{"id":"https://openalex.org/W2916260975","doi":null,"title":"Daily penicillin serum concentrations following injection of 2.4 mega-units of \"all purpose\" penicillin.","display_name":"Daily penicillin serum concentrations following injection of 2.4 mega-units of \"all purpose\" penicillin.","publication_year":1966,"publication_date":"1966-01-01","ids":{"openalex":"https://openalex.org/W2916260975","mag":"2916260975","pmid":"https://pubmed.ncbi.nlm.nih.gov/5298035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2476289"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1445973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2476289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2476289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058054469","display_name":"A E Tinkler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Tinkler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011206638","display_name":"Robert Shannon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Shannon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"6","first_page":"857","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzathine-penicillin","display_name":"benzathine penicillin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/procaine-penicillin","display_name":"procaine penicillin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/penicillin-g-potassium","display_name":"penicillin G potassium","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6890000104904175},{"id":"https://openalex.org/keywords/absorption-rate","display_name":"absorption rate","score":0.6480000019073486},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.9357595443725586},{"id":"https://openalex.org/C2779828710","wikidata":"https://www.wikidata.org/wiki/Q423741","display_name":"Procaine","level":2,"score":0.632655918598175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6247222423553467},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.46390172839164734},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4199901223182678},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2962478995323181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2930188775062561},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2571171820163727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2286001443862915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07839807868003845},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06850132346153259}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010401","descriptor_name":"Penicillin G Benzathine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010402","descriptor_name":"Penicillin G Procaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1445973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2476289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:5298035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5298035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2476289","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2476289/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull World Health Organ","raw_type":"Text"},{"id":"mag:2916260975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5298035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1445973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2476289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1595759791","https://openalex.org/W2261288220","https://openalex.org/W2278897938"],"related_works":["https://openalex.org/W1595759791","https://openalex.org/W2111389718","https://openalex.org/W2040388813","https://openalex.org/W2008946490","https://openalex.org/W4409132813","https://openalex.org/W1981839476","https://openalex.org/W1482462033","https://openalex.org/W2220299403","https://openalex.org/W1513188175","https://openalex.org/W2782090798"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,74,189,196,264],"investigate":[3],"the":[4,26,72,75,86,90,93,104,127,141,161,165,197,209,218,239,266],"reliability":[5],"with":[6,35,138],"which":[7,171,183,201],"a":[8,114,122,254],"given":[9],"dose":[10,162,247],"of":[11,19,40,60,85,92,95,117,121,132,140,148,199,220,226,235,241,258,270],"benzathine":[12,61,236,273],"penicillin":[13,42,47,53,237],"will":[14],"result":[15],"in":[16,82,113,207,212,244],"predictable":[17],"ranges":[18,112,225],"penicillinaemia":[20,227],"on":[21,185],"any":[22],"particular":[23],"day":[24,77],"during":[25],"week":[27],"after":[28,78,217,229],"injection,":[29],"ambulant":[30],"adult":[31],"males":[32],"were":[33,66,135],"injected":[34],"2":[36],"400":[37],"000":[38,44,50,58],"IU":[39,45,51,59],"\"all-purpose\"":[41,133],"(600":[43],"potassium":[46],"G,":[48],"600":[49],"procaine":[52],"G":[54],"and":[55,152,177,232,238,248,272],"1":[56],"200":[57],"penicillin).":[62],"Penicillin":[63],"serum":[64,155,213,250],"assays":[65,81,97],"performed,":[67],"24":[68,96],"each":[69],"day,":[70],"from":[71],"third":[73],"seventh":[76],"injection":[79],"(120":[80],"all).Statistical":[83],"evaluation":[84],"results":[87,120],"showed":[88],"that":[89,103,181,253],"means":[91],"groups":[94],"fell":[98],"within":[99],"narrow":[100,224],"ranges,":[101],"indicating":[102],"long-acting":[105,268],"component":[106],"(benzathine":[107],"penicillin)":[108,134],"gives":[109],"reliable":[110],"daily":[111,154,166],"high":[115],"proportion":[116],"cases.":[118],"The":[119,168,223],"previous":[123],"trial,":[124],"using":[125],"half":[126],"present":[128,142],"dosage":[129,151],"(1.2":[130],"mega-units":[131,231,234],"compared":[136],"statistically":[137],"those":[139],"trial.":[143],"A":[144],"very":[145],"satisfactory":[146],"degree":[147,240],"correlation":[149,242],"between":[150,246],"resulting":[153,249],"concentration":[156],"was":[157],"observed-in":[158],"general":[159,245],"double":[160,164],"yielded":[163],"concentration.":[167],"many":[169],"factors":[170],"affect":[172],"absorption":[173,191],"rate":[174],"are":[175],"discussed":[176],"it":[178],"is":[179],"suggested":[180],"preparations":[182],"depend":[184],"an":[186,193,204],"oily":[187],"gel":[188],"delay":[190],"add":[192],"avoidable":[194],"factor":[195],"list":[198],"variables":[200],"may":[202],"play":[203],"important":[205],"part":[206],"producing":[208],"significant":[210],"differences":[211],"levels":[214,251],"commonly":[215],"reported":[216],"use":[219],"PAM":[221,271],"preparations.":[222],"observed":[228,243],"1.2":[230],"2.4":[233],"suggest":[252],"large-scale":[255],"controlled":[256],"series":[257],"parallel":[259],"trials":[260],"should":[261],"be":[262],"undertaken":[263],"compare":[265],"relative":[267],"qualities":[269],"penicillin.":[274]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-03-02T00:00:00"}