{"id":"https://openalex.org/W2915909129","doi":"https://doi.org/10.1021/acsbiomaterials.8b01522","title":"Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc\u2014Pitching a Next-Generation Research Platform To Study Disc Degeneration","display_name":"Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc\u2014Pitching a Next-Generation Research Platform To Study Disc Degeneration","publication_year":2019,"publication_date":"2019-02-26","ids":{"openalex":"https://openalex.org/W2915909129","doi":"https://doi.org/10.1021/acsbiomaterials.8b01522","mag":"2915909129","pmid":"https://pubmed.ncbi.nlm.nih.gov/31763444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6874371"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.8b01522","doi":"https://doi.org/10.1021/acsbiomaterials.8b01522","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b01522","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6874371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029911700","display_name":"Jun Dai","orcid":"https://orcid.org/0000-0001-5155-8838","observed_orcids":["https://orcid.org/0000-0001-5155-8838"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jun Dai","raw_affiliation_strings":["Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue Qiaokou District, Wuhan 430030, P.R. China","Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":"https://orcid.org/0000-0001-5155-8838","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue Qiaokou District, Wuhan 430030, P.R. China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005895228","display_name":"Yuan Xing","orcid":"https://orcid.org/0000-0002-1596-1862","observed_orcids":["https://orcid.org/0000-0002-1596-1862"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Xing","raw_affiliation_strings":["Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100607286","display_name":"Li Xiao","orcid":"https://orcid.org/0000-0003-1403-7472","observed_orcids":["https://orcid.org/0000-0003-1403-7472","https://orcid.org/0000-0001-8665-7481"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Xiao","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":"https://orcid.org/0000-0003-1403-7472","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399433","display_name":"Jingyi Li","orcid":"https://orcid.org/0000-0002-3126-7889","observed_orcids":["https://orcid.org/0000-0002-3126-7889","https://orcid.org/0000-0001-9968-9933"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingyi Li","raw_affiliation_strings":["Department of Chemistry, University of Virginia, 409 McCormick Road, Charlottesville, Virginia 22904, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, 409 McCormick Road, Charlottesville, Virginia 22904, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041226583","display_name":"Ruofan Cao","orcid":"https://orcid.org/0000-0002-0171-5089","observed_orcids":["https://orcid.org/0000-0002-0171-5089"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruofan Cao","raw_affiliation_strings":["W.M. Keck Center for Cellular Imaging, University of Virginia, 90 Geldard Drive, Charlottesville, Virginia 22904, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Center for Cellular Imaging, University of Virginia, 90 Geldard Drive, Charlottesville, Virginia 22904, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045687590","display_name":"Ying He","orcid":"https://orcid.org/0000-0002-0072-8566","observed_orcids":["https://orcid.org/0000-0002-0072-8566","https://orcid.org/0000-0003-3464-4018"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi He","raw_affiliation_strings":["Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huang Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huang Fang","raw_affiliation_strings":["Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue Qiaokou District, Wuhan 430030, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue Qiaokou District, Wuhan 430030, P.R. China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036459144","display_name":"Ammasi Periasamy","orcid":"https://orcid.org/0000-0001-5431-509X","observed_orcids":["https://orcid.org/0000-0001-5431-509X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ammasi Periasamy","raw_affiliation_strings":["W.M. Keck Center for Cellular Imaging, University of Virginia, 90 Geldard Drive, Charlottesville, Virginia 22904, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Center for Cellular Imaging, University of Virginia, 90 Geldard Drive, Charlottesville, Virginia 22904, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002413492","display_name":"Jose Oberhozler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Oberhozler","raw_affiliation_strings":["Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102020073","display_name":"Li Jin","orcid":"https://orcid.org/0000-0002-4648-0500","observed_orcids":["https://orcid.org/0000-0002-4648-0500"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Jin","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031563436","display_name":"James P. Landers","orcid":"https://orcid.org/0000-0002-9310-1796","observed_orcids":["https://orcid.org/0000-0002-9310-1796"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Landers","raw_affiliation_strings":["Department of Chemistry, University of Virginia, 409 McCormick