{"id":"https://openalex.org/W2915074445","doi":"https://doi.org/10.18632/aging.101803","title":"Towards a more precise and individualized assessment of breast cancer risk","display_name":"Towards a more precise and individualized assessment of breast cancer risk","publication_year":2019,"publication_date":"2019-02-20","ids":{"openalex":"https://openalex.org/W2915074445","doi":"https://doi.org/10.18632/aging.101803","mag":"2915074445","pmid":"https://pubmed.ncbi.nlm.nih.gov/30787204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6402518"},"language":"en","primary_location":{"id":"doi:10.18632/aging.101803","doi":"https://doi.org/10.18632/aging.101803","is_oa":false,"landing_page_url":"https://doi.org/10.18632/aging.101803","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6402518","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013149664","display_name":"Marie E. Wood","orcid":"https://orcid.org/0000-0002-6053-7200","observed_orcids":["https://orcid.org/0000-0002-6053-7200"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marie E. Wood","raw_affiliation_strings":["Division of Hematology and Oncology, The Robert Larner MD College of Medicine, University of Vermont Medical Center, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, The Robert Larner MD College of Medicine, University of Vermont Medical Center, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I2801980284"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072484706","display_name":"Nicholas H. Farina","orcid":"https://orcid.org/0000-0002-6061-590X","observed_orcids":["https://orcid.org/0000-0002-6061-590X"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas H. Farina","raw_affiliation_strings":["Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079241058","display_name":"Thomas Patrick Ahern","orcid":"https://orcid.org/0000-0003-0440-8727","observed_orcids":["https://orcid.org/0000-0003-0440-8727"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Ahern","raw_affiliation_strings":["Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","Department of Surgery, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Surgery, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038861632","display_name":"Melissa E. Cuke","orcid":"https://orcid.org/0000-0002-6258-8415","observed_orcids":["https://orcid.org/0000-0002-6258-8415"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa E. Cuke","raw_affiliation_strings":["Division of Hematology and Oncology, The Robert Larner MD College of Medicine, University of Vermont Medical Center, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, The Robert Larner MD College of Medicine, University of Vermont Medical Center, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I2801980284"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet L. Stein","raw_affiliation_strings":["Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103217263","display_name":"Gary S. Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary S. Stein","raw_affiliation_strings":["Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","Department of Surgery, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Surgery, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031362021","display_name":"Jane B. Lian","orcid":"https://orcid.org/0000-0001-8683-9138","observed_orcids":["https://orcid.org/0000-0001-8683-9138"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane B. Lian","raw_affiliation_strings":["Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, and The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013149664"],"corresponding_institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"],"apc_list":null,"apc_paid":null,"fwci":1.2044,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76731317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"1305","last_page":"1316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk-prediction","display_name":"breast cancer risk prediction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/personalized-risk-prediction","display_name":"personalized risk prediction","score":0.8489999771118164},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.8849999904632568},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9779999852180481},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.8999999761581421},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8399999737739563},{"id":"https://openalex.org/keywords/high-risk-women","display_name":"high-risk women","score":0.781000018119812},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8930000066757202},{"id":"https://openalex.org/keywords/overtreatment-avoidance","display_name":"overtreatment