{"id":"https://openalex.org/W2915097021","doi":"https://doi.org/10.1093/neuros/nyz029","title":"\u201cLiquid Biopsy\u201d of Circulating Tumor DNA Characterizes Treatment Response in Pediatric Patients Diffuse Midline Glioma","display_name":"\u201cLiquid Biopsy\u201d of Circulating Tumor DNA Characterizes Treatment Response in Pediatric Patients Diffuse Midline Glioma","publication_year":2019,"publication_date":"2019-01-27","ids":{"openalex":"https://openalex.org/W2915097021","doi":"https://doi.org/10.1093/neuros/nyz029","mag":"2915097021","pmid":"https://pubmed.ncbi.nlm.nih.gov/30793197"},"language":"en","primary_location":{"id":"doi:10.1093/neuros/nyz029","doi":"https://doi.org/10.1093/neuros/nyz029","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuros/nyz029","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033283927","display_name":"Jeffrey Isaac Traylor","orcid":"https://orcid.org/0000-0003-1749-8143","observed_orcids":["https://orcid.org/0000-0003-1749-8143"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey I Traylor","raw_affiliation_strings":["Department of Neurosurgery Dell Medical School The University of Texas at Austin Austin, Texas"],"raw_orcid":"https://orcid.org/0000-0003-1749-8143","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Dell Medical School The University of Texas at Austin Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054371127","display_name":"John S. Kuo","orcid":"https://orcid.org/0000-0001-6809-4806","observed_orcids":["https://orcid.org/0000-0001-6809-4806"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S Kuo","raw_affiliation_strings":["Department of Neurosurgery Dell Medical School The University of Texas at Austin Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Dell Medical School The University of Texas at Austin Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":0.276,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54638566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"85","issue":"2","first_page":"E167","last_page":"E168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0658000037074089,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-midline-glioma","display_name":"diffuse midline glioma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/diffuse-intrinsic-pontine-glioma","display_name":"diffuse intrinsic pontine glioma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.968999981880188},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":1.0},{"id":"https://openalex.org/keywords/h3k27m-mutation","display_name":"H3K27M mutation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pediatric-brainstem-tumors","display_name":"pediatric brainstem tumors","score":0.6850000023841858},{"id":"https://openalex.org/keywords/mutant-allele-frequency","display_name":"mutant allele frequency","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.777999997138977},{"id":"https://openalex.org/keywords/cyst-fluid","display_name":"cyst fluid","score":0.578000009059906},{"id":"https://openalex.org/keywords/droplet-digital-pcr","display_name":"droplet digital PCR","score":0.7149999737739563},{"id":"https://openalex.org/keywords/histone-mutations","display_name":"histone mutations","score":0.5410000085830688},{"id":"https://openalex.org/keywords/acvr1","display_name":"ACVR1","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pik3r1","display_name":"PIK3R1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.6949999928474426},{"id":"https://openalex.org/keywords/ppm1d","display_name":"PPM1D","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8143564462661743},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.7405090928077698},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6233383417129517},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6229934692382812},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6078959703445435},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4974499046802521},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47670289874076843},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3249165415763855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31768277287483215},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3115207254886627},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17648231983184814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0960