0002-9855-046X","observed_orcids":["https://orcid.org/0000-0002-9855-046X"]},"institutions":[{"id":"https://openalex.org/I4210162619","display_name":"NRG Oncology","ror":"https://ror.org/050draa26","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162619"]},{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine L. Pogue-Geile","raw_affiliation_strings":["3National Surgical Adjuvant Breast and Bowel Project (now NRG Oncology), Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Surgical Adjuvant Breast and Bowel Project (now NRG Oncology), Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I4210162619","https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035099790","display_name":"Aixa E. Soyano\u2010Muller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aixa E. Soyano-Muller","raw_affiliation_strings":["1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034422841","display_name":"Afshin Mashadi-Hossein","orcid":"https://orcid.org/0000-0002-2337-2195","observed_orcids":["https://orcid.org/0000-0002-2337-2195"]},"institutions":[{"id":"https://openalex.org/I4210099129","display_name":"Nanostring Technologies (United States)","ror":"https://ror.org/00xzdzk88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Afshin Mashadi-Hossein","raw_affiliation_strings":["4NanoString Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4NanoString Inc., Seattle, Washington","institution_ids":["https://openalex.org/I4210099129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082913203","display_name":"Sarah E. Warren","orcid":"https://orcid.org/0000-0001-9465-8636","observed_orcids":["https://orcid.org/0000-0001-9465-8636"]},"institutions":[{"id":"https://openalex.org/I4210099129","display_name":"Nanostring Technologies (United States)","ror":"https://ror.org/00xzdzk88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Warren","raw_affiliation_strings":["4NanoString Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4NanoString Inc., Seattle, Washington","institution_ids":["https://openalex.org/I4210099129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034847496","display_name":"Yanyan Lou","orcid":"https://orcid.org/0000-0001-6207-9461","observed_orcids":["https://orcid.org/0000-0001-6207-9461"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyan Lou","raw_affiliation_strings":["1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057155689","display_name":"Gerardo Col\u00f3n\u2010Otero","orcid":"https://orcid.org/0000-0002-9159-2421","observed_orcids":["https://orcid.org/0000-0002-9159-2421"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerardo Colon-Otero","raw_affiliation_strings":["1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith L. Knutson","raw_affiliation_strings":["5Department of Immunology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Immunology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065306642","display_name":"Edith A. Perez","orcid":"https://orcid.org/0000-0002-5037-6677","observed_orcids":["https://orcid.org/0000-0002-5037-6677","https://orcid.org/0000-0001-7009-7467"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith A. Perez","raw_affiliation_strings":["1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","6Genentech Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"6Genentech Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027821205","display_name":"Alvaro Moreno\u2010Aspitia","orcid":"https://orcid.org/0000-0002-2317-2580","observed_orcids":["https://orcid.org/0000-0002-2317-2580"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvaro Moreno-Aspitia","raw_affiliation_strings":["1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026692399","display_name":"E. Aubrey Thompson","orcid":"https://orcid.org/0000-0002-9001-4240","observed_orcids":["https://orcid.org/0000-0002-9001-4240"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Aubrey Thompson","raw_affiliation_strings":["7Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5052187738"],"corresponding_institution_ids":["https://openalex.org/I4210146710"],"apc_list":null,"apc_paid":null,"fwci":0.2051,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.53553745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"14","first_page":"4422","last_page":"4430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.28780001401901245,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.5519999861717224},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/immune-landscape","display_name":"immune landscape","score":0.6639999747276306},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.718999981880188},{"id":"https://openalex.org/keywords/lymphocyte-predominant-breast-cancer","display_name":"lymphocyte-predominant breast cancer","score":0.9179999828338623},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.42899999022483826},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7275100350379944},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6624429821968079},{"id":"https://openalex.org/C2778431023","wikidata":"https://www.wikidata.org/wiki/Q878249","display_name":"Alliance","level":2,"score":0.5698044896125793},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5618562698364258},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5404902100563049},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5402683019638062},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.51543128490448},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.5118964910507202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4199044108390808},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24357813596725464},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-18-2206","doi":"https://doi.org/10.1158/1078-0432.ccr-18-2206","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-18-2206","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:30808774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30808774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:pubmedcentral.nih.gov:6634998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6634998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1410909402","display_name":"Alliance