avoidance","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7386795282363892},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.7326894998550415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5817270874977112},{"id":"https://openalex.org/C150241267","wikidata":"https://www.wikidata.org/wiki/Q7336285","display_name":"Risk management tools","level":3,"score":0.43158721923828125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42703476548194885},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37284767627716064},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33264821767807007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2757919430732727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13238641619682312},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13035589456558228},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.18632/aging.101803","doi":"https://doi.org/10.18632/aging.101803","is_oa":false,"landing_page_url":"https://doi.org/10.18632/aging.101803","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5395522","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6402518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6402518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6402518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:30787204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30787204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5395522","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6402518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1050675488","display_name":"Vermont Breast Cancer Molecular Characterization Laboratory","funder_award_id":"U01CA196383","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4837097260","display_name":"Nuclear Structure and Gene Expression","funder_award_id":"P01CA082834","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8908234354","display_name":"Vermont Center on Behavior and Health","funder_award_id":"P20GM103644","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000859308","display_name":"Northern New England Clinical and Translational Research Network","funder_award_id":"U54GM115516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W1497253532","https://openalex.org/W1766127718","https://openalex.org/W1868757306","https://openalex.org/W1889489351","https://openalex.org/W1930449581","https://openalex.org/W1939801702","https://openalex.org/W1959917743","https://openalex.org/W1964814553","https://openalex.org/W1968981131","https://openalex.org/W1977768811","https://openalex.org/W1978532948","https://openalex.org/W1980540383","https://openalex.org/W1981678006","https://openalex.org/W1987915768","https://openalex.org/W1993013702","https://openalex.org/W1993850432","https://openalex.org/W1995388182","https://openalex.org/W1996415723","https://openalex.org/W2002715948","https://openalex.org/W2003206209","https://openalex.org/W2007498093","https://openalex.org/W2008945738","https://openalex.org/W2010517573","https://openalex.org/W2013840898","https://openalex.org/W2017219619","https://openalex.org/W2021066073","https://openalex.org/W2026866676","https://openalex.org/W2028647698","https://openalex.org/W2032696674","https://openalex.org/W2045733577","https://openalex.org/W2048984063","https://openalex.org/W2050148284","https://openalex.org/W2053258918","https://openalex.org/W2056893663","https://openalex.org/W2057752054","https://openalex.org/W2059534464","https://openalex.org/W2065658468","https://openalex.org/W2068187102","https://openalex.org/W2071572959","https://openalex.org/W2071601608","https://openalex.org/W2089155477","https://openalex.org/W2092913756","https://openalex.org/W2094077020","https://openalex.org/W2097233439","https://openalex.org/W2098433299","https://openalex.org/W2099644906","https://openalex.org/W2101457306","https://openalex.org/W2101699473","https://openalex.org/W2102311474","https://openalex.org/W2107458416","https://openalex.org/W2109227959","https://openalex.org/W2109535392","https://openalex.org/W2110073356","https://openalex.org/W2110467884","https://openalex.org/W2110485192","https://openalex.org/W2111061352","https://openalex.org/W2111198437","https://openalex.org/W2111663113","https://openalex.org/W2111784232","https://openalex.org/W2115093090","https://openalex.org/W2119043140","https://openalex.org/W2120004516","https://openalex.org/W2121548996","https://openalex.org/W2123704562","https://openalex.org/W2124033868","https://openalex.org/W2125481183","https://openalex.org/