{"id":"https://openalex.org/W2914845720","doi":"https://doi.org/10.1371/journal.pone.0210995","title":"Circulating microRNA and automated motion analysis as novel methods of assessing chemotherapy-induced peripheral neuropathy in mice","display_name":"Circulating microRNA and automated motion analysis as novel methods of assessing chemotherapy-induced peripheral neuropathy in mice","publication_year":2019,"publication_date":"2019-01-24","ids":{"openalex":"https://openalex.org/W2914845720","doi":"https://doi.org/10.1371/journal.pone.0210995","mag":"2914845720","pmid":"https://pubmed.ncbi.nlm.nih.gov/30677061","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6345499"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0210995","doi":"https://doi.org/10.1371/journal.pone.0210995","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0210995","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0210995&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0210995&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qinghai Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinghai Peng","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082184731","display_name":"Jordan Mechanic","orcid":"https://orcid.org/0000-0002-3303-5571","observed_orcids":["https://orcid.org/0000-0002-3303-5571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan Mechanic","raw_affiliation_strings":["Vium Inc., Milpitas, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vium Inc., Milpitas, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111965972","display_name":"Ahmed M. Shoieb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Shoieb","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001203583","display_name":"Ingrid D. R. Pardo","orcid":"https://orcid.org/0000-0002-3517-3804","observed_orcids":["https://orcid.org/0000-0002-3517-3804"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingrid D. Pardo","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074993188","display_name":"Laura R. Schaevitz","orcid":"https://orcid.org/0000-0002-1591-381X","observed_orcids":["https://orcid.org/0000-0002-1591-381X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Schaevitz","raw_affiliation_strings":["Vium Inc., Milpitas, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vium Inc., Milpitas, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008503743","display_name":"Judith E. Fenyk-Melody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Fenyk-Melody","raw_affiliation_strings":["Comparative Medicine, Pfizer Worldwide Research & Development, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine, Pfizer Worldwide Research & Development, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073257913","display_name":"Allison Vitsky","orcid":"https://orcid.org/0000-0001-6888-789X","observed_orcids":["https://orcid.org/0000-0001-6888-789X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Vitsky","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075929229","display_name":"Magalie Boucher","orcid":"https://orcid.org/0009-0008-6293-6775","observed_orcids":["https://orcid.org/0009-0008-6293-6775","https://orcid.org/0000-0001-9935-5749"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magalie Boucher","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111704015","display_name":"Chris J. Somps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Somps","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090619825","display_name":"Jon C. Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon C. Cook","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047111166","display_name":"Chang\u2010Ning Liu","orcid":"https://orcid.org/0000-0002-2094-1401","observed_orcids":["https://orcid.org/0000-0002-2094-1401"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chang-Ning Liu","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2094-1401","affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut, United States of America","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047111166"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":1595,"currency":"USD","value_usd":1595},"apc_paid":{"value":1595,"currency":"USD","value_usd":1595},"fwci":1.6405,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.84978438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"e0210995","last_page":"e0210995"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":1.0},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mir-183","display_name":"miR-183","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mir-338","display_name":"miR-338","score":1.0},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7229999899864197},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.9769999980926514},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cold-allodynia","display_name":"cold allodynia","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7642918825149536},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.7381032705307007},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5365808606147766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5305626392364502},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42394310235977173},{"id":"https://openalex.org/C2779289229","wikidata":"https://www.wikidata.org/wiki/Q17153857","display_name":"Chemotherapy-induced peripheral neuropathy","level":4,"score":0.42163601517677307},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33953478932380676},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32105553150177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2820335924625397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2525903284549713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17174097895622253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12281712889671326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06919226050376892},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074166","descriptor_name":"Circulating MicroRNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074166","descriptor_name":"Circulating MicroRNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000074166","descriptor_name":"Circulating MicroRNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0210995","doi":"https://doi.org/10.1371/journal.pone.0210995","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0210995","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0210995&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5339306","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6345499","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6345499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6345499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:30677061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30677061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8f47c27734024cfcbad2fc27965351b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f47c27734024cfcbad2fc27965351b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 14, Iss 1, p e0210995 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7626152","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Circulating_microRNA_and_automated_motion_analysis_as_novel_methods_of_assessing_chemotherapy-induced_peripheral_neuropathy_in_mice/7626152","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0210995","doi":"https://doi.org/10.1371/journal.pone.0210995","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0210995","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0210995&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914845720.pdf","grobid_xml":"https://content.openalex.org/works/W2914845720.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1541012296","https://openalex.org/W1573473244","https://openalex.org/W1641859816","https://openalex.org/W1925972401","https://openalex.org/W1967377184","https://openalex.org/W1968322192","https://openalex.org/W1972122283","https://openalex.org/W1972446498","https://openalex.org/W1975784041","https://openalex.org/W1977642249","https://openalex.org/W1980897034","https://openalex.org/W1983077857","https://openalex.org/W1984732914","https://openalex.org/W1985498551","https://openalex.org/W1989745698","https://openalex.org/W1992977276","https://openalex.org/W1999136348","https://openalex.org/W2004637463","https://openalex.org/W2005721871","https://openalex.org/W2006210070","https://openalex.org/W2010077275","https://openalex.org/W2014004239","https://openalex.org/W2019164555","https://openalex.org/W2025574029","https://openalex.org/W2027263159","https://openalex.org/W2027584400","https://openalex.org/W2028993619","https://openalex.org/W2030491451","https://openalex.org/W2034580378","https://openalex.org/W2040848336","https://openalex.org/W2043760959","https://openalex.org/W2047592132","https://openalex.org/W2052895610","https://openalex.org/W2057710964","https://openalex.org/W2063653640","https://openalex.org/W2064869544","https://openalex.org/W2070546766","https://openalex.org/W2081971402","https://openalex.org/W2085103168","https://openalex.org/W2090715929","https://openalex.org/W2090998770","https://openalex.org/W2092800391","https://openalex.org/W2108549903","https://openalex.org/W2127283537","https://openalex.org/W2131762605","https://openalex.org/W2141505882","https://openalex.org/W2146911993","https://openalex.org/W2170259378","https://openalex.org/W2344203686","https://openalex.org/W2461115222","https://openalex.org/W2473398027","https://openalex.org/W2537586856","https://openalex.org/W2620036274","https://openalex.org/W2749722475","https://openalex.org/W2766640281","https://openalex.org/W2769588922","https://openalex.org/W4232160789","https://openalex.org/W4243057745"],"related_works":["https://openalex.org/W7154948567","https://openalex.org/W4205706173","https://openalex.org/W4293714554","https://openalex.org/W2999006388","https://openalex.org/W4417152421","https://openalex.org/W4408514623","https://openalex.org/W2749722475","https://openalex.org/W4283320457","https://openalex.org/W3130583556","https://openalex.org/W3011246460"],"abstract_inverted_index":{"Chemotherapy-induced":[0],"peripheral":[1,233],"neuropathy":[2],"(CiPN)":[3],"is":[4],"a":[5,61,67],"serious":[6],"adverse":[7],"effect":[8],"in":[9,16,60,172,182,207,213,218],"the":[10,49,88,94,148,195],"clinic,":[11],"but":[12],"nonclinical":[13],"assessment":[14],"methods":[15],"animal":[17],"studies":[18],"are":[19,221],"limited":[20],"to":[21],"labor":[22],"intensive":[23],"behavioral":[24,37,81],"tests":[25,82],"or":[26,106,121],"semi-quantitative":[27],"microscopic":[28,85],"evaluation.":[29],"Hence,":[30],"microRNA":[31],"(miRNA)":[32],"biomarkers":[33],"and":[34,58,74,83,93,132,160,166,179,185,216,236],"automated":[35],"in-life":[36,80],"tracking":[38],"were":[39,97,136],"assessed":[40],"for":[41,117,125,144,194],"their":[42],"utility":[43],"as":[44],"non-invasive":[45],"methods.":[46],"To":[47],"address":[48],"lack":[50],"of":[51,87,119],"diagnostic":[52],"biomarkers,":[53],"we":[54],"explored":[55],"miR-124,":[56],"miR-183":[57],"miR-338":[59],"CiPN":[62,239],"model":[63],"induced":[64],"by":[65,129],"paclitaxel,":[66],"well-known":[68],"neurotoxic":[69],"agent.":[70],"In":[71],"addition,":[72],"conventional":[73],"Vium's":[75],"innovative":[76],"Digital":[77],"Vivarium":[78],"technology-based":[79],"postmortem":[84],"examination":[86],"dorsal":[89],"root":[90],"ganglion":[91],"(DRG)":[92],"sciatic":[95,133,186],"nerve":[96,134,234],"performed.":[98],"Terminal":[99],"blood":[100],"was":[101,112,154,201],"collected":[102,137],"on":[103,141,163],"days":[104],"8":[105,165],"16,":[107,168],"after":[108],"20":[109],"mg/kg":[110],"paclitaxel":[111],"administered":[113],"every":[114],"other":[115],"day":[116,142,164,167],"total":[118],"4":[120],"7":[122],"doses,":[123],"respectively,":[124],"plasma":[126],"miRNA":[127,145],"quantification":[128],"RT-qPCR.":[130],"DRG":[131,184],"samples":[135],"from":[138],"mice":[139],"sacrificed":[140],"16":[143],"quantification.":[146],"Among":[147],"three":[149],"miRNAs":[150],"analyzed,":[151],"only":[152],"miR-124":[153,174,215],"statistically":[155],"significantly":[156,202],"increased":[157],"(5":[158],"fold":[159,162],"10":[161],"respectively).":[169],"The":[170],"increase":[171,212],"circulating":[173,214],"correlated":[175],"with":[176],"cold":[177],"allodynia":[178],"axonal":[180],"degeneration":[181],"both":[183,211],"nerve.":[187],"Automated":[188],"home":[189],"cage":[190],"motion":[191,200,220],"analysis":[192],"revealed":[193],"first":[196],"time":[197],"that":[198],"nighttime":[199,219],"decreased":[203],"(P":[204],"<":[205],"0.05)":[206],"paclitaxel-dosed":[208],"animals.":[209],"Although":[210],"decrease":[217],"compelling,":[222],"our":[223],"results":[224],"provide":[225],"positive":[226],"evidence":[227],"warranting":[228],"further":[229],"testing":[230],"using":[231],"additional":[232],"toxicants":[235],"diverse":[237],"experimental":[238],"models.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-02-21T00:00:00"}