Statistics and Data Management Center","funder_award_id":"U10CA180882","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2305271638","display_name":null,"funder_award_id":"6BC05","funder_id":"https://openalex.org/F4320310997","funder_display_name":"Bankhead-Coley Foundation"},{"id":"https://openalex.org/G2983694760","display_name":"NRG Oncology NCORP Research Base","funder_award_id":"UG1CA189867","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4319480698","display_name":"NRG Oncology Network Group Operations Center","funder_award_id":"U10CA180868","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7628471067","display_name":null,"funder_award_id":"BCRF-17-161","funder_id":"https://openalex.org/F4320306260","funder_display_name":"Breast Cancer Research Foundation"},{"id":"https://openalex.org/G8740451518","display_name":"Alliance for Clinical Trials in Oncology Operations Center","funder_award_id":"U10CA180821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000872750","display_name":"The Alliance NCTN Biorepository and Biospecimen Resource","funder_award_id":"U24CA196171","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000885485","display_name":"NRG Oncology Biospecimen Bank","funder_award_id":"U24CA196067","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G982783723","display_name":"NRG Oncology - Statistical and Data Management Center","funder_award_id":"U10CA180822","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320310997","display_name":"Bankhead-Coley Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W70267596","https://openalex.org/W1757030565","https://openalex.org/W1880181228","https://openalex.org/W1961978963","https://openalex.org/W1979538859","https://openalex.org/W1996778928","https://openalex.org/W2000269004","https://openalex.org/W2000798782","https://openalex.org/W2005830551","https://openalex.org/W2019263634","https://openalex.org/W2040935952","https://openalex.org/W2041586952","https://openalex.org/W2043228552","https://openalex.org/W2094436094","https://openalex.org/W2096884232","https://openalex.org/W2098683355","https://openalex.org/W2102392885","https://openalex.org/W2112434826","https://openalex.org/W2120431466","https://openalex.org/W2128402413","https://openalex.org/W2130034035","https://openalex.org/W2133483909","https://openalex.org/W2134878729","https://openalex.org/W2135061646","https://openalex.org/W2140916758","https://openalex.org/W2141393790","https://openalex.org/W2141546964","https://openalex.org/W2146384083","https://openalex.org/W2157058802","https://openalex.org/W2158734599","https://openalex.org/W2160332393","https://openalex.org/W2161849165","https://openalex.org/W2164459172","https://openalex.org/W2214665719","https://openalex.org/W2560367415","https://openalex.org/W2606700663","https://openalex.org/W2806866264","https://openalex.org/W2952406594"],"related_works":["https://openalex.org/W2622017248","https://openalex.org/W4213249743","https://openalex.org/W4251334535","https://openalex.org/W2332130251","https://openalex.org/W2164459172","https://openalex.org/W3018818368","https://openalex.org/W4229032102","https://openalex.org/W4379284480","https://openalex.org/W4389816165","https://openalex.org/W2599972742"],"abstract_inverted_index":{"PURPOSE:":[0],"Young":[1],"age":[2,82,137],"has":[3],"been":[4],"shown":[5],"to":[6,167],"be":[7],"an":[8],"independent":[9],"predictor":[10],"of":[11,23,32,136],"poor":[12,86,177],"outcome":[13,87,165],"in":[14,88,99,116,164],"breast":[15,19,140],"cancer.":[16],"In":[17],"HER2-positive":[18],"cancer,":[20],"the":[21,89,95,176],"effects":[22],"aging":[24],"remain":[25],"largely":[26],"unknown.":[27],"EXPERIMENTAL":[28],"DESIGN:":[29],"A":[30],"total":[31],"4,547":[33],"patients":[34,76,127,132,155],"were":[35,70,124],"included":[36],"[3,132":[37],"from":[38,48],"North":[39],"Central":[40],"Cancer":[41],"Treatment":[42],"Group":[43],"(NCCTG)":[44],"N9831":[45],"and":[46,53,63,109,119],"1,415":[47],"National":[49],"Surgical":[50],"Adjuvant":[51],"Breast":[52],"Bowel":[54],"Project":[55],"(NSABP)":[56],"B-31].":[57],"Pathologic":[58],"stromal":[59],"tumor-infiltrating":[60],"lymphocyte":[61,67],"(sTIL)":[62],"molecular":[64],"tumor":[65],"infiltrating":[66],"(mTIL)":[68],"signatures":[69,123],"evaluated.":[71],"RESULTS:":[72],"<":[73],"0.001).":[74],"Among":[75,126,154],"who":[77,128],"received":[78,129],"chemotherapy":[79,130],"alone,":[80,131],"younger":[81],"was":[83,104,160],"associated":[84,179],"with":[85,138,145,157,180],"hormone":[90,96],"receptor-positive":[91],"subset,":[92,98],"but":[93,113],"not":[94],"receptor-negative":[97],"both":[100],"trials.":[101],"Although":[102],"there":[103,159],"no":[105,161],"association":[106],"between":[107],"sTILs":[108],"age,":[110],"a":[111],"small,":[112],"significant":[114,162],"increase":[115],"mTIL":[117],"CD45":[118],"some":[120],"immune":[121],"subset":[122],"observed.":[125],"over":[133],"40":[134],"years":[135],"lymphocyte-predominant":[139],"cancer":[141],"had":[142],"excellent":[143],"outcome,":[144],"95%":[146],"remaining":[147],"recurrence":[148],"free":[149],"at":[150],"15":[151],"years.":[152],"CONCLUSIONS:":[153],"treated":[156],"trastuzumab,":[158],"difference":[163],"related":[166],"age.":[168,182],"Our":[169],"study":[170],"suggests":[171],"that":[172],"trastuzumab":[173],"can":[174],"negate":[175],"prognosis":[178],"young":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-02T00:00:00"}