W2127098343","https://openalex.org/W2127165438","https://openalex.org/W2130388134","https://openalex.org/W2132055476","https://openalex.org/W2132086691","https://openalex.org/W2132763951","https://openalex.org/W2135665336","https://openalex.org/W2137839901","https://openalex.org/W2140245250","https://openalex.org/W2142011430","https://openalex.org/W2147464456","https://openalex.org/W2151187882","https://openalex.org/W2151744107","https://openalex.org/W2155329254","https://openalex.org/W2157156146","https://openalex.org/W2161827216","https://openalex.org/W2162307063","https://openalex.org/W2165516672","https://openalex.org/W2165664908","https://openalex.org/W2169031112","https://openalex.org/W2170740525","https://openalex.org/W2171076100","https://openalex.org/W2182350758","https://openalex.org/W2182602105","https://openalex.org/W2188748308","https://openalex.org/W2215553937","https://openalex.org/W2269179103","https://openalex.org/W2283566542","https://openalex.org/W2305003128","https://openalex.org/W2329116257","https://openalex.org/W2331692487","https://openalex.org/W2381489064","https://openalex.org/W2409971582","https://openalex.org/W2513145707","https://openalex.org/W2516720184","https://openalex.org/W2521569068","https://openalex.org/W2551243656","https://openalex.org/W2557885933","https://openalex.org/W2565784393","https://openalex.org/W2573962702","https://openalex.org/W2580193500","https://openalex.org/W2609963726","https://openalex.org/W2627871710","https://openalex.org/W2769401095","https://openalex.org/W2790162132","https://openalex.org/W2809546220","https://openalex.org/W2889646458","https://openalex.org/W4237330003"],"related_works":["https://openalex.org/W4392925727","https://openalex.org/W4313898012","https://openalex.org/W2967735181","https://openalex.org/W4415279070","https://openalex.org/W4410818645","https://openalex.org/W3060187452","https://openalex.org/W4388633479","https://openalex.org/W2587966923","https://openalex.org/W2513145707","https://openalex.org/W3132437054"],"abstract_inverted_index":{"Many":[0],"clinically":[1,124],"based":[2,127],"models":[3,13,51],"are":[4,14],"available":[5],"for":[6,34,196],"breast":[7,75,145,180],"cancer":[8,76,146],"risk":[9,38,49,58,80,99,163,169,177,189],"assessment;":[10],"however,":[11,103],"these":[12],"not":[15],"particularly":[16],"useful":[17],"at":[18,175,187],"the":[19,159,192],"individual":[20],"level,":[21],"despite":[22],"being":[23],"designed":[24],"with":[25,74],"that":[26],"intent.":[27],"There":[28],"is,":[29],"therefore,":[30],"a":[31,95,139,148],"significant":[32],"need":[33],"improved,":[35],"precise":[36],"individualized":[37],"assessment.":[39],"In":[40],"this":[41,90],"Research":[42],"Perspective,":[43],"we":[44],"highlight":[45],"commonly":[46],"used":[47],"clinical":[48],"assessment":[50,59,100,164,170],"and":[52,78,108,190],"recent":[53],"scientific":[54],"advances":[55],"to":[56,97],"individualize":[57],"using":[60,89],"precision":[61],"biomarkers.":[62],"Genome-wide":[63],"association":[64],"studies":[65],"have":[66,83],"identified":[67,138],">100":[68],"single":[69],"nucleotide":[70],"polymorphisms":[71],"(SNPs)":[72],"associated":[73],"risk,":[77],"polygenic":[79],"scores":[81],"(PRS)":[82],"been":[84,157],"developed":[85],"by":[86],"several":[87],"groups":[88],"information.":[91],"The":[92],"ability":[93],"of":[94,117,131,143,151,161,178,185],"PRS":[96],"improve":[98],"is":[101,112],"promising;":[102],"validation":[104],"in":[105,147],"both":[106],"genetically":[107],"ethnically":[109],"diverse":[110],"populations":[111],"needed.":[113],"Additionally,":[114],"novel":[115],"classes":[116],"biomarkers,":[118],"such":[119],"as":[120],"microRNAs,":[121],"may":[122],"capture":[123],"relevant":[125],"information":[126],"on":[128],"epigenetic":[129],"regulation":[130],"gene":[132],"expression.":[133],"Our":[134],"group":[135],"has":[136,156],"recently":[137],"circulating-microRNA":[140],"signature":[141],"predictive":[142],"long-term":[144],"prospective":[149],"cohort":[150],"high-risk":[152],"women.":[153],"While":[154],"progress":[155],"made,":[158],"importance":[160],"accurate":[162],"cannot":[165],"be":[166],"understated.":[167],"Precision":[168],"will":[171],"identify":[172],"those":[173],"women":[174,186],"greatest":[176],"developing":[179],"cancer,":[181],"thus":[182],"avoiding":[183],"overtreatment":[184],"average":[188],"identifying":[191],"most":[193],"appropriate":[194],"candidates":[195],"chemoprevention":[197],"or":[198],"surgical":[199],"prevention.":[200]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-03-02T00:00:00"}