Road, Charlottesville, Virginia 22904, United States","Department of Mechanical and Aerospace Engineering, University of Virginia, 122 Engineer\u2019s Way, Charlottesville, Virginia 22904, United States","Department of Pathology, University of Virginia, 415 Lane Road, Charlottesville, Virginia 22908, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, 409 McCormick Road, Charlottesville, Virginia 22904, United States","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of Virginia, 122 Engineer\u2019s Way, Charlottesville, Virginia 22904, United States","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Pathology, University of Virginia, 415 Lane Road, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424513","display_name":"Yong Wang","orcid":"https://orcid.org/0000-0003-0448-9619","observed_orcids":["https://orcid.org/0000-0003-0448-9619"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Wang","raw_affiliation_strings":["Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Virginia, 345 Cripell Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100354497","display_name":"Xudong Joshua Li","orcid":"https://orcid.org/0000-0002-2688-740X","observed_orcids":["https://orcid.org/0000-0002-2688-740X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xudong Li","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States","Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, Virginia 22908, United States"],"raw_orcid":"https://orcid.org/0000-0002-2688-740X","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Virginia, 135 Hospital Drive, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, Virginia 22908, United States","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100354497","https://openalex.org/A5100424513"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.5162,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88557502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"4","first_page":"2041","last_page":"2051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9359999895095825},{"id":"https://openalex.org/keywords/low-back-pain","display_name":"low back pain","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nucleus-pulposus","display_name":"nucleus pulposus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/annulus-fibrosus","display_name":"annulus fibrosus","score":1.0},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.8912338614463806},{"id":"https://openalex.org/C2778051963","wikidata":"https://www.wikidata.org/wiki/Q11773731","display_name":"Degenerative disc disease","level":3,"score":0.6540553569793701},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5378773212432861},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5162872672080994},{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.5049589276313782},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4700431227684021},{"id":"https://openalex.org/C2780907711","wikidata":"https://www.wikidata.org/wiki/Q852163","display_name":"Low back pain","level":3,"score":0.46610555052757263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4279562532901764},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36980634927749634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3598572015762329},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3336185812950134},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3245154619216919},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.30066636204719543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27401983737945557},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2493642270565033},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22736996412277222},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10622382164001465},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsbiomaterials.8b01522","doi":"https://doi.org/10.1021/acsbiomaterials.8b01522","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b01522","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},{"id":"pmid:31763444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31763444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6074846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6874371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6874371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6874371","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Biomater Sci Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6074846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6874371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4635972238","display_name":null,"funder_award_id":"207\u201010\u201018","funder_id":"https://openalex.org/F4320314504","funder_display_name":"Commonwealth Health Research Board"},{"id":"https://openalex.org/G5001198520","display_name":"Treatment of disc degeneration by nano-fullerenes","funder_award_id":"R21AR057512","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5120495636","display_name":"Disc-on-a-chip: microfluidic nutrition and biomechanical loading integrated mouse disc culture system","funder_award_id":"R21AR072334","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7165290105","display_name":"Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B","funder_award_id":"R01AR064792","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8757986894","display_name":"Zeiss 