104763507843},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuros/nyz029","doi":"https://doi.org/10.1093/neuros/nyz029","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuros/nyz029","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:30793197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30793197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2028643362","https://openalex.org/W2107381090","https://openalex.org/W2321002580","https://openalex.org/W2366536035","https://openalex.org/W2791790432","https://openalex.org/W2802016878","https://openalex.org/W2897593242"],"related_works":["https://openalex.org/W2897593242","https://openalex.org/W2997077146","https://openalex.org/W2767793536","https://openalex.org/W4389799395","https://openalex.org/W3135823466","https://openalex.org/W4388588753","https://openalex.org/W3035811149","https://openalex.org/W2809014655","https://openalex.org/W2620453004","https://openalex.org/W4241673764"],"abstract_inverted_index":{"Mostly":[0],"found":[1,361,414,505,528],"in":[2,40,76,135,162,292,300,332,340,374,415,433,444,508,598,631,660,720,729],"children,":[3],"diffuse":[4,9],"midline":[5],"gliomas":[6],"(DMG),":[7],"including":[8],"intrinsic":[10],"pontine":[11],"glioma":[12],"(DIPG),":[13],"are":[14,120,559,681,698],"aggressive":[15],"malignancies":[16],"of":[17,28,33,62,79,86,116,146,150,172,192,243,249,260,272,376,381,392,425,446,450,484,488,496,590,609,658,722],"the":[18,53,58,77,112,144,167,176,220,241,247,355,389,420,470,543,588,607,622,654,661,723],"central":[19],"nervous":[20],"system":[21],"with":[22,84,200,227,282,296,330,516,672,691],"an":[23],"associated":[24,226,281,341],"median":[25],"overall":[26,45],"survival":[27,46],"11":[29],"months.1":[30],"The":[31,285,454,473,552,711],"presence":[32],"a":[34,43,80,93,147,289,297,311,429,494,626,638,645,664,704],"histone":[35,333,364,370,595],"3":[36,365,371,596],"K27M":[37],"(H3K27M)":[38],"mutation":[39,372,640],"DMG":[41,196,328,357,532,600,632,650],"confers":[42,66],"shorter":[44],"than":[47],"H3K27M":[48,174,231,293,439],"wild-type":[49,230],"gliomas.2,3":[50],"Adding":[51],"to":[52,91,122,208,307,351,362,419,436,462,465,506,529,539,572,577,624,667,700],"therapeutic":[54,103],"challenges":[55],"for":[56,71,97,131,156,224,288,317,564,594,613,628,649,675,707],"DMG,":[57],"relatively":[59],"inaccessible":[60],"location":[61],"these":[63,136,679],"brainstem":[64],"tumors":[65],"significant":[67],"operative":[68],"risks.":[69],"Recommendations":[70],"biopsy":[72,106,315],"or":[73,717,726],"tumor":[74,99,127,152,157,187,265,277,301,421,477,485,518,540,617,651,676],"sampling":[75,416,562],"context":[78],"clinical":[81,170,283,705],"trial":[82],"along":[83,671],"interpretation":[85],"imaging":[87],"findings":[88],"is":[89,107,621],"critical":[90],"developing":[92],"differential":[94],"diagnosis":[95],"and":[96,124,129,159,169,186,206,229,251,267,275,319,336,338,347,385,407,448,480,503,548,557,576,643,694,702],"future":[98,683],"biology":[100],"insights":[101],"into":[102],"targets.4":[104],"Consequently,":[105],"rarely":[108],"performed":[109],"after":[110,511],"establishing":[111],"initial":[113],"diagnosis.":[114],"Development":[115],"noninvasive":[117],"diagnostic":[118,580,693],"techniques":[119],"needed":[121,699],"safely":[123],"accurately":[125],"establish":[126,310,701],"progression":[128],"monitor":[130],"any":[132,721],"treatment":[133,160,497,574,695],"response":[134,575],"patients.":[137,601],"Panditharatna":[138],"et":[139],"al5":[140],"recently":[141],"reported":[142,655],"on":[143,303,521],"efficacy":[145,608],"\u201cliquid":[148,591,688],"biopsy\u201d":[149,592,689],"circulating":[151],"deoxyribonucleic":[153],"acid":[154],"(ctDNA)":[155],"characterization":[158],"surveillance":[161,498,593,696],"pediatric":[163,599],"DMGs.":[164],"To":[165,309],"assess":[166,573],"feasibility":[168],"utility":[171],"measuring":[173],"mutations,":[175,322],"authors":[177,286,474,553,712],"collected":[178],"whole":[179],"blood,":[180],"cerebrospinal":[181],"fluid":[182,479],"(CSF),":[183],"cyst":[184,478],"fluid,":[185],"tissue":[188],"samples":[189,452],"from":[190,219,327],"subsets":[191],"84-enrolled":[193],"subjects":[194],"(48":[195],"patients,":[197,358],"36":[198],"controls":[199],"nonCNS":[201],"disease).":[202],"ctDNA":[203,221,274,426,440,458,467,490,525,537,566,629,659],"was":[204,217