{"id":"https://openalex.org/W2916104580","doi":"https://doi.org/10.3390/ijms20040948","title":"HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch","display_name":"HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch","publication_year":2019,"publication_date":"2019-02-22","ids":{"openalex":"https://openalex.org/W2916104580","doi":"https://doi.org/10.3390/ijms20040948","mag":"2916104580","pmid":"https://pubmed.ncbi.nlm.nih.gov/30813222","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6412492"},"language":"en","primary_location":{"id":"doi:10.3390/ijms20040948","doi":"https://doi.org/10.3390/ijms20040948","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20040948","pdf_url":"https://www.mdpi.com/1422-0067/20/4/948/pdf?version=1550805881","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/20/4/948/pdf?version=1550805881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031613696","display_name":"Nadir Yehya","orcid":"https://orcid.org/0000-0002-2996-217X","observed_orcids":["https://orcid.org/0000-0002-2996-217X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nadir Yehya","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Children\u2019 Hospital of Philadelphia and University of Pennsylvania, Suite 7C-26, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA","Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0002-2996-217X","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Children\u2019 Hospital of Philadelphia and University of Pennsylvania, Suite 7C-26, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039233729","display_name":"Min Jae Song","orcid":"https://orcid.org/0000-0003-1744-0806","observed_orcids":["https://orcid.org/0000-0003-1744-0806"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Jae Song","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0003-1744-0806","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003798249","display_name":"Gladys G. Lawrence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gladys G. Lawrence","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005906505","display_name":"Susan Sheps Margulies","orcid":"https://orcid.org/0000-0002-3615-7902","observed_orcids":["https://orcid.org/0000-0002-3615-7902"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan S. Margulies","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA","Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering, Emory University School of Medicine, Atlanta, GA 30332, USA"],"raw_orcid":"https://orcid.org/0000-0002-3615-7902","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 40 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering, Emory University School of Medicine, Atlanta, GA 30332, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031613696"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.7309,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71590895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"4","first_page":"948","last_page":"948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-signaling","display_name":"HER2 signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/amphiregulin","display_name":"amphiregulin","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cyclic-stretch","display_name":"cyclic strain","score":0.6309999823570251},{"id":"https://openalex.org/keywords/alveolar-epithelial-permeability","display_name":"alveolar epithelial permeability","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ventilator-induced-lung-injury","display_name":"ventilator-induced lung injury","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.7760000228881836},{"id":"https://openalex.org/keywords/claudin-7","display_name":"claudin-7","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mir-15b","display_name":"miR-15b","score":0.9639999866485596},{"id":"https://openalex.org/keywords/her2-inhibition","display_name":"HER2 inhibition","score":0.597000002861023},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8297626972198486},{"id":"https://openalex.org/C2778560701","wikidata":"https://www.wikidata.org/wiki/Q14914188","display_name":"Neuregulin 1","level":3,"score":0.696580708026886},{"id":"https://openalex.org/C2780806702","wikidata":"https://www.wikidata.org/wiki/Q14866198","display_name":"Amphiregulin","level":4,"score":0.6489735841751099},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5973138213157654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5458136796951294},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47113341093063354},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.46539080142974854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4499548077583313},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3839430809020996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33380115032196045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30400294065475464},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.26717621088027954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10716313123703003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06834548711776733},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055397","descriptor_name":"Ventilator-Induced Lung Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056809","descriptor_name":"Alveolar Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056809","descriptor_name":"Alveolar Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms20040948","doi":"https://doi.org/10.3390/ijms20040948","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20040948","pdf_url":"https://www.mdpi.com/1422-0067/20/4/948/pdf?version=1550805881","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5434289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6412492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6412492","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6412492","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:30813222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30813222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:18c7f25e8a794f24b0825a16aeb1af81","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/18c7f25e8a794f24b0825a16aeb1af81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 