780 NLO High Sensitivity Multiphoton Microscopy System","funder_award_id":"1s10od016446-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"},{"id":"https://openalex.org/F4320314504","display_name":"Commonwealth Health Research Board","ror":"https://ror.org/01x5qb890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1529713568","https://openalex.org/W1970044252","https://openalex.org/W1979264581","https://openalex.org/W1979968811","https://openalex.org/W1988649175","https://openalex.org/W1991089577","https://openalex.org/W2016447173","https://openalex.org/W2017384250","https://openalex.org/W2020009917","https://openalex.org/W2025218083","https://openalex.org/W2026757354","https://openalex.org/W2030604088","https://openalex.org/W2031979528","https://openalex.org/W2041657167","https://openalex.org/W2050274932","https://openalex.org/W2050475565","https://openalex.org/W2058794699","https://openalex.org/W2063133791","https://openalex.org/W2071206980","https://openalex.org/W2076053527","https://openalex.org/W2088272358","https://openalex.org/W2096158665","https://openalex.org/W2099323502","https://openalex.org/W2100850508","https://openalex.org/W2101158280","https://openalex.org/W2106755981","https://openalex.org/W2132841853","https://openalex.org/W2133115356","https://openalex.org/W2136186538","https://openalex.org/W2140513925","https://openalex.org/W2146758892","https://openalex.org/W2149854502","https://openalex.org/W2157132102","https://openalex.org/W2157826907","https://openalex.org/W2166727066","https://openalex.org/W2167884550","https://openalex.org/W2212247246","https://openalex.org/W2230631869","https://openalex.org/W2274033147","https://openalex.org/W2290667306","https://openalex.org/W2320117782","https://openalex.org/W2320347978","https://openalex.org/W2345658134","https://openalex.org/W2381903373","https://openalex.org/W2399355330","https://openalex.org/W2474088718","https://openalex.org/W2508473328","https://openalex.org/W2519838117","https://openalex.org/W2530603140","https://openalex.org/W2564092475","https://openalex.org/W2571546455","https://openalex.org/W2605264998","https://openalex.org/W2606788503","https://openalex.org/W2614030581","https://openalex.org/W2614894859","https://openalex.org/W2751652417","https://openalex.org/W2771242281","https://openalex.org/W2774806878","https://openalex.org/W2783632669","https://openalex.org/W2904272106","https://openalex.org/W2965659274","https://openalex.org/W4293765706"],"related_works":["https://openalex.org/W4386204419","https://openalex.org/W4388572809","https://openalex.org/W7204526281","https://openalex.org/W4376619110","https://openalex.org/W4415430406","https://openalex.org/W7162193667","https://openalex.org/W4210366630","https://openalex.org/W2606788503","https://openalex.org/W2404764145","https://openalex.org/W4391933589"],"abstract_inverted_index":{"Low":[0],"back":[1,21,26],"pain":[2,27],"is":[3,15,28,182],"the":[4,121,171],"most":[5],"common":[6],"cause":[7,18],"of":[8,19,94,174],"disability":[9],"worldwide,":[10],"and":[11,46,133,140,195],"intervertebral":[12,175],"disc":[13,44,60,72,114,176,200],"degeneration":[14],"a":[16,65,87,165,186],"major":[17,53],"low":[20,25],"pain.":[22],"Unfortunately,":[23],"discogenic":[24],"often":[29],"treated":[30],"with":[31],"symptomatic":[32],"relief":[33],"interventions,":[34],"as":[35,74],"no":[36],"disease-modifying":[37],"medications":[38],"are":[39,52],"yet":[40],"available.":[41],"Both":[42],"to-be-deciphered":[43],"biology/pathology":[45],"inadequate":[47],"in":[48,76,101,112,136,151,164,188],"vitro":[49,77,189],"research":[50,78,190],"platform":[51,181,191],"hurdles":[54],"limiting":[55],"drug":[56],"discovery":[57],"progress":[58],"for":[59,70,143,160],"degeneration.":[61,177],"Here,":[62],"we":[63],"developed":[64],"microfluidic":[66,88,122],"disc-on-a-chip":[67],"device":[68,89,105,123,157],"tailored":[69],"mouse":[71,96,117],"organ":[73,168],"an":[75],"platform.":[79],"We":[80],"hypothesize":[81],"that":[82],"continuous":[83,107],"nutrients":[84],"empowered":[85],"by":[86],"would":[90],"improve":[91],"biological":[92],"performance":[93],"cultured":[95,119],"discs":[97,118],"compared":[98,148],"to":[99,110,145,149,192,198],"those":[100,150],"static":[102,152],"condition.":[103],"This":[104,154],"permitted":[106],"media":[108],"flow":[109],"mimic":[111],"vivo":[113],"microenvironment.":[115],"Intriguingly,":[116],"on":[120],"exhibited":[124],"much":[125],"higher":[126],"cell":[127],"viability,":[128],"better":[129],"preserved":[130],"structure":[131],"integrity":[132],"anabolic-catabolic":[134],"metabolism":[135],"both":[137],"nucleus":[138],"pulposus":[139],"annulus":[141],"fibrosus,":[142],"up":[144],"21":[146],"days":[147],"culture.":[153],"first":[155],"\"disc-on-a-chip\"":[156],"lays":[158],"groundwork":[159],"future":[161],"preclinical":[162],"studies":[163],"relative":[166],"long-term":[167],"culture":[169],"given":[170],"chronic":[172],"nature":[173],"In":[178],"addition,":[179],"this":[180],"readily":[183],"transformable":[184],"into":[185],"streamlined":[187],"recapitulate":[193],"physiological":[194],"pathophysiological":[196],"microenvironment":[197],"accelerate":[199],"research.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-02T00:00:00"}
