{"id":"https://openalex.org/W2915601726","doi":"https://doi.org/10.3389/fimmu.2019.00280","title":"Studies Into \u03b2-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway","display_name":"Studies Into \u03b2-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway","publication_year":2019,"publication_date":"2019-02-26","ids":{"openalex":"https://openalex.org/W2915601726","doi":"https://doi.org/10.3389/fimmu.2019.00280","mag":"2915601726","pmid":"https://pubmed.ncbi.nlm.nih.gov/30863400","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6400144"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.00280","doi":"https://doi.org/10.3389/fimmu.2019.00280","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00280","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00280/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00280/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014980265","display_name":"Jules Petit","orcid":"https://orcid.org/0000-0003-1114-4125","observed_orcids":["https://orcid.org/0000-0003-1114-4125"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jules Petit","raw_affiliation_strings":["Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041216185","display_name":"Erin C. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin C. Bailey","raw_affiliation_strings":["Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, United States","Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, United States","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006376956","display_name":"Robert T. Wheeler","orcid":"https://orcid.org/0000-0003-3223-7021","observed_orcids":["https://orcid.org/0000-0003-3223-7021"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Wheeler","raw_affiliation_strings":["Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, United States","Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, United States","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028919791","display_name":"Carlos Alberto Ferreira de Oliveira","orcid":"https://orcid.org/0000-0002-6304-6562","observed_orcids":["https://orcid.org/0000-0002-6304-6562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos A. F. de Oliveira","raw_affiliation_strings":["Department of Research and Development, Biorigin Company, Len\u00e7\u00f3is Paulista, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development, Biorigin Company, Len\u00e7\u00f3is Paulista, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041425126","display_name":"Maria Forlenza","orcid":"https://orcid.org/0000-0001-9026-7320","observed_orcids":["https://orcid.org/0000-0001-9026-7320"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maria Forlenza","raw_affiliation_strings":["Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008535260","display_name":"Geert Frits Wiegertjes","orcid":"https://orcid.org/0000-0001-9265-3436","observed_orcids":["https://orcid.org/0000-0001-9265-3436"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Geert F. Wiegertjes","raw_affiliation_strings":["Aquaculture and Fisheries Group, Wageningen University & Research, Wageningen, Netherlands","Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aquaculture and Fisheries Group, Wageningen University & Research, Wageningen, Netherlands","institution_ids":["https://openalex.org/I913481162"]},{"raw_affiliation_string":"Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands","institution_ids":["https://openalex.org/I913481162"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008535260"],"corresponding_institution_ids":["https://openalex.org/I913481162"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.1734,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.95239707,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"10","issue":null,"first_page":"280","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-type-lectin-receptors","display_name":"C-type lectin receptors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/curdlan","display_name":"curdlan","score":0.6990000009536743},{"id":"https://openalex.org/keywords/synteny-conservation","display_name":"synteny conservation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/zebrafish-genome","display_name":"zebrafish genome","score":0.8740000128746033},{"id":"https://openalex.org/keywords/aquaculture-feed-additives","display_name":"aquaculture feed additives","score":0.6880000233650208},{"id":"https://openalex.org/keywords/fish-innate-immunity","display_name":"fish innate immunity","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C106257327","wikidata":"https://www.wikidata.org/wiki/Q24788214","display_name":"C-type lectin","level":3,"score":0.7312812805175781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6675240993499756},{"id":"https://openalex.org/C2781257293","wikidata":"https://www.wikidata.org/wiki/Q76098","display_name":"Grass