20, Iss 4, p 948 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms20040948","doi":"https://doi.org/10.3390/ijms20040948","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20040948","pdf_url":"https://www.mdpi.com/1422-0067/20/4/948/pdf?version=1550805881","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1526133384","display_name":null,"funder_award_id":"NHLBI K23","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1561858362","display_name":"Mechanical Injury of the Alveolar Epithelium","funder_award_id":"R01HL057204","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2816149824","display_name":null,"funder_award_id":"HL109009","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3873264029","display_name":"Clinical and Proteomic Characterization of Nucleosomes in Pediatric Acute Respiratory Distress Syndrome","funder_award_id":"K23HL136688","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4088604082","display_name":null,"funder_award_id":"HL-57204","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5932186303","display_name":"Enabling Medical Research Growth in Emergency Medicine","funder_award_id":"K12HL109009","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G640430542","display_name":null,"funder_award_id":"NHLBI R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2916104580.pdf","grobid_xml":"https://content.openalex.org/works/W2916104580.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1476289819","https://openalex.org/W1601076886","https://openalex.org/W1766556848","https://openalex.org/W1888618913","https://openalex.org/W1910618583","https://openalex.org/W1949178966","https://openalex.org/W1964321121","https://openalex.org/W1990112482","https://openalex.org/W2016586043","https://openalex.org/W2043447260","https://openalex.org/W2043932858","https://openalex.org/W2050157039","https://openalex.org/W2063404320","https://openalex.org/W2084694142","https://openalex.org/W2105999224","https://openalex.org/W2122641338","https://openalex.org/W2140302836","https://openalex.org/W2142485527","https://openalex.org/W2161469273","https://openalex.org/W2181000927","https://openalex.org/W2184912832","https://openalex.org/W2316982122","https://openalex.org/W2597070792"],"related_works":["https://openalex.org/W2084694142","https://openalex.org/W2598340489","https://openalex.org/W2142485527","https://openalex.org/W4387453835","https://openalex.org/W2014116796","https://openalex.org/W1978717485","https://openalex.org/W2059888335","https://openalex.org/W2063404320","https://openalex.org/W2468945149","https://openalex.org/W3157689839"],"abstract_inverted_index":{"Mechanical":[0],"ventilation":[1],"can":[2,6],"be":[3],"damaging,":[4],"and":[5,29,55,65,75,83,105,137,175,222],"cause":[7],"or":[8,127],"exacerbate":[9],"ventilator-induced":[10],"lung":[11],"injury":[12],"(VILI).":[13],"The":[14,70,147,161],"human":[15],"epidermal":[16],"growth":[17],"factor":[18],"receptor":[19],"(HER)":[20],"ligand":[21,74,204],"neuregulin-1":[22],"(NRG1)":[23],"activates":[24,199],"HER2":[25,39,76,135,158,200,233,239],"heterodimerization":[26],"with":[27,108,122,142,153,178],"HER3,":[28],"has":[30],"been":[31],"implicated":[32],"in":[33,84,89,118],"inflammatory":[34],"injuries.":[35],"We":[36,44,194],"hypothesized":[37],"that":[38,196],"activation":[40,240],"contributes":[41],"to":[42,167,207],"VILI.":[43,94,193,237,247],"analyzed":[45],"a":[46,90,154,242],"database":[47],"of":[48,72,93,96,103,130,145,157,163,216,219,229],"differentially":[49],"expressed":[50],"genes":[51],"between":[52],"cyclically":[53],"stretched":[54],"unstretched":[56],"rat":[57,91],"alveolar":[58],"epithelial":[59],"cells":[60],"(RAEC)":[61],"for":[62,245],"HER":[63],"ligands":[64],"validated":[66],"the":[67,73,101,143,202,214,226],"differential":[68],"expression.":[69],"effect":[71],"inhibition":[77,228,234],"on":[78],"RAEC":[79],"permeability":[80],"was":[81,87,176],"tested,":[82],"vivo":[85,232],"relevance":[86],"assessed":[88],"model":[92],"Analysis":[95],"our":[97],"expression":[98],"array":[99],"revealed":[100],"upregulation":[102,144],"NRG1":[104,110,180,220],"amphiregulin":[106],"(AREG)":[107],"stretch.":[109],"protein,":[111],"but":[112],"not":[113],"AREG,":[114],"increased":[115,208],"after":[116],"stretch":[117,198],"culture":[119],"media.":[120],"Treatment":[121],"an":[123,128],"NRG1-cleavage":[124],"inhibitor":[125,129,156],"(TAPI2)":[126],"NRG1-binding":[131],"(anti-HER3":[132],"antibody)":[133],"reduced":[134],"phosphorylation":[136,159],"partially":[138],"mitigated":[139,212],"stretch-induced":[140,173],"permeability,":[141,174],"claudin-7.":[146],"results":[148],"were":[149,211],"reproduced":[150],"by":[151,213,225],"treatment":[152],"direct":[155,227],"(AG825).":[160],"transfection":[162],"microRNA":[164],"miR-15b,":[165],"predicted":[166],"negatively":[168],"regulate":[169],"NRG1,":[170,205,217],"also":[171,235],"attenuated":[172,192,236],"associated":[177],"lower":[179],"mRNA":[181],"levels.":[182],"In":[183,231],"rats":[184],"ventilated":[185],"at":[186],"damaging":[187],"tidal":[188],"volumes,":[189],"AG825":[190],"partly":[191],"concluded":[195],"cyclic":[197],"via":[201],"HER3":[203],"leading":[206],"permeability.":[209],"Outcomes":[210],"downregulation":[215],"prevention":[218],"binding,":[221],"most":[223],"strongly":[224],"HER2.":[230],"Ligand-dependent":[238],"is":[241],"potential":[243],"target":[244],"reducing":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-03-02T00:00:00"}