,237,441,504],"extracted":[205],"subjected":[207],"polymerase":[209],"chain":[210],"reaction":[211],"(PCR)":[212],"amplification.":[213],"Raw":[214],"spectral":[215],"data":[216,586,670],"analyzed":[218,476],"PCR":[222,325],"product":[223],"signals":[225],"mutant":[228,244,250],"alleles.":[232,254],"Mutant":[233],"allele":[234],"frequency":[235],"(MAF)":[236],"then":[238],"calculated":[239],"as":[240,493],"percentage":[242],"alleles":[245],"over":[246],"sum":[248],"wild":[252],"type":[253],"Brain":[255],"magnetic":[256],"resonance":[257],"images":[258],"(MRI)":[259],"all":[261],"enrolled":[262],"patients":[263,329,377,510],"measured":[264],"volume":[266,302],"growth.":[268],"Blinded":[269],"serial":[270],"assessments":[271],"plasma":[273,451,457,501,556],"MRI":[276,305],"measurements":[278],"were":[279,349,360,413,460,491,527],"temporally":[280],"outcomes.":[284],"assessed":[287],"50%":[290],"decrease":[291,299,507],"MAF":[294,411],"concordant":[295],"10%":[298],"postradiation":[304],"compared":[306,350,435],"baseline.":[308],"clinically":[312],"relevant":[313],"liquid":[314],"platform":[316],"detecting":[318,565],"quantifying":[320],"genomic":[321],"digital":[323],"droplet":[324],"probes":[326],"mutations":[331,339,597],"proteins":[334],"H3F3A":[335],"HIST1H3B":[337],"partner":[342],"genes":[343],"ACVR1,":[344],"PPM1D,":[345],"PIK3R1,":[346],"BRAF":[348],"control":[352],"specimens.6":[353],"Of":[354],"48":[356],"94%":[359],"have":[363,713],"mutations.":[366],"CSF":[367,393,434,447,536,558,662],"analysis":[368],"confirmed":[369,545],"status":[373],"75%":[375],"at":[378,531],"diagnosis,":[379],"67%":[380],"those":[382],"during":[383],"treatment,":[384],"90%":[386,449],"postmortem.":[387],"Although":[388],"various":[390],"locations":[391,417,563],"collection":[394],"did":[395],"not":[396],"affect":[397],"detection":[398],"(lateral":[399],"ventricles,":[400],"lumbar":[401],"spine,":[402,404],"cervical":[403],"ventriculoperitoneal":[405],"shunt,":[406],"fourth":[408],"ventricle),":[409],"higher":[410,431],"concentrations":[412,459,526,657],"adjacent":[418],"site.":[422],"A":[423],"comparison":[424],"sources":[427],"revealed":[428],"significantly":[430],"concentration":[432],"plasma,":[437],"although":[438],"successfully":[442],"detected":[443],"87%":[445],"overall.":[453],"lower":[455],"observed":[456,481,520],"thought":[461],"be":[463,570],"due":[464],"low":[466],"transfer":[468],"across":[469],"blood\u2013brain":[471],"barrier.":[472],"also":[475,569],"high":[482,656],"enrichment":[483],"DNA.":[486],"Levels":[487],"detectable":[489],"investigated":[492],"method":[495,627,648,690],"by":[499,546],"analyzing":[500],"longitudinally":[502],"DIPG":[509],"radiotherapy.":[512],"This":[513,582],"finding":[514],"correlated":[515],"decreased":[517],"volumes":[519],"follow-up":[522],"imaging.":[523],"Further,":[524],"increase":[530],"progression,":[533],"however,":[534],"only":[535],"corresponded":[538],"spread":[541],"beyond":[542],"pons,":[544],"MRIs":[547],"postmortem":[549],"histopathologic":[550],"review.":[551],"concluded":[554],"that":[555],"both":[560],"suitable":[561],"which":[567],"can":[568],"utilized":[571],"supplement":[578],"other":[579],"modalities.":[581],"study":[583,620],"provides":[584,644],"preliminary":[585],"supporting":[587],"use":[589],"Though":[602,678],"previous":[603],"research":[604],"has":[605],"demonstrated":[606],"minimally":[610],"invasive":[611,647],"methods":[612],"obtaining":[614],"primary":[615],"brain":[616],"material,":[618],"this":[619,635,687,708,730],"first":[623],"describe":[625],"quantification":[630],"patients.7":[633],"Specifically,":[634],"technique":[636],"detects":[637],"particular":[639],"influencing":[641],"prognosis":[642],"less":[646],"characterization.":[652],"Additionally,":[653],"indicates":[663],"potential":[665],"opportunity":[666],"collect":[668],"additional":[669],"standard":[673],"biopsies":[674],"tissue.":[677],"results":[680],"promising,":[682],"prospective":[684],"studies":[685],"comparing":[686],"conventional":[692],"strategies":[697],"validate":[703],"role":[706],"technique.":[709],"Disclosures":[710],"no":[714],"personal,":[715],"financial,":[716],"institutional":[718],"interest":[719],"drugs,":[724],"materials,":[725],"devices":[727],"described":[728],"article.":[731]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2019-03-02T00:00:00"}