carp","level":3,"score":0.6481990814208984},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6339871287345886},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.589392364025116},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5832130908966064},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5484868884086609},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5056488513946533},{"id":"https://openalex.org/C2776123893","wikidata":"https://www.wikidata.org/wiki/Q416796","display_name":"Glucan","level":2,"score":0.4932324290275574},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4662892520427704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4435787796974182},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.4428223967552185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3466659188270569},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.32073551416397095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2831087112426758},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22420024871826172},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.14425960183143616},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002347","descriptor_name":"Carps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002347","descriptor_name":"Carps","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002347","descriptor_name":"Carps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D026801","descriptor_name":"Synteny","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026801","descriptor_name":"Synteny","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029941","descriptor_name":"Fish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029941","descriptor_name":"Fish Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D029941","descriptor_name":"Fish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D047071","descriptor_name":"beta-Glucans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D047071","descriptor_name":"beta-Glucans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3389/fimmu.2019.00280","doi":"https://doi.org/10.3389/fimmu.2019.00280","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00280","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00280/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5397513","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6400144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6400144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6400144","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:30863400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30863400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/549620","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/studies-into-\u03b2-glucan-recognition-in-fish-suggests-a-key-role-for","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 1664-3224","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:doaj.org/article:afc53596e87f44299fe8c5af5044cb01","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/afc53596e87f44299fe8c5af5044cb01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/549620","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/studies-into-\u03b2-glucan-recognition-in-fish-suggests-a-key-role-for","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 10","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.00280","doi":"https://doi.org/10.3389/fimmu.2019.00280","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00280","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00280/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1978596339","display_name":"Intravital study of innate immunity to mucosal candidiasis","funder_award_id":"R15AI133415","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2620518150","display_name":null,"funder_award_id":"729.004.002","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G9000891837","display_name":"The Maine Biomedical Research Network (INBRE)","funder_award_id":"P20GM103423","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2915601726.pdf","grobid_xml":"https://content.openalex.org/works/W2915601726.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W642902308","https://openalex.org/W1131024997","https://openalex.org/W1495600965","https://openalex.org/W1644600578","https://openalex.org/W1971642906","https://openalex.org/W1973094248","https://openalex.org/W1976925504","https://openalex.org/W1981735559","https://openalex.org/W1984199556","https://openalex.org/W1985309399","https://openalex.org/W1987025222","https://openalex.org/W1988940275","https://openalex.org/W1992960705","https://openalex.org/W1998844312","https://openalex.org/W2000658504","https://openalex.org/W2004336750","https://openalex.org/W2004579562","https://openalex.org/W2010980655","https://openalex.org/W2013277175","https://openalex.org/W2024193563","https://openalex.org/W2027756598","https://openalex.org/W2027847170","https://openalex.org/W2030966943","https://openalex.org/W2038963685","https://openalex.org/W2039811087","https://openalex.org/W2039869888","https://openalex.org/W2047529289","https://openalex.org/W2050484662","https://openalex.org/W2054827887","https://openalex.org/W2056289544","https://openalex.org/W2062018285","https://openalex.org/W2066967399","https://openalex.org/W2077784238","https://openalex.org/W2087748323","https://openalex.org/W2092384509","https://openalex.org/W2097065948","https://openalex.org/W2099053491","https://openalex.org/W2107531246","https://openalex.org/W2108234281","https://openalex.org/W2113916199","https://openalex.org/W2114104545","https://openalex.org/W2125165289","https://openalex.org/W2129104462","https://openalex.org/W2130116522","https://openalex.org/W2132926880","https://openalex.org/W2133526046","https://openalex.org/W2134526812","https://openalex.org/W2139731534","https://openalex.org/W2142140715","https://openalex.org/W2148954950","https://openalex.org/W2159482845","https://openalex.org/W2160927236","https://openalex.org/W2161343783","https://openalex.org/W2179438025","https://openalex.org/W2224056471","https://openalex.org/W2288056706","https://openalex.org/W2288992930","https://openalex.org/W2345022389","https://openalex.org/W2515743109","https://openalex.org/W2528257722","https://openalex.org/W2594364105","https://openalex.org/W2769126412","https://openalex.org/W2789802325","https://openalex.org/W2799524357","https://openalex.org/W2802141100","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2959555968","https://openalex.org/W2024193563","https://openalex.org/W2179338424","https://openalex.org/W4380997539","https://openalex.org/W1995755994","https://openalex.org/W4206390634","https://openalex.org/W1964257721","https://openalex.org/W1982994377","https://openalex.org/W2133526046","https://openalex.org/W7110073618"],"abstract_inverted_index":{"Immune-modulatory":[0],"effects":[1,88,312],"of":[2,15,38,57,89,100,121,133,147,162,193,224,232,251,253,267,287,293,304,313,322,328],"\u03b2-glucans":[3,16,129,155],"are":[4],"generally":[5],"considered":[6,75],"beneficial":[7],"to":[8,27,124,246],"fish":[9,52],"health.":[10],"Despite":[11],"the":[12,20,39,46,101,105,114,183,191,219,254,262,273,285,302,329],"frequent":[13],"application":[14],"in":[17,65,80,91,206,215,236,315],"aquaculture":[18],"practice,":[19],"exact":[21],"receptors":[22],"and":[23,45],"downstream":[24],"signalling":[25,108,159,295,323],"remains":[26],"be":[28,60,95,319],"described":[29],"for":[30,49,172,185],"fish.":[31],"In":[32,51,113],"mammals,":[33],"Dectin-1":[34,58,256],"is":[35],"a":[36,76,98,157,194,202,222,242,270,288,294,320,326],"member":[37,99,327],"C-type":[40,178],"lectin":[41],"receptor":[42,48],"(CLR)":[43],"family":[44,103],"best-described":[47],"\u03b2-glucans.":[50],"genomes,":[53],"no":[54],"clear":[55],"homologue":[56],"could":[59,69,94,318],"identified":[61,168,198],"so":[62],"far.":[63],"Yet,":[64],"previous":[66],"studies":[67],"we":[68,117],"activate":[70],"carp":[71,92,123,237,316],"macrophages":[72,93,120,317],"with":[73,140,174,269,298],"curdlan,":[74],"Dectin-1-specific":[77],"\u03b2-(1,3)-glucan":[78],"ligand":[79],"mammals.":[81],"It":[82],"was":[83,258],"therefore":[84,248],"proposed":[85],"that":[86,153,310],"immune-modulatory":[87,311],"\u03b2-glucan":[90,143,187,282,307,314],"triggered":[96],"by":[97,128,260,325],"CLR":[102,107,163,299,330],"activating":[104],"classical":[106],"pathway,":[109],"different":[110,142],"from":[111],"Dectin-1.":[112],"current":[115],"study,":[116],"used":[118],"primary":[119],"common":[122],"examine":[125],"immune":[126],"modulation":[127],"using":[130],"transcriptome":[131],"analysis":[132,146,167],"RNA":[134],"isolated":[135],"six":[136,225],"hours":[137],"after":[138],"stimulation":[139],"two":[141,278],"preparations.":[144],"Pathway":[145],"differentially":[148],"expressed":[149,214],"genes":[150,170,200,227,279],"(DEGs)":[151],"showed":[152],"both":[154],"regulate":[156],"comparable":[158],"pathway":[160,296],"typical":[161,292],"activation.":[164],"Carp":[165],"genome":[166],"239":[169],"encoding":[171,201],"proteins":[173],"at":[175],"least":[176],"one":[177],"Lectin":[179],"Domains":[180],"(CTLD).":[181],"Narrowing":[182],"search":[184],"candidate":[186,281,306],"receptors,":[188,308],"based":[189],"on":[190,272],"presence":[192],"conserved":[195],"glucan-binding":[196],"motif,":[197],"13":[199],"WxH":[203],"sugar-binding":[204],"motif":[205],"their":[207],"CTLD.":[208],"These":[209],"genes,":[210],"however,":[211],"were":[212,228,234],"not":[213],"macrophages.":[216,238],"Instead,":[217],"among":[218],"\u03b2-glucan-stimulated":[220],"DEGs,":[221],"total":[223],"CTLD-encoding":[226],"significantly":[229],"regulated,":[230],"all":[231],"which":[233],"down-regulated":[235],"Several":[239],"candidates":[240],"had":[241],"protein":[243],"architecture":[244],"similar":[245],"Dectin-1,":[247],"potential":[249],"conservation":[250,266],"synteny":[252,268],"mammalian":[255],"region":[257,271],"investigated":[259],"mining":[261],"zebrafish":[263,274],"genome.":[264],"Partial":[265],"chromosome":[275],"16":[276],"highlighted":[277],"as":[280],"receptor.":[283],"Altogether,":[284],"regulation":[286],"gene":[289],"expression":[290],"profile":[291],"associated":[297],"activation":[300],"and,":[301],"identification":[303],"several":[305],"suggest":[309],"result":[321],"mediated":[324],"family.":[331]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-03-02T00:00:00"}
